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公开(公告)号：US20100055121A1
公开(公告)日：2010-03-04
申请号：US12528796
申请日：2008-02-27
IPC分类号： A61K39/12 , C07K7/06 , C07H21/04 , C12N15/63 , C12N1/19 , C12N7/01 , A61K35/76 , C12N5/02 , A61K35/12 , G01N33/53
CPC分类号： C12N15/113 , A61K39/00 , A61K2039/53 , C07K14/4702 , C07K14/82 , G01N33/56972 , G01N33/574 , G01N2333/70517 , Y02A50/466
摘要： It is disclosed herein that Brachyury is expressed in human tumors, specifically in tumors of the small intestine, stomach, kidney, bladder, uterus, ovary, and testes, as well as in lung, colon and prostate carcinomas. Immunogenic Brachyury polypeptides are disclosed herein. These polypeptides can be used in diagnostic assays for Brachyury expression, as well as for inducing an immune response to Brachyury. Polynucleotides encoding the immunogenic Brachyury polypeptides, vectors including these polypeptides, host cells transformed with these vectors, and methods of using these polypeptides, polynucleotides, vectors, and host cells are provided. Methods of diagnosing a Brachyury-expressing cancer are also provided. Exemplary cancers include lung, colon, small intestine, stomach, kidney, bladder, uterus, ovary, and testes and prostate cancers. Methods of treating cancer are also disclosed.
摘要翻译： 本文公开了Brachyury在人肿瘤中，特别是在小肠，胃，肾，膀胱，子宫，卵巢和睾丸以及肺，结肠和前列腺癌的肿瘤中表达。 免疫原性Brachyury多肽在本文中公开。 这些多肽可用于Brachyury表达的诊断测定，以及用于诱导Brachyury的免疫应答。 提供了编码免疫原性Brachyury多肽的多核苷酸，包括这些多肽的载体，用这些载体转化的宿主细胞，以及使用这些多肽，多核苷酸，载体和宿主细胞的方法。 还提供了诊断Brachyury表达癌症的方法。 示例性的癌症包括肺，结肠，小肠，胃，肾，膀胱，子宫，卵巢，睾丸和前列腺癌。 还公开了治疗癌症的方法。
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公开(公告)号：US08188214B2
公开(公告)日：2012-05-29
申请号：US12528796
申请日：2008-02-27
CPC分类号： C12N15/113 , A61K39/00 , A61K2039/53 , C07K14/4702 , C07K14/82 , G01N33/56972 , G01N33/574 , G01N2333/70517 , Y02A50/466
摘要： It is disclosed herein that Brachyury is expressed in human tumors, specifically in tumors of the small intestine, stomach, kidney, bladder, uterus, ovary, and testes, as well as in lung, colon and prostate carcinomas. Immunogenic Brachyury polypeptides are disclosed herein. These polypeptides can be used in diagnostic assays for Brachyury expression, as well as for inducing an immune response to Brachyury. Polynucleotides encoding the immunogenic Brachyury polypeptides, vectors including these polypeptides, host cells transformed with these vectors, and methods of using these polypeptides, polynucleotides, vectors, and host cells are provided. Methods of diagnosing a Brachyury-expressing cancer are also provided. Exemplary cancers include lung, colon, small intestine, stomach, kidney, bladder, uterus, ovary, and testes and prostate cancers. Methods of treating cancer are also disclosed.
