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公开(公告)号：US08690129B2
公开(公告)日：2014-04-08
申请号：US12921407
申请日：2009-03-18
申请人： Jens Ludwig , Oscar-Werner Reif , Gerhard Greller , Wolfgang Kahlert , Guenther Pradel , Michael Bates , Magail Barbaroux , Stephane Baud , Isabelle Gay , Sebastian Chaussin
发明人： Jens Ludwig , Oscar-Werner Reif , Gerhard Greller , Wolfgang Kahlert , Guenther Pradel , Michael Bates , Magail Barbaroux , Stephane Baud , Isabelle Gay , Sebastian Chaussin
IPC分类号： B01F3/04
CPC分类号： B01F3/04269 , B01F7/00633 , B01F7/00691 , B01F7/1695 , B01F7/22 , B01F13/0827 , B01F13/0872 , B01F15/00071 , B01F15/00123 , B01F15/00396 , B01F15/00707 , B01F15/00831 , B01F15/0085 , B01F15/065 , B01F2003/04326 , B01F2003/04361 , B01F2003/04879 , B01F2003/04893 , B01F2015/062 , B01F2215/0073 , C12M23/26 , C12M27/02 , C12M29/06
摘要： A disposable mixing vessel comprising a flexible container, a centrally disposed shaft having first and second ends with one or more impellers thereon and a magnetic element associated with a first shaft end, a first flange adapted to rotatably engage the first shaft end and a second flange adapted to rotatably engage the second shaft end.
摘要翻译： 一种一次性混合容器，包括柔性容器，居中设置的轴，其具有在其上的一个或多个叶轮的第一和第二端和与第一轴端相关联的磁性元件，适于可旋转地接合第一轴端的第一凸缘和第二凸缘 适于可旋转地接合第二轴端。
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公开(公告)号：US20110013474A1
公开(公告)日：2011-01-20
申请号：US12921407
申请日：2009-03-18
申请人： Jens Ludwig , Oscar-Werner Reif , Gerhard Greller , Wolfgang Kahlert , Guenther Pradel , Michael Bates , Magail Barbaroux , Stephane Baud , Isabelle Gay , Sebastian Chaussin
发明人： Jens Ludwig , Oscar-Werner Reif , Gerhard Greller , Wolfgang Kahlert , Guenther Pradel , Michael Bates , Magail Barbaroux , Stephane Baud , Isabelle Gay , Sebastian Chaussin
CPC分类号： B01F3/04269 , B01F7/00633 , B01F7/00691 , B01F7/1695 , B01F7/22 , B01F13/0827 , B01F13/0872 , B01F15/00071 , B01F15/00123 , B01F15/00396 , B01F15/00707 , B01F15/00831 , B01F15/0085 , B01F15/065 , B01F2003/04326 , B01F2003/04361 , B01F2003/04879 , B01F2003/04893 , B01F2015/062 , B01F2215/0073 , C12M23/26 , C12M27/02 , C12M29/06
摘要： A disposable mixing vessel comprising a flexible container, a centrally disposed shaft having first and second ends with one or more impellers thereon and a magnetic element associated with a first shaft end, a first flange adapted to rotatably engage the first shaft end and a second flange adapted to rotatably engage the second shaft end.
摘要翻译： 一种一次性混合容器，包括柔性容器，居中设置的轴，其具有在其上的一个或多个叶轮的第一和第二端和与第一轴端相关联的磁性元件，适于可旋转地接合第一轴端的第一凸缘和第二凸缘 适于可旋转地接合第二轴端。
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公开(公告)号：US08690418B2
公开(公告)日：2014-04-08
申请号：US12921412
申请日：2009-03-18
申请人： Jens Ludwig , Oscar-Werner Reif , Gerhard Greller , Wolfgang Kahlert , Guenther Pradel , Michael Bates , Magail Barbaroux , Stephane Baud , Isabelle Gay , Sebastian Chaussin
发明人： Jens Ludwig , Oscar-Werner Reif , Gerhard Greller , Wolfgang Kahlert , Guenther Pradel , Michael Bates , Magail Barbaroux , Stephane Baud , Isabelle Gay , Sebastian Chaussin
CPC分类号： B01F3/04269 , B01F7/00633 , B01F7/00691 , B01F7/1695 , B01F7/22 , B01F13/0827 , B01F13/0872 , B01F15/00071 , B01F15/00123 , B01F15/00396 , B01F15/00707 , B01F15/00831 , B01F15/0085 , B01F15/065 , B01F2003/04326 , B01F2003/04361 , B01F2003/04879 , B01F2003/04893 , B01F2015/062 , B01F2215/0073 , C12M23/26 , C12M27/02 , C12M29/06
摘要： A method of mixing including providing a flexible container which comprises at least two components, assembling the components from outside the flexible container to form a centrally disposed magnetic driven shaft with at least one impeller, whereby the integrity of the flexible container is maintained, filling the flexible container having the centrally disposed magnetic driven shaft with one or more ingredients of the contents to be mixed; engaging a magnetic element of the centrally disposed magnetic driven shaft with an external magnetic drive element; analyzing the contents of the flexible container using at least one sensor or a sampling line on the flexible container; and draining the contents of the flexible container through a drain port at the bottom of the flexible container.
