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    USE OF D-RIBOSE FOR FATIGUED SUBJECTS
    2.
    发明申请
    USE OF D-RIBOSE FOR FATIGUED SUBJECTS 审中-公开
    用于疲劳物质的D-呋喃酮的使用

    公开(公告)号：US20120264701A1

    公开(公告)日：2012-10-18

    申请号：US13444279

    申请日：2012-04-11

    申请人： John A. St. Cyr ,  Dean J. MacCarter

    发明人： John A. St. Cyr ,  Dean J. MacCarter

    IPC分类号： A61K31/7004 ,  A61P25/00

    CPC分类号： A61K31/7004 ,  A61K9/0056 ,  A61K9/08 ,  A61K9/20

    摘要： Low doses of D-ribose raise the level of fitness and lower the perception of fatigue in baby boomers aged 45-65 who perceive themselves as fatigued. The doses range from 0.100 grams to 3.0 grams, bid, for a total of 0.200 to 6.0 grams daily. Objective measures of cardiopulmonary parameters confirm the improvement of fitness and questionnaires confirm that quality of life and mental states are improved with D-ribose administration.

    摘要翻译： 低剂量的D-核糖提高健身水平，降低45-65岁的婴儿潮一代的疲劳感觉，感觉自己疲劳。 剂量范围从0.100克到3.0克，出价为每天0.200至6.0克。 心肺参数的客观指标证实了健康状况的改善和调查表明，D-核糖管理可以改善生活质量和精神状态。

    Use of D-ribose for fatigued subjects
    3.
    发明申请
    Use of D-ribose for fatigued subjects 审中-公开
    使用D-核糖作疲劳的受试者

    公开(公告)号：US20100189785A1

    公开(公告)日：2010-07-29

    申请号：US12583430

    申请日：2009-08-20

    申请人： John A. St. Cyr ,  Dean J. MacCarter

    发明人： John A. St. Cyr ,  Dean J. MacCarter

    IPC分类号： A61K9/22 ,  A61K31/70 ,  A61P9/00 ,  A61P11/00 ,  A61P3/00

    CPC分类号： A61K31/7004 ,  A61K9/0056 ,  A61K9/08 ,  A61K9/20

    摘要： Low doses of D-ribose raise the level of fitness and lower the perception of fatigue in baby boomers aged 45-65 who perceive themselves as fatigued. The doses range from 0.100 grams to 3.0 grams, bid, for a total of 0.200 to 6.0 grams daily. Objective measures of cardiopulmonary parameters confirm the improvement of fitness and questionnaires confirm that quality of life and mental states are improved with D-ribose administration.

    摘要翻译： 低剂量的D-核糖提高健身水平，降低45-65岁的婴儿潮一代的疲劳感觉，感觉自己疲劳。 剂量范围从0.100克到3.0克，出价为每天0.200至6.0克。 心肺参数的客观指标证实了健康状况的改善和调查表明，D-核糖管理可以改善生活质量和精神状态。

    Method for improving ventilatory efficiency
    4.
    发明申请
    Method for improving ventilatory efficiency 审中-公开
    提高通气效率的方法

    公开(公告)号：US20100099630A1

    公开(公告)日：2010-04-22

    申请号：US11639476

    申请日：2006-12-15

    申请人： Dean J. MacCarter ,  John A. St. Cyr

    发明人： Dean J. MacCarter ,  John A. St. Cyr

    IPC分类号： A61K31/7004 ,  A61P11/00

    CPC分类号： A61K31/70

    摘要： This invention is a method of improving the function of the pulmonary arm of the cardiac-pulmonary axis by the administration of a pharmaceutical or nutritional supplement to a patient in which the function of the pulmonary arm is suboptimal, but not as a sequella of dysfunction of the cardiac arm. The exemplar patient is one suffering from chronic obstructive pulmonary disease. The preferred pentose is D-ribose, to be administered chronically.

