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公开(公告)号：US08248081B2
公开(公告)日：2012-08-21
申请号：US12200623
申请日：2008-08-28
IPC分类号： G01R35/00
CPC分类号： G06F3/0416 , G06F3/03547 , G06F3/0418 , G06F3/044 , G06F2203/0339
摘要： A single-layer touch-sensor device having a calibration mechanism coupled therewith is described. Included is a charge measurement circuit coupled, by a pair of electrical traces, with a slider of the single-layer touch-sensor device. A pair of calibration capacitors is included, each calibration capacitor coupled, between the slider and the charge measurement circuit, with one of the pair of electrical traces. A pair of connection switches is also included, each connection switch coupled with one of the pair of calibration capacitors.
摘要翻译： 描述了具有与其耦合的校准机构的单层触摸传感器装置。 包括通过一对电迹线与单层触摸传感器装置的滑块耦合的电荷测量电路。 包括一对校准电容器，每个校准电容器在滑块和电荷测量电路之间耦合，具有一对电迹线之一。 还包括一对连接开关，每个连接开关与一对校准电容器中的一个耦合。
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公开(公告)号：US20110183969A1
公开(公告)日：2011-07-28
申请号：US12994443
申请日：2009-05-29
IPC分类号： A61K31/541 , A01N43/84 , A61K31/437 , A01N43/40 , A61K31/4745 , A61K31/5377 , A61K31/496 , A01N43/60 , A01P3/00 , A61P31/00
CPC分类号： A61K45/06 , A61K31/437 , A61K2300/00
摘要： The invention provides pharmaceutical combinations comprising a combination of an antifungal indolizine compound of formula (I) or a pharmaceutically acceptable salt thereof and a second antifungal agent: wherein: R1, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. The invention also provides pharmaceutical compositions comprising an antifungal indolizine compound of formula (I) or a pharmaceutically acceptable salt thereof, a second antifungal agent and a pharmaceutically acceptable diluent or carrier. The combinations and compositions are useful in the prevention or treatment of a fungal disease. A combination of an indolizine compound of formula (I) or agriculturally acceptable salts thereof and a second antifungal agent may also be used as an agricultural fungicide.
摘要翻译： 本发明提供包含式（I）的抗真菌中氮茚化合物或其药学上可接受的盐与第二抗真菌剂的组合的药物组合：其中：R1，R2，R3，R4，R5，R6，R7，X和X1分别为 如本文所定义。 本发明还提供包含式（I）的抗真菌中氮茚化合物或其药学上可接受的盐，第二抗真菌剂和药学上可接受的稀释剂或载体的药物组合物。 组合和组合物可用于预防或治疗真菌病。 式（I）的中氮茚化合物或其农业上可接受的盐和第二抗真菌剂的组合也可以用作农业杀真菌剂。
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公开(公告)号：US20090313547A1
公开(公告)日：2009-12-17
申请号：US12547271
申请日：2009-08-25
申请人： Michael Birch
发明人： Michael Birch
CPC分类号： G06Q10/10
摘要： A system for collaboratively producing artwork includes a server and a plurality of user computers coupled to a network. The server transmits a request for submissions to collaborators and who prepare portions of the artwork using multimedia tools provided by the server computer. The collaborators transmit their completed portions of the artwork back to the server computer where they are compiled and transmitted to a recipient on a designated time.
摘要翻译： 用于协同制作艺术品的系统包括耦合到网络的服务器和多个用户计算机。 服务器向协作者发送提交的请求，并且使用由服务器计算机提供的多媒体工具准备艺术品的部分。 合作者将其完成的图像部分传送回服务器计算机，并在指定的时间将其编译并传送给收件人。
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4.发明授权Dihydroorotate dehydrogenase as antifungal drug target and quinazolinone-based inhibitors thereof 有权脱氢山梨醇脱氢酶作为抗真菌药物靶标和基于喹唑啉酮的抑制剂公开(公告)号：US09034887B2
公开(公告)日：2015-05-19
申请号：US12990478
申请日：2009-05-01
申请人： Jason David Oliver , John Leslie Thain , Michael John Bromley , Graham Edward Morris Sibley , Michael Birch
发明人： Jason David Oliver , John Leslie Thain , Michael John Bromley , Graham Edward Morris Sibley , Michael Birch
IPC分类号： A61K31/517 , G01N33/573 , C12Q1/32 , C12N9/04 , C07D239/72 , A61P31/10 , C07D239/95 , C12N9/02
CPC分类号： C12Q1/32 , C07D239/95 , C12N9/001 , C12Y103/05002 , G01N2333/90206 , G01N2500/02
摘要： A method of identifying an antifungal agent which targets a DHODH protein (alias PyrE, dihydroorotate dehydrogenase, EC: 1.3.99.11) of a fungus comprising contacting a candidate substance with a fungal DHODH protein and determining whether the candidate substance binds or modulates the DHODH protein, wherein binding or modulation indicates that the candidate substance is an antifungal agent. Specific examples concern Aspergillus fumigatus and Candida albicans DHODH proteins. DHODH inhibitors with a Quinazolinone core are also disclosed.
