公开(公告)号：US20110077414A1

公开(公告)日：2011-03-31

申请号：US12686996

申请日：2010-01-13

申请人： Jih-Ru Hwu ,  Yu-Sern Lin ,  Chen-Sheng Yeh ,  Dar-Bin Shieh

发明人： Jih-Ru Hwu ,  Yu-Sern Lin ,  Chen-Sheng Yeh ,  Dar-Bin Shieh

IPC分类号： C07D305/14

CPC分类号： C07F9/65512 ,  A61K47/6923

摘要： A phosphate-containing nanoparticle delivery vehicle includes a nanoparticle, an active ingredient, and a phosphodiester moiety connecting the nanoparticle and the active ingredient and forms a prodrug. The nanoparticle delivery vehicle achieves the function of increasing hydrophilicity of the active ingredient and specificity against tumor cells. Advantages of the nanoparticle material include biocompatibility, magnetism and/or controllable drug release.

摘要翻译： 含磷酸盐的纳米颗粒递送载体包括连接纳米颗粒和活性成分并形成前药的纳米颗粒，活性成分和磷酸二酯部分。 纳米颗粒递送载体实现增加活性成分的亲水性和对肿瘤细胞的特异性的功能。 纳米颗粒材料的优点包括生物相容性，磁性和/或可控制的药物释放。

公开(公告)号：US08679542B2

公开(公告)日：2014-03-25

申请号：US12782170

申请日：2010-05-18

申请人： Dar-Bin Shieh ,  Tsung-Lin Tsai ,  Wu-Chou Su ,  Kao-Shu Chuang ,  Jih-Ru Hwu

发明人： Dar-Bin Shieh ,  Tsung-Lin Tsai ,  Wu-Chou Su ,  Kao-Shu Chuang ,  Jih-Ru Hwu

IPC分类号： A61K48/00 ,  C12M1/34 ,  A61P43/00 ,  A61K9/00 ,  G01N27/26

CPC分类号： C12N15/111 ,  A61K47/549 ,  C12N2310/11 ,  C12N2310/152 ,  C12N2310/3511

摘要： A nucleic acid cleavage kit is used to cleave a target nucleic acid. The nucleic acid cleavage kit includes a carrier, an oligonucleotide, and a nucleic acid cleavage agent. The oligonucleotide recognizes at least partial sequence of the target nucleic acid. Then, the nucleic acid cleavage agent cleaves the target nucleic acid. A nucleic acid cleavage detection apparatus including the nucleic acid cleaving kit and a gene therapy by administering the nucleic acid cleavage kit are also disclosed.

摘要翻译： 核酸切割试剂盒用于切割靶核酸。 核酸切割试剂盒包括载体，寡核苷酸和核酸切割剂。 寡核苷酸识别靶核酸的至少部分序列。 然后，核酸裂解剂切割靶核酸。 还公开了包括核酸切割试剂盒和通过施用核酸切割试剂盒的基因治疗的核酸切割检测装置。

公开(公告)号：US07585826B2

公开(公告)日：2009-09-08

申请号：US11726703

申请日：2007-03-22

申请人： Jih-Ru Hwu ,  Shwu-Chen Tsay

发明人： Jih-Ru Hwu ,  Shwu-Chen Tsay

IPC分类号： A61K31/28

CPC分类号： A62D3/38 ,  A61L9/01 ,  A62D2101/04 ,  Y10S71/903

摘要： This invention relates to compositions that counteract chemicals such as pesticides and malodorants. Also disclosed are a method for preparing such compositions and a method for applying such compositions to counteract pesticides or malordorants.

摘要翻译： 本发明涉及抵抗诸如杀虫剂和恶臭剂的化学物质的组合物。 还公开了制备这种组合物的方法以及用于施用这样的组合物以抵抗农药或恶臭剂的方法。

公开(公告)号：US20090098098A1

公开(公告)日：2009-04-16

申请号：US12240755

申请日：2008-09-29

申请人： Jih-Ru Hwu ,  Shwu-Chen Tsay

发明人： Jih-Ru Hwu ,  Shwu-Chen Tsay

IPC分类号： A01N59/20 ,  A01N59/16 ,  A01N55/02 ,  A01N43/14 ,  A01P1/00 ,  A01P3/00

CPC分类号： A61L2/22 ,  A61K31/28 ,  A61K33/24 ,  A61K45/06 ,  A61L2/186 ,  A61K2300/00

摘要： The present invention relates to an anti-bacterial, anti-virus, and anti-fungus composition, its preparation and use. The composition of the present invention mainly includes the following three ingredients in an adequate ratio: (A) a metal compound having a catalytic function; (B) a mixture of a coenzyme having reducing ability and quinones, and (C) an additive. The anti-bacterial, anti-virus, and anti-fungus composition of the present invention is capable of destroying viruses as well as killing bacterial and fungi. Therefore, the composition can be formulated as an aerosol and a film for applying to protection devices such as respirators, masks, gloves, filters, condoms, etc. The present composition can also be used in household, vehicle, hospital, school, restaurant, hotel, internet coffee shop for applying to filter of air-conditioner, tap, stool, interior of elevator and its keyboard. Additionally, the present composition can be applied to human being such as applying to hand, foot, genital organs, oral cavity, and the like in a lower dose to attain the effect of destroying of bacteria, viruses, and fungi.

