DETERMINING PRODUCT PRICE
    1.
    发明申请
    DETERMINING PRODUCT PRICE 审中-公开
    确定产品价格

    公开(公告)号:US20140019210A1

    公开(公告)日:2014-01-16

    申请号:US13547804

    申请日:2012-07-12

    IPC分类号: G06Q10/00

    CPC分类号: G06Q30/02

    摘要: Methods, systems, and computer-readable and executable instructions are provided for determining a product price. Determining a product price can include determining an initial market attraction value, a market price sensitivity, and cost information for a product. Determining a product price can also include receiving a market constraint with respect to the product and pricing the product based on the initial market attraction value, the market price sensitivity, the cost information, and the market constraint.

    摘要翻译: 提供了用于确定产品价格的方法,系统和计算机可读和可执行指令。 确定产品价格可以包括确定产品的初始市场吸引力值,市场价格敏感度和成本信息。 确定产品价格还可以包括根据初始市场吸引力值,市场价格敏感性,成本信息和市场约束来接收关于产品的市场约束和定价产品。

    Substituted pyrazolo-pyrimidine compounds
    3.
    发明授权
    Substituted pyrazolo-pyrimidine compounds 有权
    取代的吡唑并嘧啶化合物

    公开(公告)号:US08343983B2

    公开(公告)日:2013-01-01

    申请号:US12751404

    申请日:2010-03-31

    CPC分类号: C07D471/16 C07D487/16

    摘要: The present invention relates to substituted pyrazolo-pyrimidine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted pyrazolo-pyrimidine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.

    摘要翻译: 本发明涉及取代的吡唑并嘧啶化合物及其合成方法。 本发明还涉及含有取代的吡唑并嘧啶化合物的药物组合物和通过将这些化合物或药物组合物施用于有需要的受试者来治疗细胞增殖性疾病如癌症的方法。

    Bicyclic heterocyclic p-38 kinase inhibitors
    6.
    发明申请
    Bicyclic heterocyclic p-38 kinase inhibitors 失效
    双环杂环p-38激酶抑制剂

    公开(公告)号:US20070142405A1

    公开(公告)日:2007-06-21

    申请号:US10584076

    申请日:2004-12-23

    摘要: Provided are bicyclic heterocycle-based p38 kinase, including p38α and p38β kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and compositions are also provided, including methods of treatment, prevention, or amelioration of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders.

    摘要翻译: 提供基于双环杂环的p38激酶,包括p38alpha和p38beta激酶抑制剂。 还提供了含有这些化合物的药物组合物。 还提供了使用化合物和组合物的方法,包括治疗,预防或改善p38激酶介导的疾病和病症(包括但不限于炎性疾病和病症)的一种或多种症状的方法。

    Substituted pyrrolo-aminopyrimidine compounds
    7.
    发明授权
    Substituted pyrrolo-aminopyrimidine compounds 有权
    取代的吡咯并 - 氨基嘧啶化合物

    公开(公告)号:US08580803B2

    公开(公告)日:2013-11-12

    申请号:US12981138

    申请日:2010-12-29

    CPC分类号: C07D487/04

    摘要: The present invention relates to substituted pyrrolo-aminopyrimidine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted pyrrolo-aminopyrimidine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof. The substituted pyrrolo-aminopyrimidine compounds have the following general formula:

    摘要翻译: 本发明涉及取代的吡咯并 - 氨基嘧啶化合物及其合成方法。 本发明还涉及含有取代的吡咯并 - 氨基嘧啶化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗细胞增殖性疾病如癌症的方法。 取代的吡咯并 - 氨基嘧啶化合物具有以下通式:

    Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
    8.
    发明授权
    Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer 有权
    吡咯烷酮,吡咯烷-2,5-二酮,吡咯烷和硫代琥珀酰亚胺衍生物,治疗癌症的组合物和方法

    公开(公告)号:US08304425B2

    公开(公告)日:2012-11-06

    申请号:US12664550

    申请日:2008-06-19

    IPC分类号: A01N43/42 A61K31/44

    CPC分类号: C07D403/14

    摘要: The present invention relates to pyrrolidin-2-one, pyrrolidin-2,5-dione, pyrrolidine and thiosucciniroide compounds of formulae (I)-(IV), and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrrolidin-2-one, pyrrolidin-2,5-dione, pyrrolidine and thiosuccinimide compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound of pyrrolidin-2-one, pyrrolidin-2,5-dione, pyrrolidine and thiosuccinimide compound of the present invention.

    摘要翻译: 本发明涉及式(I) - (IV)的吡咯烷-2-酮,吡咯烷-2,5-二酮,吡咯烷和硫代半胱氨酰化合物及其制备方法。 本发明还涉及包含吡咯烷-2-酮,吡咯烷-2,5-二酮,吡咯烷和硫代琥珀酰亚胺化合物的药物组合物。 本发明提供了治疗细胞增殖性疾病如癌症的方法,通过向有需要的受试者施用治疗有效量的吡咯烷-2-酮,吡咯烷-2,5-二酮,吡咯烷和硫代琥珀酰亚胺的化合物 本发明化合物。