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    Bioreactor
    7.
    发明授权
    Bioreactor 有权
    生物反应器

    公开(公告)号：US09255244B2

    公开(公告)日：2016-02-09

    申请号：US12867647

    申请日：2009-02-12

    申请人： Juergen Van Den Boogaard ,  Gerhard Greller ,  Jens Ludwig ,  Oscar-Werner Reif

    发明人： Juergen Van Den Boogaard ,  Gerhard Greller ,  Jens Ludwig ,  Oscar-Werner Reif

    IPC分类号： C12M1/00 ,  C12M3/00 ,  C12M1/06 ,  B01F7/16 ,  B01F15/00 ,  C12M1/12 ,  F16C33/76

    CPC分类号： C12M27/02 ,  B01F7/1695 ,  B01F15/00831 ,  B01F15/0085 ,  C12M23/26 ,  C12M37/04 ,  F16C33/76

    摘要： A bioreactor (1) having a container (2), a shaft housing (3) for guiding a shaft (5) through a wall (7), a stirrer (6) connected to the shaft (5) in the interior (9) of the container (2), and a drive (4) arranged outside the container (2) and connectable to the shaft (5). The shaft (5) is mounted in the shaft housing (3) via at least one ball bearing (23) and is sealed in relation to the shaft housing (3) by at least one seal (11, 20). The seal (11, 20) is configured as a radial shaft seal (28) having two sealing lips (30, 31) that are arranged one behind the other in the longitudinal direction of the shaft (5) and are able to run on the shaft (5) without lubricant.

    摘要翻译： 具有容器（2）的生物反应器（1），用于通过壁（7）引导轴（5）的轴壳体（3），与内部（9）中的轴（5）连接的搅拌器（6） 和位于所述容器（2）的外部并且可连接到所述轴（5）的驱动器（4）。 轴（5）经由至少一个滚珠轴承（23）安装在轴壳体（3）中，并通过至少一个密封件（11,20）相对于轴壳体（3）密封。 密封件（11,20）被构造为具有两个密封唇（30,31）的径向轴密封件（28），所述密封唇缘（30,31）沿轴（5）的纵向方向一个接一个地布置，并且能够在 轴（5）无润滑剂。

    BIOREACTOR
    8.
    发明申请
    BIOREACTOR 有权

    公开(公告)号：US20110003374A1

    公开(公告)日：2011-01-06

    申请号：US12867647

    申请日：2009-02-12

    申请人： Juergen Van Den Boogaard ,  Gerhard Greller ,  Jens Ludwig ,  Oscar-Werner Reif

    发明人： Juergen Van Den Boogaard ,  Gerhard Greller ,  Jens Ludwig ,  Oscar-Werner Reif

    IPC分类号： C12M1/02

    CPC分类号： C12M27/02 ,  B01F7/1695 ,  B01F15/00831 ,  B01F15/0085 ,  C12M23/26 ,  C12M37/04 ,  F16C33/76

    摘要： A bioreactor (1) having a container (2), a shaft housing (3) for guiding a shaft (5) through a wall (7), a stirrer (6) connected to the shaft (5) in the interior (9) of the container (2), and a drive (4) arranged outside the container (2) and connectable to the shaft (5). The shaft (5) is mounted in the shaft housing (3) via at least one ball bearing (23) and is sealed in relation to the shaft housing (3) by at least one seal (11, 20). The seal (11, 20) is configured as a radial shaft seal (28) having two sealing lips (30, 31) that are arranged one behind the other in the longitudinal direction of the shaft (5) and are able to run on the shaft (5) without lubricant.

    摘要翻译： 具有容器（2）的生物反应器（1），用于通过壁（7）引导轴（5）的轴壳体（3），与内部（9）中的轴（5）连接的搅拌器（6） 和位于所述容器（2）的外部并且可连接到所述轴（5）的驱动器（4）。 轴（5）经由至少一个滚珠轴承（23）安装在轴壳体（3）中，并通过至少一个密封件（11,20）相对于轴壳体（3）密封。 密封件（11,20）被构造为具有两个密封唇（30,31）的径向轴密封件（28），所述密封唇缘（30,31）沿轴（5）的纵向方向一个接一个地布置，并且能够在 轴（5）无润滑剂。

    Waste gas system for bioreactors
    9.
    发明授权
    Waste gas system for bioreactors 有权
    生物反应器废气系统

