公开(公告)号：US20130211516A1

公开(公告)日：2013-08-15

申请号：US13812226

申请日：2011-07-25

申请人： Ronald D. Blum ,  Amitava Gupta ,  Jean-Noel Fehr ,  Jean-Christophe Roulet ,  Urban Schnell ,  Walter Doll ,  Roland Michaely

发明人： Ronald D. Blum ,  Amitava Gupta ,  Jean-Noel Fehr ,  Jean-Christophe Roulet ,  Urban Schnell ,  Walter Doll ,  Roland Michaely

IPC分类号： A61F2/16

CPC分类号： A61F2/1624 ,  A61F2/14 ,  A61F2/1613 ,  A61F2002/482 ,  A61F2240/001 ,  A61F2250/0069 ,  G02F1/1341 ,  H01L23/15 ,  H01L23/5389 ,  H05K3/301 ,  H05K3/36 ,  Y10T29/49126

摘要： Many modern implantable ophthalmic devices include electronic components, such as electro-active cells, that can leak harmful substances into the eye and/or surrounding tissue. In the implantable ophthalmic devices disclosed herein, electronic components are hermetically scaled within cavities formed by bonding together two or more glass wafers. Bonding the glass wafers together with laser fusion bonding, pressure bonding, or anodic bonding creates a seal that leaks at a rate of less than about 5×10−12 Pa m3 s−1 when subjected to a helium leak test. Hermetically sealed feedthroughs formed of conductive material running through channels in the wafers provide electrical connections to components inside the sealed cavities. In some cases, the conductive material has a coefficient of thermal expansion (CTE) that is roughly equal to (e.g., within 10% of) the CTE of the glass wafers to minimize leakage due to thermally induced expansion and contraction of the conductive material and the glass wafer.

摘要翻译： 许多现代可植入眼科装置包括可将有害物质渗入眼睛和/或周围组织的电子部件，例如电活性细胞。 在本文公开的可植入眼科装置中，电子部件通过将两个或更多个玻璃晶片结合在一起形成的空腔内被气密地缩放。 通过激光熔接，压力粘合或阳极接合将玻璃晶片结合在一起形成密封，当进行氦气泄漏测试时，密封件以小于约5×10-12 Pa m3 s-1的速率泄漏。 由导电材料形成的密封馈通通过晶片中的通道提供电连接到密封空腔内的组件。 在一些情况下，导电材料的热膨胀系数（CTE）大致等于玻璃晶片的CTE的（例如，在10％以内），以最小化由于导致导电材料的热诱导的膨胀和收缩引起的泄漏， 玻璃晶片。

公开(公告)号：US08992610B2

公开(公告)日：2015-03-31

申请号：US13812226

申请日：2011-07-25

申请人： Ronald D. Blum ,  Amitava Gupta ,  Jean-Noel Fehr ,  Jean-Christophe Roulet ,  Urban Schnell ,  Walter Doll ,  Roland Michaely

发明人： Ronald D. Blum ,  Amitava Gupta ,  Jean-Noel Fehr ,  Jean-Christophe Roulet ,  Urban Schnell ,  Walter Doll ,  Roland Michaely

IPC分类号： A61F2/16 ,  A61F2/14

CPC分类号： A61F2/1624 ,  A61F2/14 ,  A61F2/1613 ,  A61F2002/482 ,  A61F2240/001 ,  A61F2250/0069 ,  G02F1/1341 ,  H01L23/15 ,  H01L23/5389 ,  H05K3/301 ,  H05K3/36 ,  Y10T29/49126

摘要： Many modern implantable ophthalmic devices include electronic components, such as electro-active cells, that can leak harmful substances into the eye and/or surrounding tissue. In the implantable ophthalmic devices disclosed herein, electronic components are hermetically scaled within cavities formed by bonding together two or more glass wafers. Bonding the glass wafers together with laser fusion bonding, pressure bonding, or anodic bonding creates a seal that leaks at a rate of less than about 5×10−12 Pa m3 s−1 when subjected to a helium leak test. Hermetically sealed feedthroughs formed of conductive material running through channels in the wafers provide electrical connections to components inside the sealed cavities. In some cases, the conductive material has a coefficient of thermal expansion (CTE) that is roughly equal to (e.g., within 10% of) the CTE of the glass wafers to minimize leakage due to thermally induced expansion and contraction of the conductive material and the glass wafer.

