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公开(公告)号：US20120276123A1
公开(公告)日：2012-11-01
申请号：US13432296
申请日：2012-03-28
申请人： Joanne VAN RYN , Keith CANADA , Robert COPENHAVER , Norbert HAUEL , Tobias LITZENBURGER , Christopher Ronald SARKO , Sanjaya SINGH , Alisa K. WATERMAN
发明人： Joanne VAN RYN , Keith CANADA , Robert COPENHAVER , Norbert HAUEL , Tobias LITZENBURGER , Christopher Ronald SARKO , Sanjaya SINGH , Alisa K. WATERMAN
IPC分类号： C07K16/44 , A61P7/02 , C12P21/02 , A61K39/395
CPC分类号： C07K16/44 , A61K31/4439 , A61K39/395 , A61K39/39583 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants.
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公开(公告)号：US20140377265A1
公开(公告)日：2014-12-25
申请号：US14337357
申请日：2014-07-22
申请人： Joanne VAN RYN , Keith CANADA , Robert COPENHAVER , Norbert HAUEL , Tobias LITZENBURGER , Christopher Ronald SARKO , Sanjaya SINGH , Alisa K. WATERMAN
发明人： Joanne VAN RYN , Keith CANADA , Robert COPENHAVER , Norbert HAUEL , Tobias LITZENBURGER , Christopher Ronald SARKO , Sanjaya SINGH , Alisa K. WATERMAN
IPC分类号： C07K16/44 , A61K31/4439 , A61K39/395
CPC分类号： C07K16/44 , A61K31/4439 , A61K39/395 , A61K39/39583 , A61K2039/505 , C07K2299/00 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants.
摘要翻译： 本发明涉及针对抗凝剂，特别是达比加群的抗体分子，以及它们作为这种抗凝剂的解毒剂的用途。
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公开(公告)号：US20130289248A1
公开(公告)日：2013-10-31
申请号：US13916994
申请日：2013-06-13
申请人： Joanne VAN RYN , John Edward PARK , Norbert HAUEL , Ulrich KUNZ , Tobias LITZENBURGER , Keith CANADA , Sanjaya SINGH , Alisa WATERMAN
发明人： Joanne VAN RYN , John Edward PARK , Norbert HAUEL , Ulrich KUNZ , Tobias LITZENBURGER , Keith CANADA , Sanjaya SINGH , Alisa WATERMAN
IPC分类号： C07K16/44
CPC分类号： C07K16/44 , A61K31/4439 , A61K39/39583 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2317/76 , G01N33/86 , G01N2500/02 , G01N2500/10
摘要： The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants.
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公开(公告)号：US20110243932A1
公开(公告)日：2011-10-06
申请号：US13075303
申请日：2011-03-30
申请人： Rachel Rebecca BARRETT , Scott Ronald BRODEUR , Keith CANADA , Tobias LITZENBURGER , Sanjaya SINGH
发明人： Rachel Rebecca BARRETT , Scott Ronald BRODEUR , Keith CANADA , Tobias LITZENBURGER , Sanjaya SINGH
CPC分类号： C07K16/2878 , A61K9/0019 , A61K2039/505 , C07K1/22 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/53 , C07K2317/565 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to new humanized antagonistic anti-CD40 antibodies and therapeutic and diagnostic methods and compositions for using the same.
摘要翻译： 本发明涉及新的人源化拮抗性抗CD40抗体及其使用的治疗和诊断方法及组合物。
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公开(公告)号：US20140179907A1
公开(公告)日：2014-06-26
申请号：US14046121
申请日：2013-10-04
申请人： Rachel Rebecca BARRETT , Scott Ronald BRODEUR , Keith CANADA , Tobias LITZENBURGER , Sanjaya SINGH
发明人： Rachel Rebecca BARRETT , Scott Ronald BRODEUR , Keith CANADA , Tobias LITZENBURGER , Sanjaya SINGH
IPC分类号： C07K16/28
CPC分类号： C07K16/2878 , A61K9/0019 , A61K2039/505 , C07K1/22 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/53 , C07K2317/565 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to new humanized antagonistic anti-CD40 antibodies and therapeutic and diagnostic methods and compositions for using the same.
