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1.发明申请公开(公告)号：US20050220645A1
公开(公告)日：2005-10-06
申请号：US10907114
申请日：2005-03-21
申请人： John Kerr , Michael Birch , Joseph Scranton , Tauna Leonardi , Randall Vessels
发明人： John Kerr , Michael Birch , Joseph Scranton , Tauna Leonardi , Randall Vessels
CPC分类号： E21B36/001 , E21B33/035 , E21B43/128 , F04B17/03 , F04B47/00
摘要： A booster pumping system is disclosed for producing hydrocarbons from a subsea production well. The booster pumping system includes: (1) a submersible pump hydraulically connected to the production well to provide energy to the hydrocarbon flow and boost production to another destination such as a subsea production facility or the surface via a riser; (2) an inlet conduit to receive the flow from the production well and isolate the flow from the dummy wellbore and direct the flow to the intake of the pump; and (3) a motor exposed to the dummy wellbore to drive the pump. The dummy wellbore may be flooded or circulated with seawater to cool the motor.
摘要翻译： 公开了一种用于从海底生产井生产碳氢化合物的增压泵送系统。 增压泵系统包括：（1）液压连接到生产井的潜水泵，以向碳氢化合物流提供能量，并通过提升管将生产提高到另一目的地，例如海底生产设施或地面; （2）入口管道，用于接收来自生产井的流动，并将流体与假井眼井隔离并将流体引导到泵的入口; 和（3）暴露于假井眼的马达驱动泵。 假井眼可能被海水淹没或循环，以冷却马达。
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2.发明授权公开(公告)号：US07914266B2
公开(公告)日：2011-03-29
申请号：US10907114
申请日：2005-03-21
CPC分类号： E21B36/001 , E21B33/035 , E21B43/128 , F04B17/03 , F04B47/00
摘要： A booster pumping system is disclosed for producing hydrocarbons from a subsea production well. The booster pumping system includes: (1) a submersible pump hydraulically connected to the production well to provide energy to the hydrocarbon flow and boost production to another destination such as a subsea production facility or the surface via a riser; (2) an inlet conduit to receive the flow from the production well and isolate the flow from the dummy wellbore and direct the flow to the intake of the pump; and (3) a motor exposed to the dummy wellbore to drive the pump. The dummy wellbore may be flooded or circulated with seawater to cool the motor.
摘要翻译： 公开了一种用于从海底生产井生产碳氢化合物的增压泵送系统。 增压泵系统包括：（1）液压连接到生产井的潜水泵，以向碳氢化合物流提供能量，并通过提升管将生产提高到另一目的地，例如海底生产设施或地面; （2）入口管道，用于接收来自生产井的流动，并将流体与假井眼井隔离并将流体引导到泵的入口; 和（3）暴露于假井眼的马达驱动泵。 假井眼可能被海水淹没或循环，以冷却马达。
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公开(公告)号：US07596598B2
公开(公告)日：2009-09-29
申请号：US11546159
申请日：2006-10-10
申请人： Michael Birch
发明人： Michael Birch
CPC分类号： G06Q10/10
摘要： A system for collaboratively producing artwork includes a server and a plurality of user computers coupled to a network. The server transmits a request for submissions to collaborators and who prepare portions of the artwork using multimedia tools provided by the server computer. The collaborators transmit their completed portions of the artwork back to the server computer where they are compiled and transmitted to a recipient on a designated time.
摘要翻译： 用于协同制作艺术品的系统包括耦合到网络的服务器和多个用户计算机。 服务器向协作者发送提交的请求，并且使用由服务器计算机提供的多媒体工具准备艺术品的部分。 合作者将其完成的图像部分传送回服务器计算机，并在指定的时间将其编译并传送给收件人。
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公开(公告)号：US20110183969A1
公开(公告)日：2011-07-28
申请号：US12994443
申请日：2009-05-29
IPC分类号： A61K31/541 , A01N43/84 , A61K31/437 , A01N43/40 , A61K31/4745 , A61K31/5377 , A61K31/496 , A01N43/60 , A01P3/00 , A61P31/00
CPC分类号： A61K45/06 , A61K31/437 , A61K2300/00
摘要： The invention provides pharmaceutical combinations comprising a combination of an antifungal indolizine compound of formula (I) or a pharmaceutically acceptable salt thereof and a second antifungal agent: wherein: R1, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. The invention also provides pharmaceutical compositions comprising an antifungal indolizine compound of formula (I) or a pharmaceutically acceptable salt thereof, a second antifungal agent and a pharmaceutically acceptable diluent or carrier. The combinations and compositions are useful in the prevention or treatment of a fungal disease. A combination of an indolizine compound of formula (I) or agriculturally acceptable salts thereof and a second antifungal agent may also be used as an agricultural fungicide.
