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公开(公告)号：US5410022A
公开(公告)日：1995-04-25
申请号：US49585
申请日：1993-04-20
申请人： Johann Eibl , Friedrich Elsinger , Herbert Gritsch , Yendra Linnau , Otto Schwarz , Peter Turecek , Gunther Wober
发明人： Johann Eibl , Friedrich Elsinger , Herbert Gritsch , Yendra Linnau , Otto Schwarz , Peter Turecek , Gunther Wober
IPC分类号： A61K38/43 , A61K38/00 , A61K38/37 , A61L2/04 , A61L2/16 , A61L2/18 , A61P7/04 , C07K1/14 , C07K1/16 , C07K14/435 , C07K14/745 , C07K14/755 , C12N9/74 , C07K3/20 , C07K15/06
CPC分类号： C07K14/755 , A61K38/00 , Y10S530/83 , Y10S530/831
摘要： The invention relates to a method of producing virus-safe highly purified factor VIII. The method includes a combination of the following measures:a) chromatographic purification of a factor VIII-containing fraction,b) tenside treatment of factor VIII in an aqueous solution at a tenside/protein ratio of from 1:1 to 1000:1, andc) heat treatment of the factor VIII preparation in the solid state.
摘要翻译： 本发明涉及一种生产病毒安全高度纯化因子VIII的方法。 该方法包括以下措施的组合：a）含有因子VIII的级分的色谱纯化，b）在表面活性剂/蛋白质比例为1:1至1000:1的水溶液中进行因子VIII的表面活性剂处理，以及 c）在固体状态下热处理VIII因子制剂。
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2.发明授权Method and compositions for specifically detecting physiologically acceptable polymer molecules 有权专门检测生理上可接受的聚合物分子的方法和组合物公开(公告)号：US08557534B2
公开(公告)日：2013-10-15
申请号：US12342405
申请日：2008-12-23
申请人： Peter Turecek , Juergen Siekmann , Alfred Weber , Herbert Gritsch , Katalin Varadi , Susanne Vejda
发明人： Peter Turecek , Juergen Siekmann , Alfred Weber , Herbert Gritsch , Katalin Varadi , Susanne Vejda
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： G01N33/86 , G01N33/5308 , G01N2430/60
摘要： The present invention relates to a method for determining the amount of a physiologically acceptable polymer molecule bound to a protein, an antibody or other composition being capable of specifically binding to a physiologically acceptable polymer molecule, and a kit containing said antibody or composition.
摘要翻译： 本发明涉及一种用于测定与蛋白质结合的生理学上可接受的聚合物分子的量的方法，能够特异性结合生理上可接受的聚合物分子的抗体或其它组合物，以及含有所述抗体或组合物的试剂盒。
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3.发明授权Von Willebrand factor- and factor VIII-polymer conjugates having a releasable linkage 有权Von Willebrand因子和因子VIII-聚合物缀合物具有可释放的连接公开(公告)号：US08349800B2
公开(公告)日：2013-01-08
申请号：US13371275
申请日：2012-02-10
申请人： Mary J. Bossard , Gayle Stephenson , Zhihao Fang , Harold Zappe , Stacy Mitchell , Ping Zhang , Friedrich Scheiflinger , Peter Turecek , Juergen Siekmann , Katalin Varadi , Herbert Gritsch
发明人： Mary J. Bossard , Gayle Stephenson , Zhihao Fang , Harold Zappe , Stacy Mitchell , Ping Zhang , Friedrich Scheiflinger , Peter Turecek , Juergen Siekmann , Katalin Varadi , Herbert Gritsch