摘要翻译： 本文公开了Brachyury在人肿瘤中，特别是在小肠，胃，肾，膀胱，子宫，卵巢和睾丸以及肺，结肠和前列腺癌的肿瘤中表达。 免疫原性Brachyury多肽在本文中公开。 这些多肽可用于Brachyury表达的诊断测定，以及用于诱导Brachyury的免疫应答。 提供了编码免疫原性Brachyury多肽的多核苷酸，包括这些多肽的载体，用这些载体转化的宿主细胞，以及使用这些多肽，多核苷酸，载体和宿主细胞的方法。 还提供了诊断Brachyury表达癌症的方法。 示例性的癌症包括肺，结肠，小肠，胃，肾，膀胱，子宫，卵巢，睾丸和前列腺癌。 还公开了治疗癌症的方法。
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公开(公告)号：US20120230948A1
公开(公告)日：2012-09-13
申请号：US13460587
申请日：2012-04-30
IPC分类号： A61K39/00 , A61K38/20 , G01N33/574 , A61K38/19 , A61P35/00 , C12N15/63 , A61K35/76 , A61K38/21
CPC分类号： C12N15/113 , A61K39/00 , A61K2039/53 , C07K14/4702 , C07K14/82 , G01N33/56972 , G01N33/574 , G01N2333/70517 , Y02A50/466
摘要： It is disclosed herein that Brachyury is expressed in human tumors, specifically in tumors of the small intestine, stomach, kidney, bladder, uterus, ovary, and testes, as well as in lung, colon and prostate carcinomas. Immunogenic Brachyury polypeptides are disclosed herein. These polypeptides can be used in diagnostic assays for Brachyury expression, as well as for inducing an immune response to Brachyury. Polynucleotides encoding the immunogenic Brachyury polypeptides, vectors including these polypeptides, host cells transformed with these vectors, and methods of using these polypeptides, polynucleotides, vectors, and host cells are provided. Methods of diagnosing a Brachyury-expressing cancer are also provided. Exemplary cancers include small lung, colon, intestine, stomach, kidney, bladder, uterus, ovary, and testes and prostate cancers. Methods of treating cancer are also disclosed.
摘要翻译： 本文公开了Brachyury在人肿瘤中，特别是在小肠，胃，肾，膀胱，子宫，卵巢和睾丸以及肺，结肠和前列腺癌的肿瘤中表达。 免疫原性Brachyury多肽在本文中公开。 这些多肽可用于Brachyury表达的诊断测定，以及用于诱导Brachyury的免疫应答。 提供了编码免疫原性Brachyury多肽的多核苷酸，包括这些多肽的载体，用这些载体转化的宿主细胞，以及使用这些多肽，多核苷酸，载体和宿主细胞的方法。 还提供了诊断Brachyury表达癌症的方法。 示例性的癌症包括小肺，结肠，肠，胃，肾，膀胱，子宫，卵巢，睾丸和前列腺癌。 还公开了治疗癌症的方法。
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公开(公告)号：US08613933B2
公开(公告)日：2013-12-24
申请号：US13460587
申请日：2012-04-30
IPC分类号： A61K39/12
CPC分类号： C12N15/113 , A61K39/00 , A61K2039/53 , C07K14/4702 , C07K14/82 , G01N33/56972 , G01N33/574 , G01N2333/70517 , Y02A50/466
摘要： It is disclosed herein that Brachyury is expressed in human tumors, specifically in tumors of the small intestine, stomach, kidney, bladder, uterus, ovary, and testes, as well as in lung, colon and prostate carcinomas. Immunogenic Brachyury polypeptides are disclosed herein. These polypeptides can be used in diagnostic assays for Brachyury expression, as well as for inducing an immune response to Brachyury. Polynucleotides encoding the immunogenic Brachyury polypeptides, vectors including these polypeptides, host cells transformed with these vectors, and methods of using these polypeptides, polynucleotides, vectors, and host cells are provided. Methods of diagnosing a Brachyury-expressing cancer are also provided. Exemplary cancers include small lung, colon, intestine, stomach, kidney, bladder, uterus, ovary, and testes and prostate cancers. Methods of treating cancer are also disclosed.
摘要翻译： 本文公开了Brachyury在人肿瘤中，特别是在小肠，胃，肾，膀胱，子宫，卵巢和睾丸以及肺，结肠和前列腺癌的肿瘤中表达。 免疫原性Brachyury多肽在本文中公开。 这些多肽可用于Brachyury表达的诊断测定，以及用于诱导Brachyury的免疫应答。 提供了编码免疫原性Brachyury多肽的多核苷酸，包括这些多肽的载体，用这些载体转化的宿主细胞，以及使用这些多肽，多核苷酸，载体和宿主细胞的方法。 还提供了诊断Brachyury表达癌症的方法。 示例性的癌症包括小肺，结肠，肠，胃，肾，膀胱，子宫，卵巢，睾丸和前列腺癌。 还公开了治疗癌症的方法。
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5.发明授权Human cytotoxic T-lymphocyte epitope and its agonist epitope from the non-variable number of tandem repeat sequence of MUC-1 有权人类细胞毒性T淋巴细胞表位及其激动剂表位来自MUC-1的非可变数目的串联重复序列公开(公告)号：US08957192B2
公开(公告)日：2015-02-17
申请号：US13176341
申请日：2011-07-05
申请人： Jeffrey Schlom , Kwong-Yok Tsang
发明人： Jeffrey Schlom , Kwong-Yok Tsang
IPC分类号： C07H21/02 , A61K39/00 , C07K14/47 , C07K14/705 , C12N15/85
CPC分类号： A61K39/0011 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , C07K14/4727 , C07K14/70596 , C12N15/85
摘要： Novel MUC-1 epitopes outside the VNTR region are identified. In addition, the first agonist epitope of MUC-1 is described. The employment of agonist epitopes in peptide, protein and vector-based vaccine may well aid in the development of effective vaccines for a range of human cancers.
