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公开(公告)号：US20120328565A1
公开(公告)日：2012-12-27
申请号：US13528920
申请日：2012-06-21
申请人： John A. Brinkman , Andrew F. Donnell , Robert Francis Kester , Yimin Qian , Ramakanth Sarabu , Sung-Sau So
发明人： John A. Brinkman , Andrew F. Donnell , Robert Francis Kester , Yimin Qian , Ramakanth Sarabu , Sung-Sau So
IPC分类号： A61K31/4178 , C07D417/14 , C07D401/14 , C07D487/04 , C12N5/071 , A61K31/4439 , A61K31/551 , A61K38/21 , A61P31/14 , C07D403/14 , A61K31/428
CPC分类号： C07D487/04 , C07D401/14 , C07D403/14 , C07D417/14
摘要： The present invention discloses compounds of Formula I wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the treatment of HCV infection.
摘要翻译： 本发明公开了式I的化合物，其中式I中的变量如本文所述定义。 还公开了含有这些化合物的药物组合物和使用式I化合物治疗HCV感染的方法。
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公开(公告)号：US07741327B2
公开(公告)日：2010-06-22
申请号：US12400065
申请日：2009-03-09
申请人： Steven Joseph Berthel , John A Brinkman , Stuart Hayden , Nancy-Ellen Haynes , Robert Francis Kester , Lee Apostle McDermott , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Jefferson Wright Tilley
发明人： Steven Joseph Berthel , John A Brinkman , Stuart Hayden , Nancy-Ellen Haynes , Robert Francis Kester , Lee Apostle McDermott , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Jefferson Wright Tilley
IPC分类号： A61K31/497 , A61K31/4439 , A61K31/433 , A61K31/428 , A61K31/426 , A61K31/423 , A61K31/421 , A61K31/4155 , C07D403/12 , C07D401/12 , C07D285/08 , C07D277/82 , C07D277/38 , C07D263/54 , C07D263/48 , C07D231/56 , C07D231/38
CPC分类号： C07D403/12 , C07D401/12 , C07D405/14 , C07D413/14 , C07D417/12
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症，例如II型糖尿病。
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公开(公告)号：US20090264445A1
公开(公告)日：2009-10-22
申请号：US12400065
申请日：2009-03-09
申请人： Steven Joseph Berthel , John A. Brinkman , Stuart Hayden , Nancy-Ellen Haynes , Robert Francis Kester , Lee Apostle McDermott , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Jefferson Wright Tilley
发明人： Steven Joseph Berthel , John A. Brinkman , Stuart Hayden , Nancy-Ellen Haynes , Robert Francis Kester , Lee Apostle McDermott , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Jefferson Wright Tilley
IPC分类号： A61K31/497 , C07D403/12 , A61K31/4155
CPC分类号： C07D403/12 , C07D401/12 , C07D405/14 , C07D413/14 , C07D417/12
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症，例如II型糖尿病。
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公开(公告)号：US08258134B2
公开(公告)日：2012-09-04
申请号：US12400319
申请日：2009-03-09
申请人： Steven Joseph Berthel , Nancy-Ellen Haynes , Robert Francis Kester , Lee Apostle McDermott , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Jefferson Wright Tilley
发明人： Steven Joseph Berthel , Nancy-Ellen Haynes , Robert Francis Kester , Lee Apostle McDermott , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Jefferson Wright Tilley
IPC分类号： C07D401/06 , C07D401/14 , C07D237/32 , C07D237/10 , A61K31/501 , A61K31/502 , A61P5/50
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D407/14
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症，例如II型糖尿病。
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公开(公告)号：US20090264434A1
公开(公告)日：2009-10-22
申请号：US12400319
申请日：2009-03-09
申请人： Steven Joseph Berthel , Nancy-Ellen Haynes , Robert Francis Kester , Lee Apostle McDermott , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Jefferson Wright Tilley
