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公开(公告)号：US20110166438A1
公开(公告)日：2011-07-07
申请号：US12896733
申请日：2010-10-01
CPC分类号： A61B5/0051 , G01R33/4814
摘要： An Electro-Magnetic Imaging (EMAI) System is presented. EMAI systems can include induction elements (e.g., an induction coil) configured to induce a target tissue to generate internally sourced ultrasounds. The induction elements can be shielded by one or more shielding elements to shape, or otherwise alter, an imaging field while attenuating radiated fields in a far zone. EMAI systems can further include a shield tuner to adjust shield parameters to achieved desired imaging or radiated field properties. A shielding element can be placed approximately one induction coil radius away from the coil to achieve suitably strong imaging field magnitudes while also achieving suitably weak radiated field magnitudes in a far zone. In some embodiments, acoustic sensors lack substantial shielding from the fields generated by the induction elements.
摘要翻译： 介绍了电磁成像（EMAI）系统。 EMAI系统可以包括被配置为诱导靶组织以产生内部来源的超声波的感应元件（例如感应线圈）。 感应元件可以被一个或多个屏蔽元件屏蔽，以形成或以其它方式改变成像场，同时衰减远区中的辐射场。 EMAI系统还可以包括屏蔽调谐器来调节屏蔽参数以实现期望的成像或辐射场特性。 屏蔽元件可以放置在大约一个感应线圈半径远离线圈，以实现适当强的成像磁场强度，同时在远区域也实现适当的弱辐射场强。 在一些实施例中，声传感器缺少与感应元件产生的场的实质屏蔽。
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公开(公告)号：US07122008B2
公开(公告)日：2006-10-17
申请号：US10934843
申请日：2004-09-03
IPC分类号： A61B5/02
CPC分类号： A61B5/0205 , A61B5/022 , A61B5/024
摘要： A medical diagnostic method using systolic and diastolic blood pressures, and pulse frequency of a patient is provided to compute a normalized diastolic distensibility value and a normalized peripheral resistance value, and to automatically compute the product of the normalized diastolic distensibility value and the normalized peripheral resistance value to generate a first product value. The first product value is compared to a stored distribution of normalized diastolic distensibility and a normalized peripheral resistance values for comparable individuals to determine if the first product value is equivalent to a value determined to indicate an abnormal condition. Particular values of the computed parameters aid in determining the etiology of hypertension and direct selection of pharmacotherapy.
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公开(公告)号：US06974415B2
公开(公告)日：2005-12-13
申请号：US10444202
申请日：2003-05-22
申请人： Stephen Anthony Cerwin , David B. Chang , James E. Drummond , Jane F. Emerson , Stuart McNaughton
发明人： Stephen Anthony Cerwin , David B. Chang , James E. Drummond , Jane F. Emerson , Stuart McNaughton
CPC分类号： A61B5/416 , A61B5/0073 , A61B5/0095 , A61B8/13
摘要： Ultrasound induced by RF irradiation within FDA exposure limits is produced with sufficient signal-to-noise ratio to allow acquisition of sub-millimeter resolution images within practical time frames.
摘要翻译： 在FDA暴露极限内通过RF照射引起的超声波产生具有足够的信噪比，以允许在实际时间范围内采集亚毫米分辨率图像。
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公开(公告)号：US06535625B1
公开(公告)日：2003-03-18
申请号：US09405236
申请日：1999-09-24
IPC分类号： G06K900
CPC分类号： A61B5/416 , A61B5/05 , A61B5/0536 , A61B8/08 , G01R33/56308 , G01S7/52017 , G01S7/52034
摘要： An apparatus having a coil of wire, energized by a repetitively pulsed radio frequency (RF) power source to provide electromagnetic fields to a region within a body. A scanning, directional hydrophone acoustically connected to the body, samples ultrasonic radiation generated by the RF fields at the RF frequency or twice the RF frequency induced from conductive spots. Signals from the hydrophone are analyzed with regard to their time of arrival relative to the RF pulses and with respect to their direction of arrival. These collected data are recorded and displayed as images of the spots within the region.