摘要翻译： 本发明提供包含式（I）的抗真菌中氮茚化合物或其药学上可接受的盐与第二抗真菌剂的组合的药物组合：其中：R1，R2，R3，R4，R5，R6，R7，X和X1分别为 如本文所定义。 本发明还提供包含式（I）的抗真菌中氮茚化合物或其药学上可接受的盐，第二抗真菌剂和药学上可接受的稀释剂或载体的药物组合物。 组合和组合物可用于预防或治疗真菌病。 式（I）的中氮茚化合物或其农业上可接受的盐和第二抗真菌剂的组合也可以用作农业杀真菌剂。
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公开(公告)号：US20090313547A1
公开(公告)日：2009-12-17
申请号：US12547271
申请日：2009-08-25
申请人： Michael Birch
发明人： Michael Birch
CPC分类号： G06Q10/10
摘要： A system for collaboratively producing artwork includes a server and a plurality of user computers coupled to a network. The server transmits a request for submissions to collaborators and who prepare portions of the artwork using multimedia tools provided by the server computer. The collaborators transmit their completed portions of the artwork back to the server computer where they are compiled and transmitted to a recipient on a designated time.
摘要翻译： 用于协同制作艺术品的系统包括耦合到网络的服务器和多个用户计算机。 服务器向协作者发送提交的请求，并且使用由服务器计算机提供的多媒体工具准备艺术品的部分。 合作者将其完成的图像部分传送回服务器计算机，并在指定的时间将其编译并传送给收件人。
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6.发明授权Dihydroorotate dehydrogenase as antifungal drug target and quinazolinone-based inhibitors thereof 有权脱氢山梨醇脱氢酶作为抗真菌药物靶标和基于喹唑啉酮的抑制剂公开(公告)号：US09034887B2
公开(公告)日：2015-05-19
申请号：US12990478
申请日：2009-05-01
申请人： Jason David Oliver , John Leslie Thain , Michael John Bromley , Graham Edward Morris Sibley , Michael Birch
发明人： Jason David Oliver , John Leslie Thain , Michael John Bromley , Graham Edward Morris Sibley , Michael Birch
IPC分类号： A61K31/517 , G01N33/573 , C12Q1/32 , C12N9/04 , C07D239/72 , A61P31/10 , C07D239/95 , C12N9/02
CPC分类号： C12Q1/32 , C07D239/95 , C12N9/001 , C12Y103/05002 , G01N2333/90206 , G01N2500/02
摘要： A method of identifying an antifungal agent which targets a DHODH protein (alias PyrE, dihydroorotate dehydrogenase, EC: 1.3.99.11) of a fungus comprising contacting a candidate substance with a fungal DHODH protein and determining whether the candidate substance binds or modulates the DHODH protein, wherein binding or modulation indicates that the candidate substance is an antifungal agent. Specific examples concern Aspergillus fumigatus and Candida albicans DHODH proteins. DHODH inhibitors with a Quinazolinone core are also disclosed.
摘要翻译： 鉴定靶向真菌的DHODH蛋白（别名PyrE，二氢叶酸脱氢酶，EC：1.3.99.11）的抗真菌剂的方法，其包括将候选物质与真菌DHODH蛋白质接触，并确定候选物质是否结合或调节DHODH蛋白 其中结合或调节表明候选物质是抗真菌剂。 具体实例涉及烟曲霉和白色念珠菌DHODH蛋白。 还公开了具有喹唑啉酮核心的DHODH抑制剂。
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7.发明申请DIHYDROOROTATE DEHYDROGENASE AS ANTIFUNGAL DRUG TARGET AND QUINAZOLINONE-BASED INHIBITORS THEREOF 有权DIHYDROOROTETE DEHYDROGENASE作为抗真菌药物靶标和基于喹唑啉酮的抑制剂公开(公告)号：US20110160231A1
公开(公告)日：2011-06-30
申请号：US12990478
申请日：2009-05-01
申请人： Jason David Oliver , John Leslie Thain , Michael John Bromley , Graham Edward Morris Sibley , Michael Birch
发明人： Jason David Oliver , John Leslie Thain , Michael John Bromley , Graham Edward Morris Sibley , Michael Birch
IPC分类号： A61K31/517 , G01N33/573 , C12Q1/32 , C12N9/04 , C07D239/72 , A61P31/10
CPC分类号： C12Q1/32 , C07D239/95 , C12N9/001 , C12Y103/05002 , G01N2333/90206 , G01N2500/02
摘要： A method of identifying an antifungal agent which targets a DHODH protein (alias PyrE, dihydroorotate dehydrogenase, EC: 1.3.99.11) of a fungus comprising contacting a candidate substance with a fungal DHODH protein and determining whether the candidate substance binds or modulates the DHODH protein, wherein binding or modulation indicates that the candidate substance is an antifungal agent. Specific examples concern Aspergillus fumigatus and Candida albicans DHODH proteins. DHODH inhibitors with a Quinazolinone core are also disclosed.