摘要翻译： 鉴定靶向真菌的DHODH蛋白（别名PyrE，二氢叶酸脱氢酶，EC：1.3.99.11）的抗真菌剂的方法，其包括将候选物质与真菌DHODH蛋白质接触，并确定候选物质是否结合或调节DHODH蛋白 其中结合或调节表明候选物质是抗真菌剂。 具体实例涉及烟曲霉和白色念珠菌DHODH蛋白。 还公开了具有喹唑啉酮核心的DHODH抑制剂。
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公开(公告)号：US20090137047A1
公开(公告)日：2009-05-28
申请号：US12039069
申请日：2008-02-28
IPC分类号： G01N35/10
CPC分类号： G01N35/04 , G01N35/00871 , G01N2001/028 , G01N2035/0091 , G01N2035/0406
摘要： An automated and autonomous diagnostic apparatus that is capable of dispensing collection vials and collections kits to users interesting in collecting a biological sample and submitting their collected sample contained within a collection vial into the apparatus for automated diagnostic services. The user communicates with the apparatus through a touch-screen monitor. A user is able to enter personnel information into the apparatus including medical history, insurance information, co-payment, and answer a series of questions regarding their illness, which is used to determine the assay most likely to yield a positive result. Remotely-located physicians can communicate with users of the apparatus using video tele-medicine and request specific assays to be performed. The apparatus archives submitted samples for additional testing. Users may receive their assay results electronically. Users may allow the uploading of their diagnoses into a central databank for disease surveillance purposes.
摘要翻译： 一种自动和自主的诊断设备，能够将收集瓶和收集套件分配给有趣的采集生物样品的用户，并将收集瓶中收集的样品提交到用于自动诊断服务的设备中。 用户通过触摸屏监视器与设备进行通信。 用户能够将人员信息输入到设备中，包括医疗史，保险信息，共同支付，以及回答关于其疾病的一系列问题，其用于确定最有可能产生阳性结果的测定。 远程医师可以使用视频远程医学与设备的用户进行通信，并请求执行特定测定。 设备存档提交的样品进行额外测试。 用户可以以电子方式收到其测定结果。 用户可以允许将其诊断上传到中央数据库，以进行疾病监视。
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6.发明申请DIHYDROOROTATE DEHYDROGENASE AS ANTIFUNGAL DRUG TARGET AND QUINAZOLINONE-BASED INHIBITORS THEREOF 有权DIHYDROOROTETE DEHYDROGENASE作为抗真菌药物靶标和基于喹唑啉酮的抑制剂公开(公告)号：US20110160231A1
公开(公告)日：2011-06-30
申请号：US12990478
申请日：2009-05-01
申请人： Jason David Oliver , John Leslie Thain , Michael John Bromley , Graham Edward Morris Sibley , Michael Birch
发明人： Jason David Oliver , John Leslie Thain , Michael John Bromley , Graham Edward Morris Sibley , Michael Birch
IPC分类号： A61K31/517 , G01N33/573 , C12Q1/32 , C12N9/04 , C07D239/72 , A61P31/10
CPC分类号： C12Q1/32 , C07D239/95 , C12N9/001 , C12Y103/05002 , G01N2333/90206 , G01N2500/02
摘要： A method of identifying an antifungal agent which targets a DHODH protein (alias PyrE, dihydroorotate dehydrogenase, EC: 1.3.99.11) of a fungus comprising contacting a candidate substance with a fungal DHODH protein and determining whether the candidate substance binds or modulates the DHODH protein, wherein binding or modulation indicates that the candidate substance is an antifungal agent. Specific examples concern Aspergillus fumigatus and Candida albicans DHODH proteins. DHODH inhibitors with a Quinazolinone core are also disclosed.
