公开(公告)号：US20100267678A1

公开(公告)日：2010-10-21

申请号：US12761540

申请日：2010-04-16

申请人： Jie Zhang ,  Kevin S. Warner ,  Sanjay Sharma

发明人： Jie Zhang ,  Kevin S. Warner ,  Sanjay Sharma

IPC分类号： A61K31/60 ,  A61K31/522 ,  A61K31/4174 ,  A61K31/137 ,  A61K31/167 ,  A61K31/445 ,  A61K31/245 ,  A61K31/517 ,  A61K31/573 ,  A61K31/58 ,  A61K31/4025 ,  A61K31/203 ,  A61K31/327 ,  A61K31/192 ,  A61K31/5415 ,  A61K31/196 ,  A61K31/405 ,  A61K31/437 ,  A61P29/00 ,  A61P17/00 ,  A61P31/00

CPC分类号： A61K9/7007 ,  A61K9/7015

摘要： The present invention is drawn to adhesive solidifying formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system comprising at least one volatile solvent, and a non-volatile solvent system comprising at least one non-volatile solvent, wherein at least one non-volatile solvent is a flux-enabling non-volatile solvent(s) capable of facilitating the delivery of the drug at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.

摘要翻译： 本发明涉及粘合剂凝固制剂，药物递送方法和用于药物真皮递送的固化层。 制剂可以包括药物，溶剂载体和固化剂。 溶剂载体可以包括包含至少一种挥发性溶剂的挥发性溶剂体系和包含至少一种非挥发性溶剂的非挥发性溶剂体系，其中至少一种非挥发性溶剂是助熔剂非挥发性溶剂（ s），其能够在持续的时间段内以治疗有效率促进药物的递送。 在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。 当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发后，制剂可以形成固化层。

公开(公告)号：US20130022564A1

公开(公告)日：2013-01-24

申请号：US13556089

申请日：2012-07-23

申请人： Jie Zhang ,  Kevin S. Warner ,  Sanjay Sharma

发明人： Jie Zhang ,  Kevin S. Warner ,  Sanjay Sharma

IPC分类号： A61K31/522 ,  A61P31/12 ,  A61P31/10 ,  A61K31/4174

CPC分类号： A61K31/74 ,  A61K9/0014 ,  A61K9/7015 ,  A61K31/4174 ,  A61K31/522 ,  A61K47/12 ,  A61K47/18 ,  A61K47/32 ,  A61K47/38

摘要： The present invention is drawn to solidifying adhesive formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug for treating various skin infections, such as fungal, bacterial, and/or viral skin infections. The formulation can include anti-infective drug, solvent vehicle, and solidifying agent. The solvent vehicle can include a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent. The non-volatile solvent system can facilitate the delivery of the drug at therapeutically effective rates for sustained periods of time. The non-volatile solvent system can also act to plasticize the solidifying agent. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.

摘要翻译： 本发明涉及固化粘合剂制剂，药物递送方法和用于皮肤递送用于治疗各种皮肤感染例如真菌，细菌和/或病毒性皮肤感染的药物的固化层。 制剂可以包括抗感染药物，溶剂载体和固化剂。 溶剂载体可以包括包含至少一种挥发性溶剂的挥发性溶剂体系和包含至少一种非挥发性溶剂的非挥发性溶剂体系。 非挥发性溶剂体系可以有助于以治疗有效率持续持续时间的药物递送。 非挥发性溶剂体系也可以起到塑化固化剂的作用。 在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。 当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发后，制剂可以形成固化层。

公开(公告)号：US20120301517A1

公开(公告)日：2012-11-29

申请号：US13566147

申请日：2012-08-03

申请人： Jie Zhang ,  Kevin S. Warner ,  Sanjay Sharma

发明人： Jie Zhang ,  Kevin S. Warner ,  Sanjay Sharma

IPC分类号： A61K9/70 ,  A61K31/522 ,  A61K31/192 ,  A61K31/437 ,  A61K31/167 ,  A61K31/135 ,  A61K31/566 ,  A61K31/445

CPC分类号： A61K9/7015 ,  A61K31/473 ,  A61K31/513 ,  A61K31/573 ,  A61K47/10 ,  A61K47/42

摘要： The present invention is drawn to adhesive formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a solidifying agent. The solvent vehicle can have a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least two non-volatile solvents. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.

