公开(公告)号：US20070203532A1

公开(公告)日：2007-08-30

申请号：US11604284

申请日：2006-11-27

申请人： Peter Tass ,  Oleksandr Popovych ,  Christian Hauptmann ,  Valeril Krachkovskyi

发明人： Peter Tass ,  Oleksandr Popovych ,  Christian Hauptmann ,  Valeril Krachkovskyi

IPC分类号： A61N1/18

CPC分类号： A61N1/36082 ,  A61B5/0006 ,  A61B5/048 ,  A61B5/4082 ,  A61B5/7225 ,  A61B5/726 ,  A61N1/0551 ,  A61N1/06 ,  A61N1/36067 ,  A61N1/36135 ,  A61N1/36146

摘要： A device for decoupling and/or desynchronizing neural, pathologically synchronous brain activity, in which, the activities in a partial region of a brain area or a functionally associated brain area are stimulated by means of an electrode, resulting in decoupling and desynchronizing the affected neuron population from the pathological area and suppression of the symptoms in a patient. In an alternative embodiment of the device, the pathologically synchronous brain activity due to the disease is desynchronized which also leads to the symptoms being suppressed. The device has a stimulation electrode and at least one sensor which are driven by a control system in such a manner that they produce decoupling and/or desynchronization in their local environment.

摘要翻译： 用于解耦和/或同步神经，病理同步脑活动的装置，其中通过电极刺激脑区域或功能相关的脑区域的部分区域中的活动，导致受影响的神经元的去耦和失同步 病理区域的人群和患者症状的抑制。 在该装置的替代实施方案中，由于疾病引起的病理同步脑活动是不同步的，这也导致症状被抑制。 该装置具有刺激电极和由控制系统驱动的至少一个传感器，使得它们在其局部环境中产生解耦和/或去同步。

公开(公告)号：US08000796B2

公开(公告)日：2011-08-16

申请号：US11604284

申请日：2006-11-27

申请人： Peter Tass ,  Oleksandr Popovych ,  Christian Hauptmann ,  Valerii Krachkovskyi

发明人： Peter Tass ,  Oleksandr Popovych ,  Christian Hauptmann ,  Valerii Krachkovskyi

IPC分类号： A61N1/372

CPC分类号： A61N1/36082 ,  A61B5/0006 ,  A61B5/048 ,  A61B5/4082 ,  A61B5/7225 ,  A61B5/726 ,  A61N1/0551 ,  A61N1/06 ,  A61N1/36067 ,  A61N1/36135 ,  A61N1/36146

摘要： A device for decoupling and/or desynchronizing neural, pathologically synchronous brain activity, in which, the activities in a partial region of a brain area or a functionally associated brain area are stimulated by means of an electrode, resulting in decoupling and desynchronizing the affected neuron population from the pathological area and suppression of the symptoms in a patient. In an alternative embodiment of the device, the pathologically synchronous brain activity due to the disease is desynchronized which also leads to the symptoms being suppressed. The device has a stimulation electrode and at least one sensor which are driven by a control system in such a manner that they produce decoupling and/or desynchronization in their local environment.

摘要翻译： 用于解耦和/或同步神经，病理同步脑活动的装置，其中通过电极刺激脑区域或功能相关的脑区域的部分区域中的活动，导致受影响的神经元的去耦和失同步 病理区域的人群和患者症状的抑制。 在该装置的替代实施方案中，由于疾病引起的病理同步脑活动是不同步的，这也导致症状被抑制。 该装置具有刺激电极和由控制系统驱动的至少一个传感器，使得它们在其局部环境中产生解耦和/或去同步。

公开(公告)号：US20100222843A1

公开(公告)日：2010-09-02

申请号：US12597918

申请日：2008-05-06

申请人： Peter Tass ,  Volker Sturm

发明人： Peter Tass ,  Volker Sturm

IPC分类号： A61N1/36

CPC分类号： A61N1/36082

摘要： The invention refers to a device comprising a generator unit for generating stimulation signals and a stimulation unit connected to the generator unit, wherein the stimulation unit is designed to stimulate nerve cells in the nucleus accumbens and/or in the amygdaloid nucleus and/or in the fasciculus medialis telencephali and/or in pathways made of dopaminergic areas of the mesencephalon leading to the nucleus accumbens or the amygdaloid nucleus and/or in fiber bundles linking the nucleus accumbens and the amygdaloid nucleus using the stimulation signals.

