-
公开(公告)号：US10040814B2
公开(公告)日：2018-08-07
申请号：US15809730
申请日：2017-11-10
发明人： Ioannis Nicolaos Houpis , Tim Hugo Maria Jonckers , Pierre Jean-Marie Bernard Raboisson , Abdellah Tahri
IPC分类号： C07H19/06 , C07H19/10 , C07H19/24 , A61K31/7072 , C07H19/11
CPC分类号： C07H19/10 , A61K31/7072 , C07H19/06 , C07H19/11 , C07H19/24
摘要： The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein, or a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
-
公开(公告)号：US20180155341A1
公开(公告)日：2018-06-07
申请号：US15736524
申请日：2016-07-01
发明人： Jérôme Émile Georges Guillemont , Magali Madeleine Simone Motte , Pierre Jean-Marie Bernard Rabiosson , Abdellah Tahri
IPC分类号： C07D471/04 , C07D487/04 , A61K31/519 , A61P31/04 , A61K45/06 , A61K31/4709 , C07D513/04 , A61K31/496 , A61K31/498
CPC分类号： C07D401/12 , A61K31/404 , A61K31/429 , A61K31/437 , A61K31/438 , A61K31/444 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/498 , A61K31/4985 , A61K31/519 , A61K45/06 , A61P31/04 , A61P31/06 , C07D401/14 , C07D403/12 , C07D471/04 , C07D487/04 , C07D487/10 , C07D513/04 , C07D519/00
摘要： The present invention relates to the following compounds wherein the integers are as defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of tuberculosis.
-
公开(公告)号：US09944638B2
公开(公告)日：2018-04-17
申请号：US15136769
申请日：2016-04-22
发明人： Ludwig Paul Cooymans , Samuël Dominique Demin , Lili Hu , Tim Hugo Maria Jonckers , Pierre Jean-Marie Bernard Raboisson , Abdellah Tahri , Sandrine Marie Helene Vendeville
IPC分类号： C07D471/04 , C07D403/06 , C07D513/02 , C07D515/02 , A61K31/437 , A61P31/12 , C07D209/10 , C07D209/12 , C07D235/26
CPC分类号： C07D471/04 , C07D209/10 , C07D209/12 , C07D235/26 , C07D403/06
摘要： Indoles having inhibitory activity on RSV replication and having the formula I the prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.
-
公开(公告)号：US09845336B2
公开(公告)日：2017-12-19
申请号：US15423985
申请日：2017-02-03
发明人： Ioannis Nicolaos Houpis , Tim Hugo Maria Jonckers , Pierre Jean-Marie Bernard Raboisson , Abdellah Tahri
IPC分类号： C07H19/10 , C07H19/06 , C07H19/11 , A61K31/7072 , C07H19/24
CPC分类号： C07H19/10 , A61K31/7072 , C07H19/06 , C07H19/11 , C07H19/24
摘要： The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein, or a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
-
公开(公告)号：US20170029455A1
公开(公告)日：2017-02-02
申请号：US15238553
申请日：2016-08-16
发明人： Ioannis Nicolaos Houpis , Tim Hugo Maria Jonckers , Pierre Jean-Marie Bernard Raboisson , Abdellah Tahri
IPC分类号： C07H19/10
CPC分类号： C07H19/10 , A61K31/7072 , C07H19/06 , C07H19/11 , C07H19/24
摘要： The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein,or a pharmaceutically acceptable salt or solvate thereof.The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
摘要翻译： 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在HCV治疗中单独或与其它HCV抑制剂组合的用途。
-
6.发明授权公开(公告)号：US09427440B2
公开(公告)日：2016-08-30
申请号：US13836168
申请日：2013-03-15
发明人： Sandrine Marie Helene Vendeville , Pierre Jean-Marie Bernard Raboisson , Tse-I Lin , Abdellah Tahri , Katie Ingrid Eduard Amssoms
IPC分类号： A61K31/55 , C07D513/14 , C07D513/18 , C07D515/18 , A61K45/06 , C07D513/22
CPC分类号： A61K31/55 , A61K45/06 , C07D513/14 , C07D513/18 , C07D513/22 , C07D515/18
摘要： Inhibitors of HCV replication of formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein R1, R2, R4, R5, R6 and R7 have the meaning defined in the claims. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use in HCV therapy.
