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公开(公告)号：US09549977B2
公开(公告)日：2017-01-24
申请号：US14238377
申请日：2012-08-24
IPC分类号： A61K39/39 , A61K39/002 , A61K39/12 , A61K39/205 , A61K39/00 , A61K39/02
CPC分类号： A61K39/39 , A61K39/0003 , A61K39/002 , A61K39/0208 , A61K39/12 , A61K39/205 , A61K2039/53 , A61K2039/552 , A61K2039/55516 , A61K2039/55566 , A61K2039/6031 , C12N2720/10034 , C12N2760/20034 , C12N2770/24334
摘要： The present invention relates to the use of the pituitary adenylate cyclase activating peptide (PACAP) as a molecular adjuvant for vaccines. Among other applications, these vaccines may be used in the protection against infectious agents such as viruses, bacteria and ectoparasites affecting mammals, birds and aquatic organisms. The PACAP, combined with a particular antigen, demonstrates its effectiveness as adjuvant increasing the host immune response against that antigen. This type of response can be observed when the vaccine compositions or combinations that include PACAP are administered orally, by injection, or by immersion baths, in case of aquatic organisms.
摘要翻译： 本发明涉及垂体腺苷酸环化酶活化肽（PACAP）作为疫苗的分子佐剂的用途。 除其他应用之外，这些疫苗可用于防止感染性物质的侵害，例如影响哺乳动物，鸟类和水生生物的病毒，细菌和外寄生虫。 与特定抗原结合的PACAP证明其作为佐剂增加针对该抗原的宿主免疫应答的有效性。 当在水生生物的情况下，当疫苗组合物或包含PACAP的组合在口服，注射或浸泡浴中进行给药时，可以观察到这种反应。
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公开(公告)号：US07919463B2
公开(公告)日：2011-04-05
申请号：US11989088
申请日：2006-06-23
申请人： Jannel Acosta Alba , Mario Pablo Estrada Garcia , Yamila Carpio Gonzalez , Reynold Morales Fernandez
发明人： Jannel Acosta Alba , Mario Pablo Estrada Garcia , Yamila Carpio Gonzalez , Reynold Morales Fernandez
CPC分类号： C07K14/61 , A23K20/147 , A23K50/80 , C07K14/461 , C12N15/81
摘要： The present invention is related to polypeptides derived from tilapia growth hormone.
摘要翻译： 本发明涉及来源于罗非鱼生长激素的多肽。
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公开(公告)号：US09034338B2
公开(公告)日：2015-05-19
申请号：US12601974
申请日：2008-05-30
IPC分类号： A61K39/395 , A61K39/00 , A61K39/38 , C07K1/00 , C07K14/00 , C07K17/00 , C07H21/02 , C07H21/04 , C07K14/435 , A23K1/18 , A61K38/00
CPC分类号： A61K39/0003 , A23K50/80 , A61K38/00 , A61K39/00 , A61K2039/53 , A61K2039/54 , A61K2039/552 , C07K14/43509 , C07K2319/00
摘要： The present invention is related with the isolation and cloning of a new gene, the production of the protein encoded by this gene by using recombinant systems, and the use of this antigen in a vaccine formulation as a purified protein and/or naked DNA, to induce an immune response in aquatic organisms against different ectoparasite species, including the known as sea lice, and pathogens associated with these infestations. The vaccine preparations, administered by oral route, immersion bath or injection, demonstrated its efficacy by producing IgM humoral immune response and reducing the number of parasites per fish in the vaccinated fishes.
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4.发明申请Nucleic Acid and Amino Acid Sequences, and Vaccine for the Control of Ectoparasite Infestations in Fish 有权核酸和氨基酸序列，以及用于控制鱼类外寄生虫感染的疫苗公开(公告)号：US20100221271A1
公开(公告)日：2010-09-02
申请号：US12601974
申请日：2008-05-30
CPC分类号： A61K39/0003 , A23K50/80 , A61K38/00 , A61K39/00 , A61K2039/53 , A61K2039/54 , A61K2039/552 , C07K14/43509 , C07K2319/00
摘要： The present invention is related with the isolation and cloning of a new gene, the production of the protein encoded by this gene by using recombinant systems, and the use of this antigen in a vaccine formulation as a purified protein and/or naked DNA, to induce an immune response in aquatic organisms against different ectoparasite species, including the known as sea lice, and pathogens associated with these infestations. The vaccine preparations, administered by oral route, immersion bath or injection, demonstrated its efficacy by producing IgM humoral immune response and reducing the number of parasites per fish in the vaccinated fishes.
