公开(公告)号：US08055716B2

公开(公告)日：2011-11-08

申请号：US11550973

申请日：2006-10-19

申请人： Janet Morgan ,  Johnny M. Shieh

发明人： Janet Morgan ,  Johnny M. Shieh

IPC分类号： G06F15/16

CPC分类号： G06Q10/107 ,  H04L51/14 ,  H04L51/28

摘要： Mail aliases are dynamically created in response to replies of an electronic mail (e-mail) communication. An e-mail communication is sent to a plurality of recipients, and one or more recipients of the e-mail communication respond to the e-mail. In response to receiving the replies, one or more mail aliases are automatically created.

摘要翻译： 邮件别名是为响应电子邮件（电子邮件）通信的回复动态创建的。 电子邮件通信被发送到多个接收者，并且电子邮件通信的一个或多个接收者响应该电子邮件。 响应收到回复，会自动创建一个或多个邮件别名。

公开(公告)号：US20080098069A1

公开(公告)日：2008-04-24

申请号：US11550973

申请日：2006-10-19

申请人： Janet Morgan ,  Johnny M. Shieh

发明人： Janet Morgan ,  Johnny M. Shieh

IPC分类号： G06F15/16

CPC分类号： G06Q10/107 ,  H04L51/14 ,  H04L51/28

摘要： Mail aliases are dynamically created in response to replies of an electronic mail (e-mail) communication. An e-mail communication is sent to a plurality of recipients, and one or more recipients of the e-mail communication respond to the e-mail. In response to receiving the replies, one or more mail aliases are automatically created.

摘要翻译： 邮件别名是为响应电子邮件（电子邮件）通信的回复而动态创建的。 电子邮件通信被发送到多个接收者，并且电子邮件通信的一个或多个接收者响应该电子邮件。 响应收到回复，会自动创建一个或多个邮件别名。

公开(公告)号：US20050284167A1

公开(公告)日：2005-12-29

申请号：US11150909

申请日：2005-06-13

申请人： Michael Morgan ,  Janet Morgan

发明人： Michael Morgan ,  Janet Morgan

IPC分类号： B01D5/00 ,  F24F5/00 ,  F24F13/22 ,  F25D3/02 ,  F25D21/00 ,  F25D21/14

CPC分类号： B01D5/009 ,  F24F5/0096 ,  F24F13/222 ,  Y02A20/109 ,  Y02B10/50

摘要： A portable, combination dehydrator, dry return air and condensed water generator/dispenser configured to alternately provide water from a reservoir of condensed water or from an alternative source of water. In one embodiment, the alternative source comprises a five-gallon bottle of water and the mounting for the bottle includes a removable cover for preventing contamination of the system when the bottle is not in place. In one embodiment, the system provides purified dry make-up air to a home or office air conditioning system and dehydration cabinet, while producing pure atmospheric condensation from humidity found in the air and purifying the air and water for breathing, dispensing and drinking purposes.

摘要翻译： 便携式组合脱水机，干式回风和冷凝水发生器/分配器，其配置为交替地从冷凝水的储存器或来自替代的水源提供水。 在一个实施例中，替代源包括五加仑瓶的水，并且用于瓶的安装件包括可移除的盖，用于在瓶不在适当位置时防止系统的污染。 在一个实施例中，系统向家庭或办公室空调系统和脱水柜提供净化的干燥补充空气，同时从空气中发现的湿度产生纯净的大气冷凝，并净化空气和水以进行呼吸，分配和饮用。

公开(公告)号：US08679459B2

公开(公告)日：2014-03-25

申请号：US12918238

申请日：2009-02-19

申请人： Ravindra K. Pandey ,  Chao Liu ,  Mahabeer Dobhal ,  William Potter ,  Janet Morgan ,  Stephanie Pincus

发明人： Ravindra K. Pandey ,  Chao Liu ,  Mahabeer Dobhal ,  William Potter ,  Janet Morgan ,  Allan Oseroff

IPC分类号： A61B5/055 ,  C07B47/00 ,  C07D487/22

CPC分类号： C07D487/22

摘要： Tetrapyrrolic photosensitizers and imaging agent compounds having A, B, C, and D rings and having a reduced B ring and an oxidized D ring. The compounds preferably have a purity of at least 95 percent and preferably have a fused system connected at an unsaturated carbon atom of the C ring nearest the D ring and at the unsaturated carbon atom between the C and D rings. The invention also includes a method of making the compounds at over 95 percent yield by starting with a B and D ring oxidized tetrapyrollic compound and dissolving it in a halogenated hydrocarbon solvent and treating it with sufficient nitroalkane solution of FeCl36H2O to oxidize the D ring and separating the resulting organic layer and drying.

