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公开(公告)号：US07259266B2
公开(公告)日：2007-08-21
申请号：US10801429
申请日：2004-03-16
申请人： Jeffry Carter , David Brown , Li Xing , Karl Aston , John Springer , Francis Koszyk , Steven Kramer , Renee Huff , Yi Yu , Bruce Hamper , Subo Laio , Angela Deprow , Teresa Fletcher , E. Ann Hallinan , James Kiefer , David Limburg , Lijuan Wang , Cindy Ludwig , John McCall , John Talley
发明人： Jeffry Carter , David Brown , Li Xing , Karl Aston , John Springer , Francis Koszyk , Steven Kramer , Renee Huff , Yi Yu , Bruce Hamper , Subo Laio , Angela Deprow , Teresa Fletcher , E. Ann Hallinan , James Kiefer , David Limburg , Lijuan Wang , Cindy Ludwig , John McCall , John Talley
IPC分类号： C07D311/04
CPC分类号： C07D311/58 , C07D311/64 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D417/04 , C07D417/06 , C07D493/04
摘要： The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula 1 Wherein Z, X, R1, R2, R3, and R4 are as described in the specification.
摘要翻译： 本发明涉及可用于治疗与环氧合酶-2介导的病症有关的病症的方法和化合物。 特别感兴趣的化合物是苯并吡喃及其由式1定义的类似物，其中Z，X，R 1，R 2，R 3和R 3， 4如说明书中所述。
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公开(公告)号：US20050148777A1
公开(公告)日：2005-07-07
申请号：US10801429
申请日：2004-03-16
申请人： Jeffery Carter , David Brown , Li Xing , Karl Aston , John Springer , Francis Koszyk , Steven Kramer , Renee Huff , Yi Yu , Bruce Hamper , Subo Laio , Angela Deprow , Theresa Fletcher , E. Hallinan , James Kiefer , David Limburg , Lijuan Wang , Cindy Ludwig , John McCall , John Talley
发明人： Jeffery Carter , David Brown , Li Xing , Karl Aston , John Springer , Francis Koszyk , Steven Kramer , Renee Huff , Yi Yu , Bruce Hamper , Subo Laio , Angela Deprow , Theresa Fletcher , E. Hallinan , James Kiefer , David Limburg , Lijuan Wang , Cindy Ludwig , John McCall , John Talley
IPC分类号： A61K31/352 , A61K31/382 , A61K31/395 , A61K31/47 , A61K31/4709 , A61P29/00 , C07D20060101 , C07D215/38 , C07D215/54 , C07D311/58 , C07D311/64 , C07D311/92 , C07D335/06 , C07D401/02 , C07D405/02 , C07D407/02 , C07D409/02 , C07D493/04
CPC分类号： C07D311/58 , C07D311/64 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D409/06 , C07D409/12 , C07D417/04 , C07D417/06 , C07D493/04
摘要： The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula 1 Wherein Z, X, R1, R 2, R3, and R4 are as described in the specification.
摘要翻译： 本发明涉及可用于治疗与环氧合酶-2介导的病症有关的病症的方法和化合物。 特别感兴趣的化合物是苯并吡喃及其由式1定义的类似物，其中Z，X，R 1，R 2，R 3和R 4 >如说明书中所述。
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公开(公告)号：US10392389B2
公开(公告)日：2019-08-27
申请号：US14438261
申请日：2013-10-25
发明人： John McCall , Robert C. Kelly , Donna L. Romero
IPC分类号： C07D487/04 , A61K31/519 , A61P3/06 , A61K45/06 , A61P35/04 , A61P3/10 , A61P3/04
摘要： Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.
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公开(公告)号：US07900433B2
公开(公告)日：2011-03-08
申请号：US11513707
申请日：2006-08-31
申请人： John McCall
发明人： John McCall
摘要： The cross sectional flow area of a fan discharge nozzle on one side of a central plane of an associated gas turbine engine power plant is greater than the corresponding flow area of the fan discharge nozzle on an opposite side of the central plane to compensate for the blockage of fan airflow by a pylon.
摘要翻译： 相关联的燃气涡轮发动机发电厂的中心平面一侧的风扇排放喷嘴的横截面积面积大于在中心平面相反侧的风扇排放喷嘴的相应流动面积，以补偿堵塞 的风扇气流由塔。
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公开(公告)号：US20150274740A1
公开(公告)日：2015-10-01
申请号：US14438268
申请日：2013-10-25
申请人： John MCCALL , Robert C. KELLY , Donna L. ROMERO , BIOENERGENIX
发明人： John McCall , Robert C. Kelly , Donna L. Romero
IPC分类号： C07D487/04 , A61K31/519
CPC分类号： A61K31/519 , C07D487/04
摘要： Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.