摘要翻译： 一种混合方法，包括提供柔性容器，其包括至少两个部件，从柔性容器外部组装部件以形成具有至少一个叶轮的居中设置的磁力驱动轴，由此维持柔性容器的完整性，填充 柔性容器具有中心设置的磁力驱动轴，其中一个或多个要混合的内容物成分; 将中心设置的磁驱动轴的磁性元件与外部磁性驱动元件接合; 使用柔性容器上的至少一个传感器或取样管线分析柔性容器的内容物; 并通过柔性容器底部的排水口排出柔性容器的内容物。
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公开(公告)号：US20110013473A1
公开(公告)日：2011-01-20
申请号：US12921412
申请日：2009-03-18
申请人： Jens Ludwig , Oscar-Werner Reif , Gerhard Greller , Wolfgang Kahlert , Guenther Pradel , Michael Bates , Magail Barbaroux , Stephane Baud , Isabelle Gay , Sebastian Chaussin
发明人： Jens Ludwig , Oscar-Werner Reif , Gerhard Greller , Wolfgang Kahlert , Guenther Pradel , Michael Bates , Magail Barbaroux , Stephane Baud , Isabelle Gay , Sebastian Chaussin
CPC分类号： B01F3/04269 , B01F7/00633 , B01F7/00691 , B01F7/1695 , B01F7/22 , B01F13/0827 , B01F13/0872 , B01F15/00071 , B01F15/00123 , B01F15/00396 , B01F15/00707 , B01F15/00831 , B01F15/0085 , B01F15/065 , B01F2003/04326 , B01F2003/04361 , B01F2003/04879 , B01F2003/04893 , B01F2015/062 , B01F2215/0073 , C12M23/26 , C12M27/02 , C12M29/06
摘要： A method of mixing including providing a flexible container which comprises at least two components, assembling the components from outside the flexible container to form a centrally disposed magnetic driven shaft with at least one impeller, whereby the integrity of the flexible container is maintained, filling the flexible container having the centrally disposed magnetic driven shaft with one or more ingredients of the contents to be mixed; engaging a magnetic element of the centrally disposed magnetic driven shaft with an external magnetic drive element; analyzing the contents of the flexible container using at least one sensor or a sampling line on the flexible container; and draining the contents of the flexible container through a drain port at the bottom of the flexible container.
摘要翻译： 一种混合方法，包括提供包括至少两个部件的柔性容器，从柔性容器外部组装部件以形成具有至少一个叶轮的居中设置的磁力驱动轴，从而保持柔性容器的完整性，填充 具有中心设置的磁力驱动轴的柔性容器，所述磁力驱动轴具有要混合的内容物的一种或多种成分; 将中心设置的磁驱动轴的磁性元件与外部磁性驱动元件接合; 使用柔性容器上的至少一个传感器或取样管线分析柔性容器的内容物; 并通过柔性容器底部的排水口排出柔性容器的内容物。
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公开(公告)号：US20110038222A1
公开(公告)日：2011-02-17
申请号：US12918351
申请日：2009-03-18
申请人： Jens Ludwig , Oscar-Werner Reif , Gerhard Greller , Wolfgang Kahlert , Gunther Pradel , Michael Bates , Magali Dominique Corinne Barbaroux , Stephane Baud , Isabelle Valerie Christine Gay , Sebastien Chaussin
发明人： Jens Ludwig , Oscar-Werner Reif , Gerhard Greller , Wolfgang Kahlert , Gunther Pradel , Michael Bates , Magali Dominique Corinne Barbaroux , Stephane Baud , Isabelle Valerie Christine Gay , Sebastien Chaussin
IPC分类号： B01F13/02
CPC分类号： B01F3/04269 , B01F7/00633 , B01F7/00691 , B01F7/1695 , B01F7/22 , B01F13/0827 , B01F13/0872 , B01F15/00071 , B01F15/00123 , B01F15/00396 , B01F15/00707 , B01F15/00831 , B01F15/0085 , B01F15/065 , B01F2003/04326 , B01F2003/04361 , B01F2003/04879 , B01F2003/04893 , B01F2015/062 , B01F2215/0073 , C12M23/26 , C12M27/02 , C12M29/06
摘要： A mixing vessel includes a flexible container, elements for mixing its contents, aeration elements, a drain/lower bearing port having a rigid flange provided with a drain passage, attached in a tight manner to the lower portion of the container wall, supporting a lower bearing that is adjacent to the drain passage. The vessel includes an extended element for dispensing aeration gas and is spaced essentially radially from the drain/bearing port; at least one tubular element for dispensing aeration gas extends from the extended dispensing element, in the inside space, along the inside surface of the lower portion and the side portion of the wall of the container and extends on the outside of the container from the upper portion; at least one mixing element is spaced essentially from the lower portion of the container wall, from the lower bearing, and from at least one extended element for dispensing aeration gas.