摘要翻译： 具有A，B，C和D环的四吡咯类光敏剂和成像剂化合物，并具有还原的B环和氧化的D环。 化合物优选具有至少95％的纯度，并且优选具有在C环的最接近D环的不饱和碳原子和C和D环之间的不饱和碳原子连接的稠合体系。 本发明还包括通过用B和D环氧化的四元醇化合物开始制备化合物百分之九十五以上的方法，并将其溶解在卤代烃溶剂中，并用足够的FeCl 3·6H 2 O的硝基烷烃溶液处理以氧化D环并分离 所得有机层并干燥。

公开(公告)号：US20050160620A1

公开(公告)日：2005-07-28

申请号：US10508105

申请日：2003-03-11

申请人： Michael Morgan ,  Janet Morgan

发明人： Michael Morgan ,  Janet Morgan

IPC分类号： F25C1/10 ,  F26B9/06 ,  F26B21/00 ,  F26B21/08 ,  F26B3/00

CPC分类号： F26B9/066 ,  F25C1/10 ,  F26B21/001 ,  F26B21/086

摘要： A portable, atmospheric dehydrator and water condenser (110) for dehydrating fruits and vegetables while producing pure atmospheric condensation from humidity found in the air and purifying the water for dispensing and drinking purposes.

摘要翻译： 一种便携式，大气脱水器和水冷凝器（110），用于使水果和蔬菜脱水，同时从空气中发现的湿度产生纯净的大气冷凝，并净化用于分配和饮用的水。

公开(公告)号：US20110288234A1

公开(公告)日：2011-11-24

申请号：US12918232

申请日：2009-02-19

申请人： Ravindra K. Pandey ,  Lalit N. Goswami ,  Allan Oseroff ,  Stephanie Pincus ,  Janet Morgan ,  Paras N. Prasad ,  Earl J. Bergey

发明人： Ravindra K. Pandey ,  Lalit N. Goswami ,  Allan Oseroff ,  Stephanie Pincus ,  Janet Morgan ,  Paras N. Prasad ,  Earl J. Bergey

IPC分类号： C08G77/38 ,  C08F130/08 ,  C08G77/388 ,  B82Y5/00

CPC分类号： A61K49/0032 ,  A61K41/0071 ,  A61K49/0093 ,  A61K51/1255

摘要： A nanoparticle including a polysiloxane base having an exterior surface and having a photosensitizer at least partly exposed at its exterior surface, said photosensitizer being secured to the exterior surface by loading the photosensitizer onto the surface after formation of the polysiloxane base of the nanoparticle. The nanoparticle may have tumor targeting moieties and may be post loaded with cyanine dye. The nanoparticle preferably includes post loaded moieties providing at least two of tumor specificity, photodynamic properties and imaging capabilities and the photosensitizer is tagged with a radioisotope. A method for preparation of the nanoparticle is also provided.

摘要翻译： 包含具有外表面并具有至少部分地在其外表面暴露的光敏剂的聚硅氧烷基的纳米颗粒，所述光敏剂通过在形成纳米颗粒的聚硅氧烷基体之后将光敏剂加载到表面上而固定到外表面。 纳米颗粒可以具有肿瘤靶向部分，并且可以用花青染料后载。 纳米颗粒优选包括提供肿瘤特异性，光动力学特性和成像能力的至少两种的后加载部分，并且用放射性同位素标记光敏剂。 还提供了制备纳米颗粒的方法。

