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公开(公告)号：US09549916B2
公开(公告)日：2017-01-24
申请号：US14969930
申请日：2015-12-15
申请人： Jiping Fu , Xianming Jin , Subramanian Karur , Guillaume Lapointe , Ann Marie Madera , Zachary Kevin Sweeney
发明人： Jiping Fu , Xianming Jin , Subramanian Karur , Guillaume Lapointe , Ann Marie Madera , Zachary Kevin Sweeney
IPC分类号： A61K31/42 , A61K45/06 , A61K31/422 , C07D261/08 , C07D413/12 , C07D413/06
CPC分类号： C07D261/08 , A61K31/42 , A61K31/422 , A61K45/06 , C07D413/06 , C07D413/12 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , A61K2300/00
摘要： This invention pertains generally to compounds of Formula I as described herein and compositions containing such compounds, as well as methods of using such compounds to treat bacterial infections. In certain aspects, the invention provides methods and compositions comprising these compounds for treating infections caused by Gram-negative bacteria.
摘要翻译： 本发明一般涉及本文所述的式I化合物和含有这些化合物的组合物，以及使用这些化合物治疗细菌感染的方法。 在某些方面，本发明提供包含这些化合物的方法和组合物，用于治疗革兰氏阴性菌引起的感染。
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公开(公告)号：US09637482B2
公开(公告)日：2017-05-02
申请号：US15304044
申请日：2015-04-22
申请人： Jiping Fu , Xianming Jin , Subramanian Karur , Guillaume Lapointe , Patrick Lee , Zachary Kevin Sweeney
发明人： Jiping Fu , Xianming Jin , Subramanian Karur , Guillaume Lapointe , Patrick Lee , Zachary Kevin Sweeney
IPC分类号： C07D417/10 , C07D261/04 , A61K31/421 , A61K45/06 , C07D413/04 , A61K31/4439 , C07D413/10 , A61K31/422 , A61K31/5377
CPC分类号： C07D261/04 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/5377 , A61K45/06 , C07D413/04 , C07D413/10 , C07D417/10
摘要： This invention pertains generally to compounds of Formula I and compositions containing such compounds, as well as methods of using such compounds to treat bacterial infections. In certain aspects, the invention pertains to methods and compositions for treating infections caused by Gram-negative bacteria.
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公开(公告)号：US20150306172A1
公开(公告)日：2015-10-29
申请号：US14717872
申请日：2015-05-20
申请人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
发明人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
摘要： The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, and A-B are as defined herein, which are non-immunosuppressive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.
摘要翻译： 本发明提供式I化合物; 或其药学上可接受的盐，其中R1，R2，R3，R4，R5和AB如本文所定义，其为非免疫抑制性，亲环蛋白结合，mPTP阻断剂，因此可用于预防或治疗疾病或病症 例如HCV感染，中风，多发性硬化，HBV感染，HPV感染，哮喘，癌症，肌营养不良，败血症，缺血/再灌注损伤和心力衰竭。
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公开(公告)号：US09072696B2
公开(公告)日：2015-07-07
申请号：US14037644
申请日：2013-09-26
申请人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
发明人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
摘要： The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein the variables R1, R2, R3, R4, R5, and A-B are defined herein, which are non-immunosuppresive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.
摘要翻译： 本发明提供式I化合物; 或其药学上可接受的盐，其中本文定义的变量R1，R2，R3，R4，R5和AB是非免疫抑制性亲环蛋白结合的mPTP阻断剂，因此可用于预防或治疗疾病或 疾病如HCV感染，中风，多发性硬化，HBV感染，HPV感染，哮喘，癌症，肌营养不良，败血症，缺血/再灌注损伤和心力衰竭。
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公开(公告)号：US20140134132A1
公开(公告)日：2014-05-15
申请号：US14037644
申请日：2013-09-26
申请人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
发明人： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
摘要： The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein the variables R1, R2, R3, R4, R5, and A-B are defined herein, which are non-immunosuppresive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.
