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公开(公告)号：US6127341A
公开(公告)日：2000-10-03
申请号：US88690
申请日：1998-06-01
申请人： Thomas Kruse Hansen , Jesper Lau , Bernd Peschke , Michael Ankersen , Kjeld Madsen , Nils Langeland Johansen
发明人： Thomas Kruse Hansen , Jesper Lau , Bernd Peschke , Michael Ankersen , Kjeld Madsen , Nils Langeland Johansen
IPC分类号： A61K38/00 , C07K5/02 , C07K5/08 , C07K7/06 , C07C233/00
CPC分类号： C07K7/06 , C07K5/0207 , C07K5/0827 , A61K38/00
摘要： Compounds of the general formula I ##STR1## compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone are described.
摘要翻译： 描述含有它们的通式I组合物的化合物及其用于治疗由生长激素缺乏引起的医学病症的用途。
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公开(公告)号：US06350767B1
公开(公告)日：2002-02-26
申请号：US09443993
申请日：1999-11-19
IPC分类号： C07D27106
CPC分类号： C07D271/06 , A61K38/00 , C07C233/38 , C07C237/22 , C07C237/32 , C07C237/36 , C07D211/62 , C07D271/10 , C07D277/56 , C07D401/12 , C07D413/12 , C07D417/12 , C07K14/60
摘要： The present invention relates to compounds, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone.
摘要翻译： 本发明涉及含有它们的化合物，组合物及其用于治疗由生长激素缺乏引起的医学病症的用途。
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公开(公告)号：US6013658A
公开(公告)日：2000-01-11
申请号：US897239
申请日：1997-07-17
IPC分类号： C07D277/20 , A61K31/165 , A61K31/27 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/4427 , A61K31/445 , A61K31/4465 , A61K38/00 , A61P43/00 , C07C233/38 , C07C237/22 , C07C237/32 , C07C237/36 , C07D211/60 , C07D211/62 , C07D257/04 , C07D271/06 , C07D271/10 , C07D277/56 , C07D401/12 , C07D413/12 , C07D417/12 , C07K5/065 , C07K14/60
CPC分类号： C07D271/06 , C07C233/38 , C07C237/22 , C07C237/32 , C07C237/36 , C07D211/62 , C07D271/10 , C07D277/56 , C07D401/12 , C07D413/12 , C07D417/12 , C07K14/60 , A61K38/00
摘要： There are disclosed novel synthetic peptides of formula (I) ##STR1## where A, B, D, E, F, G, J, m, n, and p are defined in the specification. Compounds of formula (I) promote the release of growth hormone in humans and animals. Growth promoting compositions containing such compounds of formula (I) as the active ingredient, methods of stimulating the release of growth hormone, and the use of such compounds of formula (I) are also disclosed.
摘要翻译： 公开了式（I）的新型合成肽，其中A，B，D，E，F，G，J，m，n和p在说明书中定义。 式（I）化合物促进人和动物中生长激素的释放。 还公开了含有式（I）化合物作为活性成分的生长促进组合物，刺激生长激素释放的方法，以及式（I）化合物的使用。
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公开(公告)号：US5977178A
公开(公告)日：1999-11-02
申请号：US769020
申请日：1996-12-18
申请人： Thomas Kruse Hansen , Bernd Peschke , Jesper Lau , Behrend Friedrich Lundt , Michael Ankersen , Brett Watson , Kjeld Madsen
发明人： Thomas Kruse Hansen , Bernd Peschke , Jesper Lau , Behrend Friedrich Lundt , Michael Ankersen , Brett Watson , Kjeld Madsen
IPC分类号： C07D333/20 , A61K31/00 , A61K31/17 , A61K31/18 , A61K31/216 , A61K31/27 , A61K31/38 , A61K31/381 , A61K31/41 , A61K31/4245 , A61K31/454 , A61K38/00 , A61K38/07 , A61K38/08 , A61P3/00 , A61P5/00 , A61P5/06 , A61P5/10 , A61P15/00 , A61P15/14 , A61P19/00 , B41J19/20 , C07C237/00 , C07C237/22 , C07C311/05 , C07C335/14 , C07D213/12 , C07D227/00 , C07D271/06 , C07D333/00 , C07D333/24 , C07D333/60 , C07D409/00 , C07D413/12 , C07K5/03 , C07K5/06 , C07K5/065 , C07K5/078 , C07K5/10 , C07K7/02 , C07K14/60 , A61K31/16 , C07C233/01
CPC分类号： C07D271/06 , B41J19/205 , C07C237/22 , C07D333/24 , C07D413/12 , C07K5/0606 , C07K5/06078 , C07K5/06139 , C07K5/06191 , A61K38/00
摘要： Compounds of peptide mimetic nature having the general formula I ##STR1## wherein a and b are independently 1 or 2, R.sup.1 and R.sup.2 are independently H or C.sub.1-6 alkyl, G and J are independently, inter alia, aromats, and D and E are independently several different groups are growth hormone secretagogous with improved bioavailability.