摘要翻译： 混合容器包括柔性容器，用于混合其内容物的元件，曝气元件，具有设置有排水通道的刚性凸缘的排水/下轴承端口，紧密地附接到容器壁的下部， 与排水通道相邻的轴承。 容器包括用于分配曝气气体的延伸元件，并且与排放/承载端口基本上径向间隔开; 用于分配曝气气体的至少一个管状元件从内部空间中的延伸分配元件沿容器的下部和内侧面的内表面延伸，并且从容器的外部延伸到容器的外侧 一部分; 至少一个混合元件基本上与容器壁的下部，下部轴承以及用于分配曝气的至少一个延伸元件间隔开。
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公开(公告)号：US09044718B2
公开(公告)日：2015-06-02
申请号：US12918351
申请日：2009-03-18
申请人： Jens Ludwig , Oscar-Werner Reif , Gerhard Greller , Wolfgang Kahlert , Günter Pradel , Michael Bates , Magali Barbaroux , Stephanie Baud , Isabelle Gay , Sebastien Chaussin
发明人： Jens Ludwig , Oscar-Werner Reif , Gerhard Greller , Wolfgang Kahlert , Günter Pradel , Michael Bates , Magali Barbaroux , Stephanie Baud , Isabelle Gay , Sebastien Chaussin
IPC分类号： B01F3/04 , B01F7/00 , B01F7/16 , B01F7/22 , B01F13/08 , B01F15/00 , B01F15/06 , C12M1/00 , C12M1/06
CPC分类号： B01F3/04269 , B01F7/00633 , B01F7/00691 , B01F7/1695 , B01F7/22 , B01F13/0827 , B01F13/0872 , B01F15/00071 , B01F15/00123 , B01F15/00396 , B01F15/00707 , B01F15/00831 , B01F15/0085 , B01F15/065 , B01F2003/04326 , B01F2003/04361 , B01F2003/04879 , B01F2003/04893 , B01F2015/062 , B01F2215/0073 , C12M23/26 , C12M27/02 , C12M29/06
摘要： A mixing vessel includes a flexible container, elements for mixing its contents, aeration elements, a drain/lower bearing port having a rigid flange provided with a drain passage, attached in a tight manner to the lower portion of the container wall, supporting a lower bearing that is adjacent to the drain passage. The vessel includes an extended element for dispensing aeration gas and is spaced essentially radially from the drain/bearing port; at least one tubular element for dispensing aeration gas extends from the extended dispensing element, in the inside space, along the inside surface of the lower portion and the side portion of the wall of the container and extends on the outside of the container from the upper portion; at least one mixing element is spaced essentially from the lower portion of the container wall, from the lower bearing, and from at least one extended element for dispensing aeration gas.
摘要翻译： 混合容器包括柔性容器，用于混合其内容物的元件，曝气元件，具有设置有排水通道的刚性凸缘的排水/下轴承端口，紧密地附接到容器壁的下部， 与排水通道相邻的轴承。 容器包括用于分配曝气气体的延伸元件，并且与排放/承载端口基本上径向间隔开; 用于分配曝气气体的至少一个管状元件沿着内部空间中的延伸的分配元件沿容器的下部和内侧面的内表面延伸，并从容器的上部在容器的外侧延伸 一部分; 至少一个混合元件基本上与容器壁的下部，下部轴承以及用于分配曝气的至少一个延伸元件间隔开。
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公开(公告)号：US20110003374A1
公开(公告)日：2011-01-06
申请号：US12867647
申请日：2009-02-12
IPC分类号： C12M1/02
CPC分类号： C12M27/02 , B01F7/1695 , B01F15/00831 , B01F15/0085 , C12M23/26 , C12M37/04 , F16C33/76
摘要： A bioreactor (1) having a container (2), a shaft housing (3) for guiding a shaft (5) through a wall (7), a stirrer (6) connected to the shaft (5) in the interior (9) of the container (2), and a drive (4) arranged outside the container (2) and connectable to the shaft (5). The shaft (5) is mounted in the shaft housing (3) via at least one ball bearing (23) and is sealed in relation to the shaft housing (3) by at least one seal (11, 20). The seal (11, 20) is configured as a radial shaft seal (28) having two sealing lips (30, 31) that are arranged one behind the other in the longitudinal direction of the shaft (5) and are able to run on the shaft (5) without lubricant.
