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    METHOD FOR HYDROFORMYLATION
    1.
    发明申请
    METHOD FOR HYDROFORMYLATION 审中-公开
    氢化方法

    公开(公告)号：US20100240896A1

    公开(公告)日：2010-09-23

    申请号：US12741296

    申请日：2008-11-04

    申请人： Jens Rudolph ,  Joachim Schmidt-Leithoff ,  Rocco Paciello ,  Bernhard Breit ,  Tomas Smejkal

    发明人： Jens Rudolph ,  Joachim Schmidt-Leithoff ,  Rocco Paciello ,  Bernhard Breit ,  Tomas Smejkal

    IPC分类号： C07C51/373 ,  C07F9/28 ,  C07D213/04 ,  C07F15/00 ,  C07F15/06

    CPC分类号： C07F15/008 ,  C07F9/5022 ,  C07F9/58

    摘要： The present invention relates to a process for the hydroformylation of compounds of the formula (I), where X is C, P(Rx), P(O—Rx) S or S(═O), where Rx is H, alkyl, cycloalkyl, heterocycloalkyl, aryl or hetaryl; A is a divalent bridging group having from 1 to 4 bridging atoms; and R1 is H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl or hetaryl; or salts thereof; in which the compound of the formula (I) is reacted with carbon monoxide and hydrogen in the presence of a catalyst comprising a complex of a metal of transition group VIII with a compound of the formula (II), where Pn is a pnicogen atom; W is a divalent bridging group having from 1 to 8 bridging atoms; R2 is a functional group capable of forming an intermolecular, noncovalent bond with the group —X(═O)OH; R3, R4 are each alkyl, cycloalkyl, heterocycloalkyl, aryl or hetaryl; a, b, c are each 0 or 1; and Y1, Y2 and Y3 are each O, S, NRa or SiRbRc; and also compounds of the formula (II.a), where W′ is a divalent bridging group having from 1 to 5 bridging atoms between the flanking bonds, Z is O, S, S(═O), S(═O)2, N(RIX) or C(RIX)(RX); and RI to RX are each, independently of one another, H, halogen, nitro, cyano, amino, alkyl, etc.; or two radicals RI, RII, RIV, RVI, RVIII and RIX together represent the second part of a double bond.

    摘要翻译： 本发明涉及式（I）化合物加氢甲酰化的方法，其中X为C，P（Rx），P（O-Rx）S或S（= O）），其中Rx为H，烷基， 环烷基，杂环烷基，芳基或杂芳基; A是具有1至4个桥连原子的二价桥连基团; R 1为H，烷基，烯基，炔基，环烷基，杂环烷基，芳基或杂芳基; 或其盐; 其中式（I）的化合物与一氧化碳和氢气在包含过渡族VIII的金属与式（II）的化合物的络合物的存在下反应，其中Pn是酚醛原子; W是具有1至8个桥连原子的二价桥连基团; R2是能够与基团-X（= O）OH形成分子间，非共价键的官能团; R 3，R 4各自为烷基，环烷基，杂环烷基，芳基或杂芳基; a，b，c各自为0或1; Y1，Y2和Y3分别为O，S，NRa或SiRbRc; 以及式（II.a）化合物，其中W'是在侧翼键之间具有1至5个桥连原子的二价桥连基团，Z是O，S，S（= O），S（= O）2 ，N（RIX）或C（RIX）（RX）; R 1和R 2各自独立地为H，卤素，硝基，氰基，氨基，烷基等; 或两个基团RI，RII，RIV，RVI，RVIII和RIX一起表示双键的第二部分。

    METHOD FOR THE DECARBOXYLATIVE HYDROFORMYLATION OF ALPHA, BETA- UNSATURATED CARBOXYLIC ACIDS
    2.
    发明申请
    METHOD FOR THE DECARBOXYLATIVE HYDROFORMYLATION OF ALPHA, BETA- UNSATURATED CARBOXYLIC ACIDS 审中-公开
    阿尔法，非饱和羧酸的脱羧氢化方法

