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    Method and apparatus for controlling cardiac therapy based on electromechanical timing
    1.
    发明申请
    Method and apparatus for controlling cardiac therapy based on electromechanical timing 有权
    基于机电定时控制心脏治疗的方法和装置

    公开(公告)号：US20060293714A1

    公开(公告)日：2006-12-28

    申请号：US11168024

    申请日：2005-06-28

    申请人： Rodney Salo ,  Joseph Pastore ,  Andrew Kramer ,  Jeffrey Stahmann ,  Jesse Hartley

    发明人： Rodney Salo ,  Joseph Pastore ,  Andrew Kramer ,  Jeffrey Stahmann ,  Jesse Hartley

    IPC分类号： A61N1/36

    CPC分类号： A61N1/3627 ,  A61M5/14276 ,  A61N1/36521 ,  A61N1/36585 ,  A61N1/3756

    摘要： Devices and methods for therapy control based on electromechanical timing involve detecting electrical activation of a patient's heart, and detecting mechanical cardiac activity resulting from the electrical activation. A timing relationship is determined between the electrical activation and the mechanical activity. A therapy is controlled based on the timing relationship. The therapy may improve intraventricular dyssynchrony of the patient's heart, or treat at least one of diastolic and systolic dysfunction and/or dyssynchrony of the patient's heart, for example. Electrical activation may be detected by sensing delivery of an electrical stimulation pulse to the heart or sensing intrinsic depolarization of the patient's heart. Mechanical activity may be detected by sensing heart sounds, a change in one or more of left ventricular impedance, ventricular pressure, right ventricular pressure, left atrial pressure, right atrial pressure, systemic arterial pressure and pulmonary artery pressure.

    摘要翻译： 基于机电定时的治疗控制的装置和方法涉及检测患者心脏的电激活，以及检测由电激活引起的机械心脏活动。 在电激活和机械活动之间确定时序关系。 基于时间关系控制治疗。 该治疗可以改善患者心脏的心室内不同步，或治疗患者心脏的舒张期和收缩功能障碍和/或不同步中的至少一种。 可以通过感测向心脏传递电刺激脉冲或感测患者心脏的固有去极化来检测电激活。 可以通过感测心脏声音，左心室阻抗，心室压力，右心室压力，左心房压力，右心房压力，全身动脉压力和肺动脉压力中的一个或多个的变化来检测机械活动。

    Method and apparatus for device controlled gene expression for cardiac protection
    5.
    发明申请
    Method and apparatus for device controlled gene expression for cardiac protection 有权
    心脏保护装置控制基因表达的方法和装置

    公开(公告)号：US20070054871A1

    公开(公告)日：2007-03-08

    申请号：US11220397

    申请日：2005-09-06

    申请人： Joseph Pastore ,  Jeffrey Ross ,  Tamara Baynham ,  Rodney Salo ,  Andrew Kramer ,  Julio Spinelli

    发明人： Joseph Pastore ,  Jeffrey Ross ,  Tamara Baynham ,  Rodney Salo ,  Andrew Kramer ,  Julio Spinelli

    IPC分类号： A61K48/00 ,  A61N1/00

    CPC分类号： A61N1/3627 ,  A61K48/0083 ,  A61N1/36514

    摘要： A gene regulatory system detects ischemia events and is capable of delivering a biologic therapy in response to the detection of an ischemic event or the reception of a command. The biologic therapy protects the heart from ischemic damage by regulating the expression of an exogenously introduced gene product. In one embodiment, the gene regulatory system includes an implantable system that emits at least one gene regulatory signal in response to the detection of the ischemic event or the reception of the command. The gene regulatory signal directly or indirectly regulates gene expression of the gene product.

    摘要翻译： 基因调控系统检测缺血事件，并且能够响应于缺血事件的检测或命令的接收而递送生物疗法。 生物治疗通过调节外源基因产物的表达来保护心脏免于缺血性损伤。 在一个实施方案中，基因调控系统包括可植入系统，其可以响应于缺血事件的检测或命令的接收而发射至少一个基因调节信号。 基因调控信号直接或间接调控基因产物的基因表达。

    Method and apparatus for using heart rate variability as a safety check in electrical therapies
    10.
    发明申请
    Method and apparatus for using heart rate variability as a safety check in electrical therapies 失效
    使用心率变异性作为电疗法安全检查的方法和装置

    公开(公告)号：US20060161209A1

    公开(公告)日：2006-07-20

    申请号：US11037309

    申请日：2005-01-18

    申请人： Joseph Pastore ,  Rodney Salo ,  Gerrard Carlson ,  Andrew Kramer ,  Jiang Ding ,  Yinghong Yu

    发明人： Joseph Pastore ,  Rodney Salo ,  Gerrard Carlson ,  Andrew Kramer ,  Jiang Ding ,  Yinghong Yu

    IPC分类号： A61N1/362

    CPC分类号： A61N1/365 ,  A61N1/36592

    摘要： A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used as a safety check to stop an electrical therapy when it is believed to be potentially harmful to continue the therapy.

    摘要翻译： 心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。 产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。 在一个实施例中，当HRV参数被认为对继续治疗有潜在危害时，将HRV参数用作安全检查以停止电疗法。