-
公开(公告)号:US08067181B2
公开(公告)日:2011-11-29
申请号:US10567765
申请日:2004-08-12
IPC分类号: G01N33/53
CPC分类号: G01N33/5041 , C12Q1/485 , G01N33/5023 , G01N33/5029 , G01N33/57492
摘要: Human MELK genes are identified as modulators of the RAC pathway, and thus are therapeutic targets for disorders associated with defective RAC function. Methods for identifying modulators of RAC, comprising screening for agents that modulate the activity of MELK are provided.
摘要翻译: 人类MELK基因被鉴定为RAC途径的调节剂,因此是与缺陷型RAC功能相关的疾病的治疗靶点。 提供了用于鉴定RAC调节剂的方法,包括筛选调节MELK活性的试剂。
-
公开(公告)号:US20080293044A1
公开(公告)日:2008-11-27
申请号:US10567765
申请日:2004-08-12
CPC分类号: G01N33/5041 , C12Q1/485 , G01N33/5023 , G01N33/5029 , G01N33/57492
摘要: Human MELK genes are identified as modulators of the RAC pathway, and thus are therapeutic targets for disorders associated with defective RAC function. Methods for identifying modulators of RAC, comprising screening for agents that modulate the activity of MELK are provided.
摘要翻译: 人类MELK基因被鉴定为RAC途径的调节剂,因此是与缺陷型RAC功能相关的疾病的治疗靶点。 提供了鉴定RAC调节剂的方法,包括筛选调节MELK活性的试剂。
-
公开(公告)号:US20090004180A1
公开(公告)日:2009-01-01
申请号:US12093130
申请日:2006-11-09
申请人: Joanne Adamkewicz , Craig D. Amundsen , Lynn Margaret Bjerke , George Ross Francis , Timothy S. Heuer , Kim Lickteig , Monique Nicoll
发明人: Joanne Adamkewicz , Craig D. Amundsen , Lynn Margaret Bjerke , George Ross Francis , Timothy S. Heuer , Kim Lickteig , Monique Nicoll
IPC分类号: A61K39/395 , C12Q1/68 , A61P35/00 , G01N33/574
CPC分类号: G01N33/574 , G01N2333/4703 , G01N2500/00
摘要: Human KIF23 genes are identified as modulators of the RHO pathway, and thus are therapeutic targets for disorders associated with defective RHO function. Methods for identifying modulators of RHO, comprising screening for agents that modulate the activity of KIF23 are provided.
摘要翻译: 人类KIF23基因被鉴定为RHO途径的调节剂,因此是与缺陷型RHO功能相关的疾病的治疗靶点。 提供了用于鉴定RHO调节剂的方法,包括筛选调节KIF23活性的试剂。
-
公开(公告)号:US08273536B2
公开(公告)日:2012-09-25
申请号:US10556937
申请日:2004-06-18
CPC分类号: C12Q1/485 , G01N33/5088 , G01N33/57407 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57434 , G01N2500/00
摘要: Human MARK genes are identified as modulators of the PTEN pathway, and thus are therapeutic targets for disorders associated with defective PTEN function. Methods for identifying modulators of PTEN, comprising screening for agents that modulate the activity of MARK are provided.
摘要翻译: 人MARK基因被鉴定为PTEN途径的调节剂,因此是与缺陷型PTEN功能相关的疾病的治疗靶点。 提供了用于鉴定PTEN调节剂的方法,包括筛选调节MARK活性的试剂。
-
公开(公告)号:US08481269B2
公开(公告)日:2013-07-09
申请号:US11575233
申请日:2005-09-15
IPC分类号: C12Q1/34
CPC分类号: C12Q1/485 , C12N9/1205 , G01N33/5011 , G01N33/502 , G01N33/57407 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/5743 , G01N33/57434 , G01N33/57438 , G01N33/57442 , G01N33/57446 , G01N33/57449 , G01N33/57496 , G01N2500/00
摘要: Human PIK4CA genes are identified as modulators of the RAC pathway, and thus are therapeutic targets for disorders associated with defective RAC function. Methods for identifying modulators of RAC, comprising screening for agents that modulate the activity of PIK4CA are provided.
摘要翻译: 人类PIK4CA基因被鉴定为RAC途径的调节剂,因此是与缺陷型RAC功能相关的疾病的治疗靶点。 提供了鉴定RAC调节剂的方法,包括筛选调节PIK4CA活性的试剂。
-
公开(公告)号:US20080263684A1
公开(公告)日:2008-10-23
申请号:US11575233
申请日:2005-09-15
CPC分类号: C12Q1/485 , C12N9/1205 , G01N33/5011 , G01N33/502 , G01N33/57407 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/5743 , G01N33/57434 , G01N33/57438 , G01N33/57442 , G01N33/57446 , G01N33/57449 , G01N33/57496 , G01N2500/00
摘要: Human PIK4CA genes are identified as modulators of the RAC pathway, and thus are therapeutic targets for disorders associated with defective RAC function. Methods for identifying modulators of RAC, comprising screening for agents that modulate the activity of PIK4CA are provided.
