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公开(公告)号：US20210023082A1
公开(公告)日：2021-01-28
申请号：US17012286
申请日：2020-09-04
发明人： David McGowan , Pierre Jean-Marie Bernard Raboisson , Werner Embrachts , Tim Hugo Maria Jonckers , Stefaan Julien Last , Serge Maria Aloysius Pieters , Jeromir Vlach
IPC分类号： A61K31/505 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04 , A61P31/12 , A61K31/513 , C07D401/10 , C07D403/10 , C07D239/48 , C07D487/04 , C07D495/04 , A61K31/506 , A61K31/5377
摘要： This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
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公开(公告)号：US20200061059A1
公开(公告)日：2020-02-27
申请号：US16530385
申请日：2019-08-02
发明人： David McGowan , Pierre Jean-Marie Bernard Raboisson , Werner Embrechts , Tim Hugo Maria Jonckers , Stefaan Julien Last , Serge Maria Aloysius Pieters , Jaromir Vlach
IPC分类号： A61K31/513 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04 , C07D239/48 , C07D487/04 , C07D495/04 , A61K31/506 , A61K31/5377 , A61P31/12
摘要： This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
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公开(公告)号：US10457638B2
公开(公告)日：2019-10-29
申请号：US15875929
申请日：2018-01-19
发明人： Koen Vandyck , Geerwin Yvonne Paul Haché , Stefaan Julien Last , David Craig McGowan , Geert Rombouts , Wim Gaston Verschueren , Pierre Jean-Marie Bernard Raboisson
IPC分类号： C07D207/36 , C07D403/12 , C07D405/12 , C07D207/40 , A61K45/06 , A61K31/401
摘要： Inhibitors of HBV replication of Formula (ID) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, Ra to Rd and R4 to R6 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
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公开(公告)号：US10420767B2
公开(公告)日：2019-09-24
申请号：US15867041
申请日：2018-01-10
发明人： David McGowan , Pierre Jean-Marie Bernard Raboisson , Werner Embrechts , Tim Hugo Maria Jonckers , Stefaan Julien Last , Serge Maria Aloysius Pieters , Jaromir Vlach
IPC分类号： A61K31/505 , A61K31/5377 , A61K31/506 , C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
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公开(公告)号：US10272085B2
公开(公告)日：2019-04-30
申请号：US15209637
申请日：2016-07-13
发明人： David McGowan , Pierre Jean-Marie Bernard Raboisson , Werner Embrechts , Tim Hugo Maria Jonckers , Stefaan Julien Last , Serge Maria Aloysius Pieters , Jaromir Vlach
IPC分类号： A61K31/505 , A61K31/5377 , A61K31/506 , C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
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6.发明申请公开(公告)号：US20150266890A1
公开(公告)日：2015-09-24
申请号：US14423963
申请日：2013-08-28
发明人： Koen Vandyck , Stefaan Julien Last , Geert Rombouts , Wim Gaston Verschueren , Pierre Jean-Marie Bernard Raboisson
IPC分类号： C07D493/08 , A61K31/351 , C07C311/37 , A61K31/18 , C07D305/08 , A61K31/337 , C07D307/22 , A61K31/341 , C07D211/96 , A61K31/4453 , C07D233/84 , A61K31/4164 , C07D277/56 , A61K31/426 , C07D295/13 , A61K31/495 , A61K31/5375 , A61K31/34 , C07D491/107 , A61K31/397 , C07D223/06 , A61K31/55 , C07D309/14
摘要： Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein B, R1, R2 and R4 have the meaning as defined herein.The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
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公开(公告)号：US11541050B2
公开(公告)日：2023-01-03
申请号：US17012286
申请日：2020-09-04
发明人： David Mc Gowan , Pierre Jean-Marie Bernard Raboisson , Werner Embrechts , Tim Hugo Maria Jonckers , Stefaan Julien Last , Serge Maria Aloysius Pieters , Jaromir Vlach
IPC分类号： A61K31/505 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D471/04 , A61P31/12 , A61K31/513 , C07D401/10 , C07D403/10 , C07D239/48 , C07D487/04 , C07D495/04 , A61K31/506 , A61K31/5377
摘要： This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
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公开(公告)号：US11078193B2
公开(公告)日：2021-08-03
申请号：US15117146
申请日：2015-02-05
发明人： Koen Vandyck , Geerwin Yvonne Paul Haché , Stefaan Julien Last , Geert Rombouts , Wim Gaston Verschueren , Pierre Jean-Marie Bernard Raboisson
IPC分类号： C07D401/12 , A61K31/4439 , C07D405/14 , A61K31/4545 , A61K45/06 , C07D401/14
摘要： Inhibitors of HBV replication of Formula (A) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein Ra to Rd, and R5 to R6 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
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公开(公告)号：US10160743B2
公开(公告)日：2018-12-25
申请号：US14891895
申请日：2014-05-16
发明人： Koen Vandyck , Geerwin Yvonne Paul Haché , Stefaan Julien Last , Wim Gaston Verschueren , Pierre Jean-Marie Bernard Raboisson
IPC分类号： C07D333/38 , C07D409/12
摘要： Inhibitors of HBV replication of formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X and R1 to R8 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
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公开(公告)号：US09433609B2
公开(公告)日：2016-09-06
申请号：US13836816
申请日：2013-03-15
发明人： Koen Vandyck , Stefaan Julien Last , Ioannis Nicolaos Houpis , Pierre Jean-Marie Bernard Raboisson
IPC分类号： A61K31/40 , A61K31/41 , A61K31/4164 , A61K31/4184 , C07D403/14 , A61K45/06 , C07D405/14
CPC分类号： C07D403/14 , A61K31/40 , A61K31/41 , A61K31/4164 , A61K31/4184 , A61K31/55 , A61K45/06 , C07D405/14
摘要： Inhibitors of HCV replication of formula I including stereochemically isomeric forms, and salts, solvates thereof, wherein R and R′ are, each independently, —CR1R2R3, aryl, heteroaryl or heteroC4-6cycloalkyl, whereby aryl and heteroaryl may optionally be substituted with 1 or 2 substituents selected from halo and methyl. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use in HCV therapy.
摘要翻译： 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在HCV治疗中的用途。
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