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公开(公告)号：US06468758B1
公开(公告)日：2002-10-22
申请号：US09397787
申请日：1999-09-16
IPC分类号： G01N33574
CPC分类号： C12Q1/6886
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分，编码这种部分的多核苷酸或对这些蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 还提供了用于鉴定从卵巢癌和/或其他肿瘤分泌的肿瘤抗原的方法。 本文提供的多肽和多核苷酸还可用于诊断和监测卵巢癌。
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公开(公告)号：US06699664B1
公开(公告)日：2004-03-02
申请号：US09667857
申请日：2000-09-20
申请人： Jennifer L. Mitcham , Gordon E. King , Paul A. Algate , Steven P. Fling , Marc W. Retter , Gary R. Fanger , Steven G. Reed , Thomas S. Vedvick , Darrick Carter
发明人： Jennifer L. Mitcham , Gordon E. King , Paul A. Algate , Steven P. Fling , Marc W. Retter , Gary R. Fanger , Steven G. Reed , Thomas S. Vedvick , Darrick Carter
IPC分类号： C12Q168
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K14/47 , C07K16/3069 , C07K2317/34 , C07K2319/00
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分，编码这种部分的多核苷酸或对这些蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 还提供了用于鉴定从卵巢癌和/或其他肿瘤分泌的肿瘤抗原的方法。 本文提供的多肽和多核苷酸还可用于诊断和监测卵巢癌。
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公开(公告)号：US06488931B1
公开(公告)日：2002-12-03
申请号：US09338933
申请日：1999-06-23
IPC分类号： A61K3900
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K2319/00 , Y02A50/472 , Y10S530/828 , Y10S530/853
摘要： Compositions and methods for the therapy of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors.
摘要翻译： 公开了用于治疗癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分，编码这种部分的多核苷酸或对这些蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 还提供了用于鉴定从卵巢癌和/或其他肿瘤分泌的肿瘤抗原的方法。
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公开(公告)号：US06468546B1
公开(公告)日：2002-10-22
申请号：US09404879
申请日：1999-09-24
IPC分类号： A61K3900
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/70532 , C07K2319/00 , Y02A50/472 , Y10S436/813 , Y10S530/806 , Y10S530/828 , Y10S530/853
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分，编码这种部分的多核苷酸或对这些蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 还提供了用于鉴定从卵巢癌和/或其他肿瘤分泌的肿瘤抗原的方法。 本文提供的多肽和多核苷酸还可用于诊断和监测卵巢癌。
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公开(公告)号：US07202334B1
公开(公告)日：2007-04-10
申请号：US09636801
申请日：2000-08-10
申请人： Jennifer L. Mitcham , Gordon E. King , Paul A. Algate , Steven P. Fling , Marc W. Retter , Gary R. Fanger , Steven G. Reed
发明人： Jennifer L. Mitcham , Gordon E. King , Paul A. Algate , Steven P. Fling , Marc W. Retter , Gary R. Fanger , Steven G. Reed
IPC分类号： A61K39/00
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/70532 , C07K2319/00 , Y02A50/472 , Y10S436/813 , Y10S530/806 , Y10S530/828 , Y10S530/853
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分，编码这种部分的多核苷酸或对这些蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 还提供了用于鉴定从卵巢癌和/或其他肿瘤分泌的肿瘤抗原的方法。 本文提供的多肽和多核苷酸还可用于诊断和监测卵巢癌。
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公开(公告)号：US06962980B2
公开(公告)日：2005-11-08
申请号：US09827271
申请日：2001-04-04
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K14/47 , C07K16/3069 , C07K2317/34 , C07K2317/77 , C07K2319/00
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分，编码这种部分的多核苷酸或对这些蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 还提供了用于鉴定从卵巢癌和/或其他肿瘤分泌的肿瘤抗原的方法。 本文提供的多肽和多核苷酸还可用于诊断和监测卵巢癌。
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公开(公告)号：US06670463B1
公开(公告)日：2003-12-30
申请号：US09216003
申请日：1998-12-17
IPC分类号： C07H2104
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： Compositions and methods for the therapy of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors.
摘要翻译： 公开了用于治疗癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分，编码这种部分的多核苷酸或对这些蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 还提供了用于鉴定从卵巢癌和/或其他肿瘤分泌的肿瘤抗原的方法。
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公开(公告)号：US06528253B1
公开(公告)日：2003-03-04
申请号：US09215681
申请日：1998-12-17
IPC分类号： C12Q168
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： Compositions and methods for the diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof or polynucleotides that encode such portions. Such compositions may be used, for example, for the detecting and monitoring diseases such as ovarian cancer.
摘要翻译： 公开了用于诊断癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分或编码这些部分的多核苷酸。 这样的组合物可用于例如检测和监测诸如卵巢癌之类的疾病。
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9.发明授权Compositions for the treatment and diagnosis of breast cancer and methods for their use 失效用于乳腺癌治疗和诊断的组合及其使用方法公开(公告)号：US06844325B2
公开(公告)日：2005-01-18
申请号：US09551621
申请日：2000-04-17
IPC分类号： A61K35/12 , A61K38/00 , A61K39/00 , C07K14/47 , C12N9/00 , C12Q1/68 , A01N43/04 , A61K31/70 , C07H21/04 , C07H21/02 , C12N15/74
CPC分类号： C07K14/47 , A61K35/12 , A61K38/00 , A61K39/00 , A61K2039/5154 , A61K2039/57 , C07K14/4748 , C07K2319/00 , C12N9/00 , C12Q1/6886 , C12Q2600/158 , Y10S530/806 , Y10S530/828
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如乳腺癌。 组合物可以包含一种或多种乳腺肿瘤蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达乳腺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如乳腺癌的疾病。 还提供了基于检测样品中的乳腺肿瘤蛋白或编码这种蛋白质的mRNA的诊断方法。
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公开(公告)号：US06800746B2
公开(公告)日：2004-10-05
申请号：US09759143
申请日：2001-01-12
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day , Thomas S. Vedvick , Darrick Carter , Samuel X. Li , Aijun Wang , Yasir A. W. Skeiky , William T. Hepler , Robert A. Henderson
IPC分类号： C12Q168
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2035/124 , A61K2039/5156 , A61K2039/53 , C07K14/47 , C07K14/4748 , C07K14/705 , C07K2319/00 , C12N9/6424 , C12N2760/16022
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.
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