摘要翻译： 许多现代可植入眼科装置包括可将有害物质渗入眼睛和/或周围组织的电子部件，例如电活性细胞。 在本文公开的可植入眼科装置中，电子部件通过将两个或更多个玻璃晶片结合在一起形成的空腔内被气密地缩放。 通过激光熔接，压力粘合或阳极接合将玻璃晶片结合在一起形成密封，当进行氦气泄漏测试时，密封件以小于约5×10-12 Pa m3 s-1的速率泄漏。 由导电材料形成的密封馈通通过晶片中的通道提供电连接到密封空腔内的组件。 在一些情况下，导电材料的热膨胀系数（CTE）大致等于玻璃晶片的CTE的（例如，在10％以内），以最小化由于导致导电材料的热诱导的膨胀和收缩引起的泄漏， 玻璃晶片。

公开(公告)号：US20130242256A1

公开(公告)日：2013-09-19

申请号：US13822569

申请日：2011-09-12

申请人： Jean-Noel Fehr ,  Urban Schnell ,  Walter Doll ,  Roland Michaely ,  Jean-Christophe Roulet ,  Amitava Gupta ,  Ronald Blum ,  Rudy Mazzocchi

发明人： Jean-Noel Fehr ,  Urban Schnell ,  Walter Doll ,  Roland Michaely ,  Jean-Christophe Roulet ,  Amitava Gupta ,  Ronald Blum ,  Rudy Mazzocchi

IPC分类号： A61B3/11

CPC分类号： A61B3/11 ,  A61B3/09 ,  A61B3/112 ,  A61F2/1624 ,  A61F2250/0002 ,  G02C7/083

摘要： A sensor system includes at least two sensors for distinguishing accommodative stimuli from changes in ambient lights levels and task-induced changes in the pupil diameter. When implanted, the first sensor is disposed completely within the pupil; even when fully constricted, the pupil does not occlude the first sensor, allowing the sensor to make precise measurements of ambient luminous flux levels. The pupil occludes part of the second sensor's active area(s) as the pupil dilates and constricts. As a result, the second sensor measures both ambient luminous flux and pupil diameter. A processor estimates the pupil diameter and determines whether it's changing in response to accommodative stimuli or other factors by comparing to predetermined values. The sensor system sends a signal to an optical component, which in turn can respond by changing optical power to focus for near vision upon detection of accommodative stimuli.

摘要翻译： 传感器系统包括至少两个传感器，用于区分调节刺激与环境光照水平的变化以及瞳孔直径的任务引起的变化。 当植入时，第一传感器完全设置在瞳孔内; 即使完全收缩，瞳孔也不会闭塞第一个传感器，允许传感器对环境光通量水平进行精确测量。 当瞳孔扩大和收缩时，瞳孔封闭第二传感器的有效区域的一部分。 结果，第二传感器测量环境光通量和瞳孔直径。 处理器估计瞳孔直径并且通过与预定值进行比较来确定其是否响应于调节刺激或其他因素而改变。 传感器系统将信号发送到光学部件，光学部件又可以通过改变光焦度进行响应，以便在检测到适应刺激时进行近视。

公开(公告)号：US20130211515A1

公开(公告)日：2013-08-15

申请号：US13805742

申请日：2011-06-24

申请人： Ronald D. Blum ,  Amitava Gupta ,  Julien Sauvet ,  Jean-Noel Fehr ,  Urban Schnell

发明人： Ronald D. Blum ,  Amitava Gupta ,  Julien Sauvet ,  Jean-Noel Fehr ,  Urban Schnell