    公开(公告)号：US08268059B2

    公开(公告)日：2012-09-18

    申请号：US12653506

    申请日：2009-12-15

    申请人： Juergen van den Boogard ,  Gerid Hellwig ,  Jens Ludwig ,  Oscar-Werner Reif ,  Stefan Weisshaar

    发明人： Juergen van den Boogard ,  Gerid Hellwig ,  Jens Ludwig ,  Oscar-Werner Reif ,  Stefan Weisshaar

    IPC分类号： B01D50/00

    CPC分类号： C12M29/20

    摘要： The invention relates to a waste gas system for bioreactors having a hydrophobic sterile filter, arranged at the end, and a heat exchanger which protects the sterile filter against blocking by liquid media. The gas outflow duct for discharging waste gas from a bioreactor vessel is divided in a cooling zone of the heat exchanger into a multiplicity of subducts and is extended in a heating zone of the heat exchanger to a calming zone. Due to the multiplicity of subducts, a considerably larger surface area for the removal of heat from the waste gas is available, with the result that in the case of laminar flow of the waste gas through the subducts a high effectiveness of the separation of liquids from the waste gas can be achieved. In the heating zone, the waste gas can heat up again due to the reduced flow rate until it reaches the hydrophobic sterile filter by way of taking up heat from the surroundings to a such a degree that the relative vapor contents are below 100% and separation of liquids from residual vapors at or in the hydrophobic sterile filter is precluded.

    摘要翻译： 本发明涉及一种用于生物反应器的废气系统，其具有布置在其末端的疏水性无菌过滤器和保护无菌过滤器免受液体介质堵塞的热交换器。 用于从生物反应器容器排出废气的气体流出管在热交换器的冷却区中分成多个副产物，并在热交换器的加热区中延伸到一个镇定区。 由于多余的下降，可以获得相当大的用于从废气中除去热量的表面积，结果是在废气通过下沉层流的情况下，液体从液体中分离的高效率 可以实现废气。 在加热区中，废气可以由于流速降低而再次加热，直到其通过从周围环境吸收热量达到疏水性无菌过滤器至相对蒸汽含量低于100％的程度并且分离 的疏水性无菌过滤器中或其中残留蒸气的液体被排除。

    Waste gas system for bioreactors
    10.
    发明申请
    Waste gas system for bioreactors 有权
    生物反应器废气系统

    公开(公告)号：US20100170400A1

    公开(公告)日：2010-07-08

    申请号：US12653506

    申请日：2009-12-15

    申请人： Juergen van den Boogard ,  Gerid Hellwig ,  Jens Ludwig ,  Oscar-Werner Reif ,  Stefan Weisshaar

    发明人： Juergen van den Boogard ,  Gerid Hellwig ,  Jens Ludwig ,  Oscar-Werner Reif ,  Stefan Weisshaar

    IPC分类号： B01D53/22

    CPC分类号： C12M29/20

    摘要： The invention relates to a waste gas system for bioreactors having a hydrophobic sterile filter, arranged at the end, and a heat exchanger which protects the sterile filter against blocking by liquid media. The gas outflow duct for discharging waste gas from a bioreactor vessel is divided in a cooling zone of the heat exchanger into a multiplicity of subducts and is extended in a heating zone of the heat exchanger to a calming zone. Due to the multiplicity of subducts, a considerably larger surface area for the removal of heat from the waste gas is available, with the result that in the case of laminar flow of the waste gas through the subducts a high effectiveness of the separation of liquids from the waste gas can be achieved. In the heating zone, the waste gas can heat up again due to the reduced flow rate until it reaches the hydrophobic sterile filter by way of taking up heat from the surroundings to a such a degree that the relative vapor contents are below 100% and separation of liquids from residual vapors at or in the hydrophobic sterile filter is precluded.

    摘要翻译： 本发明涉及一种用于生物反应器的废气系统，其具有布置在其末端的疏水性无菌过滤器和保护无菌过滤器免受液体介质堵塞的热交换器。 用于从生物反应器容器排出废气的气体流出管在热交换器的冷却区中分成多个副产物，并在热交换器的加热区中延伸到一个镇定区。 由于多余的下降，可以获得相当大的用于从废气中除去热量的表面积，结果是在废气通过下沉层流的情况下，液体从液体中分离的高效率 可以实现废气。 在加热区中，废气可以由于流速降低而再次加热，直到其通过从周围环境吸收热量达到疏水性无菌过滤器至相对蒸汽含量低于100％的程度并且分离 的疏水性无菌过滤器中或其中残留蒸气的液体被排除。