摘要翻译： 本发明涉及抗菌，抗病毒和抗真菌组合物，其制备和应用。 本发明的组合物主要包括足够比例的以下三种成分：（A）具有催化功能的金属化合物; （B）具有还原能力的辅酶和醌类的混合物，和（C）添加剂。 本发明的抗细菌，抗病毒和抗真菌组合物能够破坏病毒以及杀死细菌和真菌。 因此，该组合物可以配制成用于应用于诸如呼吸器，面罩，手套，过滤器，避孕套等保护装置的气雾剂和膜。本发明组合物还可以用于家庭，车辆，医院，学校，餐厅， 酒店，互联网咖啡店，适用于空调，水龙头，凳子，电梯内部及其键盘。 此外，本发明的组合物可以以较低剂量施用于人，例如施用于手，脚，生殖器，口腔等，以达到破坏细菌，病毒和真菌的效果。

公开(公告)号：US07387799B2

公开(公告)日：2008-06-17

申请号：US10628259

申请日：2003-07-29

申请人： Jih-Ru Hwu ,  Shwu-Chen Tsay

发明人： Jih-Ru Hwu ,  Shwu-Chen Tsay

IPC分类号： A01N59/00 ,  A01N59/08 ,  A01N59/16 ,  A01N55/02 ,  A61K33/26 ,  A61K33/30 ,  A61K33/00 ,  A61K31/295 ,  A61K31/315 ,  A61K33/24

CPC分类号： A61L2/22 ,  A61K31/28 ,  A61K33/24 ,  A61K45/06 ,  A61L2/186 ,  A61K2300/00

摘要： The present invention relates to an anti-bacterial, anti-viral, and anti-fungus composition, its preparation and use. The composition of the present invention mainly includes the following three ingredients in an adequate ratio: (A) a metal compound having catalytic function; (B) ionic compound, and (C) an additive. The anti-bacterial, anti-virus, and anti-fungus composition of the present invention is capable of destroying viruses as well as killing bacterial and fungi. Therefore, the composition can be formulated as an aerosol and a film for applying to protection devices such as respirators, masks, gloves, filters, condoms, etc. The present composition can also be used in household, vehicle, hospital, school, restaurant, hotel, internet coffee shop for applying to filter of air-conditioner, tap, stool, interior of elevator and its keyboard. Additionally, the present composition can be applied to human being such as applying to hand, foot, genital organs, oral cavity, and the like in a lower dose to attain the effect of destroying bacteria, viruses, and fungi.

摘要翻译： 本发明涉及抗细菌，抗病毒和抗真菌组合物，其制备和应用。 本发明的组合物主要包括以下三种成分：（A）具有催化功能的金属化合物; （B）离子化合物，（C）添加剂。 本发明的抗细菌，抗病毒和抗真菌组合物能够破坏病毒以及杀死细菌和真菌。 因此，该组合物可以配制成用于应用于诸如呼吸器，面罩，手套，过滤器，避孕套等保护装置的气雾剂和膜。本发明组合物还可以用于家庭，车辆，医院，学校，餐厅， 酒店，互联网咖啡店，适用于空调，水龙头，凳子，电梯内部及其键盘。 此外，本发明的组合物可以以较低剂量施用于人体，例如施用于手，脚，生殖器，口腔等，以达到破坏细菌，病毒和真菌的效果。

公开(公告)号：US20060246148A1

公开(公告)日：2006-11-02

申请号：US11344235

申请日：2006-02-01

申请人： Jih-Ru Hwu ,  Shwu-Chen Tsay

发明人： Jih-Ru Hwu ,  Shwu-Chen Tsay

IPC分类号： A61K38/43 ,  A61K31/28 ,  A61K31/315 ,  A61K33/42 ,  A61K33/40 ,  A61K33/24 ,  A61K33/26 ,  A61K31/12

CPC分类号： A61K31/12 ,  A01N59/16 ,  A01N59/20 ,  A61K31/28 ,  A61K31/315 ,  A61K31/7084 ,  A61K33/00 ,  A61K33/24 ,  A61K33/40 ,  A61K45/06 ,  C11D3/38654 ,  C11D3/3947 ,  C11D3/48 ,  C11D7/10 ,  A01N57/16 ,  A01N59/00 ,  A01N59/02 ,  A01N59/04 ,  A01N59/06 ,  A01N59/08 ,  A01N59/26 ,  A01N61/00 ,  A01N2300/00