公开(公告)号：US20100256136A1

公开(公告)日：2010-10-07

申请号：US12309028

申请日：2007-06-29

申请人： Ravindra K. Pandey ,  Allan Oseroff ,  Stephanie Pincus ,  Janet Morgan ,  Xiang Zheng ,  Weiguo Liu

发明人： Ravindra K. Pandey ,  Allan Oseroff ,  Stephanie Pincus ,  Janet Morgan ,  Xiang Zheng ,  Weiguo Liu

IPC分类号： A61K31/5377 ,  A61K31/517 ,  A61K31/506 ,  A61K31/4045 ,  A61K31/409 ,  A61P35/00

CPC分类号： A61K31/409 ,  A61K41/0061 ,  A61K41/0071

摘要： A method for treating hyperproliferative tissue in a mammal which tissue expresses ABCG2 including the steps of: a) systemically introducing from about 100 to about 1000 mg/kg of body weight of a tyrosine kinase inhibiting compound into the mammal; b) within from about 0.5 to about 24 hours after the introducing in step a) systemically introducing from about 0.05 to about 0.5 μmol per kilogram of body weight of a tumor avid photosensitizing compound, that acts as a substrate for ABC family transport protein, ABCG2 and that has a preferential light absorbance frequency; and c) exposing the hyperproliferative tissue to light at a fluence of from about 50 to about 150 J/cm2 delivered at a rate of from about 5 to about 25 mW/cm2 at the light absorbance frequency. The photosensitizing compound is preferably a tetrapyrollic photosensitizer compound where the tetrapyrollic compound is a chlorin, bacteriochlorin, porphyrin, pheophorbide including pyropheophorbides, purpurinimide, or bacteriopurpurinimide and derivatives thereof; provided that, the photosensizing compound is not a meso-tetra (3-hydroxyphenyl) derivative, is not a saccharide derivative and is not a hematoporphyrin.

摘要翻译： 一种用于治疗组织表达ABCG2的哺乳动物的过度增殖组织的方法，包括以下步骤：a）将约100至约1000mg / kg体重的酪氨酸激酶抑制化合物全身引入哺乳动物; b）在步骤a）中引入后约0.5至约24小时内，全身引入约0.05至约0.5μmol/千克体重的肿瘤avid光敏化合物，其作为ABC家族转运蛋白ABCG2的底物 并具有优先吸光度频率; 和c）以约5至约25mW / cm 2的速率在吸光度频率下以约50至约150J / cm 2的流量通量使过度增殖组织曝光。 光敏化合物优选为四级光敏剂化合物，其中四味化合物是二氢卟酚，细菌二氢卟酚，卟啉，含有偏高双歧杆菌，嘌呤酰亚胺或嘌呤嘌呤酰亚胺及其衍生物的脱镁叶绿素; 光敏化合物不是内消旋 - 四（3-羟基苯基）衍生物，不是糖衍生物，不是血卟啉。

公开(公告)号：US20070175063A1

公开(公告)日：2007-08-02

申请号：US11346110

申请日：2006-02-02

申请人： Michael Morgan ,  Janet Morgan

发明人： Michael Morgan ,  Janet Morgan

IPC分类号： F25D17/06 ,  F26B3/00

CPC分类号： F26B21/086 ,  F26B21/001

摘要： A portable, combination dehydrator, dry return air and condensed water generator/dispenser configured to reduce the humidity in a dry storage unit. In one embodiment, a system draws intake air from the dry storage unit across the condenser of a heat exchanger and condenses water from the air, collecting the water in a storage tank. The dried return air is ducted into the dry storage unit. In one embodiment, the source of the intake air may be selected from either the dry storage unit or an alternative source (e.g., outside air.) The selection of the intake air source may be based on the humidity of the air (e.g., if the humidity of the air in the dry storage unit is above a threshold, the dry storage unit is selected.) If both of the alternate sources of intake air have humidities below a threshold level, operation of the system may be suspended.