IPC分类号： C07K14/755 , C07K14/745 , C07K17/08
CPC分类号： C07K14/755 , A61K47/60
摘要： The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
摘要翻译： 本发明提供了von Willebrand因子 - 聚合物共轭物和因子VIII-聚合物缀合物，其各自具有可释放的连接。 还提供了制备缀合物的方法，用于施用缀合物的方法。
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4.发明申请Von Willebrand Factor- and Factor VIII-Polymer Conjugates Having a Releasable Linkage 有权Von Willebrand因子和因子VIII-聚合物缀合物具有可释放的连接公开(公告)号：US20120142594A1
公开(公告)日：2012-06-07
申请号：US13371275
申请日：2012-02-10
申请人： Mary J. Bossard , Gayle Stephenson , Zhihao Fang , Harold Zappe , Stacy Mitchell , Ping Zhang , Friedrich Scheiflinger , Peter Turecek , Juergen Siekmann , Katalin Varadi , Herbert Gritsch
发明人： Mary J. Bossard , Gayle Stephenson , Zhihao Fang , Harold Zappe , Stacy Mitchell , Ping Zhang , Friedrich Scheiflinger , Peter Turecek , Juergen Siekmann , Katalin Varadi , Herbert Gritsch
IPC分类号： C07K14/755 , C07K14/745 , C07K17/08
CPC分类号： C07K14/755 , A61K47/60
摘要： The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
摘要翻译： 本发明提供了von Willebrand因子 - 聚合物共轭物和因子VIII-聚合物缀合物，其各自具有可释放的连接。 还提供了制备缀合物的方法，用于施用缀合物的方法。
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公开(公告)号：US08053561B2
公开(公告)日：2011-11-08
申请号：US12719265
申请日：2010-03-08
IPC分类号： A61K38/00 , A61K38/37 , C07K14/435 , C07K14/755
CPC分类号： C07K14/755 , A61K47/60 , C07K14/745
摘要： The invention is a proteinaceous construct comprising a Factor VIII molecule having at least a portion of the B domain intact, which is conjugated to a water-soluble polymer such as polyethylene glycol having a molecular weight of greater than 10,000 Daltons. The construct has a biological activity of at least 80% of the biological activity of native Factor VIII, and the in vivo half-life of the construct is increased by at least 1.5 fold as compared to the in vivo half-life of native factor FVIII.
摘要翻译： 本发明是包含具有至少一部分B结构域的因子VIII分子的蛋白质构建体，其与水溶性聚合物如分子量大于10,000道尔顿的聚乙二醇缀合。 该构建体具有天然因子VIII的生物活性的至少80％的生物活性，与天然因子FVIII的体内半衰期相比，构建体的体内半衰期增加至少1.5倍 。
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公开(公告)号：US07683158B2
公开(公告)日：2010-03-23
申请号：US11729625
申请日：2007-03-29
IPC分类号： C07K14/745
CPC分类号： C07K14/755 , A61K47/60 , C07K14/745
摘要： The invention is a proteinaceous construct comprising a Factor VIII molecule having at least a portion of the B domain intact, which is conjugated to a water-soluble polymer such as polyethylene glycol having a molecular weight of greater than 10,000 Daltons. The construct has a biological activity of at least 80% of the biological activity of native Factor VIII, and the in vivo half-life of the construct is increased by at least 1.5 fold as compared to the in vivo half-life of native factor FVIII.