摘要翻译： 本发明涉及新基因的分离和克隆，通过使用重组系统产生由该基因编码的蛋白质，以及将该抗原在疫苗制剂中用作纯化的蛋白质和/或裸DNA， 在水生生物中诱导针对不同外寄生物种的免疫应答，包括已知的海虱和与这些侵染有关的病原体。 通过口服途径，浸浴或注射给药的疫苗制剂通过产生IgM体液免疫应答并减少接种的鱼类中每条鱼的寄生虫数量来证明其功效。
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5.发明授权公开(公告)号：US09119830B2
公开(公告)日：2015-09-01
申请号：US13989921
申请日：2011-11-30
申请人： Mario Pablo Estrada Garcia , Juna Maria Lugo Gonzalez , Yamila Carpio Gonzalez , Carolina Tafalla Piñeiro
发明人： Mario Pablo Estrada Garcia , Juna Maria Lugo Gonzalez , Yamila Carpio Gonzalez , Carolina Tafalla Piñeiro
IPC分类号： A61K9/08 , A61K31/7056 , A61K38/22 , A61K9/00 , A61K9/51
CPC分类号： A61K38/2278 , A61K9/0019 , A61K9/0056 , A61K9/08 , A61K9/5153 , A61K31/7056 , A61K38/22 , A61K2300/00
摘要： The present invention relates to the use of pituitary adenylate cyclase activating polypeptide (PACAP) in the treatment of viral diseases and infectious diseases caused by viruses in aquatic organisms. PACAP, alone or combined with an antiviral molecule, demonstrated its effectiveness by increasing the survival of fish or crustaceans infected by viruses when it was administered orally, by injection or by immersion baths. Furthermore, it was observed that treated organisms keep or increase its weight as compared to infected and non-treated organisms. PACAP or PACAP-containing combinations decreased the viral load in tissues and organs susceptible to viral infections as it was determined by RT-PCR.
摘要翻译： 本发明涉及垂体腺苷酸环化酶活化多肽（PACAP）用于治疗由水生生物体中的病毒引起的病毒性疾病和感染性疾病的用途。 单独或与抗病毒分子组合的PACAP通过口服，注射或浸浴进行口服，通过增加感染病毒的鱼或甲壳类动物的存活来证明其有效性。 此外，观察到与感染和未处理的生物体相比，被处理的生物体保持或增加其重量。 含PACAP或含PACAP的组合降低了病毒感染的组织和器官中的病毒载量，如通过RT-PCR确定的。
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公开(公告)号：US20090176703A1
公开(公告)日：2009-07-09
申请号：US12094339
申请日：2006-11-20
申请人： Juana Maria Lugo Gonzalez , Mario Pablo Estrada Garcia , Alina Rodriguez Mallon , Yamila Carpio Gonzalez , Antonio Morales Rojas , Osmany Rodrigo Gonzalez De Sosa , Reynold Morales Fernandez , Fidel Francisco Herrera Miyares
发明人： Juana Maria Lugo Gonzalez , Mario Pablo Estrada Garcia , Alina Rodriguez Mallon , Yamila Carpio Gonzalez , Antonio Morales Rojas , Osmany Rodrigo Gonzalez De Sosa , Reynold Morales Fernandez , Fidel Francisco Herrera Miyares
CPC分类号： A61K38/17 , A01K61/80 , A23K20/147 , A23K50/80 , C07K14/57563 , Y02A40/845
摘要： The present invention is related to the use of variants of the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) to stimulate the growth and to improve the immunological system of aquatic organisms. The variants of the peptide were provided by immersion, injection or as a food additive.
摘要翻译： 本发明涉及使用垂体腺苷酸环化酶活化多肽（PACAP）的变体来刺激生长并改善水生生物的免疫系统。 通过浸渍，注射或作为食品添加剂提供肽的变体。
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7.发明申请公开(公告)号：US20140087998A1
公开(公告)日：2014-03-27
申请号：US13989921
申请日：2011-11-30
申请人： Mario Pablo Estrada Garcia , Juana Maria Lugo Gonzalez , Yamila Carpio Gonzalez , Carolina Tafalla Piñeiro
发明人： Mario Pablo Estrada Garcia , Juana Maria Lugo Gonzalez , Yamila Carpio Gonzalez , Carolina Tafalla Piñeiro
IPC分类号： A61K38/22 , A61K31/7056
CPC分类号： A61K38/2278 , A61K9/0019 , A61K9/0056 , A61K9/08 , A61K9/5153 , A61K31/7056 , A61K38/22 , A61K2300/00
摘要： The present invention relates to the use of pituitary adenylate cyclase activating polypeptide (PACAP) in the treatment of viral diseases and infectious diseases caused by viruses in aquatic organisms. PACAP, alone or combined with an antiviral molecule, demonstrated its effectiveness by increasing the survival of fish or crustaceans infected by viruses when it was administered orally, by injection or by immersion baths. Furthermore, it was observed that treated organisms keep or increase its weight as compared to infected and non-treated organisms. PACAP or PACAP-containing combinations decreased the viral load in tissues and organs susceptible to viral infections as it was determined by RT-PCR.