发明人： Steven Joseph Berthel , Nancy-Ellen Haynes , Robert Francis Kester , Lee Apostle McDermott , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Jefferson Wright Tilley
IPC分类号： A61K31/502 , C07D237/02 , A61K31/50 , C07D237/30 , A61P3/10
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D407/14
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症，例如II型糖尿病。
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公开(公告)号：US07132425B2
公开(公告)日：2006-11-07
申请号：US10732838
申请日：2003-12-10
申请人： Shaoqing Chen , Wendy Lea Corbett , Kevin Richard Guertin , Nancy-Ellen Haynes , Robert Francis Kester , Francis A. Mennona , Steven Gregory Mischke , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar
发明人： Shaoqing Chen , Wendy Lea Corbett , Kevin Richard Guertin , Nancy-Ellen Haynes , Robert Francis Kester , Francis A. Mennona , Steven Gregory Mischke , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar
IPC分类号： A61K31/4965 , A61K31/44 , A01N43/40 , C07D401/00 , C07D241/02
CPC分类号： C07D213/75 , C07D213/76 , C07D213/78 , C07D241/20 , C07D241/26 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/04 , C07D413/04 , C07D417/06
摘要： The present invention provides a compound according to formula I where the substituent designations are provided in the specification. Pharmaceutical compositions comprising a compound according to formula I are also provided.
摘要翻译： 本发明提供了在说明书中提供了取代基名称的根据式I的化合物。 还提供了包含式I化合物的药物组合物。
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公开(公告)号：US08729078B2
公开(公告)日：2014-05-20
申请号：US13472541
申请日：2012-05-16
申请人： Roland Joseph Billedeau , Rama K. Kondru , Francisco Javier Lopez-Tapia , Yan Lou , Timothy D. Owens , Yimin Qian , Sung-Sau So , Kshitij C. Thakkar , Jutta Wanner , Omar Jose Morales
发明人： Roland Joseph Billedeau , Rama K. Kondru , Francisco Javier Lopez-Tapia , Yan Lou , Timothy D. Owens , Yimin Qian , Sung-Sau So , Kshitij C. Thakkar , Jutta Wanner , Omar Jose Morales
IPC分类号： A01N43/58 , A61K31/50 , C07D237/00
CPC分类号： C07D405/10 , C07D401/10 , C07D401/14 , C07D403/10 , C07D413/10 , C07D417/10 , C07D471/04
摘要： This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.
摘要翻译： 本申请公开了根据通式I的化合物：其中所有变量如本文所述限定，其抑制Btk。 本文公开的化合物可用于调节Btk的活性并治疗与过量Btk活性相关的疾病。 该化合物还可用于治疗与异常B细胞增殖相关的炎症和自身免疫疾病，例如类风湿性关节炎。 还公开了含有式I化合物和至少一种载体，稀释剂或赋形剂的组合物。
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公开(公告)号：US20130018043A1
公开(公告)日：2013-01-17
申请号：US13546039
申请日：2012-07-11
申请人： Joseph A. Bilotta , Adrian Wai-Hing Cheung , Fariborz Firooznia , Kevin Richard Guertin , Stuart Hayden , Nancy-Ellen Haynes , Christine M. Lukacs-Lesburg , Nicholas Marcopulos , Eric Mertz , Lida Qi , Yimin Qian , Sung-Sau So , Jenny Tan , Kshitij C. Thakkar
发明人： Joseph A. Bilotta , Adrian Wai-Hing Cheung , Fariborz Firooznia , Kevin Richard Guertin , Stuart Hayden , Nancy-Ellen Haynes , Christine M. Lukacs-Lesburg , Nicholas Marcopulos , Eric Mertz , Lida Qi , Yimin Qian , Sung-Sau So , Jenny Tan , Kshitij C. Thakkar
IPC分类号： C07D413/14 , A61K31/5377 , C07D471/04 , A61K31/4375 , C07D401/14 , A61K31/55 , A61K31/551 , A61P29/00 , A61P11/06 , A61P3/10 , A61P25/28 , A61P25/16 , A61P9/10 , A61P35/00 , A61P35/02 , A61P13/12 , A61K31/4709
CPC分类号： C07D215/48 , C07D215/233 , C07D401/12 , C07D405/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The invention relates to JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses JNK inhibitors, as described below in Formula I: wherein the variables are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.