    摘要翻译： 本发明是通过向患者的药物或营养补充剂施用药物或营养补充剂来改善心脏 - 肺轴的肺臂的功能的方法，其中肺部臂的功能不是最佳的，但不是作为功能障碍的后遗症 心脏手臂。 样本患者是患有慢性阻塞性肺疾病的患者。 优选的戊糖是D-核糖，长期施用。

    Use of ribose to treat fibromyalgia
    6.
    发明授权
    Use of ribose to treat fibromyalgia 有权
    使用核糖治疗纤维肌痛

    公开(公告)号：US07094762B2

    公开(公告)日：2006-08-22

    申请号：US10745959

    申请日：2003-12-27

    申请人： Terri L. Butler ,  Dean J. MacCarter ,  Daryl K. MacCarter

    发明人： Terri L. Butler ,  Dean J. MacCarter ,  Daryl K. MacCarter

    IPC分类号： A01N43/04 ,  A61K31/70

    CPC分类号： A61K31/70

    摘要： The present invention relates to methods and compositions comprising ribose and maleate for the treatment of fibromyalgia syndrome. The methods and compositions of the invention are especially useful for oral administration and are useful for alleviating the symptoms of pain, fatigue, and irritable bowel syndrome in fibromyalgia syndrome.

    摘要翻译： 本发明涉及包含核糖和马来酸盐用于治疗纤维肌痛综合征的方法和组合物。 本发明的方法和组合物对于口服给药特别有用，并且可用于减轻纤维肌痛综合征中的疼痛，疲劳和肠易激综合征的症状。

    Rate-responsive pacemaker with automatic rate response factor selection
    7.
    发明授权
    Rate-responsive pacemaker with automatic rate response factor selection 失效
    速率响应起搏器，具有自动速率响应因子选择

    公开(公告)号：US5792196A

    公开(公告)日：1998-08-11

    申请号：US823077

    申请日：1997-03-24

    申请人： Daniel Cooper ,  Dean J. MacCarter

    发明人： Daniel Cooper ,  Dean J. MacCarter

    IPC分类号： A61N1/365 ,  A01N1/36

    CPC分类号： A61N1/36521

    摘要： A rate responsive pacemaker senses an instantaneous metabolic indicative parameter such as minute volume and monitors this parameter over an extended time period of 30 days. A corresponding cumulative rate control parameter is generated. The cumulative rate parameter is converted into a metabolic pulsing rate for generating pulses in accordance with a set of physical activity parameters.

    摘要翻译： 速率响应起搏器感测瞬时代谢指示参数，如微小体积，并在30天的延长时间内监测该参数。 生成相应的累积速率控制参数。 累积速率参数被转换为用于根据一组身体活动参数产生脉冲的代谢脉冲速率。

    Pattern Recognition System for Classifying the Functional Status of Patients with Pulmonary Hypertension, Including Pulmonary Arterial and Pulmonary Vascular Hypertension
    8.
    发明申请
    Pattern Recognition System for Classifying the Functional Status of Patients with Pulmonary Hypertension, Including Pulmonary Arterial and Pulmonary Vascular Hypertension 有权
    用于分类肺动脉高压患者功能状态的模式识别系统，包括肺动脉和肺动脉高压

    公开(公告)号：US20100016750A1

    公开(公告)日：2010-01-21

    申请号：US12567005

    申请日：2009-09-25

    申请人： Stephen T. Anderson ,  Dean J. MacCarter

    发明人： Stephen T. Anderson ,  Dean J. MacCarter

    IPC分类号： A61B5/08

    CPC分类号： G06F19/3431 ,  A61B5/00 ,  A61B5/0205 ,  A61B5/024 ,  A61B5/0833 ,  A61B5/0836 ,  A61B5/4884 ,  A61B5/7264 ,  A61B5/7275 ,  G06F19/00 ,  G16H15/00 ,  G16H50/30

    摘要： A method employing pattern recognition techniques for identifying the functional status of patients with Pulmonary Hypertension is described. This method describes a process by which sets of cardiopulmonary exercise gas exchange variables are measured during rest, exercise and recovery and stored as unique data sets. The data sets are then analyzed by a series of feature extraction steps, yielding a multi-parametric index (MPIPH) which reflects the current functional status of a patient. The method also employs a description scheme that provides a graphical image that juxtaposes the measured value of MPI to a reference classification system. An additional description scheme provides a trend plot of MPI values measured on a patient over time to provide feedback to the physician on the efficacy of therapy provided to the patient. The method will enable physicians to gather, view, and track complicated data using well-understood visualization techniques to better understand the consequences of their therapeutic actions.

