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    Human tumor necrosis factor receptors TR13 and TR14
    2.
    发明授权
    Human tumor necrosis factor receptors TR13 and TR14 失效
    人肿瘤坏死因子受体TR13和TR14

    公开(公告)号：US06951738B2

    公开(公告)日：2005-10-04

    申请号：US10046433

    申请日：2002-01-16

    申请人： Jian Ni ,  Kevin P. Baker ,  Steven M. Ruben ,  Paul E. Young

    发明人： Jian Ni ,  Kevin P. Baker ,  Steven M. Ruben ,  Paul E. Young

    IPC分类号： A61K38/00 ,  C07H21/04 ,  C07K14/705 ,  C07K14/715 ,  C07K16/28 ,  C12N15/09 ,  C12Q1/68

    CPC分类号： C07K14/70578 ,  A61K38/00 ,  C07K14/7151

    摘要： The present invention relates to two novel proteins, TR13 and TR14, which are members of the tumor necrosis factor (TNF) receptor superfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR13 and TR14 proteins. TR13 and TR14 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR13 and TR14.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体超家族成员的两种新型蛋白质TR13和TR14。 特别地，提供编码人TR13和TR14蛋白的分离的核酸分子。 还提供TR13和TR14多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR13和TR14的激动剂和拮抗剂的筛选方法。

    Human tumor necrosis factor TR20 and methods based thereon
    4.
    发明授权
    Human tumor necrosis factor TR20 and methods based thereon 失效
    人肿瘤坏死因子TR20及其基础的方法

    公开(公告)号：US07164004B2

    公开(公告)日：2007-01-16

    申请号：US10618797

    申请日：2003-07-15

    申请人： Steven M. Ruben ,  Kevin P. Baker ,  Jian Ni

    发明人： Steven M. Ruben ,  Kevin P. Baker ,  Jian Ni

    IPC分类号： C07K14/00

    CPC分类号： C07K14/525 ,  C07K14/70575

    摘要： The present invention relates to TR20 polypeptides. In particular, isolated nucleic acid molecules are provided encoding human TR20 protein. TR20 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR20 activity.

    摘要翻译： 本发明涉及TR20多肽。 特别地，提供编码人TR20蛋白的分离的核酸分子。 还提供TR20多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR20活性的激动剂和拮抗剂的筛选方法。

    Nucleic acids encoding human tumor necrosis factor TR20
    5.
    发明授权
    Nucleic acids encoding human tumor necrosis factor TR20 失效
    编码人肿瘤坏死因子TR20的核酸

    公开(公告)号：US06623941B1

    公开(公告)日：2003-09-23

    申请号：US09848295

    申请日：2001-05-04

    申请人： Steven M. Ruben ,  Kevin P. Baker ,  Jian Ni

    发明人： Steven M. Ruben ,  Kevin P. Baker ,  Jian Ni

    IPC分类号： C12N1512

    CPC分类号： C07K14/525 ,  C07K14/70575

    摘要： The present invention relates to TR20 polypeptides. In particular, isolated nucleic acid molecules are provided encoding human TR20 protein. TR20 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR20 activity.

    摘要翻译： 本发明涉及TR20多肽。 特别地，提供编码人TR20蛋白的分离的核酸分子。 还提供TR20多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR20活性的激动剂和拮抗剂的筛选方法。

    Methods of treatment using human tumor necrosis factor receptor TR17 antibodies
    6.
    发明授权
    Methods of treatment using human tumor necrosis factor receptor TR17 antibodies 有权
    使用人肿瘤坏死因子受体TR17抗体的治疗方法

    公开(公告)号：US07498027B2

    公开(公告)日：2009-03-03

    申请号：US11221849

    申请日：2005-09-09

    申请人： Steven M. Ruben ,  Kevin P. Baker

    发明人： Steven M. Ruben ,  Kevin P. Baker

    IPC分类号： A61K39/395

    CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K14/715 ,  C07K14/7151

    摘要： The present invention relates to a novel protein, TR17, which is a member of the tumor necrosis factor (TNF) receptor superfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR17. TR17 polypeptides are also provided as anti TR17 antibodies and vectors, host cells and recombinant methods for producing the same. The invention further relates to methods of killing cells using the antibodies of the invention.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体超家族成员的新型蛋白质TR17。 特别地，提供编码人TR17的分离的核酸分子。 还提供TR17多肽作为抗TR17抗体和载体，宿主细胞和用于制备其的重组方法。 本发明还涉及使用本发明的抗体杀死细胞的方法。

    Methods of inhibiting proliferation or immunoglobulin production of B cells using human tumor necrosis factor receptor TR-17 polypeptides
    7.
    发明授权
    Methods of inhibiting proliferation or immunoglobulin production of B cells using human tumor necrosis factor receptor TR-17 polypeptides 有权
    使用人肿瘤坏死因子受体TR-17多肽抑制B细胞增殖或免疫球蛋白产生的方法

