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    Amino acid sequences for controlling pathogens
    1.
    发明授权
    Amino acid sequences for controlling pathogens 有权
    用于控制病原体的氨基酸序列

    公开(公告)号：US09549978B2

    公开(公告)日：2017-01-24

    申请号：US14346562

    申请日：2012-10-01

    申请人： Jannel Acosta Alba ,  Mario Pablo Estrada Garcia

    发明人： Jannel Acosta Alba ,  Mario Pablo Estrada Garcia

    IPC分类号： C07K14/47 ,  A61K39/39 ,  C07K14/46 ,  A61K38/00

    CPC分类号： A61K39/39 ,  A23K20/147 ,  A61K38/00 ,  C07K14/461

    摘要： The present invention relates to antimicrobial peptides, isolated and purified from extracts of tilapia (Oreochromis niloticus) gills. Such peptides may be produced by chemical synthesis or by expression in heterologous systems, such as bacteria and yeasts, by conventional molecular biology techniques. These peptides show antimicrobial activity against various organisms, including Gram positive bacteria, Gram negative bacteria, fungi and viruses. The invention also includes compositions for controlling pathogens comprising these antimicrobial peptides. The use of such peptides in vaccine preparations, as molecular adjuvants, is also part of the invention.

    摘要翻译： 本发明涉及从罗非鱼（Oreochromis niloticus）鳃提取物中分离和纯化的抗微生物肽。 这样的肽可以通过化学合成或通过常规分子生物学技术在异源系统如细菌和酵母中表达产生。 这些肽显示出对各种生物体的抗菌活性，包括革兰氏阳性菌，革兰氏阴性菌，真菌和病毒。 本发明还包括用于控制包含这些抗微生物肽的病原体的组合物。 疫苗制剂中作为分子佐剂使用这些肽也是本发明的一部分。

    AMINO ACID SEQUENCES FOR CONTROLLING PATHOGENS
    2.
    发明申请
    AMINO ACID SEQUENCES FOR CONTROLLING PATHOGENS 有权
    氨基酸序列用于控制病原体

    公开(公告)号：US20140294871A1

    公开(公告)日：2014-10-02

    申请号：US14346562

    申请日：2012-10-01

    申请人： Jannel Acosta Alba ,  Mario Pablo Estrada Garcia

    发明人： Jannel Acosta Alba ,  Mario Pablo Estrada Garcia

    IPC分类号： A61K39/39 ,  A23K1/16 ,  C07K14/46

    CPC分类号： A61K39/39 ,  A23K20/147 ,  A61K38/00 ,  C07K14/461

    摘要： The present invention relates to antimicrobial peptides, isolated and purified from extracts of tilapia (Oreochromis niloticus) gills. Such peptides may be produced by chemical synthesis or by expression in heterologous systems, such as bacteria and yeasts, by conventional molecular biology techniques. These peptides show antimicrobial activity against various organisms, including Gram positive bacteria, Gram negative bacteria, fungi and viruses. The invention also includes compositions to for controlling pathogens comprising these antimicrobial peptides. The use of such peptides in vaccine preparations, as molecular adjuvants, is also part of the invention.

    摘要翻译： 本发明涉及从罗非鱼（Oreochromis niloticus）鳃提取物中分离和纯化的抗微生物肽。 这样的肽可以通过化学合成或通过常规分子生物学技术在异源系统如细菌和酵母中表达产生。 这些肽显示出对各种生物体的抗菌活性，包括革兰氏阳性菌，革兰氏阴性菌，真菌和病毒。 本发明还包括用于控制包含这些抗微生物肽的病原体的组合物。 疫苗制剂中作为分子佐剂使用这些肽也是本发明的一部分。

    Vaccine composition for controlling ectoparasite infestations
    7.
    发明授权
    Vaccine composition for controlling ectoparasite infestations 有权
    用于控制外寄生虫感染的疫苗组合物

    公开(公告)号：US09085634B2

    公开(公告)日：2015-07-21

    申请号：US13825892

    申请日：2011-09-26

    申请人： Alina Rodriguez Mallon ,  Erlinda Fernández Díaz ,  Mario Pablo Estrada Garcia ,  Yamila Carpio González