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公开(公告)号：US06939880B2
公开(公告)日：2005-09-06
申请号：US10067895
申请日：2002-02-05
申请人： Thomas Kruse Hansen , Bernd Peschke , Jesper Lau , Behrend Friedrich Lundt , Michael Ankersen , Brett Watson , Kjeld Madsen
发明人： Thomas Kruse Hansen , Bernd Peschke , Jesper Lau , Behrend Friedrich Lundt , Michael Ankersen , Brett Watson , Kjeld Madsen
IPC分类号： C07D333/20 , A61K31/00 , A61K31/17 , A61K31/18 , A61K31/216 , A61K31/27 , A61K31/38 , A61K31/381 , A61K31/41 , A61K31/4245 , A61K31/454 , A61K38/00 , A61K38/07 , A61K38/08 , A61P3/00 , A61P5/00 , A61P5/06 , A61P5/10 , A61P15/00 , A61P15/14 , A61P19/00 , B41J19/20 , C07C237/00 , C07C237/22 , C07C311/05 , C07C335/14 , C07D213/12 , C07D227/00 , C07D271/06 , C07D333/00 , C07D333/24 , C07D333/60 , C07D409/00 , C07D413/12 , C07K5/03 , C07K5/06 , C07K5/065 , C07K5/078 , C07K5/10 , C07K7/02 , C07K14/60 , A61K31/445 , C07D211/06 , C07D401/00
CPC分类号： C07D271/06 , A61K38/00 , B41J19/205 , C07C237/22 , C07D333/24 , C07D413/12 , C07K5/0606 , C07K5/06078 , C07K5/06139 , C07K5/06191
摘要： Compounds of peptide mimetic nature having the general formula I wherein a and b are independently 1 or 2, R1 and R2 are independently H or C1-6alkyl, G and J are independently, inter alia, aromats, and D and E are independently several different groups are growth hormone secretagogous with improved bioavailability.
摘要翻译： 具有通式I的肽模拟性质的化合物，其中a和b独立地为1或2，R 1和R 2独立地为H或C 1-6 烷基，G和J独立地独立地为芳族，D和E独立地为数个不同的基团，即具有提高的生物利用度的具有促分泌素的生长激素。
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公开(公告)号：US06555570B2
公开(公告)日：2003-04-29
申请号：US09534135
申请日：2000-03-23
申请人： Thomas Kruse Hansen , Bernd Peschke , Jesper Lau , Behrend Friedrich Lundt , Michael Ankersen , Brett Watson , Kjeld Madsen
发明人： Thomas Kruse Hansen , Bernd Peschke , Jesper Lau , Behrend Friedrich Lundt , Michael Ankersen , Brett Watson , Kjeld Madsen
IPC分类号： A61K3140
CPC分类号： C07D271/06 , A61K38/00 , B41J19/205 , C07C237/22 , C07D333/24 , C07D413/12 , C07K5/0606 , C07K5/06078 , C07K5/06139 , C07K5/06191
摘要： Compounds of peptide mimetic nature having the general formula I wherein a and b are independently 1 or 2, R1 and R2 are independently H or C1-6alkyl, G and J are independently, inter alia, aromats, and D and E are independently several different groups are growth hormone secretagogous with improved bioavailability.
摘要翻译： 具有通式I的肽模拟性质的化合物，其中a和b独立地为1或2，R 1和R 2独立地为H或C 1-6烷基，G和J尤其是芳族，D和E独立地为数个不同的基团 是具有改善的生物利用度的生长激素促分泌素。
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公开(公告)号：US6127391A
公开(公告)日：2000-10-03
申请号：US218686
申请日：1998-12-21
申请人： Thomas Kruse Hansen , Bernd Peschke , Jesper Lau , Behrend Friedrich Lundt , Michael Ankersen , Brett Watson , Kjeld Madsen
发明人： Thomas Kruse Hansen , Bernd Peschke , Jesper Lau , Behrend Friedrich Lundt , Michael Ankersen , Brett Watson , Kjeld Madsen
IPC分类号： C07D333/20 , A61K31/00 , A61K31/17 , A61K31/18 , A61K31/216 , A61K31/27 , A61K31/38 , A61K31/381 , A61K31/41 , A61K31/4245 , A61K31/454 , A61K38/00 , A61K38/07 , A61K38/08 , A61P3/00 , A61P5/00 , A61P5/06 , A61P5/10 , A61P15/00 , A61P15/14 , A61P19/00 , B41J19/20 , C07C237/00 , C07C237/22 , C07C311/05 , C07C335/14 , C07D213/12 , C07D227/00 , C07D271/06 , C07D333/00 , C07D333/24 , C07D333/60 , C07D409/00 , C07D413/12 , C07K5/03 , C07K5/06 , C07K5/065 , C07K5/078 , C07K5/10 , C07K7/02 , C07K14/60 , A61K31/4439 , C07D401/12
CPC分类号： C07D271/06 , B41J19/205 , C07C237/22 , C07D333/24 , C07D413/12 , C07K5/0606 , C07K5/06078 , C07K5/06139 , C07K5/06191 , A61K38/00
摘要： Compounds of peptide mimetic nature having the general formula I ##STR1## wherein a and b are independently 1 or 2, R.sup.1 and R.sup.2 are independently H or C.sub.1-6 alkyl, G and J are independently, inter alia, aromats, and D and E are independently several different groups are growth hormone secretagogous with improved bioavailability.
