公开(公告)号：US20110093003A1

公开(公告)日：2011-04-21

申请号：US12977574

申请日：2010-12-23

Applicant: Jen-Shih Lee

Inventor： Jen-Shih Lee

IPC: A61B17/12

CPC classification number: A61B17/1355 ,  A61H9/0078 ,  A61H2201/165 ,  A61H2205/083 ,  A61M1/342

Abstract: A method of inhibiting hypotensive symptoms in a patient undergoing treatment or a procedure involves elastically constraining the internal organs within the abdomen of the patient while applying non-pulsating, compressive pressure to the internal organs within the abdomen of the patient. The method may also involve one or more of infusing fluid, applying the compressive pressure using compression device, or applying the compressive pressure based upon bio-indicator measurement parameters.

Abstract translation: 在经历治疗或手术的患者中抑制低血压症状的方法包括弹性约束患者腹部内脏，同时向患者腹部内脏施加非脉动的压缩压力。 该方法还可以包括一个或多个输注流体，使用压缩装置施加压缩压力，或者基于生物指示器测量参数施加压缩压力。

公开(公告)号：US07220229B2

公开(公告)日：2007-05-22

申请号：US10689450

申请日：2003-10-20

Applicant: Lian-Pin Lee ,  Jen-Shih Lee ,  Shyh-Hau Wang ,  Mike Min

Inventor： Lian-Pin Lee ,  Jen-Shih Lee ,  Shyh-Hau Wang ,  Mike Min

IPC: A61B8/00

CPC classification number: G01N9/24 ,  G01N29/024 ,  G01N29/30 ,  G01N2291/012 ,  G01N2291/02818 ,  G01N2291/102

Abstract: A density/solute monitor having at least one ultrasound probe, a signal processing unit, and a computing mechanism, and process for using the same, to measure phase shift between emitting and receiving ultrasound, sound velocity, compressibility, density, and solute concentration of fluid flowing through a fluid processing system. The ultrasound probe emits and receives ultrasound waves through the fluid and the signal-processing unit and computing mechanism process the ultrasound waves to determine phase and time shift. The computing mechanism converts phase shift to density, compressibility, and solute concentration measurements of the fluid. Calibrating fluids calibrate the detected phase shift in terms of sound velocity in the factory. Measurements provide information about passage of solutes and flow to achieve better solute collection efficiency, solution purity, and control of fluid processing systems. The density/solute monitor can include other detection modalities such as an optical probe, making concentration measurements of the density/solute monitor more specific to selected solutes.

Abstract translation: 具有至少一个超声波探头，信号处理单元和计算机构的密度/溶质监测器及其使用方法，测量发射和接收超声之间的相移，声速，压缩性，密度和溶质浓度 流经流体处理系统的流体。 超声波探头通过流体发射和接收超声波，信号处理单元和计算机构处理超声波以确定相位和时间偏移。 计算机制将相移转化为流体的密度，压缩性和溶质浓度测量。 校准液校准检测到的相对于工厂声速的相移。 测量提供了关于溶质和流动通过的信息，以获得更好的溶质收集效率，溶液纯度和流体处理系统的控制。 密度/溶质监测器可以包括其他检测模式，例如光学探针，使浓度/溶质监测仪的浓度测量对于所选择的溶质更具体。

公开(公告)号：US07608043B1

公开(公告)日：2009-10-27

申请号：US10849099

申请日：2004-05-19

Applicant: Lian-Pin Lee ,  Jen-Shih Lee

Inventor： Lian-Pin Lee ,  Jen-Shih Lee

IPC: A61B8/00 ,  A61B6/00 ,  A61B5/00

CPC classification number: A61B5/02042 ,  A61B8/06 ,  A61M1/342 ,  A61M1/3437 ,  A61M1/3609 ,  A61M1/361 ,  A61M1/367 ,  A61M2205/3306 ,  A61M2205/3375 ,  A61M2230/207 ,  G01N29/024 ,  G01N29/222 ,  G01N2291/012 ,  G01N2291/02466 ,  G01N2291/02818 ,  G01N2291/102

Abstract: An apparatus and method to assess the compressibility, density, and hematocrit of blood including an optical ultrasound probe clipped onto tubing in which blood is flowing. The probe includes a combination of ultrasound transducers, a light emitting diode, and photodiodes. An indicator medium is injected into the bloodstream of the subject over one or more time points. Ultrasound waves are emitted by a transducer and received by another transducer, and a novel signal-processing unit and a computer with a novel computation scheme process the ultrasound signals to assess the phase shift of ultrasound as it transmitted across the blood stream.

