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公开(公告)号：US08165823B2
公开(公告)日：2012-04-24
申请号：US11988895
申请日：2006-07-15
申请人： Jeffrey Ulmer , Nicholas Valiante , Feng Xu , Claudio Donati , Antonello Covacci
发明人： Jeffrey Ulmer , Nicholas Valiante , Feng Xu , Claudio Donati , Antonello Covacci
摘要： A method for identifying a polypeptide which acts as an adjuvant in a host organism. The invention further provides adjuvant compositions comprising said polypeptides and optionally further comprising an antigen.
摘要翻译： 用于鉴定作为宿主生物体中佐剂的多肽的方法。 本发明进一步提供了包含所述多肽并任选进一步包含抗原的佐剂组合物。
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公开(公告)号：US20090155306A1
公开(公告)日：2009-06-18
申请号：US11988895
申请日：2006-07-15
申请人： Jeffrey Ulmer , Nicholas Valiante , Feng Xu , Claudio Donati , Antonello Covacci
发明人： Jeffrey Ulmer , Nicholas Valiante , Feng Xu , Claudio Donati , Antonello Covacci
摘要： A method for identifying a polypeptide which acts as an adjuvant in a host organism. The invention further provides adjuvant compositions comprising said polypeptides and optionally further comprising an antigen.
摘要翻译： 用于鉴定作为宿主生物体中佐剂的多肽的方法。 本发明进一步提供了包含所述多肽并任选进一步包含抗原的佐剂组合物。
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公开(公告)号：US20090327170A1
公开(公告)日：2009-12-31
申请号：US12086717
申请日：2006-12-19
申请人： Claudio Donati , Duccio Medini , Antonello Covacci
发明人： Claudio Donati , Duccio Medini , Antonello Covacci
IPC分类号： G06F15/18 , C07K14/00 , C07K16/18 , C12N15/11 , A61K39/395 , A61K39/00 , A61K31/7088 , A61K38/16
CPC分类号： C07K14/195 , A61K39/00 , C40B30/04 , C40B30/06 , G16B10/00 , G16B30/00 , G16B40/00 , G16B45/00 , Y02A90/26
摘要： The invention relates to methods for clustering gene and protein sequences. In particular, it involves generation of networks of sequences where the interconnections are based upon a measure of similarity. The invention also provides methods of optimizing and improving the networks by re-wiring of the network based upon overlap of the nearest neighbors of given pairs of nodes. The invention further provides methods of identifying clusters of sequences within the networks and the optimized networks based upon the topology of the network. The clusters identified represent groups of sequences that are related by function and/or evolution. The invention has particular applicability in annotation of sequences in databases and identification of functional homologs which can be very useful for novel therapeutic and diagnostic targets based upon such targets belonging to a cluster or family that contains a known sequence such as a diagnostic sequence, antigen or other therapeutic target.
摘要翻译： 本发明涉及聚类基因和蛋白质序列的方法。 特别地，它涉及产生其中互连基于相似性度量的序列网络。 本发明还提供了通过基于给定的节点对的最近邻的重叠来重新布线网络来优化和改进网络的方法。 本发明还提供了基于网络的拓扑来识别网络内的序列簇和优化的网络的方法。 识别的簇表示与功能和/或进化相关的序列组。 本发明特别适用于数据库中的序列注释和功能同系物的鉴定，其可以对基于属于簇或家族的这样的靶标的新型治疗和诊断靶标非常有用，所述靶标包含已知序列，例如诊断序列，抗原或 其他治疗目标。
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公开(公告)号：US20110097360A1
公开(公告)日：2011-04-28
申请号：US12451736
申请日：2008-05-23
IPC分类号： A61K39/09 , C07K2/00 , C12N9/00 , C07K14/315 , C07K4/04 , C07H21/00 , C07H21/04 , C12N1/20 , A61P37/04 , A61P31/04
CPC分类号： C07K14/3156 , A61K39/00 , A61K2039/505 , A61K2039/53 , C12N9/52 , G01N33/56944 , G01N2333/315 , G01N2469/10
摘要： Polypeptides from Streptococcus pneumoniae are described. In some aspects the polypeptides include pili polypeptides from a second pili island (pilus II island (INV1 04B)) identified in Streptococcus pneumoniae isolate INV1 04. In other aspects the polypeptides include pili polypeptides and non-pilus polypeptides from Streptococcus pneumoniae strains 23F, INV200, and OXC141 that are absent from Streptococcus pneumoniae isolate INV104. The polypeptides, including fragments and variants thereof, may be used in immunogenic compositions for prophylactic or therapeutic immunization against Streptococcus pneumoniae. The polypeptides are also disclosed to be used in compositions useful for the production of antibodies and immunostimulants. Also presented are methods of inhibiting Streptococcus pneumoniae, methods of treating Streptococcus pneumoniae infection, methods of identifying inhibitors of Streptococcus pneumoniae and methods for diagnosing/detecting Streptococcus pneumoniae infection.
