公开(公告)号：US20210023082A1

公开(公告)日：2021-01-28

申请号：US17012286

申请日：2020-09-04

Applicant: JANSSEN SCIENCES IRELAND UC

Inventor： David McGowan ,  Pierre Jean-Marie Bernard Raboisson ,  Werner Embrachts ,  Tim Hugo Maria Jonckers ,  Stefaan Julien Last ,  Serge Maria Aloysius Pieters ,  Jeromir Vlach

IPC: A61K31/505 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/04 ,  A61P31/12 ,  A61K31/513 ,  C07D401/10 ,  C07D403/10 ,  C07D239/48 ,  C07D487/04 ,  C07D495/04 ,  A61K31/506 ,  A61K31/5377

Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.

公开(公告)号：US20200061059A1

公开(公告)日：2020-02-27

申请号：US16530385

申请日：2019-08-02

Applicant: JANSSEN SCIENCES IRELAND UC

Inventor： David McGowan ,  Pierre Jean-Marie Bernard Raboisson ,  Werner Embrechts ,  Tim Hugo Maria Jonckers ,  Stefaan Julien Last ,  Serge Maria Aloysius Pieters ,  Jaromir Vlach

IPC: A61K31/513 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/04 ,  C07D239/48 ,  C07D487/04 ,  C07D495/04 ,  A61K31/506 ,  A61K31/5377 ,  A61P31/12

Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.

公开(公告)号：US10457638B2

公开(公告)日：2019-10-29

申请号：US15875929

申请日：2018-01-19

Applicant: Janssen Sciences Ireland UC

Inventor： Koen Vandyck ,  Geerwin Yvonne Paul Haché ,  Stefaan Julien Last ,  David Craig McGowan ,  Geert Rombouts ,  Wim Gaston Verschueren ,  Pierre Jean-Marie Bernard Raboisson

IPC: C07D207/36 ,  C07D403/12 ,  C07D405/12 ,  C07D207/40 ,  A61K45/06 ,  A61K31/401

Abstract: Inhibitors of HBV replication of Formula (ID) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, Ra to Rd and R4 to R6 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.

公开(公告)号：US10420767B2

公开(公告)日：2019-09-24

申请号：US15867041

申请日：2018-01-10

Applicant: Janssen Sciences Ireland UC

Inventor： David McGowan ,  Pierre Jean-Marie Bernard Raboisson ,  Werner Embrechts ,  Tim Hugo Maria Jonckers ,  Stefaan Julien Last ,  Serge Maria Aloysius Pieters ,  Jaromir Vlach

IPC: A61K31/505 ,  A61K31/5377 ,  A61K31/506 ,  C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.

公开(公告)号：US10272085B2

公开(公告)日：2019-04-30

申请号：US15209637

申请日：2016-07-13

Applicant: Janssen Sciences Ireland UC

Inventor： David McGowan ,  Pierre Jean-Marie Bernard Raboisson ,  Werner Embrechts ,  Tim Hugo Maria Jonckers ,  Stefaan Julien Last ,  Serge Maria Aloysius Pieters ,  Jaromir Vlach

IPC: A61K31/505 ,  A61K31/5377 ,  A61K31/506 ,  C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.

公开(公告)号：US10208048B2

公开(公告)日：2019-02-19

申请号：US15570054

申请日：2016-04-27

Applicant: Janssen Sciences Ireland UC

Inventor： David Francis Alain Lançois ,  Jérôme Émile Georges Guillemont ,  Pierre Jean-Marie Bernard Raboisson ,  Dirk André Emmy Roymans ,  Boris Rogovoy ,  Vadim Bichko ,  Delphine Yvonne Raymonde Lardeau ,  Antoine Benjamin Michaut ,  Anil Koul

IPC: C07D487/04 ,  C07D519/00 ,  A61K31/437 ,  A61K31/519 ,  A61P31/16 ,  A61P31/14

Abstract: The invention concerns novel substituted pyrazolo- and triazolo-pyrimidine compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment of respiratory syncytial virus infection.

公开(公告)号：US10040814B2

公开(公告)日：2018-08-07

申请号：US15809730

申请日：2017-11-10

Applicant: Janssen Sciences Ireland UC

Inventor： Ioannis Nicolaos Houpis ,  Tim Hugo Maria Jonckers ,  Pierre Jean-Marie Bernard Raboisson ,  Abdellah Tahri

IPC: C07H19/06 ,  C07H19/10 ,  C07H19/24 ,  A61K31/7072 ,  C07H19/11

CPC classification number: C07H19/10 ,  A61K31/7072 ,  C07H19/06 ,  C07H19/11 ,  C07H19/24

Abstract: The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein, or a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.

公开(公告)号：US09944638B2

公开(公告)日：2018-04-17

申请号：US15136769

申请日：2016-04-22

Applicant: Janssen Sciences Ireland UC

Inventor： Ludwig Paul Cooymans ,  Samuël Dominique Demin ,  Lili Hu ,  Tim Hugo Maria Jonckers ,  Pierre Jean-Marie Bernard Raboisson ,  Abdellah Tahri ,  Sandrine Marie Helene Vendeville

IPC: C07D471/04 ,  C07D403/06 ,  C07D513/02 ,  C07D515/02 ,  A61K31/437 ,  A61P31/12 ,  C07D209/10 ,  C07D209/12 ,  C07D235/26

CPC classification number: C07D471/04 ,  C07D209/10 ,  C07D209/12 ,  C07D235/26 ,  C07D403/06

Abstract: Indoles having inhibitory activity on RSV replication and having the formula I the prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.

公开(公告)号：US09845336B2

公开(公告)日：2017-12-19

申请号：US15423985

申请日：2017-02-03

Applicant: Janssen Sciences Ireland UC

Inventor： Ioannis Nicolaos Houpis ,  Tim Hugo Maria Jonckers ,  Pierre Jean-Marie Bernard Raboisson ,  Abdellah Tahri

IPC: C07H19/10 ,  C07H19/06 ,  C07H19/11 ,  A61K31/7072 ,  C07H19/24

CPC classification number: C07H19/10 ,  A61K31/7072 ,  C07H19/06 ,  C07H19/11 ,  C07H19/24

Abstract: The present invention relates to compounds of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein, or a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.

公开(公告)号：US20170226102A1

公开(公告)日：2017-08-10

申请号：US15501730

申请日：2015-08-07

Applicant: Janssen Sciences Ireland UC

Inventor： Tim Hugo Maria Jonckers ,  Pierre Jean-Marie Bernard Raboisson ,  Jérôme Émile Georges Guillemont ,  David Craig Mc Gowan ,  Werner Constant Johan Embrechts ,  Ludwig Paul Cooymans ,  Antoine Benjamin Michaut

IPC: C07D417/14 ,  C07D403/04 ,  A61K31/506 ,  C07D413/14 ,  C07D401/14 ,  C07D401/04 ,  C07D403/14 ,  C07D405/14 ,  A61K45/06 ,  A61K31/4439

Abstract: The invention relates to compounds having the structure of formula (I) which can be used for the treatment of or against influenza infections.