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公开(公告)号：US08165823B2
公开(公告)日：2012-04-24
申请号：US11988895
申请日：2006-07-15
申请人： Jeffrey Ulmer , Nicholas Valiante , Feng Xu , Claudio Donati , Antonello Covacci
发明人： Jeffrey Ulmer , Nicholas Valiante , Feng Xu , Claudio Donati , Antonello Covacci
摘要： A method for identifying a polypeptide which acts as an adjuvant in a host organism. The invention further provides adjuvant compositions comprising said polypeptides and optionally further comprising an antigen.
摘要翻译： 用于鉴定作为宿主生物体中佐剂的多肽的方法。 本发明进一步提供了包含所述多肽并任选进一步包含抗原的佐剂组合物。
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公开(公告)号：US20090155306A1
公开(公告)日：2009-06-18
申请号：US11988895
申请日：2006-07-15
申请人： Jeffrey Ulmer , Nicholas Valiante , Feng Xu , Claudio Donati , Antonello Covacci
发明人： Jeffrey Ulmer , Nicholas Valiante , Feng Xu , Claudio Donati , Antonello Covacci
摘要： A method for identifying a polypeptide which acts as an adjuvant in a host organism. The invention further provides adjuvant compositions comprising said polypeptides and optionally further comprising an antigen.
摘要翻译： 用于鉴定作为宿主生物体中佐剂的多肽的方法。 本发明进一步提供了包含所述多肽并任选进一步包含抗原的佐剂组合物。
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公开(公告)号：US20080213308A1
公开(公告)日：2008-09-04
申请号：US11662984
申请日：2005-09-14
申请人： Nicholas Valiante , Feng Xu , Xiaodong Lin , Daniel Chu , Xiaojing Michael Wang
发明人： Nicholas Valiante , Feng Xu , Xiaodong Lin , Daniel Chu , Xiaojing Michael Wang
IPC分类号： C07D471/04 , A61K31/437 , A61K39/02 , A61K39/12 , A61K39/145 , A61K39/245 , A61K39/29 , A61P31/12
CPC分类号： C07D471/14 , C07D471/04 , Y02P20/55
摘要： The invention provides novel compositions comprising imidazoquinoline compounds. Also provided are methods of administering the compositions in an effective amount to enhance the immune response of a subject. Further provided are novel compositions and methods of administering the compositions in combination with (an)other agent(s).
摘要翻译： 本发明提供包含咪唑并喹啉化合物的新型组合物。 还提供了以有效量施用组合物以增强受试者的免疫应答的方法。 进一步提供了组合物与（一种或多种）其它试剂组合施用的新组合物和方法。
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公开(公告)号：US20100226931A1
公开(公告)日：2010-09-09
申请号：US11630551
申请日：2005-06-24
申请人： Nicholas Valiante , Feng Xu , Joel B. Silver
发明人： Nicholas Valiante , Feng Xu , Joel B. Silver
CPC分类号： A61K39/39 , C12N2710/16611 , C12N2740/15011 , C12N2770/24211 , Y02A50/388 , Y02A50/466 , Y02A50/484
摘要： Methods of stimulating an immune response and treating patients responsive thereto with 3,4-di(1H-indol-3-yl)-1H-pyrrole-2,5-diones, staurosporine analogs, derivatized pyridazines, chromen-4-ones, indolinones, quinazolines, nucleoside analogs, and other small molecules are disclosed. In a preferred embodiment benzopyrimidine derivatives such as ZD-6474, MLN-518, lapatinib, gefitinib or erlotinib are used.
摘要翻译： 刺激免疫反应并用3,4-二（1H-吲哚-3-基）-1H-吡咯-2,5-二酮，星形孢菌素类似物，衍生化哒嗪，色烯-4-酮，吲哚啉酮 ，喹唑啉，核苷类似物和其他小分子。 在优选的实施方案中，使用苯并嘧啶衍生物如ZD-6474，MLN-518，拉帕替尼，吉非替尼或厄洛替尼。
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公开(公告)号：US20130101622A1
公开(公告)日：2013-04-25
申请号：US13466021
申请日：2012-05-07
申请人： James SUTTON , Feng Xu , Nicholas Valiante , Jiong Lan
发明人： James SUTTON , Feng Xu , Nicholas Valiante , Jiong Lan
IPC分类号： A61K31/4985 , A61K39/21 , A61K39/39 , C07D487/04
CPC分类号： A61K31/4985 , A61K39/21 , A61K39/39 , C07D487/04
摘要： The invention provides novel compositions comprising imidazoquinoxaline compounds of formula (I) and analogs thereof. Also provided are methods of administering the compositions in an effective amount to enhance the immune response of a subject. Further provided are novel compositions and methods of administering the compositions in combination with (an) other agent(s).