摘要翻译： 便携式组合脱水器，干式回风和冷凝水发生器/分配器，配置为减少干燥存储单元中的湿度。 在一个实施例中，系统从干燥储存单元抽取来自热交换器的冷凝器的进气，并将来自空气的水汇集在储存罐中。 干燥的返回空气被导入干燥储存单元。 在一个实施例中，进气的源可以选自干燥储存单元或替代源（例如，外部空气）。进气空气源的选择可以基于空气的湿度（例如，如果 干燥存储单元中的空气的湿度高于阈值，则选择干燥储存单元。）如果两个替代的进气源具有低于阈值水平的湿度，则系统的操作可能被暂停。

公开(公告)号：US06799317B1

公开(公告)日：2004-09-28

申请号：US09604310

申请日：2000-06-27

申请人： Patricia E. Heywood ,  Su-Hsuan Huang ,  Janet Morgan ,  William G. Tuel, Jr.

发明人： Patricia E. Heywood ,  Su-Hsuan Huang ,  Janet Morgan ,  William G. Tuel, Jr.

IPC分类号： G06F300

CPC分类号： G06F9/544 ,  G06F9/4812

摘要： A method for transparently handling messages originating from local shared memory and from an external source. A device driver allows the local sender to identify and wake up a waiting receiver task thread, simulating a packet arrival hardware interrupt. Upon awakening, the receiver task thread examines both shared memory and hardware message queues. The method can use a software routine that simulates handling of an occurrence of a hardware interrupt. The method invokes a local notify system service module that passes a window number identifying a receiving task. The method invokes a wake thread module that passes awakens a thread associated with the window number, and examines the shared memory buffer for receipt of the local source message. The method then copies the local source message from the shared memory buffer to the receiving task.

摘要翻译： 一种透明地处理源自本地共享内存和来自外部源的消息的方法。 设备驱动程序允许本地发送方识别和唤醒等待的接收者任务线程，模拟数据包到达硬件中断。 唤醒后，接收者任务线程检查共享内存和硬件消息队列。 该方法可以使用模拟处理硬件中断发生的软件程序。 该方法调用传递标识接收任务的窗口号的本地通知系统服务模块。 该方法调用唤醒线程模块，该模块通过唤醒与窗口号相关联的线程，并检查共享内存缓冲区以接收本地源消息。 该方法然后将本地源消息从共享内存缓冲区复制到接收任务。

公开(公告)号：US20110264027A1

公开(公告)日：2011-10-27

申请号：US12918238

申请日：2009-02-19

申请人： Ravindra K. Pandey ,  Chao Liu ,  Mahabeer Dobhal ,  William Potter ,  Janet Morgan ,  Allan Oseroff ,  Stephanie Pincus

发明人： Ravindra K. Pandey ,  Chao Liu ,  Mahabeer Dobhal ,  William Potter ,  Janet Morgan ,  Allan Oseroff ,  Stephanie Pincus

IPC分类号： A61N5/00 ,  A61P35/00 ,  A61K51/04 ,  A61K49/00 ,  C07D487/22 ,  A61K49/04

CPC分类号： C07D487/22

摘要： Tetrapyrollic photosensitizers and imaging agent compounds having A, B, C, and D rings and having a reduced B ring and an oxidized D ring. The compounds preferably have a purity of at least 95 percent and preferably have a fused system connected at an unsaturated carbon atom of the C ring nearest the D ring and at the unsaturated carbon atom between the C and D rings. The invention also includes a method of making the compounds at over 95 percent yield by starting with a B and D ring oxidized tetrapyrollic compound and dissolving it in a halogenated hydrocarbon solvent and treating it with sufficient nitroalkane solution of FeCl3.6H2O to oxidize the D ring and separating the resulting organic layer and drying.

摘要翻译： 具有A，B，C和D环并且具有还原的B环和氧化的D环的四味光敏剂和显影剂化合物。 化合物优选具有至少95％的纯度，并且优选具有在C环的最接近D环的不饱和碳原子和C和D环之间的不饱和碳原子连接的稠合体系。 本发明还包括一种通过用B和D环氧化的四羰基化合物开始制备化合物超过95％的方法，并将其溶解在卤代烃溶剂中并用足量的FeCl 3·6H 2 O的硝基烷烃溶液处理以氧化D环 并分离得到的有机层并干燥。