摘要翻译： 本发明涉及一种包括用于产生刺激信号的发生器单元和连接到发生器单元的刺激单元的装置，其中刺激单元被设计成刺激伏隔核和/或杏仁核中的神经细胞和/或在 内侧中耳和/或由导致伏隔核或扁桃体核的中脑的多巴胺能区域和/或使用刺激信号连接伏隔核和杏仁核的纤维束形成的通路。

公开(公告)号：US20070135860A1

公开(公告)日：2007-06-14

申请号：US11603293

申请日：2006-11-22

申请人： Peter Tass

发明人： Peter Tass

IPC分类号： A61N1/00

CPC分类号： A61N1/36067 ,  A61N1/36082

摘要： A device for treating patients by brain stimulation and related electronic component and use of the device and of the electronic component in a medical treatment method. To achieve the brain stimulation result, a device includes at least one electrode for stimulating a brain region, at least one sensor for measuring an electrical signal, a control system which can detect the occurrence of a pathological feature of the electrical signal which was measured by the sensor and, when the pathological feature occurs, delivers at least one component from a group of stimulus sequences (a) through (d): (a) a short high-frequency pulse train, (b) a resetting short high-frequency pulse train followed by a further desynchronizing short high-frequency pulse train, (c) a resetting low-frequency sequence of a high-frequency pulse train followed by a desynchronizing high-frequency pulse train, or (d) a resetting single pulse followed by a short desynchronizing high-frequency pulse train to the electrode.

摘要翻译： 一种用于通过脑刺激和相关电子部件治疗患者的装置以及在医疗方法中使用该装置和电子部件。 为了实现脑刺激结果，装置包括用于刺激脑区域的至少一个电极，用于测量电信号的至少一个传感器，可以检测电信号的病理特征的发生的控制系统，该控制系统由 传感器，并且当发生病理特征时，从一组刺激序列（a）到（d）中递送至少一个分量：（a）短的高频脉冲串，（b）复位短的高频脉冲 然后是进一步去同步的短高频脉冲串，（c）高频脉冲序列的复位低频序列，随后是去同步高频脉冲串，或（d）复位单脉冲，随后是 短时间同步高频脉冲串到电极。

公开(公告)号：US20060212089A1

公开(公告)日：2006-09-21

申请号：US10553679

申请日：2004-04-08

申请人： Peter Tass

发明人： Peter Tass

IPC分类号： A61N1/18

CPC分类号： A61N1/36064 ,  A61N1/36017 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36135

摘要： The invention relates to a device for desynchronizing neuronal brain activity. According to the invention, the activity in at least two partial zones of a brain area or at least two functionally related brain areas is reset by means of two electrodes, surprisingly resulting in desynchronization in the targeted population of neurons of the patient and the symptoms being repressed. The inventive device comprises at least two stimulation electrodes (2) which are triggered by a control mechanism so as to cause synchronization in the local environment thereof. Preferably, the stimuli of the N electrodes are essentially out of phase by 1/N.

摘要翻译： 本发明涉及一种用于使神经元脑活动失步的装置。 根据本发明，脑区域或至少两个功能相关的脑区域的至少两个部分区域中的活性通过两个电极复位，令人惊奇地导致患者的目标群体的神经元的同步，症状为 压抑 本发明的装置包括由控制机构触发以在其局部环境中引起同步的至少两个刺激电极（2）。 优选地，N个电极的刺激基本上异相1 / N。

公开(公告)号：US08538547B2

公开(公告)日：2013-09-17

申请号：US12739426

申请日：2008-10-28

申请人： Peter Tass ,  Christian Hauptmann

发明人： Peter Tass ,  Christian Hauptmann

IPC分类号： A61N1/36

CPC分类号： A61N1/326 ,  A61N1/0551 ,  A61N1/36003 ,  A61N1/36067 ,  A61N1/36167

摘要： An apparatus (100) is described which comprises at least one measuring unit (31-34) for recording test signals from neurons, a generator unit (10) for generating electrical stimulation signals in accordance with the test signals, and a plurality of stimulation units (11-14) that are connected to the generator unit (10). The stimulation units (11-14) stimulate a plurality of neural networks in a deferred manner by means of the stimulation signals and thus induce a deferred activity in the stimulated neural networks.

摘要翻译： 描述了一种装置（100），其包括用于记录来自神经元的测试信号的至少一个测量单元（31-34），用于根据测试信号产生电刺激信号的发生器单元（10），以及多个刺激单元 （11-14），其连接到所述发电机单元（10）。 刺激单元（11-14）通过刺激信号以延迟的方式刺激多个神经网络，从而在受刺激的神经网络中诱导延迟的活动。

公开(公告)号：US08463378B2

公开(公告)日：2013-06-11

申请号：US13124571

申请日：2009-10-16

申请人： Peter Tass

发明人： Peter Tass

IPC分类号： A61H1/00

CPC分类号： A61N1/0529 ,  A61H7/004 ,  A61H23/0236 ,  A61H2033/0037 ,  A61H2201/10 ,  A61H2201/165 ,  A61H2201/5035 ,  A61H2201/5038 ,  A61H2201/5041 ,  A61H2201/5043 ,  A61H2201/5084 ,  A61H2205/06 ,  A61N1/36082 ,  A61N1/361