    公开(公告)号：US08518389B2

    公开(公告)日：2013-08-27

    申请号：US12336051

    申请日：2008-12-16

    申请人： Steven M. Ruben ,  Kevin P. Baker

    发明人： Steven M. Ruben ,  Kevin P. Baker

    IPC分类号： A61K38/16

    CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K14/715 ,  C07K14/7151

    摘要： The present invention relates to a novel protein, TR17, which is a member of the tumor necrosis factor (TNF) receptor superfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR17. TR17 polypeptides are also provided as anti TR17 antibodies and vectors, host cells and recombinant methods for producing the same. The invention further relates to methods of killing cells using the antibodies of the invention.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体超家族成员的新型蛋白质TR17。 特别地，提供编码人TR17的分离的核酸分子。 还提供TR17多肽作为抗TR17抗体和载体，宿主细胞和用于制备其的重组方法。 本发明还涉及使用本发明的抗体杀死细胞的方法。

    Human Tumor Necrosis Factor TR18 and Methods Based Thereon
    8.
    发明申请
    Human Tumor Necrosis Factor TR18 and Methods Based Thereon 审中-公开
    人类肿瘤坏死因子TR18及其方法

    公开(公告)号：US20080227714A1

    公开(公告)日：2008-09-18

    申请号：US12116717

    申请日：2008-05-07

    申请人： Steven M. Ruben ,  Kevin P. Baker

    发明人： Steven M. Ruben ,  Kevin P. Baker

    IPC分类号： A61K38/16 ,  A61P37/00 ,  A61P35/00

    CPC分类号： C07K14/70575 ,  A61K38/00 ,  C07K14/70578 ,  C07K14/7151

    摘要： The present invention relates to TR18 polypeptides. In particular, isolated nucleic acid molecules are provided encoding human TR18 protein. TR18 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR18 activity. The invention further relates to methods of treating, preventing, prognosing, or diagnosing an autoimmune disease or condition associated with an autoimmune disease, comprising administering to a patient an effective amount of polypeptides of the invention.

    摘要翻译： 本发明涉及TR18多肽。 特别地，提供编码人TR18蛋白的分离的核酸分子。 还提供TR18多肽，载体，宿主细胞和用于制备它的重组方法。 本发明还涉及用于鉴定TR18活性的激动剂和拮抗剂的筛选方法。 本发明还涉及治疗，预防，预后或诊断与自身免疫性疾病相关的自身免疫性疾病或病症的方法，其包括向患者施用有效量的本发明的多肽。

    Methods of using an agonistic antibody human tumor necrosis factor receptor (TR17)
    9.
    发明授权
    Methods of using an agonistic antibody human tumor necrosis factor receptor (TR17) 有权
    使用激动剂抗体人肿瘤坏死因子受体（TR17）的方法

    公开(公告)号：US06969519B2

    公开(公告)日：2005-11-29

    申请号：US09961376

    申请日：2001-09-25

    申请人： Steven M. Ruben ,  Kevin P. Baker

    发明人： Steven M. Ruben ,  Kevin P. Baker

    IPC分类号： A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  A61K39/395 ,  G01N33/53

    CPC分类号： C07K14/52 ,  A61K38/00 ,  C07K14/715 ,  C07K14/7151

    摘要： The present invention relates to a novel protein, TR17, which is a member of the tumor necrosis factor (TNF) receptor superfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR17. TR17 polypeptides are also provided as anti TR17 antibodies and vectors, host cells and recombinant methods for producing the same. The invention further relates to methods of killing cells using the antibodies of the invention.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体超家族成员的新型蛋白质TR17。 特别地，提供编码人TR17的分离的核酸分子。 还提供TR17多肽作为抗TR17抗体和载体，宿主细胞和用于制备其的重组方法。 本发明还涉及使用本发明的抗体杀死细胞的方法。

    Human Tumor Necrosis Factor TR18 and Methods Based Thereon
    10.
    发明申请
    Human Tumor Necrosis Factor TR18 and Methods Based Thereon 审中-公开
    人类肿瘤坏死因子TR18及其方法

    公开(公告)号：US20110020380A1

    公开(公告)日：2011-01-27

    申请号：US12892534

    申请日：2010-09-28

    申请人： Steven M. Ruben ,  Kevin P. Baker

    发明人： Steven M. Ruben ,  Kevin P. Baker

    IPC分类号： A61K39/00 ,  A61P37/06

    CPC分类号： C07K14/70575 ,  A61K38/00 ,  C07K14/70578 ,  C07K14/7151

    摘要： The present invention relates to TR18 polypeptides. In particular, isolated nucleic acid molecules are provided encoding human TR18 protein. TR18 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR18 activity. The invention further relates to methods of treating, preventing, prognosing, or diagnosing an autoimmune disease or condition associated with an autoimmune disease, comprising administering to a patient an effective amount of polypeptides of the invention.

    摘要翻译： 本发明涉及TR18多肽。 特别地，提供编码人TR18蛋白的分离的核酸分子。 还提供TR18多肽，载体，宿主细胞和用于制备它的重组方法。 本发明还涉及用于鉴定TR18活性的激动剂和拮抗剂的筛选方法。 本发明还涉及治疗，预防，预后或诊断与自身免疫性疾病相关的自身免疫性疾病或病症的方法，其包括向患者施用有效量的本发明的多肽。