    公开(公告)号：US20110028746A1

    公开(公告)日：2011-02-03

    申请号：US12934743

    申请日：2009-03-25

    申请人： Jens Rudolph ,  Joachim Schmidt-Leithoff ,  Rocco Paciello ,  Bernhard Breit ,  Thomas Smejkal

    发明人： Jens Rudolph ,  Joachim Schmidt-Leithoff ,  Rocco Paciello ,  Bernhard Breit ,  Thomas Smejkal

    IPC分类号： C07C45/49 ,  C07C319/12 ,  C07F7/08 ,  C07C51/14 ,  C07C269/06 ,  C07C67/36

    CPC分类号： C07C45/50 ,  B01J31/2404 ,  B01J2231/321 ,  B01J2531/004 ,  C07C67/29 ,  C07C2601/14 ,  C07F7/1892 ,  C07C47/228 ,  C07C47/11 ,  C07C49/185 ,  C07C47/277 ,  C07C47/21 ,  C07C47/198 ,  C07C47/02 ,  C07C69/78

    摘要： The present invention relates to a process for preparing aldehydes by reacting an α,β-unsaturated carboxylic acid or a salt thereof with carbon monoxide and hydrogen in the presence of a catalyst comprising at least one complex of a metal of transition group VIII of the Periodic Table of the Elements with at least one compound of the formula (I), where Pn is pnicogen; W is a divalent bridging group having from 1 to 8 bridge atoms between the flanking bonds; R1 is a functional group capable of forming at least one intermolecular, noncovalent bond with the —X(═O)OH group of the compound of the formula (I); R2, R3 are each in each case optionally substituted alkyl, cycloalkyl, heterocycloalkyl, aryl or hetaryl or together with the pnicogen atom and together with the groups Y2 and Y3 if present form an optionally fused and optionally substituted 5- to 8-membered heterocycle; a, b and c are each 0 or 1; and Y1,2,3 are each, independently of one another, O, S, NRa or SiRbRc, where Ra,b,c are each H or in each case optionally substituted alkyl, cycloalkyl, heterocycloalkyl, aryl or hetaryl; and the use of the above-described catalyst for the decarboxylative hydroformylation of α,β-unsaturated carboxylic acids.

    摘要翻译： 本发明涉及一种通过使α-，β-不饱和羧酸或其盐与一氧化碳和氢气在催化剂存在下反应来制备醛的方法，所述催化剂包含至少一种式 具有式（I）的至少一种化合物的元素周期表，其中Pn是pnicogen; W是在侧翼键之间具有1至8个桥原子的二价桥连基团; R1是能够与式（I）化合物的-X（= O）OH基团形成至少一个分子间，非共价键的官能团; R2，R3各自为任选取代的烷基，环烷基，杂环烷基，芳基或杂芳基，或与pnicogen原子一起并与Y2和Y3基团一起形成任选稠合的和任选取代的5-至8-元杂环; a，b和c各自为0或1; 其中R a，b，c各自为H，或者在每种情况下均为任选取代的烷基，环烷基，杂环烷基，芳基或杂芳基;其中R 1和R 2各自独立地为O，S，NR a或SiR b R c。 以及使用上述催化剂进行α，β-不饱和羧酸的脱羧加氢甲酰化反应。

    Method for synthesizing optically active carbonyl compounds
    5.
    发明授权
    Method for synthesizing optically active carbonyl compounds 有权
    光学活性羰基化合物的合成方法

    公开(公告)号：US07973198B2

    公开(公告)日：2011-07-05

    申请号：US12597025

    申请日：2008-04-17

    申请人： Joachim Schmidt-Leithoff ,  Christoph Jäkel ,  Rocco Paciello

    发明人： Joachim Schmidt-Leithoff ,  Christoph Jäkel ,  Rocco Paciello

    IPC分类号： C07C45/62

    CPC分类号： C07C29/172 ,  C07B53/00 ,  C07B2200/07 ,  C07C29/56 ,  C07C45/62 ,  C07C2601/14 ,  C07C35/12 ,  C07C35/17 ,  C07C47/21

    摘要： The present invention relates to a process for preparing optically active carbonyl compounds by asymmetrically hydrogenating α,β-unsaturated carbonyl compounds in the presence of optically active transition metal catalysts which are soluble in the reaction mixture and have at least one carbon monoxide ligand, the optically active catalyst which has at least one carbon monoxide ligand and is to be used in each case being prepared by pretreating a catalyst precursor with a gas mixture comprising carbon monoxide and hydrogen and the asymmetric hydrogenation being performed in the presence of carbon monoxide supplied additionally to the reaction mixture.