摘要： The present invention relates to an anti-bacterial, anti-virus, and anti-fungus composition, its preparation and use. The composition of the present invention mainly includes the following three ingredients in an adequate ratio: (A) a metal compound having a catalytic function; (B) a mixture of a coenzyme having reducing ability and an agent having oxidizing ability; and (C) an additive. The anti-bacterial, anti-virus, and anti-fungus composition of the present invention is capable of destroying viruses as well as killing bacterial and fungi. Therefore, the composition can be formulated as an aerosol and a film for applying to protection devices such as respirators, masks, gloves, filters, condoms, etc. The present composition can also be used in household, vehicle, hospital, school, restaurant, hotel, internet coffee shop for applying to filter of air-conditioner, tap, stool, interior of elevator and its keyboard. Additionally, the present composition can be applied to human being such as applying to hand, foot, genital organs, oral cavity, and the like in a lower dose to attain the effect of destroying of bacteria, viruses, and fungi.

摘要翻译： 本发明涉及抗菌，抗病毒和抗真菌组合物，其制备和应用。 本发明的组合物主要包括足够比例的以下三种成分：（A）具有催化功能的金属化合物; （B）具有还原能力的辅酶和具有氧化能力的试剂的混合物; 和（C）添加剂。 本发明的抗细菌，抗病毒和抗真菌组合物能够破坏病毒以及杀死细菌和真菌。 因此，该组合物可以配制成用于应用于诸如呼吸器，面罩，手套，过滤器，避孕套等保护装置的气雾剂和膜。本发明组合物还可以用于家庭，车辆，医院，学校，餐厅， 酒店，互联网咖啡店，适用于空调，水龙头，凳子，电梯内部及其键盘。 此外，本发明的组合物可以以较低剂量施用于人，例如施用于手，脚，生殖器，口腔等，以达到破坏细菌，病毒和真菌的效果。

公开(公告)号：US20070152569A1

公开(公告)日：2007-07-05

申请号：US11324480

申请日：2006-01-04

申请人： Jih-Ru Hwu ,  Shwu-Chen Tsay ,  Kao-Shuh Chuang

发明人： Jih-Ru Hwu ,  Shwu-Chen Tsay ,  Kao-Shuh Chuang

IPC分类号： H01L51/00 ,  C07D405/02

CPC分类号： H01L51/0073 ,  C07D307/86

摘要： The present invention relates to novel benzo[b]furan derivatives, particular to novel benzo[b]furan derivatives having substituents at the 4-position. The present invention also relates to a use of the benzo[b]furan derivatives as electroluminescent material in OLED.

摘要翻译： 本发明涉及新的苯并[b]呋喃衍生物，特别涉及在4-位具有取代基的新的苯并[b]呋喃衍生物。 本发明还涉及苯并[b]呋喃衍生物作为OLED中的电致发光材料的用途。

公开(公告)号：US06812247B2

公开(公告)日：2004-11-02

申请号：US10261130

申请日：2002-09-30

申请人： Kuang-Lieh Lu ,  Jih-Ru Hwu ,  Shwu-Chen Tsay ,  Sheng-Fa Yu ,  Jui-Te Hung ,  Jiann-Jyh Huang

发明人： Kuang-Lieh Lu ,  Jih-Ru Hwu ,  Shwu-Chen Tsay ,  Sheng-Fa Yu ,  Jui-Te Hung ,  Jiann-Jyh Huang

IPC分类号： A61K3324

CPC分类号： A61K31/282 ,  A61K31/555

摘要： A metal complex and its use for binding or cleaving a nucleic acid. The metal complex has the formula: M is Pt, Pd, Ni, Co, or Cu; X is aryl, heteroaryl, cyclyl, or heterocyclyl; Y is halogen, tosylate, mesylate, triflate, pyrophosphate, or carboxylate; each of A1 and A2, independently, is N or C; each of A3 and A4, independently, is N, S, or O, wherein A1, A2, A3, and A4 taken together have one positive charge; and each of R1 and R2, independently, is alkyl, aryl, heteroaryl, alkoxyl, aryloxyl, heteroaryloxyl, alkoxylcarbonyl, aryloxylcarbonyl, or heteroaryloxylcarbonyl.