摘要翻译： 含有立体化学异构形式的式（I）的HCV复制抑制剂及其盐，水合物，溶剂合物，其中R1，R2，R4，R5，R6和R7具有权利要求中限定的含义。 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在HCV治疗中的用途。
-
公开(公告)号：US10364232B2
公开(公告)日：2019-07-30
申请号：US15736375
申请日：2016-07-01
发明人： Jérõme Émile Georges Guillemont , Magali Madeleine Simone Motte , Pierre Jean-Marie Bernard Rabiosson , Abdellah Tahri
IPC分类号： C07D401/02 , C07D401/10 , A61K31/437 , A61K31/4353 , C07D401/12 , C07D403/12 , C07D401/14 , C07D471/04 , C07D487/04 , C07D487/10 , C07D513/04 , C07D519/00 , A61K45/06 , A61K31/404 , A61K31/429 , A61K31/438 , A61K31/444 , A61K31/4745 , A61K31/496 , A61K31/4985 , A61K31/519 , A61P31/04 , A61K31/4709 , A61K31/498 , A61P31/06
摘要： The present invention relates to the following compounds wherein the integers are as defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of tuberculosis.
-
公开(公告)号：US20180099990A1
公开(公告)日：2018-04-12
申请号：US15809730
申请日：2017-11-10
发明人： Ioannis Nicolaos Houpis , Tim Hugo Maria Jonckers , Pierre Jean-Marie Bernard Raboisson , Abdellah Tahri
IPC分类号： C07H19/10 , C07H19/24 , C07H19/11 , A61K31/7072 , C07H19/06
CPC分类号： C07H19/10 , A61K31/7072 , C07H19/06 , C07H19/11 , C07H19/24
摘要： The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein, or a pharmaceutically acceptable salt or solvate thereofThe present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
-
公开(公告)号：US20170145045A1
公开(公告)日：2017-05-25
申请号：US15423985
申请日：2017-02-03
发明人： Ioannis Nicolaos Houpis , Tim Hugo Maria Jonckers , Pierre Jean-Marie Bernard Raboisson , Abdellah Tahri
IPC分类号： C07H19/10
CPC分类号： C07H19/10 , A61K31/7072 , C07H19/06 , C07H19/11 , C07H19/24
摘要： The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein,or a pharmaceutically acceptable salt or solvate thereof.The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
-
公开(公告)号：US09623022B2
公开(公告)日：2017-04-18
申请号：US15137997
申请日：2016-04-25
发明人： Kenneth Alan Simmen , Herman Augustinus De Kock , Pierre Jean-Marie Bernard Raboisson , Lili Hu , Abdellah Tahri , Dominique Louis Nestor Ghislain Surleraux , Karl Magnus Nilsson , Bengt Bertil Samuelsson , Åsa Annica Kristina Rosenquist , Vladimir Ivanov , Mikael Pelcman , Anna Karin Belfrage , Per-Ola Mikael Johansson , Sandrine Marie Helene Vendeville
IPC分类号： A61K31/14 , A61K31/33 , A61K31/4709 , C07D245/04 , C07D277/56 , C07D417/04 , C07D487/04 , A61K31/427 , A61K38/21 , C07D401/14 , C07D417/14 , A61K45/06 , A61K38/05 , C07K5/078 , A61K31/7056
CPC分类号： C07D487/04 , A61K31/427 , A61K31/4709 , A61K31/7056 , A61K38/05 , A61K38/212 , A61K45/06 , A61K47/60 , C07D245/04 , C07D277/56 , C07D401/14 , C07D417/04 , C07D417/14 , C07K5/06139 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393
摘要： Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is —OR7, —NH—SO2R8; R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl; R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, C3-7cycloalkyl; R4 is aryl or Het; n is 3, 4, 5, or 6; R5 is halo, C1-6alkyl, hydroxy, C1-6alkoxy, phenyl, or Het; R6 is C1-6alkoxy, or dimethylamino; R7 is hydrogen; aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; R8 is aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; aryl is phenyl optionally substituted with one, two or three substituents; Het is a 5 or 6 membered saturated, partially unsaturated or completely unsaturated heterocyclic ring containing 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, and being optionally substituted with one, two or three substituents; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I). Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.
-
-
-
-
-
-
-
-
-
搜索结果
30 条记录 (耗时 0.03 秒)