摘要翻译： 本发明涉及粘合剂制剂，药物递送方法和用于药物真皮递送的固化层。 制剂可以包括药物，溶剂载体和固化剂。 溶剂载体可以具有包括至少一种挥发性溶剂的挥发性溶剂体系和包含至少两种非挥发性溶剂的非挥发性溶剂体系。 在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。 当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发后，制剂可以形成固化层。

公开(公告)号：US20120294926A1

公开(公告)日：2012-11-22

申请号：US13566273

申请日：2012-08-03

申请人： Jie Zhang ,  Kevin S. Warner ,  Sanjay Sharma

发明人： Jie Zhang ,  Kevin S. Warner ,  Sanjay Sharma

IPC分类号： A61K9/70 ,  A61K31/522 ,  A61K31/192 ,  A61K31/196 ,  A61K31/568 ,  A61K31/445 ,  A61K31/4745 ,  A61K31/167 ,  A61K31/135 ,  A61K47/10 ,  A61K47/06 ,  A61K47/08 ,  A61K47/14 ,  A61K47/24 ,  A61K47/12 ,  A61K47/18 ,  A61K47/32 ,  A61K47/42 ,  A61P29/00 ,  A61P17/14 ,  A61P17/00 ,  A61P17/06 ,  A61P31/12 ,  A61P31/04 ,  A61P31/10 ,  A61K31/567

CPC分类号： A61K9/7015 ,  A61K31/473 ,  A61K31/513 ,  A61K31/573 ,  A61K47/10 ,  A61K47/42

摘要： The present invention is drawn to adhesive formulations and methods of drug delivery. The formulation can include a drug, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system including at least two volatile solvents, and a non-volatile solvent system including at least one non-volatile solvent, wherein at least one non-volatile solvent is capable of facilitating the delivery of the drug at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.

摘要翻译： 本发明涉及药物递送的粘合剂制剂和方法。 制剂可以包括药物，溶剂载体和固化剂。 溶剂载体可以包括包含至少两种挥发性溶剂的挥发性溶剂体系和包含至少一种非挥发性溶剂的非挥发性溶剂体系，其中至少一种非挥发性溶剂能够有助于将药物递送到 持续的治疗有效率。 在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。 当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发后，制剂可以形成固化层。

公开(公告)号：US20090181954A1

公开(公告)日：2009-07-16

申请号：US12340246

申请日：2008-12-19

申请人： Sanjay Sharma ,  Kevin S. Warner ,  Jie Zhang ,  Guang Yan

发明人： Sanjay Sharma ,  Kevin S. Warner ,  Jie Zhang ,  Guang Yan

IPC分类号： A61K31/5513 ,  A61K47/10 ,  A61K31/485 ,  A61K31/519 ,  A61P25/22

CPC分类号： A61K31/519 ,  A61K9/0014 ,  A61K9/7023 ,  A61K9/7084 ,  A61K31/485 ,  A61K31/5517 ,  A61K45/06 ,  A61K47/10 ,  A61K47/183

摘要： The present invention is drawn to transdermal drug formulations, transdermal patches incorporating such formulations, as well as associated methods. The formulations can include about 0.3 wt % to about 5 wt % of a drug, such as alprazolam, about 4 wt % to about 30 wt % water, about 10 wt % to about 40 wt % glycerol, about 0.5 wt % to about 6 wt % oleyl alcohol. Other co-solvents and/or additives can be present to achieve a 100 wt % formulation.

