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1.发明授权Using focal myocardial stimulation to distinguish supraventricular tachycardia from ventricular tachycardia 有权使用局灶性心肌刺激来区分室上性心动过速与室性心动过速公开(公告)号：US09144685B2
公开(公告)日：2015-09-29
申请号：US13357646
申请日：2012-01-25
申请人： Yong-Fu Xiao , Jeffrey M. Gillberg , Paul J. DeGroot , Eduardo N. Warman , Scott J. Brabec , John L. Sommer , Jon F. Urban , Lepeng Zeng
发明人： Yong-Fu Xiao , Jeffrey M. Gillberg , Paul J. DeGroot , Eduardo N. Warman , Scott J. Brabec , John L. Sommer , Jon F. Urban , Lepeng Zeng
CPC分类号： A61N1/365 , A61N1/3622 , A61N1/36585
摘要： An apparatus and method to discriminate cardiac events by sensing atrial and ventricular depolarizations having associated refractory periods thereafter. A fast ventricular rate is detected in response to the sensed ventricular depolarizations. Responsive to detecting the fast ventricular rate, at least one stimulus pulse is delivered to atrial tissue within the associated refractory period of the ventricle but outside of an associated refractory period of the stimulated atrial tissue. A ventricular response to the atrial tissue stimulus pulse is determined, and the cardiac event is discriminated based on the ventricular response to the atrial tissue stimulus pulse.
摘要翻译： 通过感应心房和心室去极化来区分心脏事件的装置和方法，其后具有相关联的不良期。 响应于感测到的心室去极化，检测到快速心室率。 响应于检测快速心室率，至少一个刺激脉冲被输送到心室的相关不应期内但在受刺激的心房组织的相关不应期内之外的心房组织。 确定对心房组织刺激脉冲的心室反应，并且基于对心房组织刺激脉冲的心室响应来区分心脏事件。
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公开(公告)号：US09095715B2
公开(公告)日：2015-08-04
申请号：US13080027
申请日：2011-04-05
CPC分类号： A61N1/3621 , A61B2018/00351 , A61B2018/00577 , A61B2018/00696 , A61B2018/00839 , A61B2018/00898 , A61B2018/00904 , A61N1/3702 , A61N1/371
摘要： A medical device system and associated method for guiding ablation therapy sense cardiac signals using implantable electrodes and detect spontaneous cardiac events from the sensed cardiac signals. Pacing pulses are delivered in response to detecting a spontaneous cardiac event and a return cycle length is measured. The spontaneous cardiac event is clustered with a previously detected cardiac event in response to the measured return cycle length. Data corresponding to the clustered cardiac events is displayed to guide an ablation therapy.
摘要翻译： 用于引导消融治疗的医疗装置系统和相关方法使用可植入电极感测心脏信号，并从感测的心脏信号检测自发性心脏事件。 响应于检测自发性心脏事件而发送起搏脉冲，并且测量返回周期长度。 响应于测量的返回周期长度，自发心脏事件与先前检测的心脏事件聚集。 显示对应于聚集的心脏事件的数据以指导消融治疗。
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公开(公告)号：US08972228B2
公开(公告)日：2015-03-03
申请号：US13462480
申请日：2012-05-02
IPC分类号： G06G7/48 , A61B5/0408 , A61B5/0452 , A61B5/05 , A61B5/02 , A61B5/0402 , A61N1/04 , A61N1/362 , A61N1/368
CPC分类号： A61B5/04012 , A61B5/02 , A61B5/0402 , A61B5/04085 , A61B5/044 , A61B5/0452 , A61B5/05 , A61B5/742 , A61N1/0476 , A61N1/0484 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： Techniques for evaluating cardiac electrical dyssynchrony are described. In some examples, an activation time is determined for each of a plurality of torso-surface potential signals. The dispersion or sequence of these activation times may be analyzed or presented to provide variety of indications of the electrical dyssynchrony of the heart of the patient. In some examples, the locations of the electrodes of the set of electrodes, and thus the locations at which the torso-surface potential signals were sensed, may be projected on the surface of a model torso that includes a model heart. The inverse problem of electrocardiography may be solved to determine electrical activation times for regions of the model heart based on the torso-surface potential signals sensed from the patient.