摘要翻译: 人类PIK4CA基因被鉴定为RAC途径的调节剂,因此是与缺陷型RAC功能相关的疾病的治疗靶点。 提供了鉴定RAC调节剂的方法,包括筛选调节PIK4CA活性的试剂。
-
7.
公开(公告)号:US08105785B2
公开(公告)日:2012-01-31
申请号:US10556637
申请日:2004-06-18
申请人: Gregory D. Plowman , Felix D. Karim , Candace Swimmer , Hinrich Alexander Habeck , Thomas I. Koblizek , Stefan Schulte-Merker , Ulrike Eisenmann , Gordon Mark Stott , Torsten Trowe , Andreas Michael Vogel , Joerg Heinrich Odenthal , Jochen Konrad Scheel , Torsten Tilmann Will , Yinsheng Jin , Lynn Margaret Bjerke , Timothy S. Heuer
发明人: Gregory D. Plowman , Felix D. Karim , Candace Swimmer , Hinrich Alexander Habeck , Thomas I. Koblizek , Stefan Schulte-Merker , Ulrike Eisenmann , Gordon Mark Stott , Torsten Trowe , Andreas Michael Vogel , Joerg Heinrich Odenthal , Jochen Konrad Scheel , Torsten Tilmann Will , Yinsheng Jin , Lynn Margaret Bjerke , Timothy S. Heuer
CPC分类号: G01N33/5091 , C07K14/47 , G01N33/5008 , G01N33/5011 , G01N33/5026 , Y10T436/143333
摘要: Human MYLK genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MYLK are provided.
摘要翻译: 人MYLK基因被鉴定为分支形态发生的调节剂,因此是与缺陷支配形态发生功能相关的病症的治疗靶点。 提供了用于鉴定分支形态发生调节剂的方法,包括筛选调节MYLK活性的试剂。
-
公开(公告)号:US20090028844A1
公开(公告)日:2009-01-29
申请号:US11628560
申请日:2005-06-20
申请人: Lori S. Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Timothy S. Heuer , Lynn Margaret Bjerke
发明人: Lori S. Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Timothy S. Heuer , Lynn Margaret Bjerke
IPC分类号: A61K39/395 , G01N33/00 , C12Q1/02 , C12Q1/68 , C12Q1/48 , A61P31/00 , A61K31/7088 , G01N33/566 , A01K67/027 , C12N5/06
CPC分类号: C12Q1/485 , A61K49/0008 , C12N9/0071 , C12Q1/26 , C12Q1/68 , C12Q1/6886 , C12Y114/11002 , G01N33/574 , G01N33/74 , G01N2500/00 , Y10T436/143333
摘要: Human MIGFR genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of MIGFR are provided.
摘要翻译: 人MIGFR基因被鉴定为IGFR途径的调节剂,因此是与缺陷性IGFR功能相关的病症的治疗靶点。 提供了鉴定IGFR调节剂的方法,包括筛选调节MIGFR活性的药剂。
-
公开(公告)号:US20090022737A1
公开(公告)日:2009-01-22
申请号:US11628487
申请日:2005-06-20
IPC分类号: A61K39/395 , C12Q1/68 , C12Q1/34 , G01N33/53 , A61K31/7088 , A61P43/00 , A61K38/43 , A01K67/027 , C12N5/06
CPC分类号: G01N33/573 , C12Q1/485 , C12Q1/6886 , C12Q2600/136 , C12Q2600/16 , G01N33/57438 , G01N33/6872 , G01N2500/00 , Y10T436/143333
摘要: Human ALDO genes are identified as modulators of the IGF pathway, and thus are therapeutic targets for disorders associated with defective IGF function. Methods for identifying modulators of IGF, comprising screening for agents that modulate the activity of ALDO are provided.
摘要翻译: 人类ALDO基因被鉴定为IGF途径的调节剂,因此是与缺陷型IGF功能相关的病症的治疗靶点。 提供了用于鉴定IGF调节剂的方法,包括筛选调节ALDO活性的试剂。
-
10.
公开(公告)号:US07943302B2
公开(公告)日:2011-05-17
申请号:US10592171
申请日:2005-03-10
申请人: Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
发明人: Lori Friedman , Helen Francis-Lang , Annette L. Parks , Kenneth James Shaw , Lynn Margaret Bjerke , Timothy S. Heuer
IPC分类号: C12Q1/68 , G01N33/53 , C07H21/04 , C07K14/435
CPC分类号: G01N33/57484 , C12Q1/44 , G01N33/5011 , G01N33/74 , G01N2333/916 , Y10T436/143333
摘要: Human C20ORF23 genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of C20ORF23 are provided.
摘要翻译: 人类C20ORF23基因被鉴定为IGFR途径的调节剂,因此是与缺陷性IGFR功能相关的病症的治疗靶点。 提供了鉴定IGFR调节剂的方法,包括筛选调节C20ORF23活性的试剂。
-
-
-
-
-
-
-
-
-