摘要翻译： 本发明涉及透皮药物制剂，包含这种制剂的透皮贴剂以及相关方法。 制剂可以包括约0.3重量％至约5重量％的药物，例如阿普唑仑，约4重量％至约30重量％的水，约10重量％至约40重量％的甘油，约0.5重量％至约6重量％ 重量％油醇。 可以存在其它共溶剂和/或添加剂以实现100重量％的配方。

公开(公告)号：US08927537B2

公开(公告)日：2015-01-06

申请号：US12340246

申请日：2008-12-19

申请人： Sanjay Sharma ,  Kevin S. Warner ,  Jie Zhang ,  Guang Yan

发明人： Sanjay Sharma ,  Kevin S. Warner ,  Jie Zhang ,  Guang Yan

IPC分类号： A01N43/62 ,  A61K31/55 ,  C07D513/00 ,  C07D515/00 ,  C07D487/12 ,  A61K9/70 ,  A61K31/485 ,  A61K31/519 ,  A61K31/5517 ,  A61K9/00 ,  A61K47/10

CPC分类号： A61K31/519 ,  A61K9/0014 ,  A61K9/7023 ,  A61K9/7084 ,  A61K31/485 ,  A61K31/5517 ,  A61K45/06 ,  A61K47/10 ,  A61K47/183

摘要： The present invention is drawn to transdermal drug formulations, transdermal patches incorporating such formulations, as well as associated methods. The formulations can include about 0.3 wt % to about 5 wt % of a drug, such as alprazolam, about 4 wt % to about 30 wt % water, about 10 wt % to about 40 wt % glycerol, about 0.5 wt % to about 6 wt % oleyl alcohol. Other co-solvents and/or additives can be present to achieve a 100 wt % formulation.

公开(公告)号：US08741333B2

公开(公告)日：2014-06-03

申请号：US11640140

申请日：2006-12-14

申请人： Jie Zhang ,  Kevin S. Warner ,  Sanjay Sharma

发明人： Jie Zhang ,  Kevin S. Warner ,  Sanjay Sharma

IPC分类号： A61F13/00 ,  A61K9/00 ,  A61K9/70 ,  A61L26/00

CPC分类号： A61K47/32 ,  A61K9/0014 ,  A61K9/08 ,  A61K9/7015 ,  A61K31/569 ,  A61K31/573 ,  A61K31/59 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/34 ,  A61K47/44 ,  A61L26/0076

摘要： The present invention is drawn to adhesive solidifying formulations for treating skin disorders, such as dermatitis or psoriasis. The formulation can include a drug, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent, wherein the non-volatile solvent system is capable of facilitating the delivery of the drug at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.

摘要翻译： 本发明涉及用于治疗皮肤病，如皮炎或牛皮癣的粘合剂固化剂。 制剂可以包括药物，溶剂载体和固化剂。 溶剂载体可以包括包含至少一种挥发性溶剂的挥发性溶剂体系和包括至少一种非挥发性溶剂的非挥发性溶剂体系，其中所述非挥发性溶剂体系能够促进药物在治疗上的递送 有效率在一段持续的时间内。 在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。 当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发后，制剂可以形成固化层。

公开(公告)号：US08741332B2

公开(公告)日：2014-06-03

申请号：US11640139

申请日：2006-12-14

申请人： Jie Zhang ,  Kevin S. Warner ,  Sanjay Sharma

发明人： Jie Zhang ,  Kevin S. Warner ,  Sanjay Sharma

IPC分类号： A61F13/00 ,  A61K9/00 ,  A61K9/70 ,  A61L26/00

CPC分类号： A61K9/0014 ,  A61K9/7015 ,  A61L26/0066 ,  A61L26/0076 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/602

摘要： The present invention is drawn to adhesive solidifying formulations for treating neuropathic pain. The formulation can include a drug suitable for treating neuropathic pain, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent capable of facilitating the delivery of the drug at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.

