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    Stereoselective preparation of gamma-lactones
    3.
    发明授权
    Stereoselective preparation of gamma-lactones 有权
    γ-内酯的立体选择性制备

    公开(公告)号：US07863023B2

    公开(公告)日：2011-01-04

    申请号：US11666734

    申请日：2005-11-02

    Applicant: Joseph Zucca ,  Jean Mane

    Inventor： Joseph Zucca ,  Jean Mane

    IPC: C12P17/04

    CPC classification number: C07D307/33 ,  C12P17/04

    Abstract: Method for stereoselectively preparing a (R) or (S) gamma-lactone consists in microbially biosynthesizing gamma-lactone, wherein the biosynthesis is carried out from a substrate selected from C5 to C20 fatty acids with the aid of a strain selected from those enabling a stereoselective hydroxylation in C4 of the substrate, in particular Aspergollus sp or Mortierella sp. The biosynthesis of the gamma-lactone and the use thereof in perfumery and for food flavouring agents are also disclosed.

    Abstract translation: 用于立体选择性制备（R）或（S）γ-内酯的方法在于微生物合成γ-内酯，其中所述生物合成是在选自C5至C20脂肪酸的底物的帮助下从选自以下的菌株中进行的： 底物C4中的立体选择性羟基化，特别是Aspergollus sp或Mortierella sp。 还公开了γ-内酯的生物合成及其在香料和食品调味剂中的用途。

    SYSTEM FOR THE PRODUCTION OF AROMATIC MOLECULES IN STREPTOMYCES
    4.
    发明申请
    SYSTEM FOR THE PRODUCTION OF AROMATIC MOLECULES IN STREPTOMYCES 有权
    用于生产结构域中的芳族分子的系统

    公开(公告)号：US20100184172A1

    公开(公告)日：2010-07-22

    申请号：US12528000

    申请日：2008-02-20

    Applicant: Fanny Lambert ,  Joseph Zucca ,  Jean Mane

    Inventor： Fanny Lambert ,  Joseph Zucca ,  Jean Mane

    IPC: C12P7/42 ,  C12P7/24 ,  C12P7/22 ,  C12N1/20 ,  C12N15/63 ,  C07H21/00

    CPC classification number: C12P7/42 ,  C12N9/0006 ,  C12P7/22 ,  C12P7/24

    Abstract: A process for the production of natural ferulic acid, coniferyl alcohol and/or vanillin, includes the bio-conversion of eugenol by a bacteria belonging to the Streptomyces genes including at least one nucleotide sequence SEQ ID NO:1 or SEQ ID NO:8 or any nucleotide sequence having at least 70%, preferably 80% and very preferably 90%, identity with the sequence SEQ ID NO:1 or SEQ ID NO:8.

    Abstract translation: 生产天然阿魏酸，松柏醇和/或香草醛的方法包括由属于链霉菌基因的细菌对丁子香酚的生物转化，包括至少一个核苷酸序列SEQ ID NO：1或SEQ ID NO：8或 与序列SEQ ID NO：1或SEQ ID NO：8具有至少70％，优选80％，非常优选90％同一性的任何核苷酸序列。

    Method for the enzymatic preparation of aromatic substances
    7.
    发明授权
    Method for the enzymatic preparation of aromatic substances 失效
    芳香物质酶法制备方法

    公开(公告)号：US5712132A

    公开(公告)日：1998-01-27

    申请号：US574786

    申请日：1995-12-19

    Applicant: Jean Mane ,  Joseph Zucca

    Inventor： Jean Mane ,  Joseph Zucca

    IPC: C12P7/24 ,  C12P17/04 ,  C12P7/42 ,  C12N9/02

    CPC classification number: C12P7/24 ,  C12P17/04

    Abstract: A method for preparing aromatic substances having formula (I), wherein a substrate of formula (II) or an isomer of these precursors, also termed a substrate, in particular selected from those of formula (III), in which formulae R.sub.1 may be a --CH3, --CH2OH, --CHO, --COOH, or (a) radical, R.sub.2 may be a --H, --OH or --O--CH3 radical R.sub.3 may be a --H, --OH or --O--CH3 radical, and R.sub.2 and R.sub.3 may form a methylenedioxy bridge (b), is exposed to the activity of a lipoxygenase. ##STR1##

    Abstract translation: 一种制备具有式（I）的芳族物质的方法，其中式（II）的底物或这些前体的异构体，也称为底物，特别是选自式（III）的那些，其中式R1可以是 -CH 3，-CH 2 OH，-CHO，-COOH或（a）基团，R 2可以是-H，-OH或-O-CH 3基团R 3可以是-H，-OH或-O-CH 3基团，和 R2和R3可以形成亚甲二氧基桥（b），暴露于脂氧合酶的活性。

    Gamma-undecenolactone, method for the preparation and use thereof for cosmetics and in the form of food additives
    8.
    发明授权
    Gamma-undecenolactone, method for the preparation and use thereof for cosmetics and in the form of food additives 有权
    γ-十一碳烯酸内酯，其用于化妆品和食品添加剂形式的制备和使用方法

