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1.发明授权Process and intermediates for (s)-.alpha.-amino-1-carboxycyclopentaneacetic acid 失效（s）-α-氨基-1-羧基环戊烷乙酸的方法和中间体
公开(公告)号：US5948935A
公开(公告)日：1999-09-07
申请号：US12237
申请日：1998-01-23
申请人： Jean-Marie Ferland , Ingrid Guse , Eric Malenfant
发明人： Jean-Marie Ferland , Ingrid Guse , Eric Malenfant
IPC分类号： C07C227/18 , C07C229/46 , C07C237/14 , C07C255/31 , C07C69/74 , C07C61/06
CPC分类号： C07C237/14 , C07C227/18 , C07C255/31 , C07B2200/07 , C07C2101/08
摘要： Disclosed herein is a process for preparing (S)-.alpha.-amino-1-carboxycyclopentaneacetic acid which is a useful intermediate for preparing peptidomimetic inhibitors of herpes viral ribonucleotide reductase. The process comprises the preparation of the key intermediate ##STR1## and its subsequent conversion to the desired product.
摘要翻译： 本文公开了一种制备（S）-α-氨基-1-羧基环戊烷乙酸的方法，其是制备疱疹病毒核糖核苷酸还原酶的拟肽抑制剂的有用中间体。 该方法包括制备关键中间体及其随后转化成所需产物。
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公开(公告)号：US4131745A
公开(公告)日：1978-12-26
申请号：US852656
申请日：1977-11-18
IPC分类号： A61K31/135 , C07C233/16 , C07C103/38
CPC分类号： A61K31/135 , C07C233/16
摘要： Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 are either the same or different selected from the group consisting of hydrogen or lower alkyl; with the proviso that when R.sup.1 is lower alkyl then R.sup.2 is the same lower alkyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.
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公开(公告)号：US4273773A
公开(公告)日：1981-06-16
申请号：US78547
申请日：1979-09-24
IPC分类号： C07D487/04 , A61K31/495 , C07D241/36
CPC分类号： C07D487/04
摘要： Tricyclic isoindole derivatives characterized by having a 1,2,3,4,6,10b-hexahydropyrazino[2,1-a]isoindole or 1,3,4,10b-tetrahydropyrimido[6,1-a]isoindol-6(2H)-one nucleus are disclosed. The foregoing compounds are useful antihypertensive agents.
摘要翻译： 三环异吲哚衍生物的特征在于具有1,2,3,4,6,10b-六氢吡嗪并[2,1-a]异吲哚或1,3,4,10b-四氢嘧啶并[6,1-a]异吲哚-6（2H ） - 核。 上述化合物是有用的抗高血压药。
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公开(公告)号：US4118511A
公开(公告)日：1978-10-03
申请号：US852657
申请日：1977-11-18
IPC分类号： A61K31/135 , C07C233/16
CPC分类号： A61K31/135 , C07C233/16
摘要： Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 are either the same or different selected from the group consisting of hydrogen or lower alkyl; with the proviso that when R.sup.1 is lower alkyl then R.sup.2 is the same lower alkyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.
摘要翻译： 本文公开的是式“IMAGE”的化合物，其中Ar是苯基或1-萘基; R1是氢或低级烷基; 并且R 2和R 3可以相同或不同，选自氢或低级烷基; 条件是当R 1为低级烷基时，则R 2为相同的低级烷基。 这些化合物是抗抑郁剂，并且也公开了它们的制备和使用方法。
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公开(公告)号：US4033974A
公开(公告)日：1977-07-05
申请号：US657118
申请日：1976-02-11
IPC分类号： A61K38/00 , C07D213/30 , C07D213/55
CPC分类号： C07D213/30 , A61K38/00
摘要： Pyridylmethyl esters of N-(phenoxyalkanoyl)peptide derivatives are disclosed. The derivatives are characterized by having a phenoxyalkanoyl group and a pyridylmethyloxy group-joined together by a peptide group. They possess antihyperlipoproteinemic activity. In addition, methods for their preparation and use are disclosed.
摘要翻译： 公开了N-（苯氧基烷酰基）肽衍生物的吡啶基甲基酯。 该衍生物的特征在于具有通过肽基团连接在一起的苯氧基烷酰基和吡啶基甲氧基。 它们具有抗高脂蛋白血症活性。 另外，公开了其制备和使用的方法。
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公开(公告)号：US4323572A
公开(公告)日：1982-04-06
申请号：US232267
申请日：1981-02-06
IPC分类号： C07D487/04 , A61K31/505
CPC分类号： C07D487/04
摘要： Tricyclic isoindole derivatives characterized by having a 1,2,3,4,6,10b-hexahydropyrazino[2,1-a]isoindole or 1,3,4,10b-tetrahydropyrimido[6,1-a]isoindol-6(2H)-one nucleus are disclosed. The foregoing compounds are useful antihypertensive agents.
