摘要:
The invention relates to compounds of formula (I) B-Q-X1, wherein B is a bioactive, cell adhesive mediating molecule, selected from the group (i) and Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (SEQ ID NO: 1) (ii), Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (SEQ ID NO: 2) (iii), Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys (SEQ ID NO: 3) (iv), Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg (SEQ ID NO: 4) (v), Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn (SEQ ID NO: 5) (vi), Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg (SEQ ID NO: 6) (vii), wherein (i) X, Y, Z, R2, R3, R4, A, Ar, Hal, Het, Het1, n, m, o, p, q, s, t have the meanings cited in claim 1, Q is absent or is an organic spacer molecule, X1 is an anchor molecule selected from the group cited in claim 1, and the salts thereof, which can be used as integrin inhibitors particularly for treatment of illness, deficiencies and inflammations caused by implants and osteolytic illnesses such as osteoporosis, thrombosis, cardiac infarction and arteriosclerosis, in addition to the acceleration and strengthening of the integration process of implants or the biocompatible surface in tissue.
摘要翻译:本发明涉及式(I)BQX 1的化合物,其中B是选自(i)和Thr-Trp-Tyr-Lys-Ile-Ala的生物活性的细胞粘附介导分子 -Ph-Gln-Arg-Asn-Arg-Lys(SEQ ID NO:1)(ii),Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys(SEQ ID NO: )(iii),Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn-Arg-Lys(SEQ ID NO:3)(iv),Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln -Arg-Asn-Arg(SEQ ID NO:4)(v),Thr-Trp-Tyr-Lys-Ile-Ala-Phe-Gln-Arg-Asn(SEQ ID NO:5)(vi) -Tyr-Lys-Ile-Ala-Phe-Gln-Arg(SEQ ID NO:6)(vii),其中(i)X,Y,Z,R 2,R 3 A,Ar,Hal,Het,Het 1,n,m,o,p,q,s,t具有引用的含义 在权利要求1中,Q不存在或是有机间隔分子,X 1是选自权利要求1所述的基团的锚定分子及其盐,其可以用作整联蛋白抑制剂,特别是用于 治疗由植入物和溶骨性疾病引起的疾病,缺陷和炎症 例如骨质疏松症,血栓形成,心肌梗死和动脉硬化,以及植入物或组织中生物相容性表面的整合过程的加速和加强。
摘要:
The invention relates to compounds of formula (1) B-Q-X1, wherein B is bioactive cell adhesive mediating molecule. Q is absent or is an inorganic spacer molecule and X1 is an anchor molecule, selected from the group Lys-(CO—CH2—(CH2)n—PO3H2)2(I), -Lys-[-Lys-(CO—CH2—(CH2)a—PO3H2)2]2(ii) or -Lys-(Lys[-Lys-(CO—CH2—(CH2)n—PO3H2]2 (iii), and n independently represents 0, 1, 2 or 3, wherein a free amino group of group B is linked in peptide form to a free carboxyl group of the spacer molecule Q or of the anchor molecule X1, or a free amino group of the radical Q is linked in peptide form to a free carboxyl group of the radical X1. The invention also relates to the salts thereof. The inventive compounds can be used as integrin inhibitors for the treatment of illnesses, deficiencies, inflammations caused by implants and osteolytic illnesses such as osteoporosis, thrombosis, cardiac infarction and arteriosclerosis, in addition to the acceleration and strengthening of the integration process of implants or the biocompatible surface in tissue.
摘要:
The invention relates to a novel red emitting material of (Ba1—x—y—zSrxCayEuz)2Si5—a−bAlaN8−a−4bOa+4b having an average particle size distribution d50 of >6 μm, with 0.3≦x≦0.9, 0.01≦y≦0.1, 0.005≦z≦0.04, 0≦a≦0.2 and 0≦b≦0.2.
摘要:
The invention relates to a novel red emitting material of (Ba1—x—y—zSrxCayEuz)2Si5—a−bAlaN8'a−4bOa+4b having an average particle size distribution d50 of >6 μm, with 0.3≦x≦0.9, 0.01≦y≦0.1, 0.005≦z≦0.04, 0≦a≦0.2 and 0≦b≦0.2.
摘要翻译:本发明涉及平均粒度分布d50>6μm的(Ba1-xy-zSrxCayEuz)2Si5-a-bAlaN8'a-4bOa + 4b的新型红色发射材料,其中0.3≤x≤0.9,0.01@y @ 0.1,0.005 @ z @ 0.04,0 @ a @ 0.2和0 @ b @ 0.2。
摘要:
A method is disclosed for selectively triggering circuit breakers in the event of a short circuit, wherein an upstream circuit breaker and at least one downstream circuit breaker on the output side are provided. In at least one embodiment, the upstream circuit breaker monitors as to whether the or one of the downstream circuit breakers is already in the process of opening the switch contacts thereof to interrupt the circuit on the output side, while forming a switch arc. In order to reliably determine whether a downstream circuit breaker is already in the process of opening, according to at least one embodiment of the invention the upstream circuit breaker, so as to detect a switch arc on the output side, checks whether the ohmic resistance of the short circuit loop produced by a short circuit has an exponential curve over time in that an exponent is continually computed and based on the computer exponent the switch arc is determined if the computed exponent exceeds a threshold.
摘要:
An illumination device includes an active layer, such as a blue LED, covered with a first luminescent ceramic converter layer and partially covered with a second luminescent ceramic converter layer. The first and second conversion layers convert primary photons emitted by the active layer into photons of different, longer wavelengths. The color point of the illumination device can be adjusted by adjusting the relative size of the second conversion layer.
摘要:
The invention relates to an improved red light emitting material of the formula M1−yA1+xSi4−xN7−x−2yOx+2y:RE whereby M is selected out of the group comprising Ba, Sr, Ca, Mg or mixtures thereof, A is selected out of the group comprising Al, Ga, B or mixtures thereof, RE is selected out of the group comprising rare earth metals, Y, La, Sc or mixtures thereof and x is ≧0 and ≦1 and y is ≧0 and ≦0.2. This material is believed to crystallize in a novel structure type that comprises two individual lattice sites for rare 10 earth metal incorporation, which leads to an improved lighting behavior.
摘要:
An organic electroluminescent light source has at least one substrate and layers that are arranged on the substrate. The layers include electrodes of which at least one electrode is transparent and one acts as an anode and one as a cathode, and at least one organic electroluminescent layer that is arranged between the electrodes. The organic electroluminescent layer has regions that emit blue light and/or green light, and at least one phosphor layer that is arranged in the beam path of the light leaving the organic electroluminescent light source and that partly covers the electroluminescent layer.
摘要:
A control device is provided for a technical system (17), e.g. for a shift-by-wire vehicle transmission. The control device includes a control (actuating) element, e.g. a rotary knob (1), with at least two shifting positions. The control element (1), itself, can rotate without limitation, whereas the control device has at least one stop device (2, 3), which can be adjusted in a controlled manner and which limits the angle of rotation (W) of the control element (1).
摘要:
The subject of the present invention is a system incorporating a DBD lamp (1), a dielectric barrier discharge (DBD-) lamp (1), and a phosphor coating (2) for use as luminescent coating in a dielectric barrier discharge (DBD-) lamp (1), especially in a mercury-free DBD-lamp, comprising several phosphor grains (3a) together forming a luminescent coating layer (3) for converting a primary discharge radiation into a wanted radiation, whereby the phosphor coating (2) comprises a protective coating layer (4) at least partly surrounding the luminescent coating layer (3) for minimizing degradation of the luminescent coating layer (3) during use in a DBD-lamp (1).