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公开(公告)号：US20080007230A1
公开(公告)日：2008-01-10
申请号：US11250615
申请日：2005-10-17
申请人： Aaron Kalyuzhny , John McCall , Timothy Day
发明人： Aaron Kalyuzhny , John McCall , Timothy Day
IPC分类号： G05F1/70
摘要： A control system for an electrical power system includes an electrical corrective device, a voltage measuring device coupled to each phase of the electric power system, a current measuring device connected between each phase of the electric power system and the electrical corrective device, and a protective device connected to outputs of the voltage measuring device and the current measuring device. The protective device includes a controller configured to detect an imbalance using the measured voltages and currents output from the voltage measuring device and the current measuring device without using or independently of other recent voltage or current measurements for other points in the electrical corrective device and independently of a neutral-ground measurement at the electrical corrective device.
摘要翻译： 一种用于电力系统的控制系统，包括电气校正装置，耦合到电力系统的每个相的电压测量装置，连接在电力系统的每个相和电气校正装置之间的电流测量装置，以及保护 设备连接到电压测量装置和电流测量装置的输出端。 保护装置包括控制器，其被配置为使用从电压测量装置和电流测量装置输出的测量的电压和电流来检测不平衡，而不使用或独立于电校正装置中的其它点的其他最近的电压或电流测量，并且独立于 在电气校正装置处的中性点测量。
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公开(公告)号：US20070149527A1
公开(公告)日：2007-06-28
申请号：US11675306
申请日：2007-02-15
IPC分类号： A61K31/5375
CPC分类号： A61K31/5375
摘要： This patent application describes the treatment of Addictive disorders, Psychoactive Substance Use disorders, Intoxication disorders, Inhalation disorders, Alcohol addiction, Tobacco addiction and or Nicotine addiction; and Attention Deficit Hyperactivity Disorder (ADHD); comprising administering a therapeutically effective, nontoxic dose of Reboxetine and derivatives and or pharmaceutically acceptable salts thereof to a patient.
摘要翻译： 该专利申请描述了上瘾疾病，精神活性物质使用障碍，中毒障碍，吸入障碍，酒精成瘾，烟草成瘾和/或尼古丁成瘾的治疗; 和注意缺陷多动障碍（ADHD）; 包括向患者施用治疗有效的无毒剂量的瑞波西汀及其衍生物和/或其药学上可接受的盐。
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公开(公告)号：US08561384B2
公开(公告)日：2013-10-22
申请号：US12893042
申请日：2010-09-29
申请人： John McCall
发明人： John McCall
摘要： The cross sectional flow area of a fan discharge nozzle on one side of a central plane of an associated gas turbine engine power plant is greater than the corresponding flow area of the fan discharge nozzle on an opposite side of the central plane to compensate for the blockage of fan airflow by a pylon.
摘要翻译： 相关联的燃气涡轮发动机发电厂的中心平面一侧的风扇排放喷嘴的横截面积面积大于在中心平面相反侧的风扇排放喷嘴的相应流动面积，以补偿堵塞 的风扇气流由塔。
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公开(公告)号：US20110014045A1
公开(公告)日：2011-01-20
申请号：US12893042
申请日：2010-09-29
申请人： John McCall
发明人： John McCall
IPC分类号： F01D5/04
摘要： The cross sectional flow area of a fan discharge nozzle on one side of a central plane of an associated gas turbine engine power plant is greater than the corresponding flow area of the fan discharge nozzle on an opposite side of the central plane to compensate for the blockage of fan airflow by a pylon.
摘要翻译： 相关联的燃气涡轮发动机发电厂的中心平面一侧的风扇排放喷嘴的横截面积面积大于在中心平面相反侧的风扇排放喷嘴的相应流动面积，以补偿堵塞 的风扇气流由塔。
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公开(公告)号：US20080053061A1
公开(公告)日：2008-03-06
申请号：US11513707
申请日：2006-08-31
申请人： John McCall
发明人： John McCall
IPC分类号： F02K3/02
摘要： The cross sectional flow area of a fan discharge nozzle on one side of a central plane of an associated gas turbine engine power plant is greater than the corresponding flow area of the fan discharge nozzle on an opposite side of the central plane to compensate for the blockage of fan airflow by a pylon.
摘要翻译： 相关联的燃气涡轮发动机发电厂的中心平面一侧的风扇排放喷嘴的横截面积面积大于在中心平面相反侧的风扇排放喷嘴的相应流动面积，以补偿堵塞 的风扇气流由塔。
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