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    MATERIALS AND METHODS FOR REDUCTION OF PROTEIN TAU AND TREATMENT OF NEURODEGENERATIVE DISEASES
    4.
    发明申请
    MATERIALS AND METHODS FOR REDUCTION OF PROTEIN TAU AND TREATMENT OF NEURODEGENERATIVE DISEASES 有权
    减少蛋白质TAU和治疗神经损伤性疾病的材料与方法

    公开(公告)号：US20130184353A1

    公开(公告)日：2013-07-18

    申请号：US13810362

    申请日：2011-07-25

    申请人： Chad Dickey ,  Matthew Lebar ,  Bill J. Baker ,  Jeffrey Jones

    发明人： Chad Dickey ,  Matthew Lebar ,  Bill J. Baker ,  Jeffrey Jones

    IPC分类号： C07C43/196

    CPC分类号： C07C43/23 ,  A61K31/09 ,  A61K36/185 ,  C07B2200/07 ,  C07C43/196 ,  C07C2603/38 ,  C07C2603/92

    摘要： The subject invention provides a myricanol compound that is in predominant form of (+)-αR,11S-myricanol as compared to (−)-αS,11R-myricanol. In one embodiment, the (+)-αR,11S-myricanol is isolated from Myrica cerifera, and is in about 86% enantiomeric excess of (−)-αS,11R-myricanol. The subject invention also pertains to therapeutic compositions and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated with abnormal accumulation of protein tau. Specifically exemplified herein is the therapeutic use of myricanol and myricanone isolated from root barks of Myrica species. Also provided are methods for preparing extracts of the subject invention from Myrica species.

    摘要翻译： 本发明提供了与（ - ） - αS，11R-麦醇相比，主要形式的（+） - αR，11S-麦汁的米曲醇化合物。 在一个实施方案中，（+） - αR，11S-马来酸甲酯从Myrica cerifera中分离出来，并且在（ - ） - αS，11R-甲醇中约86％对映体过量。 本发明还涉及用于治疗神经变性疾病，特别是与蛋白质tau的异常积累相关的神经变性疾病的治疗组合物和方法。 本文具体举例说明了从Myrica物种的根皮分离的Myricanol和myricanone的治疗用途。 还提供了从Myrica物种制备本发明的提取物的方法。

    Production of biodiesel and glycerin from high free fatty acid feedstocks
    7.
    发明申请
    Production of biodiesel and glycerin from high free fatty acid feedstocks 有权
    从高游离脂肪酸原料生产生物柴油和甘油

    公开(公告)号：US20070277430A1

    公开(公告)日：2007-12-06

    申请号：US11504828

    申请日：2006-08-15

    申请人： John Jackman ,  Joel Pierce ,  Jeffrey Jones

    发明人： John Jackman ,  Joel Pierce ,  Jeffrey Jones

    IPC分类号： C10L1/18

    CPC分类号： C07C67/03 ,  C10L1/026 ,  C11C3/003 ,  Y02E50/13 ,  Y02P20/127 ,  Y02P30/20 ,  C07C69/52 ,  C07C69/24

    摘要： A system and method for the conversion of free fatty acids to glycerides and the subsequent conversion of glycerides to glycerin and biodiesel includes the transesterification of a glyceride stream with an alcohol. The fatty acid alkyl esters are separated from the glycerin to produce a first liquid phase containing a fatty acid alkyl ester rich (concentrated) stream and a second liquid phase containing a glycerin rich (concentrated) stream. The fatty acid alkyl ester rich stream is then subjected to distillation, preferably reactive distillation, wherein the stream undergoes both physical separation and chemical reaction. The fatty acid alkyl ester rich stream is then purified to produce a purified biodiesel product and a glyceride rich residue stream. The glycerin rich second liquid phase stream may further be purified to produce a purified glycerin product and a (second) wet alcohol stream. Neutralization of the alkaline stream, formed during the alkali-catalyzed transesterfication process, may proceed by the addition of a mineral or an organic acid.

    摘要翻译： 用于将游离脂肪酸转化为甘油酯的系统和方法以及随后将甘油酯转化为甘油和生物柴油包括甘油酯流与醇的酯交换反应。 将脂肪酸烷基酯与甘油分离以产生含有富含脂肪酸烷基酯（浓缩）料流的第一液相和含富甘油（浓缩）料流的第二液相。 然后将富含脂肪酸烷基酯的物流进行蒸馏，优选反应蒸馏，其中物流分离和化学反应。 然后纯化富含脂肪酸的富含烷基酯的料流以产生纯化的生物柴油产物和富含甘油酯的残余物流。 富含甘油的第二液相物流可以进一步纯化以产生纯化的甘油产物和（第二）湿的醇流。 在碱催化的酯交换过程中形成的碱性流的中和可以通过加入矿物或有机酸来进行。

    Web-based business application with streamlined integration of upsell features
    10.
    发明申请
    Web-based business application with streamlined integration of upsell features 审中-公开
    基于网络的业务应用，具有精简的加售功能集成功能

    公开(公告)号：US20060136344A1

    公开(公告)日：2006-06-22

    申请号：US11016087

    申请日：2004-12-17

    申请人： Jeffrey Jones ,  Evan Goldberg ,  Jingwei Liang ,  Alan Liu

    发明人： Jeffrey Jones ,  Evan Goldberg ,  Jingwei Liang ,  Alan Liu

    IPC分类号： G06F17/30

    CPC分类号： G06Q30/06

    摘要： A method, system, computer program product, and related business methods are described for providing streamlined integration of upsell features into a web-based business application. In one preferred embodiment, upsell source criteria are conveniently submitted by the user in a wizard-based process. The user can select from several upsell actions to be automatically executed based upon the presented results, thereby facilitating workflows associated with the upselling process. In another preferred embodiment, responsive to a single-click or no-click user command into a web page displaying a customer information record, a pre-computed list of upsell items is presented to the user for convenient and timely viewing. In another preferred embodiment, responsive to any of a variety of user activity that instantiates a listing of items, an upsell option is also provided in relation to that listing of items. Upon selection of that upsell option, one or more upsell possibilities corresponding to the listed of items is computed and displayed for convenient and timely viewing.

    摘要翻译： 描述了一种方法，系统，计算机程序产品和相关的业务方法，用于将加售特征的流程化集成到基于Web的业务应用中。 在一个优选实施例中，用户在基于向导的过程中方便地提交加售源标准。 用户可以根据所呈现的结果从多个加售动作中进行选择以自动执行，从而促进与上行过程相关联的工作流程。 在另一个优选实施例中，响应于单击或不点击用户命令到显示客户信息记录的网页中，预先计算的加售项列表被呈现给用户以方便和及时地查看。 在另一个优选实施例中，响应于实例化项目列表的各种用户活动中的任何一个，还提供了与项目列表相关的加售选项。 在选择该加售选项时，计算并显示与所列项目相对应的一个或多个加售可能性，以方便和及时地查看。