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公开(公告)号：US06579871B2
公开(公告)日：2003-06-17
申请号：US10235005
申请日：2002-09-03
申请人： Jill Ann Panetta , John Kevin Shadle , Lawrence Joseph Heinz , Michael LeRoy Phillips , John Robert Rizzo , Benjamin Alan Anderson , John Allan Rieck, III , David Lee Varie
发明人： Jill Ann Panetta , John Kevin Shadle , Lawrence Joseph Heinz , Michael LeRoy Phillips , John Robert Rizzo , Benjamin Alan Anderson , John Allan Rieck, III , David Lee Varie
IPC分类号： A61K31425
CPC分类号： C07D263/57 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/14 , C07D263/32 , C07D271/06 , C07D277/24 , C07D277/26 , C07D413/06 , C07D413/12 , C07D417/12
摘要： This invention relates to novel phenyl oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents.
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公开(公告)号：US06472387B1
公开(公告)日：2002-10-29
申请号：US10109133
申请日：2002-03-27
申请人： Jill Ann Panetta , John Kevin Shadle , Lawrence Joseph Heinz , Michael LeRoy Phillips , John Robert Rizzo , Benjamin Alan Anderson , John Allan Rieck, III , David Lee Varie
发明人： Jill Ann Panetta , John Kevin Shadle , Lawrence Joseph Heinz , Michael LeRoy Phillips , John Robert Rizzo , Benjamin Alan Anderson , John Allan Rieck, III , David Lee Varie
IPC分类号： A61K31425
CPC分类号： C07D263/57 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/14 , C07D263/32 , C07D271/06 , C07D277/24 , C07D277/26 , C07D413/06 , C07D413/12 , C07D417/12
摘要： This invention relates to novel phenyl oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents.
摘要翻译： 本发明涉及可用作神经保护剂的新型苯基恶唑，噻唑，恶唑啉，恶二唑和苯并恶唑。
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公开(公告)号：US06448396B2
公开(公告)日：2002-09-10
申请号：US09159346
申请日：1998-09-23
申请人： Benjamin Alan Anderson , Lawrence Joseph Heinz , Jill Ann Panetta , Michael LeRoy Phillips , John Allan Rieck, III , John Robert Rizzo , John Kevin Shadle , David Lee Varie
发明人： Benjamin Alan Anderson , Lawrence Joseph Heinz , Jill Ann Panetta , Michael LeRoy Phillips , John Allan Rieck, III , John Robert Rizzo , John Kevin Shadle , David Lee Varie
IPC分类号： C07D41312
CPC分类号： C07D263/57 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/14 , C07D263/32 , C07D271/06 , C07D277/24 , C07D413/12
摘要： The present invention provides a process of preparing a compound of the formula IV wherein: R1 and R2 are each individually -(C1-C6)alkyl, -(C1-C6)alkoxy or phenyl, R3 is H or -(C1-C6)alkyl, R6 is —NR7R8, morpholin-1-yl, imidazol-1-yl, 4,5-dihydro-1H-imidazol-2-yl, thiomorpholin-1-yl, piperazin-1-yl or piperazin-1-yl substituted with -(C1-C4)alkyl or and R7 and R8 are each individually hydrogen, -(C1-C6)alkyl, —(CH2)pOH, —(CH2)p-piperidyl, —(CH2)pS(C1-C6)alkyl, —(CH2)pO(C1-C6)alkyl where R9 is (C1-C6)alkyl; P is an integer from 1-3 both inclusive; q is 0 or 1; and t is 1 to 6 both inclusive; or a pharmaceutically acceptable salt, hydrate or optical isomer thereof, which is useful as a neuroprotective agent.