IPC分类号： A61F2/16

CPC分类号： A61F2/1624 ,  A61F2/1637

摘要： Astigmatism is an optical aberration that displaces the eye's vertical focal plane with respect to its horizontal focal plane. This displacement in focal planes, which may be caused by an irregularly shaped cornea and/or crystalline lens, causes images to appear blurry. Astigmatism can be corrected by implanting an optic, such as section of a spherical lens, whose projection onto a plane perpendicular to the optical axis is noncircular (e.g., rectangular or elliptical). Because the optic is noncircular, it provides more optical power along one axis than along another axis. As a result, it introduces an astigmatism that can be used to offset or compensate the eye's corneal and/or lenticular astigmatism when aligned properly with respect to the principal meridians of the cornea and/or crystalline lens.

摘要翻译： 散光是相对于其水平焦平面移动眼睛的垂直焦平面的光学像差。 可能由不规则形状的角膜和/或晶状体引起的焦平面中的位移导致图像看起来模糊。 可以通过植入诸如球面透镜的部分的光学元件校正散光，其中投影在垂直于光轴的平面上是非圆形的（例如，矩形或椭圆形）。 因为光学元件是非圆形的，所以它沿着一个轴提供比另一个轴更多的光学功率。 结果，当相对于角膜和/或晶状体的主经脉正确对准时，其引入散光，其可用于抵消或补偿眼睛的角膜和/或透镜散光。

公开(公告)号：US09259309B2

公开(公告)日：2016-02-16

申请号：US13805612

申请日：2011-06-17

申请人： Jean-Noel Fehr ,  Walter Doll ,  Urban Schnell

发明人： Jean-Noel Fehr ,  Walter Doll ,  Urban Schnell

IPC分类号： A61F2/16

CPC分类号： A61F2/1624 ,  A61F2/1627 ,  A61F2210/0076 ,  A61F2250/0001 ,  A61F2250/0002

摘要： Ophthalmic devices with dynamic electro-active elements offer variable optical power and/or depth of field that restore lost accommodation in individuals suffering from presbyopia or aphakia. An illustrative device senses physiological processes indicative of the accommodative response and actuates a dynamic electro-active element to provide the desired change in optical power and/or depth of field. The illustrative device includes two application-specific integrated circuits (ASICs) for processing the accommodative response and actuating the electro-active element: a high-voltage ASIC that steps up a low voltage from a power supply to a higher voltage suitable for actuating the electro-active element, and another ASIC that operates at low voltage (and therefore consumes little power) and controls the operating state of the high-voltage ASIC. Because each ASIC operates at the lowest possible voltage, the illustrative ophthalmic device dissipates less power than other ophthalmic devices.

摘要翻译： 具有动态电活性元件的眼科装置提供可变光学功率和/或景深，以恢复患有老花眼或无晶状体的个体的失调。 说明性装置感测指示调节响应的生理过程，并且启动动态电活性元件以提供期望的光功率和/或景深变化。 说明性装置包括用于处理调节响应并致动电活动元件的两个专用集成电路（ASIC）：将电压从低电压升高到适合于致动电极的较高电压的高压ASIC - 活性元件和另一个以低电压工作（因此消耗很少功率）并且控制高电压ASIC的工作状态的ASIC。 因为每个ASIC以尽可能低的电压工作，因此说明性的眼科装置比其他眼科装置消耗的功率更小。

公开(公告)号：US20140148899A1

公开(公告)日：2014-05-29

申请号：US13805612

申请日：2011-06-17

申请人： Jean-Noel Fehr ,  Walter Doll ,  Urban Schnell

发明人： Jean-Noel Fehr ,  Walter Doll ,  Urban Schnell

IPC分类号： A61F2/16

CPC分类号： A61F2/1624 ,  A61F2/1627 ,  A61F2210/0076 ,  A61F2250/0001 ,  A61F2250/0002

摘要： Ophthalmic devices with dynamic electro-active elements offer variable optical power and/or depth of field that restore lost accommodation in individuals suffering from presbyopia or aphakia. An illustrative device senses physiological processes indicative of the accommodative response and actuates a dynamic electro-active element to provide the desired change in optical power and/or depth of field. The illustrative device includes two application-specific integrated circuits (ASICs) for processing the accommodative response and actuating the electro-active element: a high-voltage ASIC that steps up a low voltage from a power supply to a higher voltage suitable for actuating the electro-active element, and another ASIC that operates at low voltage (and therefore consumes little power) and controls the operating state of the high-voltage ASIC. Because each ASIC operates at the lowest possible voltage, the illustrative ophthalmic device dissipates less power than other ophthalmic devices.