摘要翻译： 鉴定靶向真菌的DHODH蛋白（别名PyrE，二氢叶酸脱氢酶，EC：1.3.99.11）的抗真菌剂的方法，其包括将候选物质与真菌DHODH蛋白质接触，并确定候选物质是否结合或调节DHODH蛋白 其中结合或调节表明候选物质是抗真菌剂。 具体实例涉及烟曲霉和白色念珠菌DHODH蛋白。 还公开了具有喹唑啉酮核心的DHODH抑制剂。
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公开(公告)号：US20070016689A1
公开(公告)日：2007-01-18
申请号：US11487039
申请日：2006-07-14
申请人： Michael Birch
发明人： Michael Birch
IPC分类号： G06F15/173
CPC分类号： G06Q30/02
摘要： A social network drawing system allows users of the social network to communicate with text as well as pictures that are posted on a web site. The social network program includes a user interface having drawing tools and a drawing area. The user selects the desired tools which include a marker, marker color, marker size and canvas size to prepare the illustration using a computer mouse. The completed illustrations are posted on the posting page which allows other users to view and respond with additional illustrations to the posted drawings.
摘要翻译： 社交网络绘图系统允许社交网络的用户与文本以及在网站上发布的图片进行通信。 社交网络程序包括具有绘图工具和绘图区域的用户界面。 用户选择包括标记，标记颜色，标记尺寸和画布大小的所需工具，以使用计算机鼠标准备图示。 完成的插图张贴在发布页面上，允许其他用户查看并回复附加插图。
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公开(公告)号：US06332285B1
公开(公告)日：2001-12-25
申请号：US09343059
申请日：1999-06-29
IPC分类号： G09F2310
CPC分类号： G09F23/10 , B42F21/065
摘要： A plastic tab for indexing or marking a folder or an edge portion of an article such as an organizer or storage system. The lower portion of the tab has two downwardly extending walls, between which an edge of the folder or other article may be placed. The downwardly extending walls are configured and adapted to create an interference fit when the folder or other article is inserted between the walls of the tab. The interference fit enables the tab to remain securely in the desired position along the edge portion. The tab is made of a flexible polymeric material so that it may be mounted, re-positioned or removed easily. Removal of the tab from a wall edge causes the walls to flex apart and thereby eliminate or minimize the interference fit between the tab lower walls and the article on which the tab is mounted. Removal of the tab is therefore a smooth and simple operation that minimizes breakage of the tab or damage to the folder, organizer or storage medium.
摘要翻译： 用于对文件夹或文件夹的边缘部分进行索引或标记的塑料接头，例如组织器或存储系统。 突片的下部具有两个向下延伸的壁，两者之间可以放置折叠物或其他物品的边缘。 向下延伸的壁被构造和适配成当折叠物或其它物品插入在突片的壁之间时产生过盈配合。 过盈配合使得突片能够沿着边缘部分牢固地保持在期望的位置。 突片由柔性聚合物材料制成，使得其可以容易地安装，重新定位或移除。 从壁边缘移除凸片导致壁弯曲分开，从而消除或最小化突片下壁和安装有突片的物品之间的过盈配合。 因此，拆下突片是一种平滑而简单的操作，可最大限度地减少突片的破损或损坏文件夹，组织者或存储介质。
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公开(公告)号：US07707251B2
公开(公告)日：2010-04-27
申请号：US11487039
申请日：2006-07-14
申请人： Michael Birch
发明人： Michael Birch
IPC分类号： G06F15/16
CPC分类号： G06Q30/02
摘要： A social network drawing system allows users of the social network to communicate with text as well as pictures that are posted on a web site. The social network program includes a user interface having drawing tools and a drawing area. The user selects the desired tools which include a marker, marker color, marker size and canvas size to prepare the illustration using a computer mouse. The completed illustrations are posted on the posting page which allows other users to view and respond with additional illustrations to the posted drawings.
摘要翻译： 社交网络绘图系统允许社交网络的用户与文本以及在网站上发布的图片进行通信。 社交网络程序包括具有绘图工具和绘图区域的用户界面。 用户选择包括标记，标记颜色，标记尺寸和画布大小的所需工具，以使用计算机鼠标准备图示。 完成的插图张贴在发布页面上，允许其他用户查看并回复附加插图。
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