摘要翻译： 本发明提供式I化合物; 或其药学上可接受的盐，其中本文定义的变量R1，R2，R3，R4，R5和AB是非免疫抑制性亲环蛋白结合的mPTP阻断剂，因此可用于预防或治疗疾病或 疾病如HCV感染，中风，多发性硬化，HBV感染，HPV感染，哮喘，癌症，肌营养不良，败血症，缺血/再灌注损伤和心力衰竭。
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公开(公告)号：US20090137495A1
公开(公告)日：2009-05-28
申请号：US12249186
申请日：2008-10-10
申请人： Shawn D. Britt , Lech Andrzej Ciszewski , Jiping Fu , Subramanian Karur , Yugang Liu , Peichao Lu , David Thomas Parker , Mahavir Prashad , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng
发明人： Shawn D. Britt , Lech Andrzej Ciszewski , Jiping Fu , Subramanian Karur , Yugang Liu , Peichao Lu , David Thomas Parker , Mahavir Prashad , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng
IPC分类号： A61K38/07 , C07K5/113 , C07D498/04 , C07D207/08 , A61P31/12
CPC分类号： C07D401/12 , C07D403/12 , C07K5/0812 , C07K5/1016
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
摘要翻译： 本申请描述了可用于治疗，预防和/或改善人类疾病的有机化合物。
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公开(公告)号：US08222425B2
公开(公告)日：2012-07-17
申请号：US13185683
申请日：2011-07-19
申请人： Shawn D. Britt , Lech Andrzej Ciszewski , Jiping Fu , Subramanian Karur , Yugang Liu , Peichao Lu , David Thomas Parker , Mahavir Prashad , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng
发明人： Shawn D. Britt , Lech Andrzej Ciszewski , Jiping Fu , Subramanian Karur , Yugang Liu , Peichao Lu , David Thomas Parker , Mahavir Prashad , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng
IPC分类号： C07D207/00
CPC分类号： C07D401/12 , C07D403/12 , C07K5/0812 , C07K5/1016
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
摘要翻译： 本申请描述了可用于治疗，预防和/或改善人类疾病的有机化合物。
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公开(公告)号：US08008263B2
公开(公告)日：2011-08-30
申请号：US12249186
申请日：2008-10-10
申请人： Shawn D. Britt , Lech Andrzej Ciszewski , Jiping Fu , Subramanian Karur , Yugang Liu , Peichao Lu , David Thomas Parker , Mahavir Prashad , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng
发明人： Shawn D. Britt , Lech Andrzej Ciszewski , Jiping Fu , Subramanian Karur , Yugang Liu , Peichao Lu , David Thomas Parker , Mahavir Prashad , Prakash Raman , Pascal Rigollier , Mohindra Seepersaud , Aregahegn Yifru , Rui Zheng
CPC分类号： C07D401/12 , C07D403/12 , C07K5/0812 , C07K5/1016
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
摘要翻译： 本申请描述了可用于治疗，预防和/或改善人类疾病的有机化合物。
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公开(公告)号：US20100204159A1
公开(公告)日：2010-08-12
申请号：US12440139
申请日：2007-09-11
申请人： Trixl Brandl , Sylvain Cottens , Claus Ehrhardt , Jiping Fu , Subramanian Karur , David Thomas Parker , Michael A. Patane , Prakash Raman , Stefan Andreas Randl , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic
发明人： Trixl Brandl , Sylvain Cottens , Claus Ehrhardt , Jiping Fu , Subramanian Karur , David Thomas Parker , Michael A. Patane , Prakash Raman , Stefan Andreas Randl , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic
IPC分类号： A61K38/06 , C07D417/14 , A61P31/14 , A61K38/05 , C07K5/083
CPC分类号： C07D417/14 , C07D401/12 , C07D419/14 , C07K5/06078 , C07K5/0808 , C07K5/0823 , C12N2770/24211
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
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公开(公告)号：US20080045530A1
公开(公告)日：2008-02-21
申请号：US11697889
申请日：2007-04-09
申请人： Trixi Brandl , Shawn Britt , Sylvain Cottens , Claus Ehrhardt , Jiping Fu , Subramanian Karur , Hongju Li , Peichao Lu , David Parker , Michael Patane , Branko Radetich , Prakash Raman , Stefan Randl , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic , Ritesh Tichkule , Yanyi Zhu
发明人： Trixi Brandl , Shawn Britt , Sylvain Cottens , Claus Ehrhardt , Jiping Fu , Subramanian Karur , Hongju Li , Peichao Lu , David Parker , Michael Patane , Branko Radetich , Prakash Raman , Stefan Randl , Pascal Rigollier , Mohindra Seepersaud , Oliver Simic , Ritesh Tichkule , Yanyi Zhu
IPC分类号： A61K31/195 , A61K31/40 , A61K31/421 , A61K31/445 , A61K31/47 , A61K31/4965 , A61K31/497 , A61K31/5375 , A61P31/12 , C07D207/00 , C07D217/00 , C07D241/02
CPC分类号： C07D403/12 , C07D207/08 , C07D217/04 , C07D241/04 , C07D401/14 , C07D405/14 , C07D407/12 , C07D413/04 , C07D413/12 , C07D413/14
摘要： The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.
摘要翻译： 本申请描述了可用于治疗，预防和/或改善人类疾病的有机化合物。
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