Peptide and peptide mimetic derivatives with integrin-inhibitors properties II
    1.
    发明授权
    Peptide and peptide mimetic derivatives with integrin-inhibitors properties II 有权
    具有整合蛋白抑制剂性质的肽和肽模拟衍生物II

    公开(公告)号:US07276482B2

    公开(公告)日:2007-10-02

    申请号:US10344668

    申请日:2001-08-02

    IPC分类号: A61K38/10

    摘要: The invention relates to compounds of formula (I) B-Q-X1, wherein B is a bioactive, cell adhesive mediating molecule, selected from the group (i) and Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (SEQ ID NO: 1) (ii), Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (SEQ ID NO: 2) (iii), Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (SEQ ID NO: 3) (iv), Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg (SEQ ID NO: 4) (v), Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn (SEQ ID NO: 5) (vi), Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg (SEQ ID NO: 6) (vii), wherein (i) X, Y, Z, R2, R3, R4, A, Ar, Hal, Het, Het1, n, m, o, p, q, s, t have the meanings cited in claim 1, Q is absent or is an organic spacer molecule, X1 is an anchor molecule selected from the group cited in claim 1, and the salts thereof, which can be used as integrin inhibitors particularly for treatment of illness, deficiencies and inflammations caused by implants and osteolytic illnesses such as osteoporosis, thrombosis, cardiac infarction and arteriosclerosis, in addition to the acceleration and strengthening of the integration process of implants or the biocompatible surface in tissue.

    摘要翻译: 本发明涉及式(I)BQX 1的化合物,其中B是选自(i)和Thr-Trp-Tyr-Lys-Ile-Ala的生物活性的细胞粘附介导分子 -Ph-Gln-Arg-Asn-Arg-Lys(SEQ ID NO:1)(ii),Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys(SEQ ID NO: )(iii),Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys(SEQ ID NO:3)(iv),Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln -Arg-Asn-Arg(SEQ ID NO:4)(v),Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn(SEQ ID NO:5)(vi) -Tyr-Lys-Ile-Ala-Phe-Gln-Arg(SEQ ID NO:6)(vii),其中(i)X,Y,Z,R 2,R 3 A,Ar,Hal,Het,Het 1,n,m,o,p,q,s,t具有引用的含义 在权利要求1中,Q不存在或是有机间隔分子,X 1是选自权利要求1所述的基团的锚定分子及其盐,其可以用作整联蛋白抑制剂,特别是用于 治疗由植入物和溶骨性疾病引起的疾病,缺陷和炎症 例如骨质疏松症,血栓形成,心肌梗死和动脉硬化,以及植入物或组织中生物相容性表面的整合过程的加速和加强。

    Peptide and peptide mimetic conjugates with integrin-inhibitor properties
    2.
    发明授权
    Peptide and peptide mimetic conjugates with integrin-inhibitor properties 有权
    具有整合素抑制剂性质的肽和肽模拟物缀合物

    公开(公告)号:US07655624B2

    公开(公告)日:2010-02-02

    申请号:US10344669

    申请日:2001-08-02

    IPC分类号: A61K38/12 A61F2/02

    CPC分类号: A61K47/6435 A61K47/6425

    摘要: The invention relates to compounds of formula (1) B-Q-X1, wherein B is bioactive cell adhesive mediating molecule. Q is absent or is an inorganic spacer molecule and X1 is an anchor molecule, selected from the group Lys-(CO—CH2—(CH2)n—PO3H2)2(I), -Lys-[-Lys-(CO—CH2—(CH2)a—PO3H2)2]2(ii) or -Lys-(Lys[-Lys-(CO—CH2—(CH2)n—PO3H2]2 (iii), and n independently represents 0, 1, 2 or 3, wherein a free amino group of group B is linked in peptide form to a free carboxyl group of the spacer molecule Q or of the anchor molecule X1, or a free amino group of the radical Q is linked in peptide form to a free carboxyl group of the radical X1. The invention also relates to the salts thereof. The inventive compounds can be used as integrin inhibitors for the treatment of illnesses, deficiencies, inflammations caused by implants and osteolytic illnesses such as osteoporosis, thrombosis, cardiac infarction and arteriosclerosis, in addition to the acceleration and strengthening of the integration process of implants or the biocompatible surface in tissue.

