公开(公告)号：US06623923B1

公开(公告)日：2003-09-23

申请号：US09401064

申请日：1999-09-22

申请人： Jiangchun Xu ,  Michael J. Lodes ,  Heather Secrist ,  Madeleine Joy Meagher ,  John Stolk ,  Darin R. Benson ,  Tongtong Wang

发明人： Jiangchun Xu ,  Michael J. Lodes ,  Heather Secrist ,  Madeleine Joy Meagher ,  John Stolk ,  Darin R. Benson ,  Tongtong Wang

IPC分类号： C12Q168

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K2319/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：US06759508B2

公开(公告)日：2004-07-06

申请号：US09854133

申请日：2001-05-11

申请人： Michael J. Lodes ,  Raodoh Mohamath ,  Robert A. Henderson ,  Darin R. Benson ,  Heather Secrist

发明人： Michael J. Lodes ,  Raodoh Mohamath ,  Robert A. Henderson ,  Darin R. Benson ,  Heather Secrist

IPC分类号： C07K14435

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4748 ,  C07K2319/00 ,  Y02A50/396

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

公开(公告)号：US06468758B1

公开(公告)日：2002-10-22

申请号：US09397787

申请日：1999-09-16

申请人： Darin R. Benson ,  Michael J. Lodes ,  Jennifer L. Mitcham ,  Gordon E. King

发明人： Darin R. Benson ,  Michael J. Lodes ,  Jennifer L. Mitcham ,  Gordon E. King

IPC分类号： G01N33574

CPC分类号： C12Q1/6886

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分，编码这种部分的多核苷酸或对这些蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 还提供了用于鉴定从卵巢癌和/或其他肿瘤分泌的肿瘤抗原的方法。 本文提供的多肽和多核苷酸还可用于诊断和监测卵巢癌。