摘要翻译： 描述了评估心脏电气不同步的技术。 在一些示例中，为多个躯干表面电位信号中的每一个确定激活时间。 可以分析或呈现这些激活时间的分散或序列以提供患者心脏的电不同步的各种指征。 在一些示例中，电极组的电极的位置以及因此感测躯干表面电位信号的位置可以投影在包括模型心脏的模型躯干的表面上。 可以基于从患者感测到的躯干表面电位信号来解决心电图的逆问题，以确定模型心脏区域的电激活时间。
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公开(公告)号：US08903512B2
公开(公告)日：2014-12-02
申请号：US10630547
申请日：2003-07-29
申请人： Mark T. Marshall , Teresa A. Whitman , Eduardo N. Warman , Jeffrey M. Gillberg , Matthew D. Bonner , Mark L. Brown
发明人： Mark T. Marshall , Teresa A. Whitman , Eduardo N. Warman , Jeffrey M. Gillberg , Matthew D. Bonner , Mark L. Brown
CPC分类号： A61N1/057 , A61N1/0568 , A61N1/0573 , A61N1/368 , A61N1/3702 , A61N2001/0585
摘要： An implantable electrical medical system comprises a low voltage cathode electrode assembly, including a cathode surface adapted for, intimate contact with electrically active tissue, and a low voltage anode electrode assembly, including an anode surface and a porous layer extending over the anode surface. The cathode surface and the anode surface function as a bipolar pair for pacing and the porous layer extending over the anode surface allows conduction therethrough and prevents the anode surface from contacting the electrically active tissue in order to prevent anodal stimulation.
摘要翻译： 可植入电气医疗系统包括低电压阴极电极组件，其包括适于与电活性组织紧密接触的阴极表面，以及包括在阳极表面上延伸的阳极表面和多孔层的低压阳极电极组件。 阴极表面和阳极表面用作用于起搏的双极对，并且在阳极表面上延伸的多孔层允许通过其传导，并且防止阳极表面接触电活性组织以防止阳极刺激。
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公开(公告)号：US08876727B2
公开(公告)日：2014-11-04
申请号：US13474041
申请日：2012-05-17
IPC分类号： A61B5/04 , A61B5/08 , A61N1/36 , A61B7/04 , A61B5/00 , A61B7/00 , A61B5/0205 , A61N1/365 , A61B5/024
CPC分类号： A61N1/3611 , A61B5/0031 , A61B5/0205 , A61B5/024 , A61B5/0826 , A61B5/4029 , A61B5/7217 , A61B7/005 , A61B7/006 , A61B7/04 , A61N1/36114 , A61N1/36135 , A61N1/36535 , A61N1/36578
摘要： A method and system of detecting phrenic nerve stimulation in a patient that includes detecting an activation event, obtaining a heart sound signal of a patient from an implanted heart sound sensor, determining that an electrical stimulation has been applied to the patient, in response to detecting the activation event, monitoring a portion of the heart sound signal, the portion defined by a predetermined window after the application of the electrical stimulation, and determining whether phrenic nerve stimulation occurred based on the portion of the heart sound signal.
摘要翻译： 一种检测患者膈神经刺激的方法和系统，包括检测激活事件，响应于检测，从植入的心音传感器获得患者的心音信号，确定电刺激已经施加到患者 激活事件，监测心音信号的一部分，在施加电刺激之后由预定窗口定义的部分，以及基于心音信号的部分来确定是否发生膈神经刺激。
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公开(公告)号：US08682436B2
公开(公告)日：2014-03-25
申请号：US13336113
申请日：2011-12-23
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/3702
摘要： A method for selecting a target vein for left ventricular lead placement for cardiac resynchronization therapy includes determining electrical dispersion for the first coronary vein by calculating the difference between (i) activation time at a location of the vein that has the latest activation time of a plurality of locations in the vein and (ii) activation time at a location that has the earliest activation time of the plurality of locations. The method may further include (ii) determining whether the magnitude of the electrical dispersion for the vein meets or exceeds a predetermined threshold selecting the vein if the vein meets or exceeds the predetermined threshold; or (ii) selecting, among several veins, the vein that has the highest electrical dispersion.
摘要翻译： 用于选择用于心脏再同步治疗的左心室引导放置的目标静脉的方法包括通过计算（i）静脉位置处的激活时间之间的差异来确定第一冠状静脉的电离散，所述差异具有多个 静脉中的位置和（ii）在多个位置具有最早激活时间的位置处的激活时间。 该方法还可以包括（ii）确定静脉的电色差的大小是否满足或超过预定阈值，如果静脉达到或超过预定阈值则选择静脉; 或（ii）在几条静脉中选择具有最高电色差的静脉。
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公开(公告)号：US20130165986A1
公开(公告)日：2013-06-27
申请号：US13336113
申请日：2011-12-23
IPC分类号： A61N1/372
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/3702
摘要： A method for selecting a target vein for left ventricular lead placement for cardiac resynchronization therapy includes determining electrical dispersion for the first coronary vein by calculating the difference between (i) activation time at a location of the vein that has the latest activation time of a plurality of locations in the vein and (ii) activation time at a location that has the earliest activation time of the plurality of locations. The method may further include (ii) determining whether the magnitude of the electrical dispersion for the vein meets or exceeds a predetermined threshold selecting the vein if the vein meets or exceeds the predetermined threshold; or (ii) selecting, among several veins, the vein that has the highest electrical dispersion.