摘要翻译： 具有动态电活性元件的眼科装置提供可变光学功率和/或景深，以恢复患有老花眼或无晶状体的个体的失调。 说明性装置感测指示调节响应的生理过程，并且启动动态电活性元件以提供光功率和/或景深的期望变化。 说明性装置包括用于处理调节响应并致动电活动元件的两个专用集成电路（ASIC）：将电压从低电压升高到适合于致动电极的较高电压的高压ASIC - 活性元件和另一个以低电压工作（因此消耗很少功率）并且控制高电压ASIC的工作状态的ASIC。 因为每个ASIC以尽可能低的电压工作，因此说明性的眼科装置比其他眼科装置消耗的功率更小。

公开(公告)号：US20080054532A1

公开(公告)日：2008-03-06

申请号：US11930544

申请日：2007-10-31

申请人： Martin Lehmann ,  Jean-Noel Fehr ,  Martin Liechti ,  Urban Schnell

发明人： Martin Lehmann ,  Jean-Noel Fehr ,  Martin Liechti ,  Urban Schnell

IPC分类号： B29C44/60

CPC分类号： G01L11/02 ,  G01N21/15 ,  G01N21/3504 ,  G01N21/39

摘要： A method of monitoring pressure of a gas species up to at most a predetermined maximum pressure value is disclosed. The method includes exposing the gas species to transmission of laser light, periodically modulating the wavelength of the laser light over a wavelength band including at least one absorption line of the gas species, optoelectrically converting the transmitted laser light, thereby generating an electric output signal, performing at least one of first filtering the electric output signal with a filter characteristic having a lower cut-off frequency not lower than a transition frequency and of second filtering the electric output signal with a bandpass filter characteristic having an upper cut-off frequency not higher than the transition frequency and a lower cut-off frequency above the modulation frequency of the periodic wavelength modulation. The output of at least one of the filterings is evaluated as a pressure indicative signal.

摘要翻译： 公开了一种监测气体种类的压力至多达到预定最大压力值的方法。 该方法包括将气体物质暴露于透射激光，周期性地调制激光的波长在包括气体种类的至少一个吸收线的波长带上，光电转换透射的激光，从而产生电输出信号， 执行以具有不低于转换频率的较低截止频率的滤波器特性对所述电输出信号进行第一滤波中的至少一个，并且以具有不高于上限截止频率的带通滤波器特性对所述电输出信号进行第二滤波 超过转换频率和低于周期性波长调制调制频率的较低截止频率。 至少一个过滤器的输出被评估为压力指示信号。

公开(公告)号：US20090044629A1

公开(公告)日：2009-02-19

申请号：US12256867

申请日：2008-10-23

申请人： Martin Lehmann ,  Jean-Noel Fehr ,  Martin Liechti ,  Urban Schnell

发明人： Martin Lehmann ,  Jean-Noel Fehr ,  Martin Liechti ,  Urban Schnell

IPC分类号： G01L9/00 ,  G01B11/00

CPC分类号： G01L11/02 ,  G01N21/15 ,  G01N21/3504 ,  G01N21/39

摘要： A method of monitoring pressure of a gas species up to at most a predetermined maximum pressure value is disclosed. The method includes exposing the gas species to transmission of laser light, periodically modulating the wavelength of the laser light over a wavelength band including at least one absorption line of the gas species, optoelectrically converting the transmitted laser light, thereby generating an electric output signal, performing at least one of first filtering the electric output signal with a filter characteristic having a lower cut-off frequency not lower than a transition frequency and of second filtering the electric output signal with a bandpass filter characteristic having an upper cut-off frequency not higher than the transition frequency and a lower cut-off frequency above the modulation frequency of the periodic wavelength modulation. The output of at least one of the filterings is evaluated as a pressure indicative signal.

