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公开(公告)号：US07994120B2
公开(公告)日：2011-08-09
申请号：US11843223
申请日：2007-08-22
CPC分类号： A61K31/685 , A61K38/17 , A61K38/1709 , A61K47/6917 , A61K2300/00
摘要： The invention provides methods of treating or preventing a condition or disorder associated with dyslipidemia with compositions comprising apolipoprotein-sphingomyelin complexes. The methods of the invention permit reduction, by 4- to 20-fold, of the amount of apolipoprotein required for therapeutic administration to bring about an ameliorative effect.
摘要翻译： 本发明提供用包含载脂蛋白 - 鞘磷脂复合物的组合物治疗或预防与血脂异常相关的病症或障碍的方法。 本发明的方法允许将治疗性给药所需的载脂蛋白的量减少4至20倍以达到改善效果。
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2.发明申请Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders 审中-公开载脂蛋白A-1激动剂及其用于治疗血脂异常的疾病公开(公告)号：US20080058270A1
公开(公告)日：2008-03-06
申请号：US11704871
申请日：2007-02-09
CPC分类号： A61K38/10 , A61K38/16 , C07K14/775
摘要： The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia.
摘要翻译： 本发明提供模拟人ApoA-I的结构和药理学性质的肽和肽类似物。 肽和肽类似物可用于治疗与血脂异常相关的各种障碍。
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公开(公告)号：US07307058B2
公开(公告)日：2007-12-11
申请号：US10715895
申请日：2003-11-17
申请人： Jean-Louis Dasseux , Renate Sekul , Klaus Büttner , Isabelle Cornut , Günther Metz , Jean Dufourcq
发明人： Jean-Louis Dasseux , Renate Sekul , Klaus Büttner , Isabelle Cornut , Günther Metz , Jean Dufourcq
CPC分类号： C07K14/775 , A61K38/1709 , C07K7/08
摘要： The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia.
摘要翻译： 本发明提供模拟人ApoA-I的结构和药理学性质的肽和肽类似物。 肽和肽类似物可用于治疗与血脂异常相关的各种障碍。
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公开(公告)号：US07189411B2
公开(公告)日：2007-03-13
申请号：US10252940
申请日：2002-09-23
申请人： Jean-Louis Dasseux
发明人： Jean-Louis Dasseux
IPC分类号： A61K9/127
CPC分类号： A61K9/19 , A61K9/1075 , A61K9/1275 , A61K9/1277 , A61K38/1709 , A61K47/62 , C07K14/775
摘要： The invention relates to the formation of peptide/lipid vesicles and complexes through the co-lyophilization of peptides, preferably that are able to adopt an amphipathic alphahelical conformation, and one or more lipids. A single solution which solubilizes both the peptides and lipids or two separate solutions may be lyophilized.
摘要翻译： 本发明涉及肽/脂质囊泡和复合物的形成，其通过肽的共冻干，优选能够采用两亲性α-螺旋构象，以及一种或多种脂质。 溶解肽和脂质或两种分开的溶液的单一溶液可以被冻干。
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公开(公告)号：US06953840B2
公开(公告)日：2005-10-11
申请号：US10629892
申请日：2003-07-29
CPC分类号： A61K38/1709 , A61K47/543 , A61K47/6905 , A61K2300/00
摘要： The invention provides methods and compositions for treating disorders using non-human animal Apolipoprotein A-I (ApoA-I) protein. The invention provides methods and compositions for treating disorders in animals, including humans, associated with dyslipidemia, including hyperlipidemia, hyperlipoproteinemia, hypertriglyceridemia, hypercholesterolemia, HDL deficiency, ApoA-I deficiency, cardiovascular disease, atherosclerosis, restenosis, and other disorders such as septic shock and viral infections.
摘要翻译： 本发明提供了使用非人动物载脂蛋白A-I（ApoA-I）蛋白治疗病症的方法和组合物。 本发明提供了用于治疗与血脂异常相关的动物（包括人）的疾病的方法和组合物，包括高脂血症，高脂蛋白血症，高甘油三酯血症，高胆固醇血症，HDL缺乏症，ApoA-I缺乏症，心血管疾病，动脉粥样硬化，再狭窄和其它疾病如败血性休克 和病毒感染。
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公开(公告)号：US20050118650A1
公开(公告)日：2005-06-02
申请号：US10657810
申请日：2003-09-08
申请人： Jean-Louis Dasseux , Roger Newton , Thomas Rea , Charles Bisgaier , Michael Pape
发明人： Jean-Louis Dasseux , Roger Newton , Thomas Rea , Charles Bisgaier , Michael Pape
IPC分类号： G01N27/62 , C12Q1/08 , G01N33/00 , G01N33/15 , G01N33/483 , G01N33/50 , G01N33/68 , G01N33/53 , G01N33/567 , G06F19/00 , G01N33/48
CPC分类号： G01N33/5011 , G01N33/5008 , G01N33/502 , G01N33/5038 , G01N33/5091 , Y02A90/26 , Y10T436/24
摘要： The present invention relates to methods for high information content (HIC) analysis or screening of complex biological systems using Fourier transform mass spectrometry (FTMS). The present methods are useful for analyzing complex biological mixtures containing both high molecular weight molecules (e.g., polynucleotides, proteins, polysaccharides) and low molecular weight molecules (e.g., oligonucleotides, peptides, lipids, oligosaccharides, steroid hormones, catabolic and metabolic intermediates) permit the elucidation of molecular differences between complex biological samples, and permit the identification of biologically active molecules (e.g. therapeutically active drugs, etc.).