摘要翻译： 鉴定靶向真菌的DHODH蛋白（别名PyrE，二氢叶酸脱氢酶，EC：1.3.99.11）的抗真菌剂的方法，其包括将候选物质与真菌DHODH蛋白质接触，并确定候选物质是否结合或调节DHODH蛋白 其中结合或调节表明候选物质是抗真菌剂。 具体实例涉及烟曲霉和白色念珠菌DHODH蛋白。 还公开了具有喹唑啉酮核心的DHODH抑制剂。
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公开(公告)号：US20100111366A1
公开(公告)日：2010-05-06
申请号：US12308970
申请日：2007-06-28
IPC分类号： G06K9/62
CPC分类号： G01B11/22 , G01B11/2513
摘要： A method and apparatus for depth imaging by triangulation in which a pattern is projected on to an object scene and the scene, and the pattern, imaged, the projection and the imaging being spatially offset, in which the pattern has a characteristic dimension x and depth changes in the object scene cause deformations in the image of the pattern having a maximum dimension Δx, characterised in that Δx
摘要翻译： 一种用于通过三角测量深度成像的方法和装置，其中将图案投影到对象场景和场景，并且图案，成像，投影和成像在空间上偏移，其中图案具有特征尺寸x和深度 对象场景中的变化导致具有最大尺寸＆Dgr; x的图案的图像中的变形，其特征在于＆Dgr; x
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公开(公告)号：US20070016689A1
公开(公告)日：2007-01-18
申请号：US11487039
申请日：2006-07-14
申请人： Michael Birch
发明人： Michael Birch
IPC分类号： G06F15/173
CPC分类号： G06Q30/02
摘要： A social network drawing system allows users of the social network to communicate with text as well as pictures that are posted on a web site. The social network program includes a user interface having drawing tools and a drawing area. The user selects the desired tools which include a marker, marker color, marker size and canvas size to prepare the illustration using a computer mouse. The completed illustrations are posted on the posting page which allows other users to view and respond with additional illustrations to the posted drawings.
摘要翻译： 社交网络绘图系统允许社交网络的用户与文本以及在网站上发布的图片进行通信。 社交网络程序包括具有绘图工具和绘图区域的用户界面。 用户选择包括标记，标记颜色，标记尺寸和画布大小的所需工具，以使用计算机鼠标准备图示。 完成的插图张贴在发布页面上，允许其他用户查看并回复附加插图。
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公开(公告)号：US06332285B1
公开(公告)日：2001-12-25
申请号：US09343059
申请日：1999-06-29
IPC分类号： G09F2310
CPC分类号： G09F23/10 , B42F21/065
摘要： A plastic tab for indexing or marking a folder or an edge portion of an article such as an organizer or storage system. The lower portion of the tab has two downwardly extending walls, between which an edge of the folder or other article may be placed. The downwardly extending walls are configured and adapted to create an interference fit when the folder or other article is inserted between the walls of the tab. The interference fit enables the tab to remain securely in the desired position along the edge portion. The tab is made of a flexible polymeric material so that it may be mounted, re-positioned or removed easily. Removal of the tab from a wall edge causes the walls to flex apart and thereby eliminate or minimize the interference fit between the tab lower walls and the article on which the tab is mounted. Removal of the tab is therefore a smooth and simple operation that minimizes breakage of the tab or damage to the folder, organizer or storage medium.
摘要翻译： 用于对文件夹或文件夹的边缘部分进行索引或标记的塑料接头，例如组织器或存储系统。 突片的下部具有两个向下延伸的壁，两者之间可以放置折叠物或其他物品的边缘。 向下延伸的壁被构造和适配成当折叠物或其它物品插入在突片的壁之间时产生过盈配合。 过盈配合使得突片能够沿着边缘部分牢固地保持在期望的位置。 突片由柔性聚合物材料制成，使得其可以容易地安装，重新定位或移除。 从壁边缘移除凸片导致壁弯曲分开，从而消除或最小化突片下壁和安装有突片的物品之间的过盈配合。 因此，拆下突片是一种平滑而简单的操作，可最大限度地减少突片的破损或损坏文件夹，组织者或存储介质。
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公开(公告)号：US5701667A
公开(公告)日：1997-12-30
申请号：US442938
申请日：1995-05-17
CPC分类号： H05K1/0212 , G01R31/2805 , G01R31/2817 , G01R31/2818 , H05K1/0201 , H05K1/0266 , H05K1/0268 , H05K2201/09609 , H05K2201/09627 , H05K2201/10151 , H05K2203/1115 , H05K2203/1194 , H05K2203/162 , H05K3/429 , Y10T29/49165
摘要： This disclosure describes an Interconnect Stress Testing (IST) system and a printed wiring board test coupon which is used with the IST system. The system includes a computer device and a cabinet which is used for mounting the test coupon as well as housing a number of the other components that make up the system. During a pre-cycling phase, the system determines the correct current that should be passed through the coupon in order to heat it to a predetermined temperature. After that test current value is determined the system actually stress tests the coupon by passing the determined test current through the coupon. It does so for a selected number of cycles, and monitors resistance changes in the coupon during testing while recording test data. This disclosure also describes the test coupon, which is designed to uniformly dissipate the heat created during stress cycling.
摘要翻译： 本公开描述了与IST系统一起使用的互连压力测试（IST）系统和印刷线路板测试券。 该系统包括一个计算机设备和一个柜子，用于安装测试件以及容纳构成系统的其他组件。 在预循环阶段期间，系统确定应该通过试样的正确电流，以将其加热到预定温度。 在该测试之后，确定当前值，系统实际上通过将确定的测试电流通过优惠券来测试优惠券。 它在选定的周期内执行此操作，并在记录测试数据的同时监测测试期间优惠券的电阻变化。 本公开还描述了测试试样，其被设计成均匀地消散在应力循环期间产生的热量。
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