摘要:
A sensor system includes at least two sensors for distinguishing accommodative stimuli from changes in ambient lights levels and task-induced changes in the pupil diameter. When implanted, the first sensor is disposed completely within the pupil; even when fully constricted, the pupil does not occlude the first sensor, allowing the sensor to make precise measurements of ambient luminous flux levels. The pupil occludes part of the second sensor's active area(s) as the pupil dilates and constricts. As a result, the second sensor measures both ambient luminous flux and pupil diameter. A processor estimates the pupil diameter and determines whether it's changing in response to accommodative stimuli or other factors by comparing to predetermined values. The sensor system sends a signal to an optical component, which in turn can respond by changing optical power to focus for near vision upon detection of accommodative stimuli.
摘要:
Many modern implantable ophthalmic devices include electronic components, such as electro-active cells, that can leak harmful substances into the eye and/or surrounding tissue. In the implantable ophthalmic devices disclosed herein, electronic components are hermetically scaled within cavities formed by bonding together two or more glass wafers. Bonding the glass wafers together with laser fusion bonding, pressure bonding, or anodic bonding creates a seal that leaks at a rate of less than about 5×10−12 Pa m3 s−1 when subjected to a helium leak test. Hermetically sealed feedthroughs formed of conductive material running through channels in the wafers provide electrical connections to components inside the sealed cavities. In some cases, the conductive material has a coefficient of thermal expansion (CTE) that is roughly equal to (e.g., within 10% of) the CTE of the glass wafers to minimize leakage due to thermally induced expansion and contraction of the conductive material and the glass wafer.
摘要翻译:许多现代可植入眼科装置包括可将有害物质渗入眼睛和/或周围组织的电子部件,例如电活性细胞。 在本文公开的可植入眼科装置中,电子部件通过将两个或更多个玻璃晶片结合在一起形成的空腔内被气密地缩放。 通过激光熔接,压力粘合或阳极接合将玻璃晶片结合在一起形成密封,当进行氦气泄漏测试时,密封件以小于约5×10-12 Pa m3 s-1的速率泄漏。 由导电材料形成的密封馈通通过晶片中的通道提供电连接到密封空腔内的组件。 在一些情况下,导电材料的热膨胀系数(CTE)大致等于玻璃晶片的CTE的(例如,在10%以内),以最小化由于导致导电材料的热诱导的膨胀和收缩引起的泄漏, 玻璃晶片。
摘要:
Many modern implantable ophthalmic devices include electronic components, such as electro-active cells, that can leak harmful substances into the eye and/or surrounding tissue. In the implantable ophthalmic devices disclosed herein, electronic components are hermetically scaled within cavities formed by bonding together two or more glass wafers. Bonding the glass wafers together with laser fusion bonding, pressure bonding, or anodic bonding creates a seal that leaks at a rate of less than about 5×10−12 Pa m3 s−1 when subjected to a helium leak test. Hermetically sealed feedthroughs formed of conductive material running through channels in the wafers provide electrical connections to components inside the sealed cavities. In some cases, the conductive material has a coefficient of thermal expansion (CTE) that is roughly equal to (e.g., within 10% of) the CTE of the glass wafers to minimize leakage due to thermally induced expansion and contraction of the conductive material and the glass wafer.
摘要翻译:许多现代可植入眼科装置包括可将有害物质渗入眼睛和/或周围组织的电子部件,例如电活性细胞。 在本文公开的可植入眼科装置中,电子部件通过将两个或更多个玻璃晶片结合在一起形成的空腔内被气密地缩放。 通过激光熔接,压力粘合或阳极接合将玻璃晶片结合在一起形成密封,当进行氦气泄漏测试时,密封件以小于约5×10-12 Pa m3 s-1的速率泄漏。 由导电材料形成的密封馈通通过晶片中的通道提供电连接到密封空腔内的组件。 在一些情况下,导电材料的热膨胀系数(CTE)大致等于玻璃晶片的CTE的(例如,在10%以内),以最小化由于导致导电材料的热诱导的膨胀和收缩引起的泄漏, 玻璃晶片。
摘要:
A device and method for desynchronizing a patient's neuronal brain activity involving a neuron population firing in a pathologically synchronized manner. The device includes a stimulation unit configured to generate an acoustic stimulation signal to stimulate the neuron population when the acoustic stimulation signal is aurally received by the patient. Furthermore, the acoustic stimulation signal has a first frequency and a second frequency, with the first frequency provided to reset the phase of the neuronal brain activity in a first sub-population of the stimulated neuron population, and the second frequency provided to reset the phase of the neuronal brain activity in a second sub-population of the stimulated neuron population.
摘要:
The invention relates to a device (100) for treating a patient with vibration and/or tactile and/or thermal stimuli (20), said device (100) containing a first and second stimulating unit (11, 12) for generating first and second stimuli respectively. The stimuli are vibration and/or tactile and/or thermal stimuli, and each of the stimuli is repeated on average at a frequency of 1 to 60 Hz. The stimuli are generated at at least partly different times.
摘要:
A device and method for providing stimulation signals that reset the phase of the neuronal activity of neurons in a patient's brain. The device includes a control unit; and a stimulation unit that has a plurality of stimulation elements, and each stimulation element generates visual stimulation signals that reset the phase of the neuronal activity of the neurons when the signals are taken up via an eye of a patient and transmitted to neurons that are exhibiting a pathologically synchronous and oscillatory neuronal activity. The control unit is further capable of actuating the stimulation unit such that the stimulation elements generate the visual stimulation signals with a time offset in respect to one another and/or with differing phase and/or with differing polarity.
摘要:
A device with a control unit and a plurality of stimulation units configured to be implanted in the body of a patient and generate optical stimuli, wherein the optical stimuli reset the phase of the neuronal activity of the neurons during the stimulation of neurons exhibiting abnormally synchronous and oscillatory neuronal activity, and the control unit is configured to actuate the stimulation units such that at least two of the stimulation units reset the phases of the respectively stimulated neurons at different times.
摘要:
A device and method for desynchronizing a patient's neuronal brain activity involving a neuron population firing in a pathologically synchronized manner. The device includes a stimulation unit configured to generate an acoustic stimulation signal to stimulate the neuron population when the acoustic stimulation signal is aurally received by the patient. Furthermore, the acoustic stimulation signal has a first frequency and a second frequency, with the first frequency provided to reset the phase of the neuronal brain activity in a first sub-population of the stimulated neuron population, and the second frequency provided to reset the phase of the neuronal brain activity in a second sub-population of the stimulated neuron population.
摘要:
A device for mapping the visual field of an eye includes a projector for creating a light beam of visible light, a first light directing element for controlling the direction of the beam, and a reflection element for reflecting the light beam through a predetermined crossing point. The elements are arranged in such a way so that the light beam can be directed to well defined sites of the retina of the eye when positioned with the center of its lens substantially in the crossing point. The projector can be made to include a focusing element and a beam cross-section forming element for creating a disk of predetermined size on the retina of the eye.
摘要:
A device and method for providing stimulation signals that reset the phase of the neuronal activity of neurons in a patient's brain. The device includes a control unit; and a stimulation unit that has a plurality of stimulation elements, and each stimulation element generates visual stimulation signals that reset the phase of the neuronal activity of the neurons when the signals are taken up via an eye of a patient and transmitted to neurons that are exhibiting a pathologically synchronous and oscillatory neuronal activity. The control unit is further capable of actuating the stimulation unit such that the stimulation elements generate the visual stimulation signals with a time offset in respect to one another and/or with differing phase and/or with differing polarity.