摘要翻译： 用于选择用于心脏再同步治疗的左心室引导放置的目标静脉的方法包括通过计算（i）静脉位置处的激活时间之间的差异来确定第一冠状静脉的电离散，所述差异具有多个 静脉中的位置和（ii）在多个位置具有最早激活时间的位置处的激活时间。 该方法还可以包括（ii）确定静脉的电色差的大小是否满足或超过预定阈值，如果静脉达到或超过预定阈值则选择静脉; 或（ii）在几条静脉中选择具有最高电色差的静脉。
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公开(公告)号：US20120284003A1
公开(公告)日：2012-11-08
申请号：US13462480
申请日：2012-05-02
CPC分类号： A61B5/04012 , A61B5/02 , A61B5/0402 , A61B5/04085 , A61B5/044 , A61B5/0452 , A61B5/05 , A61B5/742 , A61N1/0476 , A61N1/0484 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： Techniques for evaluating cardiac electrical dyssynchrony are described. In some examples, an activation time is determined for each of a plurality of torso-surface potential signals. The dispersion or sequence of these activation times may be analyzed or presented to provide variety of indications of the electrical dyssynchrony of the heart of the patient. In some examples, the locations of the electrodes of the set of electrodes, and thus the locations at which the torso-surface potential signals were sensed, may be projected on the surface of a model torso that includes a model heart. The inverse problem of electrocardiography may be solved to determine electrical activation times for regions of the model heart based on the torso-surface potential signals sensed from the patient.
摘要翻译： 描述了评估心脏电气不同步的技术。 在一些示例中，为多个躯干表面电位信号中的每一个确定激活时间。 可以分析或呈现这些激活时间的分散或序列以提供患者心脏的电不同步的各种指征。 在一些示例中，电极组的电极的位置以及因此感测躯干表面电位信号的位置可以投影在包括模型心脏的模型躯干的表面上。 可以基于从患者感测到的躯干表面电位信号来解决心电图的逆问题，以确定模型心脏区域的电激活时间。
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公开(公告)号：US08301235B2
公开(公告)日：2012-10-30
申请号：US12768782
申请日：2010-04-28
IPC分类号： A61B5/0472
CPC分类号： A61B5/0464 , A61B5/0245 , A61B5/7203 , A61N1/3621 , A61N1/3956
摘要： A medical device and associated method for discriminating cardiac events sense cardiac signals that includes determining whether a first match score is within one of a first match zone corresponding to a first cardiac event, and a second match zone corresponding to the first cardiac event, and determining whether a second match score is within one of the first match zone, the second match zone, and a third match zone corresponding to a second cardiac event different from the first cardiac event. One of increasing and decreasing an event counter is performed in response to both the determination of whether the first match score is within one of the first match zone and the second match zone and the determination of whether the second match score is within one of the first match zone, the second match zone, and the third match zone.
摘要翻译： 用于识别心脏事件的医疗装置和相关联的方法检测心脏信号，所述心脏信号包括确定第一匹配分数是否在对应于第一心脏事件的第一匹配区域之内，以及对应于第一心脏事件的第二匹配区域，以及确定 第二匹配得分是否在第一匹配区域，第二匹配区域和对应于不同于第一心脏事件的第二心脏事件的第三匹配区域之一内。 响应于第一匹配分数是否在第一匹配区域和第二匹配区域之一的确定以及确定第二匹配分数是否在第一匹配区域之一内的确定来执行增加和减少事件计数器之一 匹配区，第二匹配区和第三匹配区。
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10.发明授权Detecting a condition of a patient using a probability-correlation based model 有权使用基于概率相关的模型检测患者的状况公开(公告)号：US08301233B2
公开(公告)日：2012-10-30
申请号：US12415445
申请日：2009-03-31
CPC分类号： A61B5/0452 , A61B5/7203 , A61N1/3621 , A61N1/3702 , A61N1/3962
摘要： Techniques are described for detecting a condition of a patient using a probability-correlation based model that integrates a plurality of parameters associated with the condition. A medical device that operates in accordance with the techniques obtains a plurality of parameters associated with the condition of the patient. The medical device obtains probabilities that the condition of the patient exists based on each single parameter separately and correlations between each of the parameters and the other ones of the parameters. After obtaining the probabilities and correlations associated with each of the parameters, the medical device determines whether the condition of the patient exists based on the determined probabilities and correlations. Such techniques may be particularly effective for use in distinguishing whether a rhythm of a patient is treatable, e.g., VT or VF, or non-treatable, e.g., SVT.
摘要翻译： 描述了用于使用集成了与条件相关联的多个参数的基于概率相关的模型来检测患者的状况的技术。 根据技术操作的医疗装置获得与患者状况相关联的多个参数。 医疗设备根据每个单独的参数获得病人的状况存在的概率，以及每个参数与其他参数之间的相关性。 在获得与每个参数相关联的概率和相关性之后，医疗设备基于所确定的概率和相关性来确定患者的状况是否存在。 这种技术可能特别有效地用于区分患者的节律是否可治疗，例如VT或VF，或不可治疗的，例如SVT。
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