摘要： A device having a first stimulation unit that generates electrical first stimuli suppressing a pathological synchronous activity of neurons in the brain and/or spinal cord of a patient upon administering the same to the brain and/or spinal cord of the patient, a second stimulation unit that generates optical and/or acoustic and/or tactile and/or vibratory second stimuli, and a controller that controls the first and the second stimulation units. The generation of the first and second stimuli optionally occurs in a first or in a second operating mode, and the controller actuates the first and the second stimulation units such that in the first operating mode the generation of at least 60% of the second stimuli is chronologically coupled to the generation of the first stimuli, and in the second operating mode the generation of at least 60% of the second stimuli is carried out without generating the first stimuli.

摘要翻译： 一种具有第一刺激单元的装置，其产生电的第一刺激，其将患者的脑和/或脊髓中的神经元的病理同步活动施用于患者的脑和/或脊髓时，第二刺激单元 其产生光学和/或声学和/或触觉和/或振动的第二刺激，以及控制第一和第二刺激单元的控制器。 第一和第二刺激的产生可选地以第一或第二操作模式发生，并且控制器致动第一和第二刺激单元，使得在第一操作模式中，产生至少60％的第二刺激是 按时间顺序耦合到第一刺激的产生，并且在第二操作模式中，产生至少60％的第二刺激而不产生第一刺激。

公开(公告)号：US08116874B2

公开(公告)日：2012-02-14

申请号：US11812258

申请日：2007-06-15

申请人： Peter Tass

发明人： Peter Tass

IPC分类号： A61N1/18

CPC分类号： A61N1/0529 ,  A61N1/0551 ,  A61N1/36082

摘要： A device including at least one electrode and/or at least one chip configured to stimulate cerebral neurons that have a pathological oscillatory activity with a period duration T, n contact points that are distributed over at least one electrode and/or over at least one chip and are configured to output electrical stimulus signals to the brain, and a controller configured to drive the contact points so that the contact points output a low-frequency succession of sequences of high-frequency pulse trains to the brain, wherein, for each sequence, m contact points of the n contact points are selected, with m≧2 and m

摘要翻译： 一种装置，其包括至少一个电极和/或至少一个芯片，其被配置为刺激具有病理振荡活性的脑神经元，所述脑神经元具有周期持续时间T，n个接触点，所述接触点分布在至少一个电极和/或至少一个芯片上 并且被配置为向大脑输出电刺激信号，以及控制器，被配置为驱动接触点，使得接触点将低频序列的高频脉冲序列输出到脑，其中，对于每个序列， 选择n个接触点的m个接触点，其中m≥2且m

公开(公告)号：US20080046025A1

公开(公告)日：2008-02-21

申请号：US11812258

申请日：2007-06-15

申请人： Peter Tass

发明人： Peter Tass

IPC分类号： A61N1/05

CPC分类号： A61N1/0529 ,  A61N1/0551 ,  A61N1/36082

摘要： The invention relates to a method and a device for desynchronizing neural brain activity, a controller and a method for treating neurological and/or psychiatric disorders. According to the invention, low-frequency successions of high-frequency pulse trains are applied in corresponding brain regions. This suppresses symptoms and even brings about a cure in some cases.

摘要翻译： 本发明涉及用于使神经脑活动失步的方法和装置，控制器和治疗神经和/或精神疾病的方法。 根据本发明，高频脉冲序列的低频序列应用于相应的脑区域。 这在某些情况下抑制症状甚至导致治愈。

公开(公告)号：US20060047324A1

公开(公告)日：2006-03-02

申请号：US10522933

申请日：2003-07-05

申请人： Peter Tass

发明人： Peter Tass

IPC分类号： A61N1/32

CPC分类号： A61B5/4064 ,  A61B5/0482 ,  A61B5/0484 ,  A61B5/04842 ,  A61B5/04845 ,  A61M21/00 ,  A61M2230/10

摘要： The invention relates to a device for controlled modulation of physiological and pathological neuronal rhythmic activity in the brain by means of sensory stimulation, which is capable of diagnostically ascertaining functional disorders in the brain and of alleviating or eliminating the symptoms of a functional disruption. According to the invention, the device comprises a control unit (4), a stimulator (1) and at least one means for detecting brain activity, said means being connected to the control unit (1).

摘要翻译： 本发明涉及用于通过感觉刺激来控制调节脑中生理和病理学神经元节律活动的装置，其能够诊断上确定大脑中的功能障碍以及减轻或消除功能性破坏的症状。 根据本发明，该装置包括控制单元（4），刺激器（1）和至少一个用于检测大脑活动的装置，所述装置连接到控制单元（1）。