摘要翻译： 本发明提供制备式IV化合物的方法，其中R 1和R 2各自为 - （C 1 -C 6）烷基， - （C 1 -C 6）烷氧基或苯基，R 3为H或 - （C 1 -C 6）烷基 ，R6是-NR7R8，吗啉-1-基，咪唑-1-基，4,5-二氢-1H-咪唑-2-基，硫代吗啉-1-基，哌嗪-1-基或哌嗪-1-基取代的 与（C 1 -C 4）烷基或R 7和R 8各自独立地为氢， - （C 1 -C 6）烷基， - （CH 2）p OH， - （CH 2） 烷基， - （CH 2）p O（C 1 -C 6）烷基，其中R 9为（C 1 -C 6）烷基; P为1-3的整数，其中q为0或1; andt是1至6，包括它们;或其药学上可接受的盐，水合物或旋光异构体，其可用作神经保护剂。
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公开(公告)号：US06380213B1
公开(公告)日：2002-04-30
申请号：US09715987
申请日：2000-11-17
申请人： Jill Ann Panetta , John Kevin Shadle , Lawrence Joseph Heinz , Michael LeRoy Phillips , John Robert Rizzo , Benjamin Alan Anderson , John Allan Rieck, III , David Lee Varie
发明人： Jill Ann Panetta , John Kevin Shadle , Lawrence Joseph Heinz , Michael LeRoy Phillips , John Robert Rizzo , Benjamin Alan Anderson , John Allan Rieck, III , David Lee Varie
IPC分类号： A61K31427
CPC分类号： C07D263/57 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/14 , C07D263/32 , C07D271/06 , C07D277/24 , C07D277/26 , C07D413/06 , C07D413/12 , C07D417/12
摘要： This invention relates to novel phenyl oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents.
摘要翻译： 本发明涉及可用作神经保护剂的新型苯基恶唑，噻唑，恶唑啉，恶二唑和苯并恶唑。
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公开(公告)号：US06423709B1
公开(公告)日：2002-07-23
申请号：US09996005
申请日：2001-11-28
申请人： Jill Ann Panetta , John Kevin Shadle , Lawrence Joseph Heinz , Michael LeRoy Phillips , John Robert Rizzo , Benjamin Alan Anderson , John Allan Rieck, III , David Lee Varie
发明人： Jill Ann Panetta , John Kevin Shadle , Lawrence Joseph Heinz , Michael LeRoy Phillips , John Robert Rizzo , Benjamin Alan Anderson , John Allan Rieck, III , David Lee Varie
IPC分类号： A61K31425
CPC分类号： C07D263/57 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/14 , C07D263/32 , C07D271/06 , C07D277/24 , C07D277/26 , C07D413/06 , C07D413/12 , C07D417/12
摘要： This invention relates to novel phenyl oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents.
摘要翻译： 本发明涉及可用作神经保护剂的新型苯基恶唑，噻唑，恶唑啉，恶二唑和苯并恶唑。
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公开(公告)号：US6156748A
公开(公告)日：2000-12-05
申请号：US944468
申请日：1997-10-06
申请人： Jill Ann Panetta , John Kevin Shadle , Lawrence Joseph Heinz , Michael LeRoy Phillips , John Robert Rizzo , Benjamin Alan Anderson , John Allan Rieck, III , David Lee Varie
发明人： Jill Ann Panetta , John Kevin Shadle , Lawrence Joseph Heinz , Michael LeRoy Phillips , John Robert Rizzo , Benjamin Alan Anderson , John Allan Rieck, III , David Lee Varie
IPC分类号： A61P25/00 , A61P25/28 , C07D233/64 , C07D233/68 , C07D263/14 , C07D263/32 , C07D263/56 , C07D263/57 , C07D271/06 , C07D277/22 , C07D277/24 , C07D277/26 , C07D413/06 , C07D413/12 , C07D417/12 , C07D521/00 , A61K31/425 , A61K31/415 , A61K31/42 , C07D263/30 , C07D271/12 , C07D413/00
CPC分类号： C07D263/57 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/14 , C07D263/32 , C07D271/06 , C07D277/24 , C07D277/26 , C07D413/06 , C07D413/12 , C07D417/12
摘要： This invention relates to novel phenyl oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents.
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公开(公告)号：US06166216A
公开(公告)日：2000-12-26
申请号：US368236
申请日：1999-08-04
申请人： Jill Ann Panetta , John Kevin Shadle , Lawrence Joseph Heinz , Michael LeRoy Phillips , John Robert Rizzo , Benjamin Alan Anderson , John Allan Rieck, III , David Lee Varie
发明人： Jill Ann Panetta , John Kevin Shadle , Lawrence Joseph Heinz , Michael LeRoy Phillips , John Robert Rizzo , Benjamin Alan Anderson , John Allan Rieck, III , David Lee Varie
IPC分类号： A61P25/00 , A61P25/28 , C07D233/64 , C07D233/68 , C07D263/14 , C07D263/32 , C07D263/56 , C07D263/57 , C07D271/06 , C07D277/22 , C07D277/24 , C07D277/26 , C07D413/06 , C07D413/12 , C07D417/12 , C07D521/00
CPC分类号： C07D263/57 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/14 , C07D263/32 , C07D271/06 , C07D277/24 , C07D277/26 , C07D413/06 , C07D413/12 , C07D417/12
摘要： This invention relates to novel phenyl oxazoles, thiazoles, oxazolines, oxadiazoles and benzoxazoles useful as neuro-protective agents.