摘要翻译： 本发明提供了包含式（I）的咪唑并喹喔啉化合物及其类似物的新型组合物。 还提供了以有效量施用组合物以增强受试者的免疫应答的方法。 进一步提供了组合物与（一种或多种）其它试剂组合施用的新型组合物和方法。
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公开(公告)号：US20110104186A1
公开(公告)日：2011-05-05
申请号：US11630550
申请日：2005-06-24
申请人： Nicholas Valiante , Feng Xu , Johanna Jansen , Susan Kaufman
发明人： Nicholas Valiante , Feng Xu , Johanna Jansen , Susan Kaufman
IPC分类号： A61K39/00 , C40B30/04 , A61K31/4439 , A61K31/496 , A61K31/56 , A61P31/14 , A61P35/00 , A61P37/08 , A61P11/06
CPC分类号： A61K31/7076 , A61K31/404 , A61K31/4184 , A61K31/437 , A61K31/4439 , A61K31/47 , A61K31/4706 , A61K31/4725 , A61K31/497 , A61K31/517 , A61K31/5377 , A61K31/7028 , A61K31/7056 , A61K31/706 , A61K31/7064 , A61K45/06 , Y02A50/388 , Y02A50/407 , Y02A50/466 , Y02A50/484 , Y02A50/59
摘要： The invention provides immunostimulatory compositions comprising a small molecule immuno-potentiator (SMIP) compound and methods of administration thereof. Also provided are methods of administering a SMIP compound in an effective amount to enhance the immune response of a subject to an antigen. Further provided are novel compositions and methods of administering SMIP compounds alone or in combination with another agent for the treatment of cancer, infectious diseases and/or allergies/asthma. In a further aspect, the invention relates generally to methods of screening for small molecule immuno-modulatory compositions.
摘要翻译： 本发明提供包含小分子免疫增强剂（SMIP）化合物的免疫刺激组合物及其施用方法。 还提供了有效量施用SMIP化合物以增强受试者对抗原的免疫应答的方法。 还提供了单独或与另一种药物组合施用SMIP化合物以治疗癌症，感染性疾病和/或过敏/哮喘的新型组合物和方法。 在另一方面，本发明一般涉及筛选小分子免疫调节组合物的方法。
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公开(公告)号：US08173657B2
公开(公告)日：2012-05-08
申请号：US12294233
申请日：2007-03-23
申请人： James Sutton , Feng Xu , Nicholas Valiante , Jiong Lan
发明人： James Sutton , Feng Xu , Nicholas Valiante , Jiong Lan
IPC分类号： A61K31/50 , A61K39/02 , A61K39/12 , A61K39/00 , C07D471/00 , C07D487/00
CPC分类号： A61K31/4985 , A61K39/21 , A61K39/39 , C07D487/04
摘要： The invention provides novel compositions comprising imidazoquinoxaline compounds of formula (I) and analogs thereof. Also provided are methods of administering the compositions in an effective amount to enhance the immune response of a subject. Further provided are novel compositions and methods of administering the compositions in combination with (an) other agent(s).
摘要翻译： 本发明提供了包含式（I）的咪唑并喹喔啉化合物及其类似物的新型组合物。 还提供了以有效量施用组合物以增强受试者的免疫应答的方法。 进一步提供了组合物与（一种或多种）其它试剂组合施用的新组合物和方法。
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公开(公告)号：US20110081365A1
公开(公告)日：2011-04-07
申请号：US12921129
申请日：2009-02-27
申请人： Alex Cortez , Yongkai Li , Pranab Mishra , Manmohan Singh , David Skibinski , Nicholas Valiante , Tom Yao-Hsiang Wu , Xiaoyue Zhang , Yefen Zou
发明人： Alex Cortez , Yongkai Li , Pranab Mishra , Manmohan Singh , David Skibinski , Nicholas Valiante , Tom Yao-Hsiang Wu , Xiaoyue Zhang , Yefen Zou
IPC分类号： A61K39/00 , C07D471/04 , C07D495/04 , C07D413/14 , C07D239/70 , A61K31/438 , A61K31/4985 , A61K31/5377 , A61K31/519 , A61P37/02 , A61P11/06 , A61P37/04
CPC分类号： C07D471/04 , C07D221/12 , C07D471/14 , C07D491/056 , C07D495/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is —CR4═CR5.
摘要翻译： 本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与Toll样受体（包括TLR7和TLR8）相关的疾病或病症的方法。 一方面，所述化合物可用作增强疫苗（式I）有效性的佐剂，其中：X3为N; X4是N或CR3; X5是-CR4 = CR5。
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公开(公告)号：US20100003280A1
公开(公告)日：2010-01-07
申请号：US12456851
申请日：2009-06-22
申请人： Derek O'Hagan , Nicholas Valiante
发明人： Derek O'Hagan , Nicholas Valiante
CPC分类号： A61K39/39 , A61K39/095 , A61K39/21 , A61K39/29 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , C12N7/00 , C12N2740/16034 , C12N2770/24234
摘要： Adjuvant compositions comprising type 1 interferon inducers, such as double-stranded RNA, in combination with antigen delivery systems and/or immunostimulatory molecules, such as immunostimulatory nucleic acid sequences, for enhancing the immune response of a coadministered antigen, are described.
摘要翻译： 描述了包含1型干扰素诱导剂（例如双链RNA）与抗原递送系统和/或免疫刺激分子（例如免疫刺激性核酸序列）组合的辅助组合物，用于增强共同施用的抗原的免疫应答。
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公开(公告)号：USD571170S1
公开(公告)日：2008-06-17
申请号：US29263835
申请日：2006-07-31
申请人： Nicholas Valiante
设计人： Nicholas Valiante
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