    摘要翻译: 本发明涉及式(1)B-Q-X1的化合物,其中B是生物活性细胞粘附介导分子。 Q不存在或是无机间隔分子,X1是选自Lys-(CO-CH 2 - (CH 2)n -PO 3 H 2)2(I),-Lys - [ - Lys-(CO-CH 2) - (CH 2)a-PO 3 H 2)2] 2(ⅱ)或-Lys-(Lys [-Lys-(CO-CH 2 - (CH 2)n -PO 3 H 2] 2(ⅲ),n独立地表示0,1,2 或3,其中B族的游离氨基以间隔分子Q或锚分子X1的游离羧基形式连接,或者基团Q的游离氨基以肽形式连接至游离氨基 本发明还涉及其盐。本发明化合物可用作整联蛋白抑制剂,用于治疗由植入物引起的疾病,缺血性和溶骨性疾病如骨质疏松症,血栓形成,心肌梗塞和动脉硬化 ,除了加速和加强植入物或组织中生物相容性表面的整合过程。

    Method for selectively triggering circuit breakers in the event of a short circuit
    5.
    发明授权
    Method for selectively triggering circuit breakers in the event of a short circuit 有权
    在短路情况下有选择地触发断路器的方法

    公开(公告)号:US08503142B2

    公开(公告)日:2013-08-06

    申请号:US13000897

    申请日:2009-06-26

    IPC分类号: H02H7/26

    CPC分类号: H02H7/30

    摘要: A method is disclosed for selectively triggering circuit breakers in the event of a short circuit, wherein an upstream circuit breaker and at least one downstream circuit breaker on the output side are provided. In at least one embodiment, the upstream circuit breaker monitors as to whether the or one of the downstream circuit breakers is already in the process of opening the switch contacts thereof to interrupt the circuit on the output side, while forming a switch arc. In order to reliably determine whether a downstream circuit breaker is already in the process of opening, according to at least one embodiment of the invention the upstream circuit breaker, so as to detect a switch arc on the output side, checks whether the ohmic resistance of the short circuit loop produced by a short circuit has an exponential curve over time in that an exponent is continually computed and based on the computer exponent the switch arc is determined if the computed exponent exceeds a threshold.

    摘要翻译: 公开了一种在短路的情况下选择性地触发断路器的方法,其中提供了上游断路器和输出侧的至少一个下游断路器。 在至少一个实施例中,上游断路器监视下游断路器中的一个或其中之一是否已经在打开开关触点的过程中中断输出侧的电路,同时形成开关电弧。 为了可靠地确定下游断路器是否已经处于打开过程中,根据本发明的至少一个实施例,上游断路器以检测输出侧的开关电弧,检查是否有欧姆电阻 由短路产生的短路回路具有随时间的指数曲线,因为连续计算指数,并且基于计算机指数,如果计算出的指数超过阈值,则确定开关弧。

    Control Device
    9.
    发明申请
    Control Device 有权
    控制装置

    公开(公告)号:US20090000407A1

    公开(公告)日:2009-01-01

    申请号:US11574194

    申请日:2005-08-23

    IPC分类号: F16H35/18

    摘要: A control device is provided for a technical system (17), e.g. for a shift-by-wire vehicle transmission. The control device includes a control (actuating) element, e.g. a rotary knob (1), with at least two shifting positions. The control element (1), itself, can rotate without limitation, whereas the control device has at least one stop device (2, 3), which can be adjusted in a controlled manner and which limits the angle of rotation (W) of the control element (1).

    摘要翻译: 为技术系统(17)提供控制装置,例如。 用于线路换档车辆传输。 控制装置包括控制(致动)元件,例如 旋钮(1),具有至少两个换档位置。 控制元件(1)本身可以旋转而不受限制,而控制装置具有至少一个停止装置(2,3),其可以以受控的方式调节并且限制了旋转角(W) 控制元件(1)。

    Dielectric Barrier Discharge Lamp With Protective Coating
    10.
    发明申请
    Dielectric Barrier Discharge Lamp With Protective Coating 审中-公开
    介质阻挡放电灯与保护涂层

    公开(公告)号:US20080203891A1

    公开(公告)日:2008-08-28

    申请号:US11722887

    申请日:2006-01-02

    IPC分类号: H01J61/44 C09K11/81

    摘要: The subject of the present invention is a system incorporating a DBD lamp (1), a dielectric barrier discharge (DBD-) lamp (1), and a phosphor coating (2) for use as luminescent coating in a dielectric barrier discharge (DBD-) lamp (1), especially in a mercury-free DBD-lamp, comprising several phosphor grains (3a) together forming a luminescent coating layer (3) for converting a primary discharge radiation into a wanted radiation, whereby the phosphor coating (2) comprises a protective coating layer (4) at least partly surrounding the luminescent coating layer (3) for minimizing degradation of the luminescent coating layer (3) during use in a DBD-lamp (1).

    摘要翻译: 本发明的目的是在电介质阻挡放电(DBD-2)中用作发光涂层的DBD灯(1),介质阻挡放电(DBD)灯(1)和荧光体涂层(2) )灯(1),特别是在无汞DBD灯中,包括几个荧光体颗粒(3a),一起形成用于将初级放电辐射转换成所需辐射的发光涂层(3),由此荧光体涂层 )包括至少部分地围绕所述发光涂层(3)的保护涂层(4),用于在DBD灯(1)的使用期间使所述发光涂层(3)的降解最小化。