摘要翻译： 公开了一种监测气体种类的压力至多达到预定最大压力值的方法。 该方法包括将气体物质暴露于透射激光，周期性地调制激光的波长在包括气体种类的至少一个吸收线的波长带上，光电转换透射的激光，从而产生电输出信号， 执行以具有不低于转换频率的较低截止频率的滤波器特性对所述电输出信号进行第一滤波中的至少一个，并且以具有不高于上限截止频率的带通滤波器特性对所述电输出信号进行第二滤波 超过转换频率和低于周期性波长调制调制频率的较低截止频率。 至少一个过滤器的输出被评估为压力指示信号。

公开(公告)号：US20060021441A1

公开(公告)日：2006-02-02

申请号：US11152236

申请日：2005-06-15

申请人： Martin Lehmann ,  Jean-Noel Fehr ,  Martin Liechti ,  Urban Schnell

发明人： Martin Lehmann ,  Jean-Noel Fehr ,  Martin Liechti ,  Urban Schnell

IPC分类号： G01L9/00 ,  G01N21/00

CPC分类号： G01L11/02 ,  G01N21/15 ,  G01N21/3504 ,  G01N21/39

摘要： A method of monitoring pressure of a gas species up to at most a predetermined maximum pressure value is disclosed. The method includes exposing the gas species to transmission of laser light, periodically modulating the wavelength of the laser light over a wavelength band including at least one absorption line of the gas species, optoelectrically converting the transmitted laser light, thereby generating an electric output signal, performing at least one of first filtering the electric output signal with a filter characteristic having a lower cut-off frequency not lower than a transition frequency and of second filtering the electric output signal with a bandpass filter characteristic having an upper cut-off frequency not higher than the transition frequency and a lower cut-off frequency above the modulation frequency of the periodic wavelength modulation. The output of at least one of the filterings is evaluated as a pressure indicative signal.

公开(公告)号：US20050022603A1

公开(公告)日：2005-02-03

申请号：US10894309

申请日：2004-07-20

申请人： Martin Lehmann ,  Jean-Noel Fehr ,  Martin Liechti ,  Urban Schnell

发明人： Martin Lehmann ,  Jean-Noel Fehr ,  Martin Liechti ,  Urban Schnell

IPC分类号： G01L7/10 ,  G01L11/02 ,  G01N21/31 ,  G01N21/39 ,  A61B5/08

CPC分类号： G01L11/02 ,  G01N21/39 ,  Y10T29/49 ,  Y10T29/49845

摘要： A method of monitoring pressure of a gas species up to at most a predetermined maximum pressure value is disclosed. The method includes exposing the gas species to transmission of laser light, periodically modulating the wavelength of the laser light over a wavelength band including at least one absorption line of the gas species, optoelectrically converting the transmitted laser light, thereby generating an electric output signal, performing at least one of first filtering the electric output signal with a filter characteristic having a lower cut-off frequency not lower than a transition frequency and of second filtering the electric output signal with a bandpass filter characteristic having an upper cut-off frequency not higher than the transition frequency and a lower cut-off frequency above the modulation frequency of the periodic wavelength modulation. The output of at least one of the filterings is evaluated as a pressure indicative signal.

摘要翻译： 公开了一种监测气体种类的压力至多达到预定最大压力值的方法。 该方法包括将气体物质暴露于透射激光，周期性地调制激光的波长在包括气体种类的至少一个吸收线的波长带上，光电转换透射的激光，从而产生电输出信号， 执行以具有不低于转换频率的较低截止频率的滤波器特性对所述电输出信号进行第一滤波中的至少一个，并且以具有不高于上限截止频率的带通滤波器特性对所述电输出信号进行第二滤波 超过转换频率和低于周期性波长调制调制频率的较低截止频率。 至少一个过滤器的输出被评估为压力指示信号。