    发明人： Alina Rodriguez Mallon ,  Erlinda Fernández Díaz ,  Mario Pablo Estrada Garcia ,  Yamila Carpio González

    IPC分类号： A61K39/00 ,  A61K39/002 ,  A61K39/385 ,  C07K14/435

    CPC分类号： C07K14/43509 ,  A61K39/0003 ,  C07K14/43527

    摘要： The present invention relates to the use of a peptide of P0 ribosomal protein in the manufacture of a vaccine composition to control of ectoparasite infestations and therefore the transmission of their associated pathogens. This peptide is located between 267 and 301 amino acids of the P0 protein, and can be obtained by recombinant means or by chemical synthesis. This peptide can be fused to a carrier protein or peptide, or an immuno-carrier and be included in an oily formulation. The formulations comprising the peptide vaccine confer protection against ticks and ectoparasites known as “sea lice” without generating autoimmunity in the host organism. Among these ticks may be mentioned species as Rhipicephalus microplus, Rhipicephalus sanguineus and Ixodes scapularis, and between sea lice are those of the Caligus and Lepeophtheirus genera.

    摘要翻译： 本发明涉及P0核糖体蛋白的肽在制造疫苗组合物中用于控制外寄生虫感染和因此传播其相关病原体的用途。 该肽位于P0蛋白的267和301个氨基酸之间，可以通过重组方法或通过化学合成获得。 该肽可以与载体蛋白或肽或免疫载体融合并包含在油性制剂中。 包含肽疫苗的制剂赋予对称为“海虱”的蜱和外寄生物的保护，而不在宿主生物体中产生自身免疫。 在这些蜱中，可以列举物种如红R属（Rhipicephalus microplus），R，属（Rhipicephalus sanguineus）和sc and属（Ixodes scopularis），海虱属Caligus和Lepeophtheirus属。

    VACCINE COMPOSITION FOR CONTROLLING ECTOPARASITE INFESTATIONS
    9.
    发明申请
    VACCINE COMPOSITION FOR CONTROLLING ECTOPARASITE INFESTATIONS 有权
    用于控制ECTOPARASITE INFESTATIONS的疫苗组合物

    公开(公告)号：US20130273095A1

    公开(公告)日：2013-10-17

    申请号：US13825892

    申请日：2011-09-26

    申请人： Alina Rodriguez Mallon ,  Erlinda Fernández Díaz ,  Mario Pablo Estrada Garcia ,  Yamila Carpio González

    发明人： Alina Rodriguez Mallon ,  Erlinda Fernández Díaz ,  Mario Pablo Estrada Garcia ,  Yamila Carpio González

    IPC分类号： C07K14/435 ,  A61K39/00

    CPC分类号： C07K14/43509 ,  A61K39/0003 ,  C07K14/43527

    摘要： The present invention relates to the use of a peptide of P0 ribosomal protein in the manufacture of a vaccine composition to control of ectoparasite infestations and therefore the transmission of their associated pathogens. This peptide is located between 267 and 301 amino acids of the P0 protein, and can be obtained by recombinant means or by chemical synthesis. This peptide can be fused to a carrier protein or peptide, or an immuno-carrier and be included in an oily formulation. The formulations comprising the peptide vaccine confer protection against ticks and ectoparasites known as “sea lice” without generating autoimmunity in the host organism. Among these ticks may be mentioned species as Rhipicephalus microplus, Rhipicephalus sanguineus and Ixodes scapularis, and between sea lice are those of the Caligus and Lepeophtheirus genera.

    摘要翻译： 本发明涉及P0核糖体蛋白的肽在制造疫苗组合物中用于控制外寄生虫感染和因此传播其相关病原体的用途。 该肽位于P0蛋白的267和301个氨基酸之间，可以通过重组方法或通过化学合成获得。 该肽可以与载体蛋白或肽或免疫载体融合并包含在油性制剂中。 包含肽疫苗的制剂赋予对称为“海虱”的蜱和外寄生物的保护，而不在宿主生物体中产生自身免疫。 在这些蜱中，可以列举物种如红R属（Rhipicephalus microplus），R，属（Rhipicephalus sanguineus）和sc and属（Ixodes scopularis），海虱属Caligus和Lepeophtheirus属。