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公开(公告)号:US09433609B2
公开(公告)日:2016-09-06
申请号:US13836816
申请日:2013-03-15
发明人: Koen Vandyck , Stefaan Julien Last , Ioannis Nicolaos Houpis , Pierre Jean-Marie Bernard Raboisson
IPC分类号: A61K31/40 , A61K31/41 , A61K31/4164 , A61K31/4184 , C07D403/14 , A61K45/06 , C07D405/14
CPC分类号: C07D403/14 , A61K31/40 , A61K31/41 , A61K31/4164 , A61K31/4184 , A61K31/55 , A61K45/06 , C07D405/14
摘要: Inhibitors of HCV replication of formula I including stereochemically isomeric forms, and salts, solvates thereof, wherein R and R′ are, each independently, —CR1R2R3, aryl, heteroaryl or heteroC4-6cycloalkyl, whereby aryl and heteroaryl may optionally be substituted with 1 or 2 substituents selected from halo and methyl. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use in HCV therapy.
摘要翻译: 本发明还涉及制备所述化合物的方法,含有它们的药物组合物及其在HCV治疗中的用途。
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公开(公告)号:US20160340344A1
公开(公告)日:2016-11-24
申请号:US15228720
申请日:2016-08-04
发明人: Koen Vandyck , Stefaan Julien Last , Ioannis Nicolaos Houpis , Pierre Jean-Marie Bernard Raboisson
IPC分类号: C07D403/14 , C07D405/14 , A61K31/4184 , A61K45/06 , A61K31/55
CPC分类号: C07D403/14 , A61K31/40 , A61K31/41 , A61K31/4164 , A61K31/4184 , A61K31/55 , A61K45/06 , C07D405/14
摘要: Inhibitors of HCV replication of formula I including stereochemically isomeric forms, and salts, solvates thereof, wherein R and R′ are, each independently, —CR1R2R3, aryl, heteroaryl or heteroC4-6cycloalkyl, whereby aryl and heteroaryl may optionally be substituted with 1 or 2 substituents selected from halo and methyl.The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use in HCV therapy.
摘要翻译: 本发明还涉及制备所述化合物的方法,含有它们的药物组合物及其在HCV治疗中的用途。
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公开(公告)号:US10040814B2
公开(公告)日:2018-08-07
申请号:US15809730
申请日:2017-11-10
发明人: Ioannis Nicolaos Houpis , Tim Hugo Maria Jonckers , Pierre Jean-Marie Bernard Raboisson , Abdellah Tahri
IPC分类号: C07H19/06 , C07H19/10 , C07H19/24 , A61K31/7072 , C07H19/11
CPC分类号: C07H19/10 , A61K31/7072 , C07H19/06 , C07H19/11 , C07H19/24
摘要: The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein, or a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
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公开(公告)号:US09845336B2
公开(公告)日:2017-12-19
申请号:US15423985
申请日:2017-02-03
发明人: Ioannis Nicolaos Houpis , Tim Hugo Maria Jonckers , Pierre Jean-Marie Bernard Raboisson , Abdellah Tahri
IPC分类号: C07H19/10 , C07H19/06 , C07H19/11 , A61K31/7072 , C07H19/24
CPC分类号: C07H19/10 , A61K31/7072 , C07H19/06 , C07H19/11 , C07H19/24
摘要: The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein, or a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
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公开(公告)号:US20170029455A1
公开(公告)日:2017-02-02
申请号:US15238553
申请日:2016-08-16
发明人: Ioannis Nicolaos Houpis , Tim Hugo Maria Jonckers , Pierre Jean-Marie Bernard Raboisson , Abdellah Tahri
IPC分类号: C07H19/10
CPC分类号: C07H19/10 , A61K31/7072 , C07H19/06 , C07H19/11 , C07H19/24
摘要: The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein,or a pharmaceutically acceptable salt or solvate thereof.The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
摘要翻译: 本发明还涉及制备所述化合物的方法,含有它们的药物组合物及其在HCV治疗中单独或与其它HCV抑制剂组合的用途。
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公开(公告)号:US20180327441A1
公开(公告)日:2018-11-15
申请号:US16044262
申请日:2018-07-24
发明人: Ioannis Nicolaos Houpis , Tim Hugo Maria Jonckers , Pierre Jean-Marie Bernard Raboisson , Abdellah Tahri
IPC分类号: C07H19/10 , A61K31/7072 , C07H19/06 , C07H19/24 , C07H19/11
CPC分类号: C07H19/10 , A61K31/7072 , C07H19/06 , C07H19/11 , C07H19/24
摘要: The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein, or a pharmaceutically acceptable salt or solvate thereofThe present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
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公开(公告)号:US09422323B2
公开(公告)日:2016-08-23
申请号:US14403587
申请日:2013-05-24
发明人: Ioannis Nicolaos Houpis , Tim Hugo Maria Jonckers , Pierre Jean-Marie Bernard Raboisson , Abdellah Tahri
IPC分类号: C07H19/06 , C07H19/24 , C07H19/11 , A61K31/7072
CPC分类号: C07H19/10 , A61K31/7072 , C07H19/06 , C07H19/11 , C07H19/24
摘要: The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein, or a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
摘要翻译: 本发明涉及式I化合物:包括其任何可能的立体异构体,其中R9具有本文定义的含义,或其药学上可接受的盐或溶剂合物。 本发明还涉及制备所述化合物的方法,含有它们的药物组合物及其在HCV治疗中单独或与其它HCV抑制剂组合的用途。
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公开(公告)号:US20180099990A1
公开(公告)日:2018-04-12
申请号:US15809730
申请日:2017-11-10
发明人: Ioannis Nicolaos Houpis , Tim Hugo Maria Jonckers , Pierre Jean-Marie Bernard Raboisson , Abdellah Tahri
IPC分类号: C07H19/10 , C07H19/24 , C07H19/11 , A61K31/7072 , C07H19/06
CPC分类号: C07H19/10 , A61K31/7072 , C07H19/06 , C07H19/11 , C07H19/24
摘要: The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein, or a pharmaceutically acceptable salt or solvate thereofThe present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
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公开(公告)号:US20170145045A1
公开(公告)日:2017-05-25
申请号:US15423985
申请日:2017-02-03
发明人: Ioannis Nicolaos Houpis , Tim Hugo Maria Jonckers , Pierre Jean-Marie Bernard Raboisson , Abdellah Tahri
IPC分类号: C07H19/10
CPC分类号: C07H19/10 , A61K31/7072 , C07H19/06 , C07H19/11 , C07H19/24
摘要: The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein,or a pharmaceutically acceptable salt or solvate thereof.The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
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