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19 条记录 (耗时 0.034 秒)

    4-Phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives
    4.
    发明授权
    4-Phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives 失效
    4-苯基-6-取代 - 嘧啶-2-甲腈衍生物

    公开(公告)号：US07326715B2

    公开(公告)日：2008-02-05

    申请号：US11524841

    申请日：2006-09-21

    申请人： Zoran Rankovic ,  Jiaqiang Cai

    发明人： Zoran Rankovic ,  Jiaqiang Cai

    IPC分类号： C07D239/34 ,  C07D239/38 ,  C07D239/42 ,  A61K31/505 ,  A61P9/10 ,  A61P19/02 ,  A61P19/10 ,  A61P29/00

    CPC分类号： C07D239/42 ,  C07D239/34 ,  C07D239/38 ,  C07D403/12

    摘要： Disclosed herein are 4-phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives having Formula I, wherein each of the substituents is given the definition as set forth in the specification and claims; or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions comprising these 4-phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives and use of these 4-phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives for the treatment of cathepsin K and cathepsin S related disorders, e.g. osteoporosis, atherosclerosis, inflammation and immune disorders such as rheumatoid arthritis and chronic pain.

    摘要翻译： 本文公开了具有式I的4-苯基-6-取代 - 嘧啶-2-甲腈衍生物，其中每个取代基被给出如说明书和权利要求书中所阐述的定义; 或其药学上可接受的盐。 还公开了包含这些4-苯基-6-取代 - 嘧啶-2-甲腈衍生物的药物组合物和这些4-苯基-6-取代 - 嘧啶-2-甲腈衍生物用于治疗组织蛋白酶K和组织蛋白酶S相关病症 ，例如 骨质疏松症，动脉粥样硬化，炎症和免疫疾病如类风湿性关节炎和慢性疼痛。

    4-phenyl-pyrimidine-2-carbonitrile derivatives
    5.
    发明授权
    4-phenyl-pyrimidine-2-carbonitrile derivatives 失效
    4-苯基 - 嘧啶-2-甲腈衍生物

    公开(公告)号：US07589095B2

    公开(公告)日：2009-09-15

    申请号：US11628623

    申请日：2005-06-09

    申请人： Jiaqiang Cai ,  Zoran Rankovic ,  Jennifer Helen Moir

    发明人： Jiaqiang Cai ,  Zoran Rankovic ,  Jennifer Helen Moir

    IPC分类号： C07D239/28 ,  A61K31/505 ,  A61P9/10 ,  A61P19/02 ,  A61P19/10 ,  A61P29/00

    CPC分类号： C07D239/28

    摘要： The invention relates to 4-phenyl-pyrimidine-2-carbonitrile derivatives having the general formula I wherein each of the substituents is given the definition as set forth in the specification and claims, or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising the derivatives as well as to the use thereof in the treatment of osteoporosis, atherosclerosis, inflammation and immune disorders, such as rheumatoid arthritis, and chronic pain, such as neuropathic pain.

    摘要翻译： 本发明涉及具有通式I的4-苯基 - 嘧啶-2-甲腈衍生物，其中每个取代基被给出如说明书和权利要求书中所述的定义，或其药学上可接受的盐。 本发明还涉及包含衍生物的药物组合物以及其在治疗骨质疏松症，动脉粥样硬化，炎症和免疫疾病如类风湿性关节炎和慢性疼痛如神经性疼痛中的用途。

    4-Phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives
    6.
    发明申请
    4-Phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives 失效
    4-苯基-6-取代 - 嘧啶-2-甲腈衍生物

    公开(公告)号：US20070111992A1

    公开(公告)日：2007-05-17

    申请号：US11524841

    申请日：2006-09-21

    申请人： Zoran Rankovic ,  Jiaqiang Cai

    发明人： Zoran Rankovic ,  Jiaqiang Cai

    IPC分类号： A61K31/551 ,  A61K31/5377 ,  A61K31/513 ,  C07D413/02 ,  C07D403/02

    CPC分类号： C07D239/42 ,  C07D239/34 ,  C07D239/38 ,  C07D403/12

    摘要： Disclosed herein are 4-phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives having Formula I, wherein each of the substituents is given the definition as set forth in the specification and claims; or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions comprising these 4-phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives and use of these 4-phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives for the treatment of cathepsin K and cathepsin S related disorders, e.g. osteoporosis, atherosclerosis, inflammation and immune disorders such as rheumatoid arthritis and chronic pain.

    摘要翻译： 本文公开了具有式I的4-苯基-6-取代 - 嘧啶-2-甲腈衍生物，其中每个取代基被给出如说明书和权利要求书中所阐述的定义; 或其药学上可接受的盐。 还公开了包含这些4-苯基-6-取代 - 嘧啶-2-甲腈衍生物的药物组合物和这些4-苯基-6-取代 - 嘧啶-2-甲腈衍生物用于治疗组织蛋白酶K和组织蛋白酶S相关病症 ，例如 骨质疏松症，动脉粥样硬化，炎症和免疫疾病如类风湿性关节炎和慢性疼痛。

    6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives
    7.
    发明申请
    6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives 失效
    6-苯基-1H-咪唑并[4,5-c]吡啶-4-甲腈衍生物

    公开(公告)号：US20070179138A1

    公开(公告)日：2007-08-02

    申请号：US11653600

    申请日：2007-01-16

    申请人： Jiaqiang Cai ,  Zoran Rankovic ,  Philip Jones ,  David Bennett ,  Iain Cumming ,  Jonathan Gillespie

    发明人： Jiaqiang Cai ,  Zoran Rankovic ,  Philip Jones ,  David Bennett ,  Iain Cumming ,  Jonathan Gillespie

    IPC分类号： A61K31/5377 ,  A61K31/496 ,  A61K31/4745 ,  C07D471/02

    CPC分类号： C07D471/04

    摘要： The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives having the general Formula I wherein each of the substituents is given the definition as set forth in the specification and claims, pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S and/or cathepsin K related diseases such as osteoporosis, atherosclerosis, inflammation and immune disorders, such as rheumatoid arthritis, and chronic pain, such as neuropathic pain.

    摘要翻译： 本发明涉及具有通式I的6-苯基-1H-咪唑并[4,5-c]吡啶-4-腈衍生物，其中每个取代基被给出如说明书和权利要求书中所阐述的定义，药物组合物 包括这些以及这些衍生物用于制备用于治疗组织蛋白酶S和/或组织蛋白酶K相关疾病如骨质疏松症，动脉粥样硬化，炎症和免疫疾病如类风湿性关节炎和慢性疼痛的药物的用途 ，如神经性疼痛。