摘要翻译： 本发明涉及JNK抑制剂和用于抑制JNK和治疗JNK介导的病症的相应方法，制剂和组合物。 本申请公开了如下式I所述的JNK抑制剂：其中变量如本文所定义。 本文公开的化合物和组合物可用于调节JNK的活性并治疗与JNK活性相关的疾病。 公开了用于抑制JNK和治疗JNK介导的病症等的方法和制剂，以及本文公开的化合物，以及制备所述化合物的方法和相应的组合物。
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公开(公告)号：US07807674B2
公开(公告)日：2010-10-05
申请号：US12194643
申请日：2008-08-20
申请人： Nancy Ellen Haynes , Denis J. Kertesz , Sherrie Lynn Pietranico-Cole , Yimin Qian , Nathan Robert Scott , Sung-Sau So , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley
发明人： Nancy Ellen Haynes , Denis J. Kertesz , Sherrie Lynn Pietranico-Cole , Yimin Qian , Nathan Robert Scott , Sung-Sau So , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley
IPC分类号： C07D237/14 , C07D253/07 , A61K31/50 , A61K31/53 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , A61P9/00 , A61P35/00
CPC分类号： C07D237/14 , C07D237/16 , C07D237/18 , C07D403/10 , C07D403/12
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗诸如肥胖症，高脂血症，高胆固醇血症和糖尿病等疾病和疾病的疾病，并且可用于其它疾病如NASH，动脉粥样硬化，心血管疾病，甲状腺机能减退 ，甲状腺癌及其相关疾病和疾病。
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公开(公告)号：US08501732B2
公开(公告)日：2013-08-06
申请号：US13546039
申请日：2012-07-11
申请人： Joseph A. Bilotta , Adrian Wai-Hing Cheung , Fariborz Firooznia , Kevin Richard Guertin , Stuart Hayden , Nancy-Ellen Haynes , Christine M. Lukacs-Lesburg , Nicholas Marcopulos , Eric Mertz , Lida Qi , Yimin Qian , Sung-Sau So , Jenny Tan , Kshitij C. Thakkar
发明人： Joseph A. Bilotta , Adrian Wai-Hing Cheung , Fariborz Firooznia , Kevin Richard Guertin , Stuart Hayden , Nancy-Ellen Haynes , Christine M. Lukacs-Lesburg , Nicholas Marcopulos , Eric Mertz , Lida Qi , Yimin Qian , Sung-Sau So , Jenny Tan , Kshitij C. Thakkar
IPC分类号： A61K31/55 , A61K31/551 , A61K31/5375 , A61K31/5377 , A61K31/4427 , A61K31/435 , A61K31/47 , C07D243/08 , C07D401/02 , C07D413/02 , C07D413/14 , C07D471/00 , C07D215/00
CPC分类号： C07D215/48 , C07D215/233 , C07D401/12 , C07D405/12 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The invention relates to JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses JNK inhibitors, as described below in Formula I: wherein the variables are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.
摘要翻译： 本发明涉及JNK抑制剂和用于抑制JNK和治疗JNK介导的病症的相应方法，制剂和组合物。 本申请公开了如下式I所述的JNK抑制剂：其中变量如本文所定义。 本文公开的化合物和组合物可用于调节JNK的活性并治疗与JNK活性相关的疾病。 公开了用于抑制JNK和治疗JNK介导的病症等的方法和制剂，以及本文公开的化合物，以及制备所述化合物的方法和相应的组合物。
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