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1.发明授权Dihydroorotate dehydrogenase as antifungal drug target and quinazolinone-based inhibitors thereof 有权脱氢山梨醇脱氢酶作为抗真菌药物靶标和基于喹唑啉酮的抑制剂公开(公告)号：US09034887B2
公开(公告)日：2015-05-19
申请号：US12990478
申请日：2009-05-01
申请人： Jason David Oliver , John Leslie Thain , Michael John Bromley , Graham Edward Morris Sibley , Michael Birch
发明人： Jason David Oliver , John Leslie Thain , Michael John Bromley , Graham Edward Morris Sibley , Michael Birch
IPC分类号： A61K31/517 , G01N33/573 , C12Q1/32 , C12N9/04 , C07D239/72 , A61P31/10 , C07D239/95 , C12N9/02
CPC分类号： C12Q1/32 , C07D239/95 , C12N9/001 , C12Y103/05002 , G01N2333/90206 , G01N2500/02
摘要： A method of identifying an antifungal agent which targets a DHODH protein (alias PyrE, dihydroorotate dehydrogenase, EC: 1.3.99.11) of a fungus comprising contacting a candidate substance with a fungal DHODH protein and determining whether the candidate substance binds or modulates the DHODH protein, wherein binding or modulation indicates that the candidate substance is an antifungal agent. Specific examples concern Aspergillus fumigatus and Candida albicans DHODH proteins. DHODH inhibitors with a Quinazolinone core are also disclosed.
摘要翻译： 鉴定靶向真菌的DHODH蛋白（别名PyrE，二氢叶酸脱氢酶，EC：1.3.99.11）的抗真菌剂的方法，其包括将候选物质与真菌DHODH蛋白质接触，并确定候选物质是否结合或调节DHODH蛋白 其中结合或调节表明候选物质是抗真菌剂。 具体实例涉及烟曲霉和白色念珠菌DHODH蛋白。 还公开了具有喹唑啉酮核心的DHODH抑制剂。
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2.发明申请DIHYDROOROTATE DEHYDROGENASE AS ANTIFUNGAL DRUG TARGET AND QUINAZOLINONE-BASED INHIBITORS THEREOF 有权DIHYDROOROTETE DEHYDROGENASE作为抗真菌药物靶标和基于喹唑啉酮的抑制剂公开(公告)号：US20110160231A1
公开(公告)日：2011-06-30
申请号：US12990478
申请日：2009-05-01
申请人： Jason David Oliver , John Leslie Thain , Michael John Bromley , Graham Edward Morris Sibley , Michael Birch
发明人： Jason David Oliver , John Leslie Thain , Michael John Bromley , Graham Edward Morris Sibley , Michael Birch
IPC分类号： A61K31/517 , G01N33/573 , C12Q1/32 , C12N9/04 , C07D239/72 , A61P31/10
CPC分类号： C12Q1/32 , C07D239/95 , C12N9/001 , C12Y103/05002 , G01N2333/90206 , G01N2500/02
摘要： A method of identifying an antifungal agent which targets a DHODH protein (alias PyrE, dihydroorotate dehydrogenase, EC: 1.3.99.11) of a fungus comprising contacting a candidate substance with a fungal DHODH protein and determining whether the candidate substance binds or modulates the DHODH protein, wherein binding or modulation indicates that the candidate substance is an antifungal agent. Specific examples concern Aspergillus fumigatus and Candida albicans DHODH proteins. DHODH inhibitors with a Quinazolinone core are also disclosed.
摘要翻译： 鉴定靶向真菌的DHODH蛋白（别名PyrE，二氢叶酸脱氢酶，EC：1.3.99.11）的抗真菌剂的方法，其包括将候选物质与真菌DHODH蛋白质接触，并确定候选物质是否结合或调节DHODH蛋白 其中结合或调节表明候选物质是抗真菌剂。 具体实例涉及烟曲霉和白色念珠菌DHODH蛋白。 还公开了具有喹唑啉酮核心的DHODH抑制剂。
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公开(公告)号：US20110183969A1
公开(公告)日：2011-07-28
申请号：US12994443
申请日：2009-05-29
IPC分类号： A61K31/541 , A01N43/84 , A61K31/437 , A01N43/40 , A61K31/4745 , A61K31/5377 , A61K31/496 , A01N43/60 , A01P3/00 , A61P31/00
CPC分类号： A61K45/06 , A61K31/437 , A61K2300/00
摘要： The invention provides pharmaceutical combinations comprising a combination of an antifungal indolizine compound of formula (I) or a pharmaceutically acceptable salt thereof and a second antifungal agent: wherein: R1, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. The invention also provides pharmaceutical compositions comprising an antifungal indolizine compound of formula (I) or a pharmaceutically acceptable salt thereof, a second antifungal agent and a pharmaceutically acceptable diluent or carrier. The combinations and compositions are useful in the prevention or treatment of a fungal disease. A combination of an indolizine compound of formula (I) or agriculturally acceptable salts thereof and a second antifungal agent may also be used as an agricultural fungicide.
