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公开(公告)号:US08323696B2
公开(公告)日:2012-12-04
申请号:US12231310
申请日:2008-08-29
申请人: Jeffrey A. Hubbell , Conlin P. O'Neil , Sai T. Reddy , Melody A. Swartz , Diana Velluto , André van der Vlies , Eleonora Simeoni
发明人: Jeffrey A. Hubbell , Conlin P. O'Neil , Sai T. Reddy , Melody A. Swartz , Diana Velluto , André van der Vlies , Eleonora Simeoni
IPC分类号: A61K9/14
CPC分类号: A61K9/5146 , A61K9/0034 , A61K9/006 , A61K38/19 , A61K39/0011 , A61K47/6907 , A61K47/6935 , A61K2039/6093 , B82Y5/00
摘要: Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. These particles are useful vehicles for delivering immunotherapeutics. Surface chemistries and chemical formulations for the nanoparticles are described.
摘要翻译: 描述了在不存在生物分子的情况下激活补体的纳米颗粒。 显示了纳米颗粒特异性靶向抗原呈递细胞,特别是在淋巴结中,而不用生物分子进行靶向。 这些颗粒是用于递送免疫治疗剂的有用载体。 描述了纳米颗粒的表面化学和化学配方。
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公开(公告)号:US20100055189A1
公开(公告)日:2010-03-04
申请号:US12231310
申请日:2008-08-29
申请人: Jeffrey A. Hubbell , Conlin P. O'Neil , Sai T. Reddy , Melody A. Swartz , Diana Velluto , Andre van Der Vlies , Eleonora Simeoni
发明人: Jeffrey A. Hubbell , Conlin P. O'Neil , Sai T. Reddy , Melody A. Swartz , Diana Velluto , Andre van Der Vlies , Eleonora Simeoni
CPC分类号: A61K9/5146 , A61K9/0034 , A61K9/006 , A61K38/19 , A61K39/0011 , A61K47/6907 , A61K47/6935 , A61K2039/6093 , B82Y5/00
摘要: Nanoparticles that activate complement in the absence of biological molecules are described. The nanoparticles are shown to specifically target antigen presenting cells in specifically in lymph nodes, without the use of a biological molecule for targeting. These particles are useful vehicles for delivering immunotherapeutics. Surface chemistries and chemical formulations for the nanoparticles are described.
摘要翻译: 描述了在不存在生物分子的情况下激活补体的纳米颗粒。 显示了纳米颗粒特异性靶向抗原呈递细胞,特别是在淋巴结中,而不用生物分子进行靶向。 这些颗粒是用于递送免疫治疗剂的有用载体。 描述了纳米颗粒的表面化学和化学配方。
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公开(公告)号:US09271929B2
公开(公告)日:2016-03-01
申请号:US13130892
申请日:2009-11-24
IPC分类号: A61K9/10 , A61K48/00 , A61K9/107 , A61K9/127 , A61K9/51 , C08G65/329 , C08G65/334 , C08G75/08 , C08L71/02 , C08G83/00 , C08L81/02
CPC分类号: A61K48/0041 , A61K9/1075 , A61K9/1273 , A61K9/5146 , A61K31/337 , A61K31/573 , A61K31/713 , A61K47/10 , A61K47/22 , A61K47/34 , C07K16/00 , C08G65/329 , C08G65/3344 , C08G75/08 , C08G83/008 , C08L71/02 , C08L81/02 , C08L2203/02 , C08L2205/05 , C12N15/113 , C12N15/115 , C12N2310/11 , C12N2310/14 , C12N2310/141 , C12N2310/16 , C12N2320/32 , Y02A50/387 , Y10S977/773 , Y10S977/906 , Y10S977/916 , C08L81/00
摘要: An encoding/decoding apparatus and method using a low-density parity-check code (LDPC code) is disclosed. Basic column group information, serving as a set of information regarding positions of rows with weight 1, is extracted from a reference column in each column group of a predetermined parity-check matrix. Column group information transforms the positions of rows with weight 1 into positions whose lengths are within a required parity length. A parity-check matrix is generated according to the generated column group information. Data is encoded or decoded based on the generated parity-check matrix.
摘要翻译: 公开了一种使用低密度奇偶校验码(LDPC码)的编码/解码装置和方法。 从预定奇偶校验矩阵的每列组中的参考列中提取用作关于具有权重1的行的位置的信息集合的基本列组信息。 列组信息将具有权重1的行的位置变换为长度在所需奇偶校验长度内的位置。 根据生成的列组信息生成奇偶校验矩阵。 基于生成的奇偶校验矩阵对数据进行编码或解码。
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公开(公告)号:US20110223217A1
公开(公告)日:2011-09-15
申请号:US13130892
申请日:2009-11-24
IPC分类号: A61K47/34 , C08G75/14 , A61K31/56 , A61K31/337 , A61K38/13 , A61K31/436 , A61K31/7048 , A61K31/704 , A61K38/00 , A61K31/7052 , A61K39/395 , A61K9/00 , C12N15/00
CPC分类号: A61K48/0041 , A61K9/1075 , A61K9/1273 , A61K9/5146 , A61K31/337 , A61K31/573 , A61K31/713 , A61K47/10 , A61K47/22 , A61K47/34 , C07K16/00 , C08G65/329 , C08G65/3344 , C08G75/08 , C08G83/008 , C08L71/02 , C08L81/02 , C08L2203/02 , C08L2205/05 , C12N15/113 , C12N15/115 , C12N2310/11 , C12N2310/14 , C12N2310/141 , C12N2310/16 , C12N2320/32 , Y02A50/387 , Y10S977/773 , Y10S977/906 , Y10S977/916 , C08L81/00
摘要: An encoding/decoding apparatus and method using a low-density parity-check code (LDPC code) is disclosed. Basic column group information, serving as a set of information regarding positions of rows with weight 1, is extracted from a reference column in each column group of a predetermined parity-check matrix. Column group information transforms the positions of rows with weight 1 into positions whose lengths are within a required parity length. A parity-check matrix is generated according to the generated column group information. Data is encoded or decoded based on the generated parity-check matrix.
摘要翻译: 公开了一种使用低密度奇偶校验码(LDPC码)的编码/解码装置和方法。 从预定奇偶校验矩阵的每列组中的参考列中提取用作关于具有权重1的行的位置的信息集合的基本列组信息。 列组信息将具有权重1的行的位置变换为长度在所需奇偶校验长度内的位置。 根据生成的列组信息生成奇偶校验矩阵。 基于生成的奇偶校验矩阵对数据进行编码或解码。
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