摘要翻译： 具有通式I的肽模拟性质的化合物，其中a和b独立地为1或2，R 1和R 2独立地为H或C 1-6烷基，G和J独立地为芳族，D和E独立地为数个不同的 组是具有改善的生物利用度的促分泌素。
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公开(公告)号：US06274584B1
公开(公告)日：2001-08-14
申请号：US09619227
申请日：2000-07-19
IPC分类号： A61K31495
CPC分类号： C07D207/08 , C07C237/22 , C07C281/06 , C07C311/08 , C07C311/21 , C07D217/06 , C07D241/08 , C07D333/20
摘要： Novel peptide derivatives, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone are disclosed. The peptides have the formula (1): wherein a, b, A, R1, L1, D, R3, R4, R2, L2, E and G are as defined in the specification. These peptides exhibit improved resistance to proteolytic degradation, and hence, improved bioavailability.
摘要翻译： 公开了新型肽衍生物，含有它们的组合物及其用于治疗由生长激素缺乏引起的医学疾病的用途。 肽具有式（1）：其中a，b，A，R1，L1，D，R3，R4，R2，L2，E和G如说明书中所定义。 这些肽表现出改善的蛋白水解降解抗性，因此提高了生物利用度。
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公开(公告)号：US6127354A
公开(公告)日：2000-10-03
申请号：US270862
申请日：1999-03-17
IPC分类号： A61K31/165 , A61K31/17 , A61K31/18 , A61K31/27 , A61K31/381 , A61K31/40 , A61K31/472 , A61K31/495 , A61P5/06 , C07C237/22 , C07C243/34 , C07C281/06 , C07C311/08 , C07C311/21 , C07D207/08 , C07D211/06 , C07D217/06 , C07D241/08 , C07D333/20 , A61K31/135 , A61K31/166 , C07D333/16
CPC分类号： C07D207/08 , C07C237/22 , C07C281/06 , C07C311/08 , C07C311/21 , C07D217/06 , C07D241/08 , C07D333/20
摘要： Novel peptide derivatives, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone are disclosed. The peptides have the formula (I): ##STR1## wherein a, b, A, R.sup.1, L.sup.1, D, R.sup.3, R.sup.4, R.sup.2, L.sup.2, E and G are as defined in the specification. These peptides exhibit improved resistance to proteolytic degradation, and hence, improved bioavailability.
摘要翻译： 公开了新型肽衍生物，含有它们的组合物及其用于治疗由生长激素缺乏引起的医学疾病的用途。 肽具有式（I）：其中a，b，A，R1，L1，D，R3，R4，R2，L2，E和G如说明书中所定义。 这些肽表现出改善的蛋白水解降解抗性，因此提高了生物利用度。
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公开(公告)号：US5922770A
公开(公告)日：1999-07-13
申请号：US896550
申请日：1997-07-17
IPC分类号： A61K31/165 , A61K31/17 , A61K31/18 , A61K31/27 , A61K31/381 , A61K31/40 , A61K31/472 , A61K31/495 , A61P5/06 , C07C237/22 , C07C243/34 , C07C281/06 , C07C311/08 , C07C311/21 , C07D207/08 , C07D211/06 , C07D217/06 , C07D241/08 , C07D333/20 , C07C233/11 , C07C235/34
CPC分类号： C07D207/08 , C07C237/22 , C07C281/06 , C07C311/08 , C07C311/21 , C07D217/06 , C07D241/08 , C07D333/20
摘要： Novel peptide derivatives, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone are disclosed. The peptides have the formula (I): ##STR1## wherein a, b, A, R.sup.1, L.sup.1, D, R.sup.3, R.sup.4, R.sup.2, L.sup.2, E and G are as defined in the specification. These peptides exhibit improved resistance to proteolytic degradation, and hence, improved bioavailability.
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