摘要翻译： 本发明提供包含式（I）的抗真菌中氮茚化合物或其药学上可接受的盐与第二抗真菌剂的组合的药物组合：其中：R1，R2，R3，R4，R5，R6，R7，X和X1分别为 如本文所定义。 本发明还提供包含式（I）的抗真菌中氮茚化合物或其药学上可接受的盐，第二抗真菌剂和药学上可接受的稀释剂或载体的药物组合物。 组合和组合物可用于预防或治疗真菌病。 式（I）的中氮茚化合物或其农业上可接受的盐和第二抗真菌剂的组合也可以用作农业杀真菌剂。
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公开(公告)号：US07596598B2
公开(公告)日：2009-09-29
申请号：US11546159
申请日：2006-10-10
申请人： Michael Birch
发明人： Michael Birch
CPC分类号： G06Q10/10
摘要： A system for collaboratively producing artwork includes a server and a plurality of user computers coupled to a network. The server transmits a request for submissions to collaborators and who prepare portions of the artwork using multimedia tools provided by the server computer. The collaborators transmit their completed portions of the artwork back to the server computer where they are compiled and transmitted to a recipient on a designated time.
摘要翻译： 用于协同制作艺术品的系统包括耦合到网络的服务器和多个用户计算机。 服务器向协作者发送提交的请求，并且使用由服务器计算机提供的多媒体工具准备艺术品的部分。 合作者将其完成的图像部分传送回服务器计算机，并在指定的时间将其编译并传送给收件人。
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5.发明申请公开(公告)号：US20050220645A1
公开(公告)日：2005-10-06
申请号：US10907114
申请日：2005-03-21
申请人： John Kerr , Michael Birch , Joseph Scranton , Tauna Leonardi , Randall Vessels
发明人： John Kerr , Michael Birch , Joseph Scranton , Tauna Leonardi , Randall Vessels
CPC分类号： E21B36/001 , E21B33/035 , E21B43/128 , F04B17/03 , F04B47/00
摘要： A booster pumping system is disclosed for producing hydrocarbons from a subsea production well. The booster pumping system includes: (1) a submersible pump hydraulically connected to the production well to provide energy to the hydrocarbon flow and boost production to another destination such as a subsea production facility or the surface via a riser; (2) an inlet conduit to receive the flow from the production well and isolate the flow from the dummy wellbore and direct the flow to the intake of the pump; and (3) a motor exposed to the dummy wellbore to drive the pump. The dummy wellbore may be flooded or circulated with seawater to cool the motor.
摘要翻译： 公开了一种用于从海底生产井生产碳氢化合物的增压泵送系统。 增压泵系统包括：（1）液压连接到生产井的潜水泵，以向碳氢化合物流提供能量，并通过提升管将生产提高到另一目的地，例如海底生产设施或地面; （2）入口管道，用于接收来自生产井的流动，并将流体与假井眼井隔离并将流体引导到泵的入口; 和（3）暴露于假井眼的马达驱动泵。 假井眼可能被海水淹没或循环，以冷却马达。
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公开(公告)号：US20090313547A1
公开(公告)日：2009-12-17
申请号：US12547271
申请日：2009-08-25
申请人： Michael Birch
发明人： Michael Birch
CPC分类号： G06Q10/10
摘要： A system for collaboratively producing artwork includes a server and a plurality of user computers coupled to a network. The server transmits a request for submissions to collaborators and who prepare portions of the artwork using multimedia tools provided by the server computer. The collaborators transmit their completed portions of the artwork back to the server computer where they are compiled and transmitted to a recipient on a designated time.
