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公开(公告)号:US11541050B2
公开(公告)日:2023-01-03
申请号:US17012286
申请日:2020-09-04
发明人: David Mc Gowan , Pierre Jean-Marie Bernard Raboisson , Werner Embrechts , Tim Hugo Maria Jonckers , Stefaan Julien Last , Serge Maria Aloysius Pieters , Jaromir Vlach
IPC分类号: A61K31/505 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04 , A61P31/12 , A61K31/513 , C07D401/10 , C07D403/10 , C07D239/48 , C07D487/04 , C07D495/04 , A61K31/506 , A61K31/5377
摘要: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
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公开(公告)号:US20210023082A1
公开(公告)日:2021-01-28
申请号:US17012286
申请日:2020-09-04
发明人: David McGowan , Pierre Jean-Marie Bernard Raboisson , Werner Embrachts , Tim Hugo Maria Jonckers , Stefaan Julien Last , Serge Maria Aloysius Pieters , Jeromir Vlach
IPC分类号: A61K31/505 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04 , A61P31/12 , A61K31/513 , C07D401/10 , C07D403/10 , C07D239/48 , C07D487/04 , C07D495/04 , A61K31/506 , A61K31/5377
摘要: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
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公开(公告)号:US20200061059A1
公开(公告)日:2020-02-27
申请号:US16530385
申请日:2019-08-02
发明人: David McGowan , Pierre Jean-Marie Bernard Raboisson , Werner Embrechts , Tim Hugo Maria Jonckers , Stefaan Julien Last , Serge Maria Aloysius Pieters , Jaromir Vlach
IPC分类号: A61K31/513 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04 , C07D239/48 , C07D487/04 , C07D495/04 , A61K31/506 , A61K31/5377 , A61P31/12
摘要: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
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公开(公告)号:US10420767B2
公开(公告)日:2019-09-24
申请号:US15867041
申请日:2018-01-10
发明人: David McGowan , Pierre Jean-Marie Bernard Raboisson , Werner Embrechts , Tim Hugo Maria Jonckers , Stefaan Julien Last , Serge Maria Aloysius Pieters , Jaromir Vlach
IPC分类号: A61K31/505 , A61K31/5377 , A61K31/506 , C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
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公开(公告)号:US10272085B2
公开(公告)日:2019-04-30
申请号:US15209637
申请日:2016-07-13
发明人: David McGowan , Pierre Jean-Marie Bernard Raboisson , Werner Embrechts , Tim Hugo Maria Jonckers , Stefaan Julien Last , Serge Maria Aloysius Pieters , Jaromir Vlach
IPC分类号: A61K31/505 , A61K31/5377 , A61K31/506 , C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
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公开(公告)号:US10040814B2
公开(公告)日:2018-08-07
申请号:US15809730
申请日:2017-11-10
发明人: Ioannis Nicolaos Houpis , Tim Hugo Maria Jonckers , Pierre Jean-Marie Bernard Raboisson , Abdellah Tahri
IPC分类号: C07H19/06 , C07H19/10 , C07H19/24 , A61K31/7072 , C07H19/11
CPC分类号: C07H19/10 , A61K31/7072 , C07H19/06 , C07H19/11 , C07H19/24
摘要: The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein, or a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
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公开(公告)号:US09944638B2
公开(公告)日:2018-04-17
申请号:US15136769
申请日:2016-04-22
发明人: Ludwig Paul Cooymans , Samuël Dominique Demin , Lili Hu , Tim Hugo Maria Jonckers , Pierre Jean-Marie Bernard Raboisson , Abdellah Tahri , Sandrine Marie Helene Vendeville
IPC分类号: C07D471/04 , C07D403/06 , C07D513/02 , C07D515/02 , A61K31/437 , A61P31/12 , C07D209/10 , C07D209/12 , C07D235/26
CPC分类号: C07D471/04 , C07D209/10 , C07D209/12 , C07D235/26 , C07D403/06
摘要: Indoles having inhibitory activity on RSV replication and having the formula I the prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.
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公开(公告)号:US09845336B2
公开(公告)日:2017-12-19
申请号:US15423985
申请日:2017-02-03
发明人: Ioannis Nicolaos Houpis , Tim Hugo Maria Jonckers , Pierre Jean-Marie Bernard Raboisson , Abdellah Tahri
IPC分类号: C07H19/10 , C07H19/06 , C07H19/11 , A61K31/7072 , C07H19/24
CPC分类号: C07H19/10 , A61K31/7072 , C07H19/06 , C07H19/11 , C07H19/24
摘要: The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein, or a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
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公开(公告)号:US20170226102A1
公开(公告)日:2017-08-10
申请号:US15501730
申请日:2015-08-07
发明人: Tim Hugo Maria Jonckers , Pierre Jean-Marie Bernard Raboisson , Jérôme Émile Georges Guillemont , David Craig Mc Gowan , Werner Constant Johan Embrechts , Ludwig Paul Cooymans , Antoine Benjamin Michaut
IPC分类号: C07D417/14 , C07D403/04 , A61K31/506 , C07D413/14 , C07D401/14 , C07D401/04 , C07D403/14 , C07D405/14 , A61K45/06 , A61K31/4439
摘要: The invention relates to compounds having the structure of formula (I) which can be used for the treatment of or against influenza infections.
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公开(公告)号:US20170029455A1
公开(公告)日:2017-02-02
申请号:US15238553
申请日:2016-08-16
发明人: Ioannis Nicolaos Houpis , Tim Hugo Maria Jonckers , Pierre Jean-Marie Bernard Raboisson , Abdellah Tahri
IPC分类号: C07H19/10
CPC分类号: C07H19/10 , A61K31/7072 , C07H19/06 , C07H19/11 , C07H19/24
摘要: The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein,or a pharmaceutically acceptable salt or solvate thereof.The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
摘要翻译: 本发明还涉及制备所述化合物的方法,含有它们的药物组合物及其在HCV治疗中单独或与其它HCV抑制剂组合的用途。
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