Abstract translation: 一种评估血液的压缩性，密度和血细胞比容的装置和方法，包括夹在血液流动的管上的光学超声探头。 探头包括超声换能器，发光二极管和光电二极管的组合。 一个或多个时间点将指示剂介质注入受试者的血液中。 超声波由换能器发射并由另一传感器接收，并且具有新颖计算方案的新型信号处理单元和计算机处理超声信号以评估超声波在血流中传播时的相移。

公开(公告)号：US06740036B1

公开(公告)日：2004-05-25

申请号：US10274086

申请日：2002-10-18

Applicant: Lian-Pin Lee ,  Jen-Shih Lee

Inventor： Lian-Pin Lee ,  Jen-Shih Lee

IPC: A61B800

CPC classification number: A61M1/342 ,  A61B5/02042 ,  A61B8/06 ,  A61M1/3437 ,  A61M1/361 ,  A61M1/367 ,  A61M2205/3313 ,  A61M2205/3375 ,  A61M2230/20 ,  A61M2230/207 ,  G01N2291/02818

Abstract: An apparatus and method to assess the compressibility, density, and hematocrit of blood including an optical ultrasound probe clipped onto tubing in which blood is flowing. The probe includes a combination of ultrasound transducers, a light emitting diode, and photodiodes. An indicator medium is injected into the bloodstream of the subject over one or more time points. Ultrasound waves are emitted by a transducer and received by another transducer, and a novel signal-processing unit and a computer with a novel computation scheme process the ultrasound signals to assess the phase shift of ultrasound as it transmitted across the blood stream. Based on the linear relationship between compressibility and density, changes in blood density are calculated from changes in phase shift. The optical part of the probe assesses the hematocrit of blood. Two fluid media are used to calibrate the probe on the relationship between phase shift and density in the factory. Before clinical assessment, an on-line saline injection procedure and the resulting change in density is employed to calibrate the optical density of the optical probe in terms of hematocrit and to establish the interrelation between density and hematocrit on fluid dilution of the circulating blood. One clinical protocol to monitor blood volume and microvascular pooling employs saline infusion to determine the blood volume hourly and the density and hematocrit measurements to determine the change in blood volume and the volume pooled to the microcirculation. Another clinical protocol assesses the time course of hematocrit and density over hemodialysis treatment for the prediction of hypovolemia and microvascular pooling. This cardiovascular monitoring is useful for evaluating how complications are developed during hemodialysis or the adequacy of any post-trauma fluid replacement or therapy to alleviate the complications.

Abstract translation: 一种评估血液的压缩性，密度和血细胞比容的装置和方法，包括夹在血液流动的管上的光学超声探头。 探头包括超声换能器，发光二极管和光电二极管的组合。 一个或多个时间点将指示剂介质注入受试者的血液中。 超声波由换能器发射并由另一传感器接收，并且具有新颖计算方案的新型信号处理单元和计算机处理超声信号以评估超声波在血流中传播时的相移。 基于压缩性和密度之间的线性关系，根据相移的变化计算血液密度的变化。 探针的光学部分评估血液的血细胞比容。 使用两种流体介质来校准探头在工厂中相移和密度之间的关系。 在临床评估之前，采用在线盐水注射程序和所产生的密度变化来校正光学探针在血细胞比容方面的光密度，并建立循环血液稀释液体密度和血细胞比容之间的相互关系。 监测血容量和微血管汇集的一种临床方案使用盐水输注来确定每小时的体积血容量和密度和血细胞比容测量，以确定血容量的变化以及汇集到微循环中的体积。 另一种临床方案评估血液透析治疗血细胞比容和密度的时间过程，用于预测血容量不足和微血管汇集。 这种心血管监测可用于评估血液透析过程中发生并发症的可能性，或是否有任何创伤后液体置换或治疗以减轻并发症的可能性。

公开(公告)号：US06485427B1

公开(公告)日：2002-11-26

申请号：US09908223

申请日：2001-07-18

Applicant: Jen-Shih Lee ,  Lian-Pin Lee

Inventor： Jen-Shih Lee ,  Lian-Pin Lee

IPC: A61B800

CPC classification number: A61B5/02042 ,  A61B8/06 ,  A61M1/342 ,  A61M1/3437 ,  A61M1/3458 ,  A61M1/3465 ,  A61M1/361 ,  G01N2291/02818

Abstract: An apparatus and method to assess the compressibility of blood includes a combination of ultrasound transducers attached to tubing in which blood is flowing. An indicator medium is injected into the bloodstream of the subject over one or more time points and ultrasound waves are transmitted and monitored using transducers and phase lock amplifier to assess transmission time. Using a linear relationship between compressibility and density, changes in blood density are calculated from changes in transmission time to predict blood density changes and then the blood volume and microvascular pooling. This information allows prediction of complications that can occur during hemodialysis or because of post-traumatic fluid replacement and development of therapy to alleviate the complications.

Abstract translation: 评估血液可压缩性的装置和方法包括附着在血液流动的管道上的超声换能器的组合。 指示剂介质通过一个或多个时间点注入到受试者的血流中，并且使用换能器和锁相放大器来传输和监测超声波以评估传播时间。 使用压缩性和密度之间的线性关系，从传播时间的变化计算血液密度的变化，以预测血液密度变化，然后计算血容量和微血管汇合。 该信息可以预测在血液透析期间可能发生的并发症，或者由于创伤后的液体置换和治疗的发展来缓解并发症。