摘要翻译： 一种具有线圈的装置，其由重复脉冲射频（RF）电源激励，以向身体内的区域提供电磁场。 声学连接到身体的扫描定向水听器采样RF频率产生的超声波辐射，或从导电点引起的RF频率的两倍。 关于来自水听器的信号关于它们相对于RF脉冲的到达时间以及相对于它们的到达方向进行分析。 这些收集的数据被记录并显示为该区域内的斑点的图像。
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公开(公告)号：US06463202B1
公开(公告)日：2002-10-08
申请号：US09591084
申请日：2000-06-09
申请人： Stephen A. Cerwin , David B. Chang
发明人： Stephen A. Cerwin , David B. Chang
IPC分类号： G02B610
CPC分类号： G02B6/125 , G02B6/02 , G02B2006/12119
摘要： A waveguide designed to minimize bend-induced losses. The waveguide has three regions of varying indices of refraction. The indices of refraction are chosen so that the field is a trigonometric function in the core region, evanescent in the intermediate region, and trigonometric again in the outer region. The widths of each region are calculated to further reduce losses.
摘要翻译： 设计用于最小化弯曲损耗的波导。 波导具有不同折射率的三个区域。 选择折射率使得该场是核心区域中的三角函数，在中间区域中消逝，并且再次在外部区域中进行三角函数。 计算每个区域的宽度以进一步减少损失。
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公开(公告)号：US06495819B1
公开(公告)日：2002-12-17
申请号：US09634553
申请日：2000-08-08
申请人： Stephen A. Cerwin , David B. Chang
发明人： Stephen A. Cerwin , David B. Chang
IPC分类号： G01J400
CPC分类号： G01B11/161
摘要： A method of two interferometric configurations to measure bending of an extended element. The measurement arm of each configuration is a long optical fiber. A first interferometric configuration has a segment of its measurement arm attached to one side of the element. The second interferometric configuration has a segment of its measurement arm attached to one side of the element and another segment of its measurement arm attached to an opposing side of the element. The two configurations are used to obtain two sets of interference fringe measurement values. If one set is subtracted from the other, the result is intensity differential values that indicate only the effects of bending and not of temperature or pressure. Variations of the method can be used for irregularly shaped elements.
摘要翻译： 一种用于测量延伸元件的弯曲的两种干涉测量配置的方法。 每个配置的测量臂是长光纤。 第一干涉配置具有连接到元件一侧的其测量臂的一段。 第二干涉结构具有附接到元件的一侧的其测量臂的一部分，并且其测量臂的另一段附接到元件的相对侧。 这两种配置用于获得两组干涉条纹测量值。 如果从另一组中减去一组，则结果是仅指示弯曲效果而不是温度或压力的强度差异值。 该方法的变化可用于不规则形状的元件。
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公开(公告)号：US07372031B2
公开(公告)日：2008-05-13
申请号：US11384574
申请日：2006-03-20
申请人： Stephen A. Cerwin , David B. Chang
发明人： Stephen A. Cerwin , David B. Chang
IPC分类号： G01J1/00
CPC分类号： G01J1/42 , G01J1/02 , G01J1/0295 , G01J1/04 , G01J1/0422 , G01J1/044 , G01J1/0459
摘要： A sensitive photon detection system generates an electronic photon sensor signal as a K factor times a number N photons per unit time. The system is configured by combining a separate optical amplifier with a gain factor K1 with a photo detector with a gain factor K2 such that K may be realized as the product of K1 and K2. The values of K1 and K2 are chosen to meet a predetermined K while optimizing a signal quality of the photon sensor signal. The optical amplifier may be preceded by a photon gathering device and/or a light chopping device to further optimize system performance. Further, the photon sensor signal may be further processed analog circuitry or may be digitized and processed using digital signal processing to generate an enhanced photon sensor signal with enhanced signal quality by adding gain and/or bandwidth limiting.