摘要翻译： 具有容器（2）的生物反应器（1），用于通过壁（7）引导轴（5）的轴壳体（3），与内部（9）中的轴（5）连接的搅拌器（6） 和位于所述容器（2）的外部并且可连接到所述轴（5）的驱动器（4）。 轴（5）经由至少一个滚珠轴承（23）安装在轴壳体（3）中，并通过至少一个密封件（11,20）相对于轴壳体（3）密封。 密封件（11,20）被构造为具有两个密封唇（30,31）的径向轴密封件（28），所述密封唇缘（30,31）沿轴（5）的纵向方向一个接一个地布置，并且能够在 轴（5）无润滑剂。
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公开(公告)号：US09255244B2
公开(公告)日：2016-02-09
申请号：US12867647
申请日：2009-02-12
CPC分类号： C12M27/02 , B01F7/1695 , B01F15/00831 , B01F15/0085 , C12M23/26 , C12M37/04 , F16C33/76
摘要： A bioreactor (1) having a container (2), a shaft housing (3) for guiding a shaft (5) through a wall (7), a stirrer (6) connected to the shaft (5) in the interior (9) of the container (2), and a drive (4) arranged outside the container (2) and connectable to the shaft (5). The shaft (5) is mounted in the shaft housing (3) via at least one ball bearing (23) and is sealed in relation to the shaft housing (3) by at least one seal (11, 20). The seal (11, 20) is configured as a radial shaft seal (28) having two sealing lips (30, 31) that are arranged one behind the other in the longitudinal direction of the shaft (5) and are able to run on the shaft (5) without lubricant.
摘要翻译： 具有容器（2）的生物反应器（1），用于通过壁（7）引导轴（5）的轴壳体（3），与内部（9）中的轴（5）连接的搅拌器（6） 和位于所述容器（2）的外部并且可连接到所述轴（5）的驱动器（4）。 轴（5）经由至少一个滚珠轴承（23）安装在轴壳体（3）中，并通过至少一个密封件（11,20）相对于轴壳体（3）密封。 密封件（11,20）被构造为具有两个密封唇（30,31）的径向轴密封件（28），所述密封唇缘（30,31）沿轴（5）的纵向方向一个接一个地布置，并且能够在 轴（5）无润滑剂。
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公开(公告)号：US08746515B2
公开(公告)日：2014-06-10
申请号：US13132572
申请日：2009-11-17
IPC分类号： B65D47/24
CPC分类号： B65D75/5877 , B01J19/0053 , B01J19/2415 , B01L3/523 , B01L2300/049 , B01L2300/0672 , C12M23/26 , C12M23/28 , C12M23/38
摘要： A closure for a container has an upper part (1) that can be connected to the container. The upper part (1) has an opening (2) and an outer hollow body (3). An inner hollow body (4) is arranged coaxially in the outer hollow body (3) with an intermediate space therebetween. A lower part (7) in the form of a hollow body can be displaced longitudinally in the intermediate space. A plug (5) is held coaxially in the lower part (7) and opens or closes the opening as the lower part (7) is displaced longitudinally in the intermediate space.
摘要翻译： 容器的盖子具有可连接到容器的上部（1）。 上部（1）具有开口（2）和外部空心体（3）。 内空心体（4）同轴地设置在外空心体（3）中，其间具有中间空间。 中空体形式的下部（7）可以在中间空间中纵向移位。 当下部（7）在中间空间中纵向移位时，插头（5）同轴地保持在下部（7）中并打开或关闭开口。
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公开(公告)号：US20110233210A1
公开(公告)日：2011-09-29
申请号：US13132572
申请日：2009-11-17
CPC分类号： B65D75/5877 , B01J19/0053 , B01J19/2415 , B01L3/523 , B01L2300/049 , B01L2300/0672 , C12M23/26 , C12M23/28 , C12M23/38
摘要： A closure for a container has an upper part (1) that can be connected to the container. The upper part (1) has an opening (2) and an outer hollow body (3). An inner hollow body (4) is arranged coaxially in the outer hollow body (3) with an intermediate space therebetween. A lower part (7) in the form of a hollow body can be displaced longitudinally in the intermediate space. A plug (5) is held coaxially in the lower part (7) and opens or closes the opening as the lower part (7) is displaced longitudinally in the intermediate space.
摘要翻译： 容器的盖子具有可连接到容器的上部（1）。 上部（1）具有开口（2）和外部空心体（3）。 内空心体（4）同轴地设置在外空心体（3）中，其间具有中间空间。 中空体形式的下部（7）可以在中间空间中纵向移位。 当下部（7）在中间空间中纵向移位时，插头（5）同轴地保持在下部（7）中并打开或关闭开口。
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