摘要翻译： 鉴定出VNTR区以外的新型MUC-1表位。 此外，描述了MUC-1的第一激动剂表位。 在肽，蛋白质和基于载体的疫苗中使用激动剂表位可能有助于开发一系列人类癌症的有效疫苗。
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公开(公告)号：US08933041B2
公开(公告)日：2015-01-13
申请号：US10579007
申请日：2004-11-12
申请人： Dennis L. Panicali , Gail P. Mazzara , Linda R. Gritz , Jeffrey Schlom , Kwong-Yok Tsang , James W. Hodge
发明人： Dennis L. Panicali , Gail P. Mazzara , Linda R. Gritz , Jeffrey Schlom , Kwong-Yok Tsang , James W. Hodge
CPC分类号： C12N15/86 , A61K39/0011 , A61K48/005 , A61K2039/53 , A61K2039/545 , A61K2039/55522 , C12N7/00 , C12N2710/24043 , C12N2710/24071 , C12N2710/24143 , C12N2710/24171 , C12N2799/023
摘要： The present invention is directed to a system for treating individuals at risk of or suffering from breast cancer. The system comprises administering to the individual a recombinant poxvirus, where the poxvirus contains in a foreign nucleic acid encoding at least one breast cancer antigen.
摘要翻译： 本发明涉及用于治疗患有或患有乳腺癌的个体的系统。 该系统包括向个体施用重组痘病毒，其中痘病毒含有编码至少一种乳腺癌抗原的外源核酸。
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公开(公告)号：US08748390B2
公开(公告)日：2014-06-10
申请号：US13265490
申请日：2010-04-19
申请人： Jeffrey Schlom , Kwong-Yok Tsang , Ira Pastan
发明人： Jeffrey Schlom , Kwong-Yok Tsang , Ira Pastan
CPC分类号： A61K39/0011 , A61K38/00 , A61K38/191 , A61K38/193 , A61K38/20 , A61K38/217 , A61K39/00 , C07K7/06 , C07K14/4748 , C07K14/705 , Y02A50/466
摘要： The invention provides a peptide comprising a human cytolytic T lymphocyte (CTL) epitope from the human tumor-associated antigen (TAA) New Gene Expressed in Prostate (NGEP), which can be used in vaccine prevention or therapy of prostate cancer, as well as a nucleic acid encoding the peptide, a vector comprising the nucleic acid, a cell comprising the peptide, nucleic acid, or vector, and compositions thereof.
摘要翻译： 本发明提供了一种肽，其包含来自人肿瘤相关抗原（TAA）在前列腺中表达的新基因（NGEP）的人溶细胞T淋巴细胞（CTL）表位，其可用于预防或治疗前列腺癌，以及 编码所述肽的核酸，包含所述核酸的载体，包含所述肽，核酸或载体的细胞及其组合物。
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8.发明授权公开(公告)号：US08178508B2
公开(公告)日：2012-05-15
申请号：US12977660
申请日：2010-12-23
申请人： Jeffrey Schlom , Kwong-Yok Tsang , Sam Zaremba
发明人： Jeffrey Schlom , Kwong-Yok Tsang , Sam Zaremba
IPC分类号： A61K48/00
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K2035/124 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/55522 , A61K2039/55527 , C12N5/0636 , C12N9/6445 , C12N2710/24143 , Y10S435/975
摘要： The invention provides a prostate specific antigen oligo-epitope peptide (PSA-OP) that is useful as an immunogen in the prevention or treatment of prostatic cancer and in the inhibition of prostatic cancer cells and in the establishment and characterization of PSA-specific cytotoxic T-cell lines. In particular, the invention provides methods for eliciting an immune response against PSA comprising administering (i) a priming inoculation of a first recombinant virus encoding PSA-OP and (ii) one or more boosting inoculations of a second recombinant virus encoding PSA-OP, wherein the first and second recombinant viruses are from a different genus.