摘要翻译： 本发明涉及用于治疗神经性疼痛的粘合剂固化剂。 制剂可以包括适合于治疗神经性疼痛的药物，溶剂载体和固化剂。 溶剂载体可以包括包含至少一种挥发性溶剂的挥发性溶剂体系和包含至少一种能够在持续的时间内以治疗有效速率递送药物的至少一种非挥发性溶剂的非挥发性溶剂体系。 在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。 当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发后，制剂可以形成固化层。

公开(公告)号：US20120294907A1

公开(公告)日：2012-11-22

申请号：US13567289

申请日：2012-08-06

申请人： Jie Zhang ,  Kevin S. Warner ,  Sanjay Sharma

发明人： Jie Zhang ,  Kevin S. Warner ,  Sanjay Sharma

IPC分类号： A61K47/32 ,  A61K31/573 ,  A61K31/192 ,  A61K31/167 ,  A61P17/06 ,  A61K31/196 ,  A61K31/522 ,  A61P25/04 ,  A61P29/00 ,  A61K9/70 ,  A61K31/445

CPC分类号： A61K9/7015 ,  A61F13/0253 ,  A61K31/473 ,  A61K31/513 ,  A61K31/573 ,  A61K47/10 ,  A61K47/42 ,  A61L15/44 ,  A61L15/58 ,  A61L2300/402

摘要： The present invention is drawn to adhesive solidifying formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and at least two solidifying agents. The solvent vehicle can include a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent, wherein at least one non-volatile solvent is flux-enabling non-volatile solvent(s) capable of facilitating the delivery of the drug at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.

摘要翻译： 本发明涉及粘合剂凝固制剂，药物递送方法和用于药物真皮递送的固化层。 制剂可以包括药物，溶剂载体和至少两种固化剂。 溶剂载体可以包括包含至少一种挥发性溶剂的挥发性溶剂体系和包括至少一种非挥发性溶剂的非挥发性溶剂体系，其中至少一种非挥发性溶剂是助熔剂的非挥发性溶剂 ），其能够在持续的时间段内以治疗有效率促进药物的递送。 在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。 当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发后，制剂可以形成固化层。

公开(公告)号：US20090005745A1

公开(公告)日：2009-01-01

申请号：US12156473

申请日：2008-05-30

申请人： Jie Zhang ,  Kevin S. Warner

发明人： Jie Zhang ,  Kevin S. Warner

IPC分类号： A61K9/70 ,  A61F7/08

CPC分类号： A61F7/034 ,  A61F7/007 ,  A61F2007/0078 ,  A61K9/7061 ,  A61K31/192 ,  A61K31/196 ,  A61M37/00 ,  A61M37/0092

摘要： Systems for delivering an anti-inflammatory drug and methods for treating osteoarthritis are provided. Such systems can comprise, in one embodiment, a transdermal patch with a sufficient amount of anti-inflammatory drug in a formulation for sustained transdermal delivery at a human skin site. The system can further include a permeation composition or device, such as a heating device. The heating device can be configured for application over the transdermal patch and the human skin site. Further, the heating device can be configured for heating the human skin site to a specific temperature range from 36° C. to 42° C., and for maintaining the human skin site within that temperature range for a period of at least 4 or 5 hours.

摘要翻译： 提供用于递送抗炎药物的系统和治疗骨关节炎的方法。 在一个实施方案中，这样的系统可以包括在人皮肤部位用于持续经皮递送的制剂中具有足够量的抗炎药物的透皮贴剂。 该系统还可以包括渗透组合物或装置，例如加热装置。 加热装置可以配置用于施用于透皮贴剂和人皮肤部位上。 此外，加热装置可以被配置用于将人皮肤部位加热至特定的温度范围为36℃至42℃，并且用于将人皮肤部位保持在该温度范围内至少4或5 小时。