摘要翻译： 本发明涉及使用傅里叶变换质谱（FTMS）的复杂生物系统的高信息含量（HIC）分析或筛选方法。 本方法可用于分析含有高分子量分子（例如多核苷酸，蛋白质，多糖）和低分子量分子（例如寡核苷酸，肽，脂质，寡糖，类固醇激素，分解代谢和代谢中间体）的复杂生物混合物 澄清复杂生物样品之间的分子差异，并允许鉴定生物活性分子（例如治疗活性药物等）。
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公开(公告)号：US20050080013A1
公开(公告)日：2005-04-14
申请号：US10937767
申请日：2004-09-08
IPC分类号： A61K38/00 , A61K38/16 , A61K38/17 , A61K48/00 , A61P3/06 , A61P9/00 , A61P9/10 , C07K14/00 , C07K14/775 , C07K7/08
CPC分类号： A61K38/1709 , A61K48/00 , C07K7/08 , C07K14/001 , C07K14/775
摘要： The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia.
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公开(公告)号：US20050004082A1
公开(公告)日：2005-01-06
申请号：US10893791
申请日：2004-07-16
申请人： Jean-Louis Dasseux , Carmen Oniciu
发明人： Jean-Louis Dasseux , Carmen Oniciu
IPC分类号： C07D233/74 , A61K31/08 , A61K31/6615 , A61P1/18 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/12 , A61P13/12 , A61P15/10 , A61P25/28 , A61P29/00 , A61P35/00 , A61P43/00 , C07C31/20 , C07C31/36 , C07C41/01 , C07C41/18 , C07C43/13 , C07C59/125 , C07C311/04 , C07C311/24 , C07D233/72 , C07F9/09 , A61K31/66 , A61K31/185 , A61K31/19
CPC分类号： C07D233/72 , C07C43/132 , C07C59/125 , C07C311/04 , C07F9/091 , Y10S514/866 , Y10S514/909
摘要： The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要翻译： 本发明涉及新型醚化合物，包含醚化合物的组合物和用于治疗和预防心血管疾病，血脂异常，dysproteinemias和葡萄糖代谢紊乱的方法，包括施用包含醚化合物的组合物。 本发明的化合物，组合物和方法还可用于治疗和预防阿尔茨海默病，综合征X，过氧化物酶体增殖物激活受体相关病症，败血症，血栓形成障碍，肥胖症，胰腺炎，高血压，肾脏疾病，癌症，炎症和 阳。 在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。
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公开(公告)号：US06630450B1
公开(公告)日：2003-10-07
申请号：US09453826
申请日：1999-12-01
申请人： Jean-Louis Dasseux , Renate Sekul , Klaus Büttner , Isabelle Cornut , Günther Metz , Jean Dufourcq
发明人： Jean-Louis Dasseux , Renate Sekul , Klaus Büttner , Isabelle Cornut , Günther Metz , Jean Dufourcq
IPC分类号： A61K3810
CPC分类号： C07K14/775 , A61K38/1709 , C07K7/08
摘要： The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia.
摘要翻译： 本发明提供模拟人ApoA-I的结构和药理学性质的肽和肽类似物。 肽和肽类似物可用于治疗与血脂异常相关的各种障碍。
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公开(公告)号：US6004925A
公开(公告)日：1999-12-21
申请号：US940095
申请日：1997-09-29
申请人： Jean-Louis Dasseux , Renate Sekul , Klaus Buttner , Isabelle Cornut , Gunther Metz , Jean Dufourcq
发明人： Jean-Louis Dasseux , Renate Sekul , Klaus Buttner , Isabelle Cornut , Gunther Metz , Jean Dufourcq
IPC分类号： C12N15/09 , A61K9/19 , A61K38/00 , A61K38/10 , A61K38/16 , A61K38/17 , A61K47/48 , A61P3/04 , A61P3/06 , A61P9/02 , A61P9/10 , C07K7/00 , C07K7/08 , C07K14/00 , C07K14/725 , C07K14/775 , C12N5/10 , C12P21/02
CPC分类号： C07K14/775 , A61K38/1709 , C07K7/08
摘要： The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia.
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