    公开(公告)号：US07884130B2

    公开(公告)日：2011-02-08

    申请号：US11666987

    申请日：2005-11-02

    Applicant: Joseph Zucca ,  Jean Mane

    Inventor： Joseph Zucca ,  Jean Mane

    IPC: A61K31/341 ,  C07D307/33

    CPC classification number: C07D307/33 ,  A23L27/2052 ,  A61K8/4973 ,  A61Q13/00 ,  C12P17/04

    Abstract: The invention relates to a gamma-undecenolactone of formula (i), wherein a lactonic cycle can carry an unsaturation between carbon No. 2 and carbon No. 3 and is preferably saturated, RI is a possibly substituted C7 alkenyl or alkynyl group having at least one unsaturation, and preferably RI is an CH2═CH—CH2—CH2—CH2—CH2—CH2 group, the gamma-undecenolactone contains an asymetric carbon in position 4 having (R) or (S) configuration. The biosynthesis of the gamma-undecenolactone and the use thereon for perfumery and for a food flavoring agent are also disclosed.

    Abstract translation: 本发明涉及式（ⅰ）的γ-十一碳烯内酯，其中内酯循环可以在碳2号和第3号碳之间具有不饱和键，最好是饱和的，RI是至少有可能被取代的C7烯基或炔基 一个不饱和度，优选地，R 1是CH 2 = CH-CH 2 -CH 2 -CH 2 -CH 2 - 基团，γ-十一内酯含有位置4上具有（R）或（S）构型的不对称碳。 还公开了γ-十一内酯的生物合成及其用于香料和食品调味剂的用途。

    Gamma-Undecenolactone, Method for the Preparation and Use Thereof for Cosmetics and in the Form of Food Additives
    9.
    发明申请
    Gamma-Undecenolactone, Method for the Preparation and Use Thereof for Cosmetics and in the Form of Food Additives 有权
    γ-乳酸内酯，其制备和使用化妆品和食品添加剂形式的方法

    公开(公告)号：US20080125345A1

    公开(公告)日：2008-05-29

    申请号：US11666987

    申请日：2005-11-02

    Applicant: Joseph Zucca ,  Jean Mane

    Inventor： Joseph Zucca ,  Jean Mane

    IPC: A61K8/49 ,  C12P17/04 ,  C07D307/02

    CPC classification number: C07D307/33 ,  A23L27/2052 ,  A61K8/4973 ,  A61Q13/00 ,  C12P17/04

    Abstract: The invention relates to a gamma-undecenolactone of formula (I), wherein a lactonic cycle can carry an unsaturation between carbon No2 and carbon No3 and is preferably saturated, RI is a possibly substituted C7 alkenyl or alkynyl group comprising at least one unsaturation, and preferably RI is an CH2═CH—CH2—CH2—CH2—CH2—CH2 group, said gamma-undecenolactone contains an asymmetric carbon in position 4 having (R) or (S) configuration. The biosynthesis of said gamma-undecenolactone and the use thereon for perfumery and for a food flavouring agent are also disclosed.

    Abstract translation: 本发明涉及式（I）的γ-十一内酯，其中内酯循环可以在碳N 2和碳N 3之间具有不饱和键，并且优选饱和 ，RI是可能被取代的C 7链烯基或炔基，其包含至少一个不饱和键，并且优选地，R 1是CH 2 CH 2 -CH 2 CH 2 -CH 2 CH 2 CH 2 CH 2 CH 2 CH 2，所述γ-十一碳烯酸内酯含有不对称的 具有（R）或（S）构型的位置4的碳。 还公开了所述γ-十一内酯的生物合成及其用于香料和食品调味剂的用途。

    System for the production of aromatic molecules in Streptomyces
    10.
    发明授权
    System for the production of aromatic molecules in Streptomyces 有权
    在链霉菌中生产芳香族分子的系统

    公开(公告)号：US08344119B2

    公开(公告)日：2013-01-01

    申请号：US12528000

    申请日：2008-02-20

    Applicant: Fanny Lambert ,  Joseph Zucca ,  Jean Mane

    Inventor： Fanny Lambert ,  Joseph Zucca ,  Jean Mane

    IPC: C07H21/04 ,  C12N1/21 ,  C12N9/04 ,  C12P7/24 ,  C12P7/42 ,  C12P7/22

    CPC classification number: C12P7/42 ,  C12N9/0006 ,  C12P7/22 ,  C12P7/24

    Abstract: A process for the production of natural ferulic acid, coniferyl alcohol and/or vanillin, includes the bio-conversion of eugenol by a bacteria belonging to the Streptomyces genes including at least one nucleotide sequence SEQ ID NO:1 or SEQ ID NO:8 or any nucleotide sequence having at least 70%, preferably 80% and very preferably 90%, identity with the sequence SEQ ID NO:1 or SEQ ID NO:8.

    Abstract translation: 生产天然阿魏酸，松柏醇和/或香草醛的方法包括由属于链霉菌基因的细菌对丁子香酚的生物转化，包括至少一个核苷酸序列SEQ ID NO：1或SEQ ID NO：8或 与序列SEQ ID NO：1或SEQ ID NO：8具有至少70％，优选80％，非常优选90％同一性的任何核苷酸序列。

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