    摘要翻译： 本发明涉及一种通过在光学活性的过渡金属催化剂的存在下不对称氢化α，β-不饱和羰基化合物来制备光学活性的羰基化合物的方法，其可溶于反应混合物并具有至少一种一氧化碳配体， 具有至少一种一氧化碳配体并且在每种情况下使用的光学活性催化剂通过用包含一氧化碳和氢气的气体混合物预处理催化剂前体而制备，并且在另外提供的一氧化碳的存在下进行不对称氢化 反应混合物。

    METHOD FOR SYNTHESIZING OPTICALLY ACTIVE CARBONYL COMPOUNDS
    7.
    发明申请
    METHOD FOR SYNTHESIZING OPTICALLY ACTIVE CARBONYL COMPOUNDS 有权
    用于合成光学活性碳化合物的方法

    公开(公告)号：US20100152494A1

    公开(公告)日：2010-06-17

    申请号：US12597025

    申请日：2008-04-17

    申请人： Joachim Schmidt-Leithoff ,  Christoph Jäkel ,  Rocco Paciello

    发明人： Joachim Schmidt-Leithoff ,  Christoph Jäkel ,  Rocco Paciello

    IPC分类号： C07C45/00 ,  C07C35/12

    CPC分类号： C07C29/172 ,  C07B53/00 ,  C07B2200/07 ,  C07C29/56 ,  C07C45/62 ,  C07C2601/14 ,  C07C35/12 ,  C07C35/17 ,  C07C47/21

    摘要： The present invention relates to a process for preparing optically active carbonyl compounds by asymmetrically hydrogenating α,β-unsaturated carbonyl compounds in the presence of optically active transition metal catalysts which are soluble in the reaction mixture and have at least one carbon monoxide ligand, the optically active catalyst which has at least one carbon monoxide ligand and is to be used in each case being prepared by pretreating a catalyst precursor with a gas mixture comprising carbon monoxide and hydrogen and the asymmetric hydrogenation being performed in the presence of carbon monoxide supplied additionally to the reaction mixture.

    摘要翻译： 本发明涉及一种通过在光学活性的过渡金属催化剂的存在下不对称氢化α，β-不饱和羰基化合物来制备光学活性的羰基化合物的方法，其可溶于反应混合物并具有至少一种一氧化碳配体， 具有至少一种一氧化碳配体并且在每种情况下使用的光学活性催化剂通过用包含一氧化碳和氢气的气体混合物预处理催化剂前体而制备，并且在另外提供的一氧化碳的存在下进行不对称氢化 反应混合物。

    Method for the production of N-substituted (3-dihalomethyl-1-methylpyrazol-4-yl) carboxamides
    9.
    发明授权
    Method for the production of N-substituted (3-dihalomethyl-1-methylpyrazol-4-yl) carboxamides 有权
    制备N-取代的（3-二卤代甲基-1-甲基吡唑-4-基）甲酰胺的方法

    公开(公告)号：US08153820B2

    公开(公告)日：2012-04-10

    申请号：US12601966

    申请日：2008-05-30

    申请人： Thomas Zierke ,  Joachim Rheinheimer ,  Michael Rack ,  Sebastian Peer Smidt ,  Ansgar Gereon Altenhoff ,  Joachim Schmidt-Leithoff ,  Nina Challand

    发明人： Thomas Zierke ,  Joachim Rheinheimer ,  Michael Rack ,  Sebastian Peer Smidt ,  Ansgar Gereon Altenhoff ,  Joachim Schmidt-Leithoff ,  Nina Challand