摘要翻译： 用于协同制作艺术品的系统包括耦合到网络的服务器和多个用户计算机。 服务器向协作者发送提交的请求，并且使用由服务器计算机提供的多媒体工具准备艺术品的部分。 合作者将其完成的图像部分传送回服务器计算机，并在指定的时间将其编译并传送给收件人。
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7.发明授权公开(公告)号：US07914266B2
公开(公告)日：2011-03-29
申请号：US10907114
申请日：2005-03-21
CPC分类号： E21B36/001 , E21B33/035 , E21B43/128 , F04B17/03 , F04B47/00
摘要： A booster pumping system is disclosed for producing hydrocarbons from a subsea production well. The booster pumping system includes: (1) a submersible pump hydraulically connected to the production well to provide energy to the hydrocarbon flow and boost production to another destination such as a subsea production facility or the surface via a riser; (2) an inlet conduit to receive the flow from the production well and isolate the flow from the dummy wellbore and direct the flow to the intake of the pump; and (3) a motor exposed to the dummy wellbore to drive the pump. The dummy wellbore may be flooded or circulated with seawater to cool the motor.
摘要翻译： 公开了一种用于从海底生产井生产碳氢化合物的增压泵送系统。 增压泵系统包括：（1）液压连接到生产井的潜水泵，以向碳氢化合物流提供能量，并通过提升管将生产提高到另一目的地，例如海底生产设施或地面; （2）入口管道，用于接收来自生产井的流动，并将流体与假井眼井隔离并将流体引导到泵的入口; 和（3）暴露于假井眼的马达驱动泵。 假井眼可能被海水淹没或循环，以冷却马达。
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公开(公告)号：US07707251B2
公开(公告)日：2010-04-27
申请号：US11487039
申请日：2006-07-14
申请人： Michael Birch
发明人： Michael Birch
IPC分类号： G06F15/16
CPC分类号： G06Q30/02
摘要： A social network drawing system allows users of the social network to communicate with text as well as pictures that are posted on a web site. The social network program includes a user interface having drawing tools and a drawing area. The user selects the desired tools which include a marker, marker color, marker size and canvas size to prepare the illustration using a computer mouse. The completed illustrations are posted on the posting page which allows other users to view and respond with additional illustrations to the posted drawings.
摘要翻译： 社交网络绘图系统允许社交网络的用户与文本以及在网站上发布的图片进行通信。 社交网络程序包括具有绘图工具和绘图区域的用户界面。 用户选择包括标记，标记颜色，标记尺寸和画布大小的所需工具，以使用计算机鼠标准备图示。 完成的插图张贴在发布页面上，允许其他用户查看并回复附加插图。
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公开(公告)号：US20070094328A1
公开(公告)日：2007-04-26
申请号：US11546159
申请日：2006-10-10
申请人： Michael Birch
发明人： Michael Birch
IPC分类号： G06F15/16
CPC分类号： G06Q10/10
摘要： A system for collaboratively producing artwork includes a server and a plurality of user computers coupled to a network. The server transmits a request for submissions to collaborators and who prepare portions of the artwork using multimedia tools provided by the server computer. The collaborators transmit their completed portions of the artwork back to the server computer where they are compiled and transmitted to a recipient on a designated time.
摘要翻译： 用于协同制作艺术品的系统包括耦合到网络的服务器和多个用户计算机。 服务器向协作者发送提交的请求，并且使用由服务器计算机提供的多媒体工具准备艺术品的部分。 合作者将其完成的图像部分传送回服务器计算机，并在指定的时间将其编译并传送给收件人。
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10.发明申请Providing a Subsea Optical Junction Assembly for Coupling Fiber Optic Cables 审中-公开提供用于耦合光纤电缆的海底光学连接组件公开(公告)号：US20070053629A1
公开(公告)日：2007-03-08
申请号：US11467206
申请日：2006-08-25
IPC分类号： G02B6/26
CPC分类号： G02B6/3816 , G02B6/4428 , G02B6/4441 , G02B6/506
摘要： A system for use in a subsea environment includes at least one fiber optic cable for connection to surface equipment, and a subsea optical junction assembly connected to the at least one fiber optic cable. The system further includes subsea components, and plural fiber optic cables connected to corresponding subsea components. The subsea optical junction assembly couples the at least one fiber optic cable for connection with the surface equipment to the plural fiber optic cables connected to the subsea components.
摘要翻译： 一种在海底环境中使用的系统包括用于连接到地面设备的至少一根光缆，以及连接至该至少一根光缆的海底光学连接组件。 该系统还包括海底部件和连接到对应的海底部件的多根光缆。 海底光学连接组件将至少一个光纤电缆与表面设备连接到连接到海底部件的多个光纤电缆。
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