摘要翻译： 本发明是包含具有至少一部分B结构域的因子VIII分子的蛋白质构建体，其与水溶性聚合物如分子量大于10,000道尔顿的聚乙二醇缀合。 该构建体具有天然因子VIII的生物活性的至少80％的生物活性，与天然因子FVIII的体内半衰期相比，构建体的体内半衰期增加至少1.5倍 。
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7.发明授权Von willebrand factor- and factor VIII-polymer conjugates having a releasable linkage 有权具有释放键的冯维勒布兰因子和因子VIII-聚合物共轭物公开(公告)号：US09493544B2
公开(公告)日：2016-11-15
申请号：US13620285
申请日：2012-09-14
申请人： Mary J. Bossard , Gayle Stephenson , Zhihao Fang , Harold Zappe , Stacy Mitchell , Ping Zhang , Friedrich Scheiflinger , Peter Turecek , Juergen Siekmann , Katalin Varadi , Herbert Gritsch
发明人： Mary J. Bossard , Gayle Stephenson , Zhihao Fang , Harold Zappe , Stacy Mitchell , Ping Zhang , Friedrich Scheiflinger , Peter Turecek , Juergen Siekmann , Katalin Varadi , Herbert Gritsch
IPC分类号： C07K14/755 , C07K14/745 , C07K17/08 , A61K47/48
CPC分类号： C07K14/755 , A61K47/60
摘要： The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
摘要翻译： 本发明提供了von Willebrand因子 - 聚合物共轭物和因子VIII-聚合物缀合物，其各自具有可释放的连接。 还提供了制备缀合物的方法，用于施用缀合物的方法。
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公开(公告)号：US20100168391A1
公开(公告)日：2010-07-01
申请号：US12719265
申请日：2010-03-08
IPC分类号： C07K14/755
CPC分类号： C07K14/755 , A61K47/60 , C07K14/745
摘要： The invention is a proteinaceous construct comprising a Factor VIII molecule having at least a portion of the B domain intact, which is conjugated to a water-soluble polymer such as polyethylene glycol having a molecular weight of greater than 10,000 Daltons. The construct has a biological activity of at least 80% of the biological activity of native Factor VIII, and the in vivo half-life of the construct is increased by at least 1.5 fold as compared to the in vivo half-life of native factor FVIII.
摘要翻译： 本发明是包含具有至少一部分B结构域的因子VIII分子的蛋白质构建体，其与水溶性聚合物如分子量大于10,000道尔顿的聚乙二醇缀合。 该构建体具有天然因子VIII的生物活性的至少80％的生物活性，与天然因子FVIII的体内半衰期相比，构建体的体内半衰期增加至少1.5倍 。
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公开(公告)号：US20070244301A1
公开(公告)日：2007-10-18
申请号：US11729625
申请日：2007-03-29
IPC分类号： C07K14/745
CPC分类号： C07K14/755 , A61K47/60 , C07K14/745
摘要： The invention is a proteinaceous construct comprising a Factor VIII molecule having at least a portion of the B domain intact, which is conjugated to a water-soluble polymer such as polyethylene glycol having a molecular weight of greater than 10,000 Daltons. The construct has a biological activity of at least 80% of the biological activity of native Factor VIII, and the in vivo half-life of the construct is increased by at least 1.5 fold as compared to the in vivo half-life of native factor FVIII.
摘要翻译： 本发明是包含具有至少一部分B结构域的因子VIII分子的蛋白质构建体，其与水溶性聚合物如分子量大于10,000道尔顿的聚乙二醇缀合。 该构建体具有天然因子VIII的生物活性的至少80％的生物活性，与天然因子FVIII的体内半衰期相比，构建体的体内半衰期增加至少1.5倍 。
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10.发明申请Transgenic Mouse Lacking Endogenous FVIII and VWF - A Model of Hemophilia A 审中-公开转基因小鼠缺乏内源性FVIII和VWF - A型血友病A公开(公告)号：US20110072524A1
公开(公告)日：2011-03-24
申请号：US12850243
申请日：2010-08-04
IPC分类号： A61K38/36 , A01K67/00 , A01K67/027 , A61K49/00 , A61P7/04
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/052 , A01K2217/054 , A01K2217/072 , A01K2227/105 , A01K2267/03
摘要： The present invention relates, generally, to a transgenic non-human animal model of hemophilia A, wherein the transgenic animal is deficient in endogenous Factor VIII and endogenous von Willebrand Factor, and methods to treat hereditary or acquired hemophilia A or von Willebrand Disease (VWD) by administration of exogenous human VWF.
摘要翻译： 本发明通常涉及血友病A的转基因非人动物模型，其中转基因动物缺乏内源因子VIII和内源性血管性血友病因子，以及治疗遗传性或获得性血友病A或血管性血友病（VWD）的方法 ）通过外源人VWF的施用。
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