摘要翻译： 本发明提供了前列腺特异性抗原寡表位肽（PSA-OP），其可用作预防或治疗前列腺癌和抑制前列腺癌细胞的免疫原，以及PSA特异性细胞毒性T的建立和表征 细胞线。 特别地，本发明提供了引发针对PSA的免疫应答的方法，包括施用（i）编码PSA-OP的第一重组病毒的引发接种和（ii）编码PSA-OP的第二重组病毒的一种或多种加强接种， 其中所述第一和第二重组病毒来自不同属。
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公开(公告)号：US20110165117A1
公开(公告)日：2011-07-07
申请号：US13025094
申请日：2011-02-10
申请人： Jeffrey Schlom , Kwong-Yok Tsang , Ira H. Pastan
发明人： Jeffrey Schlom , Kwong-Yok Tsang , Ira H. Pastan
IPC分类号： A61K38/21 , A61K38/20 , A61P35/00 , A61K39/00 , A61K35/12 , C12N7/01 , C12N5/10 , C12N5/02 , C12N15/63 , A61K38/00 , A61K31/7088 , C07K14/435 , C07H21/04
CPC分类号： C07K14/4748 , A61K38/08 , A61K39/0011 , C07K14/82 , C12N2799/023 , C12N2800/00 , G01N2333/70517
摘要： The PAGE4 gene is expressed in reproductive tissues, and is expressed in reproductive cancers, such as prostate cancer, uterine cancer, and testicular cancer. Immunogenic PAGE4 polypeptides are disclosed herein, as are nucleic acids encoding the immunogenic PAGE4 polypeptides, vectors including these polynucleotides, and host cells transformed with these vectors. These polypeptides, polynucleotides, vectors, and host cells can be used to induce an immune response to PAGE4. Diagnostic methods to detect PAGE4 are also described.
摘要翻译： PAGE4基因在生殖组织中表达，并在生殖癌中表达，如前列腺癌，子宫癌和睾丸癌。 本文公开了免疫原性PAGE4多肽，以及编码免疫原性PAGE4多肽的核酸，包括这些多核苷酸的载体和用这些载体转化的宿主细胞。 这些多肽，多核苷酸，载体和宿主细胞可用于诱导对PAGE4的免疫应答。 还描述了检测PAGE4的诊断方法。
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公开(公告)号：US20100303720A1
公开(公告)日：2010-12-02
申请号：US12819920
申请日：2010-06-21
IPC分类号： A61K51/10 , A61K39/395 , A61P35/00
CPC分类号： A61K49/0002 , A61K38/00 , A61K51/1045 , A61K2039/505 , C07K16/30 , C07K16/3046 , C07K16/4208 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2799/026 , G01N33/5743
摘要： The invention is directed towards mouse-human chimeric variants of CC49 monoclonal antibodies with minimal murine content. A first aspect of the invention provides CDR variants of humanized monoclonal antibody (HuCC49) in which less than all six (three heavy chain and three light chain) Complementarity DeterminingRegions (CDRs) of CC49 are present. A second aspect of the invention provides SDR variants of humanized monoclonal antibody (HuCC49) in which only Specificity Determining Regions (SDRs) of at least one CDR from CC49 are present. The invention is also directed towards biotechnological methods of making the variants and therapeutic methods of using the variants.
摘要翻译： 本发明针对具有最小鼠含量的CC49单克隆抗体的小鼠 - 人嵌合变体。 本发明的第一方面提供了存在CC49的全部六（三个重链和三个轻链）互补决定区（CDR）的人源化单克隆抗体（HuCC49）的CDR变体。 本发明的第二方面提供了仅存在来自CC49的至少一个CDR的特异性确定区（SDR）的人源化单克隆抗体（HuCC49）的SDR变体。 本发明还涉及制备使用变体的变体和治疗方法的生物技术方法。
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