摘要翻译： 描述了来自肺炎链球菌的多肽。 在一些方面，多肽包括来自肺炎链球菌分离株INV104中鉴定的第二个皮岛（pilus II岛（INV1 04B））的多肽。在其它方面，多肽包括来自肺炎链球菌菌株23F，INV200的多肽和非菌毛多肽 和OXC141，其不存在于肺炎链球菌分离株INV104中。 多肽，包括其片段和变体，可用于免疫原性组合物用于针对肺炎链球菌的预防性或治疗性免疫。 还公开了将多肽用于可用于生产抗体和免疫增强剂的组合物中。 还提出了抑制肺炎链球菌的方法，肺炎链球菌感染的治疗方法，肺炎链球菌抑制剂的鉴定方法和肺炎链球菌感染的诊断方法。
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5.发明授权Packaging system with marking system including a marking server to store templates 有权包装系统，带有标记系统，包括一个标记服务器来存储模板公开(公告)号：US09557733B2
公开(公告)日：2017-01-31
申请号：US13824702
申请日：2011-10-20
IPC分类号： G05B19/418 , B65B61/26
CPC分类号： G05B19/418 , B65B61/26 , G05B19/4185 , G05B19/41865 , G05B19/4188 , G05B2219/31344 , G05B2219/31372 , G05B2219/32025 , G05B2219/45048 , Y02P90/12 , Y02P90/18 , Y02P90/20 , Y02P90/24 , Y02P90/265
摘要： A Packaging System having a Packaging Line designed to produce Packaged Consumer Products; a Marking System designed to mark individual or packs of Packaged Consumer Products with graphical information, and a Line Controller designed to control the Packaging Line and the Marking System. The Marking System includes: Marking Equipment and a Marking Server. The Marking Server is designed to receive Production Batch Data and associated Template Identifier(s); and a Marking Device Controller. The Line Controller is designed to: receive Production Batch Data and generate Marking Instruction(s) for associated Marking Device Controller(s). The Marking Device Controller is designed to: receive Marking Instruction(s) from the Line Controller, fetch out from a Repository in the Marking Server stored Mark Layout Template(s) and Production Batch Data, and generate Marking Command(s) for Marking Device(s) controlled by the Marking Device Controller based on fetched Mark Layout Template(s) and Production Batch Data.
摘要翻译： 包装系统，包括生产包装消费品的包装线; 标记系统旨在使用图形信息标记包装消费品的个人或包装，以及旨在控制包装线和标记系统的线路控制器。 标记系统包括：标记设备和标记服务器。 标记服务器旨在接收生产批次数据和关联的模板标识符; 和标记设备控制器。 线路控制器设计为：接收生产批次数据并生成相关标记设备控制器的标记指令。 标记设备控制器设计为：从线路控制器接收标记指令，从标记服务器中的存储库存储的标记布局模板和生产批次数据中获取标记指令，并生成标记设备的标记命令 由标记设备控制器基于获取的标记布局模板和生产批次数据控制。
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公开(公告)号：US08543233B2
公开(公告)日：2013-09-24
申请号：US12744194
申请日：2008-12-31
申请人： Claudio Donati , Lorenzo Tacconi , Fabio Zerri
发明人： Claudio Donati , Lorenzo Tacconi , Fabio Zerri
IPC分类号： G06F19/00
CPC分类号： G05B19/41865 , G05B19/41845 , G05B19/4185 , G05B19/4188 , G05B2219/31054 , G05B2219/31379 , G05B2219/32015 , G05B2219/32085 , G05B2219/32208 , G05B2219/32336 , G05B2219/45048 , Y02P90/04 , Y02P90/16 , Y02P90/18 , Y02P90/20 , Y02P90/22 , Y02P90/24 , Y02P90/265
摘要： A packaging system includes a packaging line comprising a filling machine for producing sealed packages containing food product and downstream distribution equipment connected by conveyors and each including a control system, a line controller for managing configuration, communication and control of the packaging line, a common overhead message display which displays visual information on the operation of the equipment, and a communication network for connecting the line controller to the equipment. The line controller includes a line configurator which reduces and secures effective line installation, start up and tuning at the manufacturing floor via “plug and play”, a line commander which optimizes line performance and product flows during production, a recipe manager which accommodates production flexibility by improving “easy to use” line resources and material, and a conveyor optimizer which optimizes product transportation along the conveyors.