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公开(公告)号：US06713645B1
公开(公告)日：2004-03-30
申请号：US09688106
申请日：2000-10-13
申请人： Nicholas James Bach , Susan Elizabeth Draheim , Robert Delane Dillard , Edward David Mihelich , Jason Scott Sawyer , Douglas Wade Beight , Michael LeRoy Phillips , Tulio Suarez , Daniel Jon Sall , Jolie Anne Bastian , Michael Lyle Denney , Gary Alan Hite , Michael Dean Kinnick , Robert Theodore Vasileff , John Michael Morin, Jr. , Ho-Shen Lin , Michael Enrico Richett , Richard Waltz Harper , John McNeill McGill, III , Benjamin Alan Anderson , Nancy Kay Harn , Richard James Loncharich , Richard Walter Schevitz
发明人： Nicholas James Bach , Susan Elizabeth Draheim , Robert Delane Dillard , Edward David Mihelich , Jason Scott Sawyer , Douglas Wade Beight , Michael LeRoy Phillips , Tulio Suarez , Daniel Jon Sall , Jolie Anne Bastian , Michael Lyle Denney , Gary Alan Hite , Michael Dean Kinnick , Robert Theodore Vasileff , John Michael Morin, Jr. , Ho-Shen Lin , Michael Enrico Richett , Richard Waltz Harper , John McNeill McGill, III , Benjamin Alan Anderson , Nancy Kay Harn , Richard James Loncharich , Richard Walter Schevitz
IPC分类号： C07C6976
CPC分类号： C07D409/04 , C07D209/88 , C07F9/5728
摘要： A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
摘要翻译： 公开了一类新型三环类药物，以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗诸如败血性休克的病症。
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公开(公告)号：US06177440B1
公开(公告)日：2001-01-23
申请号：US09063066
申请日：1998-04-21
申请人： Nicholas James Bach , Susan Elizabeth Draheim , Robert Delane Dillard , Edward David Mihelich , Jason Scott Sawyer , Douglas Wade Beight , Michael LeRoy Phillips , Tulio Suarez , Daniel Jon Sall , Jolie Anne Bastian , Michael Lyle Denney , Gary Alan Hite , Michael Dean Kinnick , Robert Theodore Vasileff , John Michael Morin, Jr. , Ho-Shen Lin , Michael Enrico Richett , Richard Waltz Harper , John McNeill McGill, III , Benjamin Alan Anderson , Nancy Kay Harn , Richard James Loncharich , Richard Walter Schevitz
发明人： Nicholas James Bach , Susan Elizabeth Draheim , Robert Delane Dillard , Edward David Mihelich , Jason Scott Sawyer , Douglas Wade Beight , Michael LeRoy Phillips , Tulio Suarez , Daniel Jon Sall , Jolie Anne Bastian , Michael Lyle Denney , Gary Alan Hite , Michael Dean Kinnick , Robert Theodore Vasileff , John Michael Morin, Jr. , Ho-Shen Lin , Michael Enrico Richett , Richard Waltz Harper , John McNeill McGill, III , Benjamin Alan Anderson , Nancy Kay Harn , Richard James Loncharich , Richard Walter Schevitz
IPC分类号： A61K3144
CPC分类号： C07D209/88
摘要： A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
摘要翻译： 公开了一类新型三环类药物，以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗诸如败血性休克的病症。
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公开(公告)号：US06608099B1
公开(公告)日：2003-08-19
申请号：US09762070
申请日：2001-01-30
IPC分类号： A61K31404
CPC分类号： C07D209/18 , C07D209/22
摘要： A class of novel acylsulfonamide substituted indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of inflammatory diseases.
摘要翻译： 公开了一类新的酰基磺酰胺取代的吲哚化合物以及这些化合物用于抑制sPLA2介导的脂肪酸释放用于治疗炎性疾病的用途。
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