    摘要翻译： 描述了采用模式识别技术识别肺动脉高压患者功能状态的方法。 该方法描述了在休息，运动和恢复期间测量心肺运动气体交换变量的集合并作为唯一数据集存储的过程。 然后通过一系列特征提取步骤分析数据集，产生反映患者当前功能状态的多参数指数（MPIPH）。 该方法还采用描述方案，其提供将参考分类系统的MPI的测量值并置的图形图像。 额外的描述方案提供了随着时间的推移在患者身上测量的MPI值的趋势图，以向医师提供关于提供给患者的疗效的反馈。 该方法将使医师能够使用熟悉的可视化技术来收集，查看和跟踪复杂的数据，以更好地了解其治疗行为的后果。

    Method of defining continuous heart rate vs AV delay values and sensed to paced AV delay offset in patients undergoing cardiac resynchronization therapy
    10.
    发明授权
    Method of defining continuous heart rate vs AV delay values and sensed to paced AV delay offset in patients undergoing cardiac resynchronization therapy 有权
    在进行心脏再同步治疗的患者中定义连续心率与AV延迟值并感测到起搏AV延迟偏移的方法

    公开(公告)号：US08768463B2

    公开(公告)日：2014-07-01

    申请号：US12944001

    申请日：2010-11-11

    申请人： Stephen T. Anderson ,  Dean J. MacCarter

    发明人： Stephen T. Anderson ,  Dean J. MacCarter

    IPC分类号： A61N1/37

    CPC分类号： A61N1/3682 ,  A61N1/3627

    摘要： A method of data management for optimizing the patient outcome from the provision of cardiac resynchronization therapy (CRT) is described. A regression equation is constructed using 3 data points on a plot of AV delay vs. HR. The x-axis consist of the three points consist of resting HR, HR at the optimal AV delay value during light exercise, and the upper tracking or paced HR. The y-values associated with the three points consist of the AV delay values computed using an equation for ventricular filling time and the optimally determined AV delay value. Also described is a process for determining the sensed to paced AV delay offset. The combined processes yield 4 (the three constant values in the polynomial regression equation Y=b2X2+b1X+a and the sensed to paced AV delay offset) which can be stored on the patient's pacemaker for determining dynamically the AV delay value which is physiologically fine-tuned for each patient from resting HR to the upper tracking or paced HR. In combination with visual observation and computer-assisted ranking of the dependent variables, a physician can utilize the resulting information to render decisions on the optimal choice of the programming biventricular pacemakers/ICDs and DDDR pacemakers for individual patients.

    摘要翻译： 描述了一种用于从提供心脏再同步治疗（CRT）中优化患者结果的数据管理方法。 在AV延迟与HR的图上使用3个数据点构建回归方程。 x轴由休息HR，轻度运动期间最佳AV延迟值处的HR以及上跟踪或起搏HR组成的三个点组成。 与三点相关联的y值包括使用用于心室充盈时间的方程和最佳确定的AV延迟值计算的AV延迟值。 还描述了一种用于确定感测到的起搏AV延迟偏移的过程。 组合过程产生4（多项式回归方程中的三个常数值Y = b2X2 + b1X + a和感测到的AV延迟偏移），其可以存储在患者起搏器上以动态地确定生理学上良好的AV延迟值 将每个患者的休息时间从静息HR调整到上部跟踪或节奏的HR。 结合视觉观察和计算机辅助排列的因变量，医师可以利用所得到的信息来对个体患者的双心室起搏器/ ICD和DDDR起搏器编程的最佳选择作出决定。