摘要翻译： 包装系统包括包装线，包括用于生产包含食品的密封包装的填充机和由输送机连接的下游分配设备，每个包括控制系统，用于管理包装线的配置，通信和控制的线路控制器， 显示关于设备操作的视觉信息的消息显示，以及用于将线路控制器连接到设备的通信网络。 线路控制器包括一个线路配置器，它通过“即插即用”降低并确保了生产线上的有效线路安装，启动和调谐，线路指挥员可以优化线路性能和生产过程中的产品流程，配方管理器可以适应生产灵活性 通过改进“易于使用”的生产线资源和材料，以及优化输送机产品运输的输送机优化器。
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公开(公告)号：US20130178969A1
公开(公告)日：2013-07-11
申请号：US13824702
申请日：2011-10-20
IPC分类号： G05B19/418
CPC分类号： G05B19/418 , B65B61/26 , G05B19/4185 , G05B19/41865 , G05B19/4188 , G05B2219/31344 , G05B2219/31372 , G05B2219/32025 , G05B2219/45048 , Y02P90/12 , Y02P90/18 , Y02P90/20 , Y02P90/24 , Y02P90/265
摘要： A Packaging System comprising: a Packaging Line designed to produce Packaged Consumer Products; a Marking System designed to mark individual or packs of Packaged Consumer Products with graphical information, and a Line Controller designed to control the Packaging Line and the Marking System. The Marking System includes: Marking Equipment and a Marking Server. The Marking Server is designed to receive Production Batch Data and associated Template Identifier(s); and a Marking Device Controller. The Line Controller is designed to: receive Production Batch Data and generate Marking Instruction(s) for associated Marking Device Controller(s). The Marking Device Controller is designed to: receive Marking Instruction(s) from the Line Controller, fetch out from a Repository in the Marking Server stored Mark Layout Template(s) and Production Batch Data, and generate Marking Command(s) for Marking Device(s) controlled by the Marking Device Controller based on fetched Mark Layout Template(s) and Production Batch Data.
摘要翻译： 包装系统包括：包装线，用于生产包装消费品; 标记系统旨在使用图形信息标记包装消费品的个人或包装，以及旨在控制包装线和标记系统的线路控制器。 标记系统包括：标记设备和标记服务器。 标记服务器旨在接收生产批次数据和关联的模板标识符; 和标记设备控制器。 线路控制器设计为：接收生产批次数据并生成相关标记设备控制器的标记指令。 标记设备控制器设计为：从线路控制器接收标记指令，从标记服务器中的存储库存储的标记布局模板和生产批次数据中获取标记指令，并生成标记设备的标记命令 由标记设备控制器基于获取的标记布局模板和生产批次数据控制。
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公开(公告)号：US20100287879A1
公开(公告)日：2010-11-18
申请号：US12744194
申请日：2008-12-31
申请人： Claudio Donati , Lorenzo Tacconi , Fabio Zerri
发明人： Claudio Donati , Lorenzo Tacconi , Fabio Zerri
IPC分类号： B65B57/00
CPC分类号： G05B19/41865 , G05B19/41845 , G05B19/4185 , G05B19/4188 , G05B2219/31054 , G05B2219/31379 , G05B2219/32015 , G05B2219/32085 , G05B2219/32208 , G05B2219/32336 , G05B2219/45048 , Y02P90/04 , Y02P90/16 , Y02P90/18 , Y02P90/20 , Y02P90/22 , Y02P90/24 , Y02P90/265
摘要： A packaging system includes a packaging line comprising a filling machine for producing sealed packages containing food product and downstream distribution equipment connected by conveyors and each including a control system, a line controller for managing configuration, communication and control of the packaging line, a common overhead message display which displays visual information on the operation of the equipment, and a communication network for connecting the line controller to the equipment. The line controller includes a line configurator which reduces and secures effective line installation, start up and tuning at the manufacturing floor via “plug and play”, a line commander which optimizes line performance and product flows during production, a recipe manager which accommodates production flexibility by improving “easy to use” line resources and material, and a conveyor optimizer which optimizes product transportation along the conveyors.
摘要翻译： 包装系统包括包装线，包括用于生产包含食品的密封包装的填充机和由输送机连接的下游分配设备，每个包括控制系统，用于管理包装线的配置，通信和控制的线路控制器， 显示关于设备操作的视觉信息的消息显示，以及用于将线路控制器连接到设备的通信网络。 线路控制器包括一个线路配置器，它通过“即插即用”降低并确保了生产线上的有效线路安装，启动和调谐，线路指挥员可以优化线路性能和生产过程中的产品流程，配方管理器可以适应生产灵活性 通过改进“易于使用”的生产线资源和材料，以及优化输送机产品运输的输送机优化器。
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