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公开(公告)号：US06468758B1
公开(公告)日：2002-10-22
申请号：US09397787
申请日：1999-09-16
IPC分类号： G01N33574
CPC分类号： C12Q1/6886
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分，编码这种部分的多核苷酸或对这些蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 还提供了用于鉴定从卵巢癌和/或其他肿瘤分泌的肿瘤抗原的方法。 本文提供的多肽和多核苷酸还可用于诊断和监测卵巢癌。
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公开(公告)号：US06468546B1
公开(公告)日：2002-10-22
申请号：US09404879
申请日：1999-09-24
IPC分类号： A61K3900
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/70532 , C07K2319/00 , Y02A50/472 , Y10S436/813 , Y10S530/806 , Y10S530/828 , Y10S530/853
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分，编码这种部分的多核苷酸或对这些蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 还提供了用于鉴定从卵巢癌和/或其他肿瘤分泌的肿瘤抗原的方法。 本文提供的多肽和多核苷酸还可用于诊断和监测卵巢癌。
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公开(公告)号：US06699664B1
公开(公告)日：2004-03-02
申请号：US09667857
申请日：2000-09-20
申请人： Jennifer L. Mitcham , Gordon E. King , Paul A. Algate , Steven P. Fling , Marc W. Retter , Gary R. Fanger , Steven G. Reed , Thomas S. Vedvick , Darrick Carter
发明人： Jennifer L. Mitcham , Gordon E. King , Paul A. Algate , Steven P. Fling , Marc W. Retter , Gary R. Fanger , Steven G. Reed , Thomas S. Vedvick , Darrick Carter
IPC分类号： C12Q168
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K14/47 , C07K16/3069 , C07K2317/34 , C07K2319/00
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分，编码这种部分的多核苷酸或对这些蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 还提供了用于鉴定从卵巢癌和/或其他肿瘤分泌的肿瘤抗原的方法。 本文提供的多肽和多核苷酸还可用于诊断和监测卵巢癌。
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公开(公告)号：US06488931B1
公开(公告)日：2002-12-03
申请号：US09338933
申请日：1999-06-23
IPC分类号： A61K3900
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K2319/00 , Y02A50/472 , Y10S530/828 , Y10S530/853
摘要： Compositions and methods for the therapy of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors.
摘要翻译： 公开了用于治疗癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分，编码这种部分的多核苷酸或对这些蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 还提供了用于鉴定从卵巢癌和/或其他肿瘤分泌的肿瘤抗原的方法。
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公开(公告)号：US07202334B1
公开(公告)日：2007-04-10
申请号：US09636801
申请日：2000-08-10
申请人： Jennifer L. Mitcham , Gordon E. King , Paul A. Algate , Steven P. Fling , Marc W. Retter , Gary R. Fanger , Steven G. Reed
发明人： Jennifer L. Mitcham , Gordon E. King , Paul A. Algate , Steven P. Fling , Marc W. Retter , Gary R. Fanger , Steven G. Reed
IPC分类号： A61K39/00
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/70532 , C07K2319/00 , Y02A50/472 , Y10S436/813 , Y10S530/806 , Y10S530/828 , Y10S530/853
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分，编码这种部分的多核苷酸或对这些蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 还提供了用于鉴定从卵巢癌和/或其他肿瘤分泌的肿瘤抗原的方法。 本文提供的多肽和多核苷酸还可用于诊断和监测卵巢癌。
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公开(公告)号：US06962980B2
公开(公告)日：2005-11-08
申请号：US09827271
申请日：2001-04-04
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K14/47 , C07K16/3069 , C07K2317/34 , C07K2317/77 , C07K2319/00
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分，编码这种部分的多核苷酸或对这些蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 还提供了用于鉴定从卵巢癌和/或其他肿瘤分泌的肿瘤抗原的方法。 本文提供的多肽和多核苷酸还可用于诊断和监测卵巢癌。
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公开(公告)号：US06670463B1
公开(公告)日：2003-12-30
申请号：US09216003
申请日：1998-12-17
IPC分类号： C07H2104
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： Compositions and methods for the therapy of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors.
摘要翻译： 公开了用于治疗癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分，编码这种部分的多核苷酸或对这些蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 还提供了用于鉴定从卵巢癌和/或其他肿瘤分泌的肿瘤抗原的方法。
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公开(公告)号：US06528253B1
公开(公告)日：2003-03-04
申请号：US09215681
申请日：1998-12-17
IPC分类号： C12Q168
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： Compositions and methods for the diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof or polynucleotides that encode such portions. Such compositions may be used, for example, for the detecting and monitoring diseases such as ovarian cancer.
摘要翻译： 公开了用于诊断癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分或编码这些部分的多核苷酸。 这样的组合物可用于例如检测和监测诸如卵巢癌之类的疾病。
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9.发明申请公开(公告)号：US20080317755A1
公开(公告)日：2008-12-25
申请号：US11768101
申请日：2007-06-25
IPC分类号： A61K39/395 , C07H21/00 , C07K2/00 , C12N15/63 , C12N5/00 , A61K35/12 , A61K31/7052 , A61P35/00 , A61K38/02 , A61K38/16 , C07K16/00 , G01N33/574 , C07K14/00
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly colon cancer, are disclosed. Illustrative compositions comprise one or more colon tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly colon cancer.
摘要翻译： 公开了用于治疗和诊断癌症，特别是结肠癌的组合物和方法。 示例性组合物包含一种或多种结肠肿瘤多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及表达该多肽的细胞特异的T细胞。 公开的组合物可用于例如疾病，特别是结肠癌的诊断，预防和/或治疗。
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