摘要翻译： 本发明涉及垂体腺苷酸环化酶活化多肽（PACAP）用于治疗由水生生物体中的病毒引起的病毒性疾病和感染性疾病的用途。 单独或与抗病毒分子组合的PACAP通过口服，注射或浸浴进行口服，通过增加感染病毒的鱼或甲壳类动物的存活来证明其有效性。 此外，观察到与感染和未处理的生物体相比，被处理的生物体保持或增加其重量。 含PACAP或含PACAP的组合降低了病毒感染的组织和器官中的病毒载量，如通过RT-PCR确定的。
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公开(公告)号：US08833306B2
公开(公告)日：2014-09-16
申请号：US12094339
申请日：2006-11-20
申请人： Juana Maria Lugo González , Mario Pablo Estrada Garcia , Alina Rodriguez Mallon , Yamila Carpio González , Antonio Morales Rojas , Osmany Rodrigo González De Sosa , Reynold Morales Fernández , Fidel Francisco Herrera Miyares
发明人： Juana Maria Lugo González , Mario Pablo Estrada Garcia , Alina Rodriguez Mallon , Yamila Carpio González , Antonio Morales Rojas , Osmany Rodrigo González De Sosa , Reynold Morales Fernández , Fidel Francisco Herrera Miyares
CPC分类号： A61K38/17 , A01K61/80 , A23K20/147 , A23K50/80 , C07K14/57563 , Y02A40/845
摘要： The present invention is related to the use of variants of the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) to stimulate the growth and to improve the immunological system of aquatic organisms. The variants of the peptide were provided by immersion, injection or as a food additive.
摘要翻译： 本发明涉及使用垂体腺苷酸环化酶活化多肽（PACAP）的变体来刺激生长并改善水生生物的免疫系统。 通过浸渍，注射或作为食品添加剂提供肽的变体。
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公开(公告)号：US20140294871A1
公开(公告)日：2014-10-02
申请号：US14346562
申请日：2012-10-01
CPC分类号： A61K39/39 , A23K20/147 , A61K38/00 , C07K14/461
摘要： The present invention relates to antimicrobial peptides, isolated and purified from extracts of tilapia (Oreochromis niloticus) gills. Such peptides may be produced by chemical synthesis or by expression in heterologous systems, such as bacteria and yeasts, by conventional molecular biology techniques. These peptides show antimicrobial activity against various organisms, including Gram positive bacteria, Gram negative bacteria, fungi and viruses. The invention also includes compositions to for controlling pathogens comprising these antimicrobial peptides. The use of such peptides in vaccine preparations, as molecular adjuvants, is also part of the invention.
摘要翻译： 本发明涉及从罗非鱼（Oreochromis niloticus）鳃提取物中分离和纯化的抗微生物肽。 这样的肽可以通过化学合成或通过常规分子生物学技术在异源系统如细菌和酵母中表达产生。 这些肽显示出对各种生物体的抗菌活性，包括革兰氏阳性菌，革兰氏阴性菌，真菌和病毒。 本发明还包括用于控制包含这些抗微生物肽的病原体的组合物。 疫苗制剂中作为分子佐剂使用这些肽也是本发明的一部分。
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10.发明申请Peptidic Growth Hormone Secretagogues Analog Compounds and Preparations Thereof 有权肽生长激素促分泌素类似物及其制备方法公开(公告)号：US20100055118A1
公开(公告)日：2010-03-04
申请号：US12281085
申请日：2007-02-28
申请人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia Del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
发明人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia Del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
摘要： Peptidic chemical compounds obtained by in silico molecular modelling, having a structure that enables them to perform the same functions of peptidic growth hormone secretagogues. The invention also comprises the preparations containing such compounds and the use in medicines, food additives, nutritional supplements or other formulations of human or animal use.
摘要翻译： 通过在硅分子模拟中获得的肽化学化合物，其具有使得它们能够执行肽生长激素促分泌素相同功能的结构。 本发明还包括含有这些化合物的制剂以及在药物，食品添加剂，营养补充剂或人或动物使用的其它制剂中的用途。
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