摘要翻译： 敏感光子检测系统产生电子光子传感器信号作为每单位时间数N个光子的K因子。 该系统通过将具有增益因子K 1的单独光学放大器与增益因子K 2的光电检测器组合，使得可以实现K作为K 1和K 2的乘积来配置该系统。 选择K 1和K 2的值以在优化光子传感器信号的信号质量的同时满足预定的K。 光放大器之前可以有光子收集装置和/或光斩波装置，以进一步优化系统性能。 此外，光子传感器信号可以进一步处理模拟电路，或者可以使用数字信号处理进行数字化和处理，以通过增加增益和/或带宽限制来产生增强的信号质量的增强的光子传感器信号。
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8.发明申请Micro-Vesicles Providing Contrast To Target Tissue Electrical Property Gradients 审中-公开提供与目标组织电性能梯度对比的微囊泡公开(公告)号：US20120134924A1
公开(公告)日：2012-05-31
申请号：US12956519
申请日：2010-11-30
申请人： Stephen Anthony Cerwin , Jane F. Emerson , David B. Chang , Martin Fessenmaier , Nicholas J. Witchey
发明人： Stephen Anthony Cerwin , Jane F. Emerson , David B. Chang , Martin Fessenmaier , Nicholas J. Witchey
IPC分类号： A61K49/00
CPC分类号： A61K41/0028
摘要： Micro-vesicles that become acoustically sensitive in the presence of a Radio Frequency (RF) Electromagnetic (EM) field are presented. The micro-vesicles can comprise a main body having one or more affinity ligands configured to preferentially bind to a target tissue. Once bound, the micro-vesicles and the target tissue can be bathed in an RF EM field, which induces the target tissue or micro-vesicles to generate an acoustic signal. The micro-vesicles can also become receptive to acoustic energy. An acoustic therapeutic signal can be directed toward the target tissue and micro-vesicles, which causes therapeutic excitation of the micro-vesicles. The therapeutic excitation can include heating the target tissue, releasing a drug formulation, or other excitation. The disclosed techniques can be used with a high degree of precision to activate micro-vesicles local to the target tissue.
摘要翻译： 提出了在存在射频（RF）电磁场的情况下变得声学敏感的微囊泡。 微囊泡可以包含具有配体优先结合靶组织的一种或多种亲和配体的主体。 一旦结合，微囊泡和目标组织可以沐浴在RF EM场中，其诱导靶组织或微囊泡产生声信号。 微囊泡也可以接受声能。 声学治疗信号可以被引向目标组织和微泡，这引起微泡的治疗激发。 治疗激发可以包括加热靶组织，释放药物制剂或其它激发。 可以高度精确地使用所公开的技术以激活靶组织局部的微小囊泡。
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公开(公告)号：US20110288411A1
公开(公告)日：2011-11-24
申请号：US12913586
申请日：2010-10-27
CPC分类号： A61B8/08 , A61B8/4472 , A61B8/463 , A61B8/466 , A61B8/483 , A61B8/5223
摘要： A multi-mode Electro-Magnetic Acoustic Imaging (EMAI) system is disclosed. The EMAI system utilizes an electromagnetic energy source to induce multiple acoustic signals in surrounding objects including a target tissue area or a transducer. The induced acoustic signals can be collected and converted to imaging data, which can be used to display a tissue area image. The collected acoustic signals can be filtered or isolated based on one or more signal proprieties including frequency. A signal's frequency can indicate a property of the target tissue including the tissue's conductivity or its density.
摘要翻译： 公开了一种多模式电磁成像（EMAI）系统。 EMAI系统利用电磁能量来引导包括目标组织区域或换能器在内的周围物体中的多个声学信号。 感应的声信号可以被收集并转换成成像数据，其可用于显示组织区域图像。 所收集的声信号可以基于包括频率在内的一个或多个信号特性进行滤波或隔离。 信号的频率可以指示包括组织的电导率或其密度的目标组织的性质。
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公开(公告)号：US4792683A
公开(公告)日：1988-12-20
申请号：US4009
申请日：1987-01-16
CPC分类号： G01N25/72
摘要： A system for inspecting the electronic integrity of solder joints by repetitive pulse-heating the solder joints with radiant energy and determining the temperature oscillation of pulse-heated solder joints by measuring the infrared emissions from the solder joints during heating and non-heating periods. Advantageously, the exposed solder joints of a circuit board can be tested all at one time by pulse-heating the entire circuit board. The temperature oscillation of each joint can be compared to the temperature oscillations of corresponding standard solder joints of known good electronic integrity on properly operating boards.
摘要翻译： 用于通过用辐射能重复脉冲加热焊点并确定脉冲加热焊点的温度振荡来测量加热和非加热期间焊点的红外发射，来检测焊点的电子完整性的系统。 有利地，可以通过脉冲加热整个电路板来一次性地测试电路板的暴露的焊点。 可以将每个接头的温度振荡与正确操作的板上的已知良好电子完整性的相应标准焊点的温度振荡进行比较。
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