摘要翻译： 金属络合物及其用于结合或切割核酸的用途。 金属络合物具有下式：M是Pt，Pd，Ni，Co或Cu; X是芳基，杂芳基，环基或杂环基; Y是卤素，甲苯磺酸酯，甲磺酸酯，三氟甲磺酸酯，焦磷酸酯或羧酸酯; A1和A2各自独立地为N或C; A3和A4各自独立地为N，S或O，其中A1，A2，A3和A4一起具有一个正电荷; R 1和R 2各自独立地是烷基，芳基，杂芳基，烷氧基，芳氧基，杂芳氧基，烷氧基羰基，芳氧基羰基或杂芳氧基羰基。

公开(公告)号：US06458833B1

公开(公告)日：2002-10-01

申请号：US09989768

申请日：2001-11-20

申请人： Kuang-Lieh Lu ,  Jih-Ru Hwu ,  Shwu-Chen Tsay ,  Sheng-Fa Yu ,  Jui-Te Hung ,  Jiann-Jyh Huang

发明人： Kuang-Lieh Lu ,  Jih-Ru Hwu ,  Shwu-Chen Tsay ,  Sheng-Fa Yu ,  Jui-Te Hung ,  Jiann-Jyh Huang

IPC分类号： A61K3324

CPC分类号： A61K31/282 ,  A61K31/555

摘要： A metal complex and its use for binding or cleaving a nucleic acid. The metal complex has the formula: M is Pt, Pd, Ni, Co, or Cu; X is aryl, heteroaryl, cyclyl, or heterocyclyl; Y is halogen, tosylate, mesylate, triflate, pyrophosphate, or carboxylate; each of A1 and A2, independently, is N or C; each of A3 and A4, independently, is N, S, or 0, wherein A1, A2, A3, and A4 taken together have one positive charge; and each of R1 and R2, independently, is alkyl, aryl, heteroaryl, alkoxyl, aryloxyl, heteroaryloxyl, alkoxylcarbonyl, aryloxylcarbonyl, or heteroaryloxylcarbonyl.

摘要翻译： 金属络合物及其用于结合或切割核酸的用途。 金属络合物具有下式：M是Pt，Pd，Ni，Co或Cu; X是芳基，杂芳基，环基或杂环基; Y是卤素，甲苯磺酸酯，甲磺酸酯，三氟甲磺酸酯，焦磷酸酯或羧酸酯; A1和A2各自独立地为N或C; A3和A4各自独立地为N，S或0，其中A1，A2，A3和A4一起具有一个正电荷; R 1和R 2各自独立地是烷基，芳基，杂芳基，烷氧基，芳氧基，杂芳氧基，烷氧基羰基，芳氧基羰基或杂芳氧基羰基。

公开(公告)号：US5679861A

公开(公告)日：1997-10-21

申请号：US481111

申请日：1995-06-07

申请人： Tung-Ying Kuo ,  Jih-Ru Hwu ,  Tsong-Ming Chang

发明人： Tung-Ying Kuo ,  Jih-Ru Hwu ,  Tsong-Ming Chang

IPC分类号： C07C211/42 ,  C08G69/26 ,  C07C211/36

CPC分类号： C08G69/26 ,  C07C211/42 ,  C07C2104/00

摘要： The present invention is directed to C.sub.60 diamine adducts, processes for preparing them and polymers prepared from them. C.sub.60 diamine adducts is a symmetrical icosahegron which is composed of 12 pentagons and 20 hexagons and links to 2 to 4 diamines. The processes for preparing the product comprises the steps of: adding C.sub.60 in benzene or toluene of a constant concentration to a certain amount of linear aliphatic diamine having the structural formula H.sub.2 N--(CH.sub.2)n--NH.sub.2 wherein n=2, 4 or 6 for reaction, or adding a definite amount of C.sub.60 directly to linear diamine of a definite concentration to produce C.sub.60 diamine adducts. Elemental analysis shows that the product contain about 5.9% nitrogen, about 72.6% carbon and about 3.84% hydrogen, and the number of diamine linked to C.sub.60 is in the range of 2 to 4. C.sub.60 diamine is useful as a polymerization monomer for the preparation of polyamides or relevant polymers.

摘要翻译： 本发明涉及C60二胺加合物，其制备方法和由它们制备的聚合物。 C60二胺加合物是一种对称的二十面体，由12个五边形和20个六边形组成，并连接到2至4个二胺。 制备产物的方法包括以下步骤：将C60在恒定浓度的苯或甲苯中加入到具有结构式H 2 N-（CH 2）n -NH 2的一定量的线性脂族二胺中，其中n = 2,4或6，用于 反应或将一定量的C60直接加入到确定浓度的线性二胺中以产生C 60二胺加合物。 元素分析表明，该产物含有约5.9％的氮，约72.6％的碳和约3.84％的氢，并且与C60连接的二胺的数量在2至4的范围内。C 60二胺可用作制备的聚合单体 的聚酰胺或相关聚合物。