Presenilin enhancers assays
    6.
    发明授权
    Presenilin enhancers assays 有权
    早老素增强剂测定

    公开(公告)号:US07125687B1

    公开(公告)日:2006-10-24

    申请号:US09568942

    申请日:2000-05-05

    CPC分类号: C07K14/4705 A61K38/00

    摘要: The invention provides methods and compositions relating to pen polypeptides having pen-specific structure and activity, related polynucleotides and modulators of pen function. The invention provides isolated pen hybridization probes and primers capable of specifically hybridizing with natural pen genes, pen-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis (e.g. genetic hybridization screens for pen transcripts), therapy (e.g. pen inhibitors to modulate APP processing) and in the biopharmaceutical industry (e.g. as immunogens, reagents for screening chemical libraries for lead pharmacological agents, etc.).

    摘要翻译: 本发明提供了与具有笔特异性结构和活性的笔多肽相关的方法和组合物,相关的多核苷酸和笔功能的调节剂。 本发明提供了能够与天然笔基因,笔特异性结合剂如特异性抗体特异性杂交的分离的笔式杂交探针和引物,以及在诊断中制备和使用该主题组合物的方法(例如,用于笔式转录物的遗传杂交筛选),治疗 (例如用于调节APP处理的Pen抑制剂)和生物制药工业(例如作为免疫原,用于筛选铅药理学试剂化学文库的试剂等)。