摘要翻译： 三环异吲哚衍生物的特征在于具有1,2,3,4,6,10b-六氢吡嗪并[2,1-a]异吲哚或1,3,4,10b-四氢嘧啶并[6,1-a]异吲哚-6（2H ） - 核。 上述化合物是有用的抗高血压药。
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7.发明授权
公开(公告)号：US4170653A
公开(公告)日：1979-10-09
申请号：US829769
申请日：1977-09-01
IPC分类号： C07D295/092 , C07D295/13 , A61K31/445 , C07D211/14
CPC分类号： C07D295/088 , C07D295/13
摘要： Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 together with the nitrogen atom to which they are joined form a heterocyclic amine radical selected from the group consisting of 1-pyrrolidinyl, piperidino, morpholino and 4-(lower alkyl)-1-piperazinyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.
摘要翻译： 本文公开的是式“IMAGE”的化合物，其中Ar是苯基或1-萘基; R1是氢或低级烷基; 和R2和R3与它们所连接的氮原子一起形成选自1-吡咯烷基，哌啶子基，吗啉代和4-（低级烷基）-1-哌嗪基的杂环胺基。 这些化合物是抗抑郁剂，并且也公开了它们的制备和使用方法。
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公开(公告)号：US4071552A
公开(公告)日：1978-01-31
申请号：US687852
申请日：1976-05-19
IPC分类号： A61K31/135 , C07C233/16 , C07C91/16 , C07C93/18
CPC分类号： A61K31/135 , C07C233/16
摘要： Disclosed herein are compounds of the formula ##STR1## in which Ar is phenyl or 1-naphthyl; R.sup.1 is hydrogen or lower alkyl; and R.sup.2 and R.sup.3 are either the same or different selected from the group consisting of hydrogen or lower alkyl; with the proviso that when R.sup.1 is lower alkyl then R.sup.2 is the same lower alkyl. The compounds are antidepressant agents and methods for their preparation and use also are disclosed.
摘要翻译： 本文公开的是式“IMAGE”的化合物，其中Ar是苯基或1-萘基; R1是氢或低级烷基; 并且R 2和R 3可以相同或不同，选自氢或低级烷基; 条件是当R 1为低级烷基时，则R 2为相同的低级烷基。 这些化合物是抗抑郁剂，并且也公开了它们的制备和使用方法。
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9.发明授权Pyridylmethyl esters of N-(phenoxyalkanoyl)peptide derivatives for therepeutic use 失效N-（苯氧基烷酰基）肽衍生物的吡啶基甲基酯用于该方法
公开(公告)号：US3956484A
公开(公告)日：1976-05-11
申请号：US505103
申请日：1974-09-11
IPC分类号： A61K38/00 , C07D213/30 , C07K5/06 , A61K31/44 , A61K37/00
CPC分类号： C07D213/30 , C07K5/06191 , A61K38/00
摘要： Pyridylmethyl esters of N-(phenoxyalkanoyl)peptide derivatives are disclosed. The derivatives are characterized by having a phenoxyalkanoyl group and a pyridylmethyloxy group-joined together by a peptide group. They possess antihyperlipoproteinemic activity. In addition, methods for their preparation and use are disclosed.
摘要翻译： 公开了N-（苯氧基烷酰基）肽衍生物的吡啶基甲基酯。 该衍生物的特征在于具有通过肽基团连接在一起的苯氧基烷酰基和吡啶基甲氧基。 它们具有抗高脂蛋白血症活性。 另外，公开了其制备和使用的方法。
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公开(公告)号：US06284768B1
公开(公告)日：2001-09-04
申请号：US09438647
申请日：1999-11-12
申请人： Rajashekhar Betageri , Pierre L. Beaulieu , Jean-Marie Ferland , Montse Llinas-Brunet , Neil Moss , Usha Patel , John R. Proudfoot , Mario Cardozo
发明人： Rajashekhar Betageri , Pierre L. Beaulieu , Jean-Marie Ferland , Montse Llinas-Brunet , Neil Moss , Usha Patel , John R. Proudfoot , Mario Cardozo
IPC分类号： A61K31435
CPC分类号： C07D213/75 , C07D401/12 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/12
摘要： This invention relates to compounds of formula (I): wherein Ring a, A, B, C, D, E, R and Q are defined herein. These compounds possess the ability to disrupt the interaction between regulatory proteins possessing one or more SH2 domains and their native ligands.
摘要翻译： 本发明涉及式（I）化合物：其中环a，A，B，C，D，E，R和Q在本文中定义。 这些化合物具有破坏具有一个或多个SH2结构域及其天然配体的调节蛋白之间相互作用的能力。
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