摘要翻译： 本发明涉及新的人源化拮抗性抗-CD40抗体以及使用该抗CD40抗体的治疗和诊断方法和组合物。
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公开(公告)号：US20140363444A1
公开(公告)日：2014-12-11
申请号：US14302986
申请日：2014-06-12
申请人： Rachel Rebecca BARRETT , Keith CANADA , Katrina Mary CATRON , Robert COPENHAVER , Lee Edward Frego , Ernest Lee Raymond , Sanjaya SINGH , Xiangyang ZHU
发明人： Rachel Rebecca BARRETT , Keith CANADA , Katrina Mary CATRON , Robert COPENHAVER , Lee Edward Frego , Ernest Lee Raymond , Sanjaya SINGH , Xiangyang ZHU
IPC分类号： C07K16/24
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N15/113
摘要： The present invention relates to anti-IL-23p19 binding compounds, in particular new humanized anti-IL-23p19 antibodies and therapeutic and diagnostic methods and compositions for using the same.
摘要翻译： 本发明涉及抗IL-23p19结合化合物，特别是新的人源化抗IL-23p19抗体以及用于其的治疗和诊断方法和组合物。
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公开(公告)号：US20130224224A1
公开(公告)日：2013-08-29
申请号：US13775307
申请日：2013-02-25
申请人： Sanjaya SINGH , Alisa K. WATERMAN , Erik DEPLA , Toon LAEREMANS , Diane VAN HOORICK , Cedric Jozef Néotère VERVERKEN
发明人： Sanjaya SINGH , Alisa K. WATERMAN , Erik DEPLA , Toon LAEREMANS , Diane VAN HOORICK , Cedric Jozef Néotère VERVERKEN
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K39/3955 , A61K2039/505 , C07H21/04 , C07K16/28 , C07K2317/22 , C07K2317/24 , C07K2317/30 , C07K2317/35 , C07K2317/52 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/30 , C12N15/09 , C12N15/11 , C12N15/63
摘要： The present invention relates to CX3CR1-binding polypeptides, in particular polypeptides comprising specific immunoglobulin domains. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions comprising such polypeptides; and to uses of such polypeptides or such compositions, in particular for prophylactic, therapeutic and diagnostic purposes.
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8.发明申请CX3CR1-TARGETING IMAGING AGENTS AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF DISEASE 有权CX3CR1靶向成像剂及其在诊断和治疗疾病中的应用公开(公告)号：US20150056133A1
公开(公告)日：2015-02-26
申请号：US14463689
申请日：2014-08-20
申请人： Alisa K. WATERMAN , Nick Mark Devoogdt , Tony Lahoutte , Matthias SCHNEIDER , Sanjaya SINGH , Cedric Jozef Néotère VERVERKEN
发明人： Alisa K. WATERMAN , Nick Mark Devoogdt , Tony Lahoutte , Matthias SCHNEIDER , Sanjaya SINGH , Cedric Jozef Néotère VERVERKEN
CPC分类号： C07K16/28 , A61K49/0058 , A61K49/04 , A61K49/221 , A61K51/10 , A61K51/1021 , A61K51/1093 , A61K2039/505 , A61P9/10 , C07K16/2866 , C07K2317/22 , C07K2317/569 , C07K2317/94 , G01N33/56966 , G01N33/6872 , G01N2333/7158
摘要： The present invention relates to CX3CR1-targeting imaging agents and their use in treatment and diagnosis of diseases. Single domain CX3CR1-targeting polypeptides linked to detection labels and their use in in vivo imaging of atherosclerotic plaques are described. The CX3CR1-targeting imaging agents are useful in the treatment and diagnosis of CX3CR1-mediated diseases including atherosclerosis.
摘要翻译： 本发明涉及CX3CR1靶向成像剂及其在疾病治疗和诊断中的应用。 描述了与检测标记物连接的单结构域CX3CR1靶向多肽及其在动脉粥样硬化斑块体内成像中的应用。 CX3CR1靶向成像剂可用于治疗和诊断CX3CR1介导的疾病，包括动脉粥样硬化。
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