    IPC分类号： C07D231/10

    CPC分类号： C07D231/14

    摘要： The present invention relates to a process for preparing N-substituted (3-dihalomethylpyrazol-4-yl)carboxamides of the formula (I) in which R1 is optionally substituted phenyl or C3-C7-cycloalkyl, R1a is hydrogen or fluorine, or R1a together with R1 is optionally substituted C3-C5-alkanediyl or C5-C7-cycloalkanediyl, R2 is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl or C1-C4-alkoxy-C1-C2-alkyl, X is F or Cl and n is 0, 1, 2 or 3; which comprises A) providing a compound of the formula (II) in which X is F or Cl, Y is Cl or Br and R2 has one of the meanings given above and B) reacting a compound of the formula (II) with carbon monoxide and a compound of the formula (III) in which R1, R1a and n have one of the meanings given above; in the presence of a palladium catalyst; to intermediates used for the preparation according to the process according to the invention, and also to processes for their preparation.

    摘要翻译： 本发明涉及式（I）的N-取代的（3-二卤代甲基吡唑-4-基）甲酰胺的制备方法，其中R 1为任选取代的苯基或C 3 -C 7 - 环烷基，R 1a为氢或氟，或R 1a R 1是C 1 -C 6 - 烷基，C 2 -C 6 - 烯基，C 2 -C 6炔基或C 1 -C 4 - 烷氧基-C 1 -C 2 - 烷基，其中R 1是任选取代的C 3 -C 5 - 烷二基或C 5 -C 7 - 环烷二基， X是F或Cl，n是0,1,2或3; 其包括A）提供其中X为F或Cl，Y为Cl或Br的式（II）化合物，R 2具有上述含义之一，B）使式（II）化合物与一氧化碳 和其中R1，R1a和n具有上述含义之一的式（III）化合物; 在钯催化剂的存在下; 用于根据本发明的方法制备的中间体，以及其制备方法。

    Method for Producing Substituted Biphenyls
    10.
    发明申请
    Method for Producing Substituted Biphenyls 有权
    生产取代联苯的方法

    公开(公告)号：US20110105766A1

    公开(公告)日：2011-05-05

    申请号：US13001070

    申请日：2009-06-22

    申请人： Sebastian Peer Smidt ,  Volker Maywald ,  Kathrin Wissel-Stoll ,  Joachim Schmidt-Leithoff ,  Ansgar Gereon Altenhoff ,  Michael Keil

    发明人： Sebastian Peer Smidt ,  Volker Maywald ,  Kathrin Wissel-Stoll ,  Joachim Schmidt-Leithoff ,  Ansgar Gereon Altenhoff ,  Michael Keil

    IPC分类号： C07D231/10 ,  C07C205/06 ,  C07C211/43

    CPC分类号： C07C205/11 ,  C07C201/12

    摘要： A process for preparing substituted biphenyls of the formula I where R1=nitro or amino, R2=cyano, halogen, C1-C4-haloalkyl, C1-C4-haloalkoxy or C1-C4-haloalkylthio, n=from 0 to 3, and R3=hydrogen, cyano or halogen, which comprises reacting a halobenzene of the formula II in which Hal is chlorine or bromine, in the presence of a base and of a palladium catalyst which consists of palladium and a bidentate phosphorus ligand of the formula III where Ar is phenyl which is substituted if desired and R4 and R5 are each C1-C8-alkyl or C3-C6-cycloalkyl or together form a 2- to 7-membered bridge which may, if desired, bear a C1-C6-alkyl substituent, in a solvent or diluent, with a phenylboronic acid IVa a diphenylborinic acid IVb or a mixture of IVa and IVb.

    摘要翻译： 制备式I的取代的联苯的方法，其中R 1 =硝基或氨基，R 2 =氰基，卤素，C 1 -C 4卤代烷基，C 1 -C 4卤代烷氧基或C 1 -C 4卤代烷硫基，n = 0至3， =氢，氰基或卤素，其包括在碱的存在下使Hal为氯或溴的式II的卤代苯与由式III的二齿磷配体组成的钯催化剂反应，其中Ar 是如果需要被取代的苯基，并且R 4和R 5各自是C 1 -C 8 - 烷基或C 3 -C 6 - 环烷基或一起形成2-7元桥，如果需要，其可以具有C 1 -C 6烷基取代基， 在溶剂或稀释剂中与苯基硼酸IVa为二苯基硼酸IVb或IVa和IVb的混合物。