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公开(公告)号：US5159911A
公开(公告)日：1992-11-03
申请号：US718981
申请日：1991-06-21
CPC分类号： F02M57/021 , F02M55/00 , F02M59/38
摘要： A fuel leakage prevention system for preventing undesired leakage of fuel into the combustion chambers of an internal combustion engine equipped with a pressure/time, cam actuated unit fuel injection system. The system includes a main housing containing an evacuatable chamber adapted to be connected by a first fluid conduit to a source of sub-atmospheric pressure by a check valve and manual shut off valve. The evacuatable chamber is also adapted to be fluidically connected to a common rail supplying fuel to the injectors by a solenoid controlled valve which is open during engine shutdown and closed during engine operation whereby fuel is withdrawn from the injectors by the vacuum upon engine shutdown.
摘要翻译： 一种用于防止燃料进入配有压力/时间，凸轮致动单元燃料喷射系统的内燃机的燃烧室的不期望的泄漏的燃料泄漏防止系统。 该系统包括一个包含可排气室的主壳体，其适于通过止回阀和手动截止阀由第一流体导管连接到亚大气压源。 可抽空室还适于流体连接到共轨，通过螺线管控制的阀向喷射器供应燃料，该电磁阀在发动机关闭期间打开并且在发动机操作期间关闭，由此在发动机关闭时通过真空从喷射器中抽出燃料。
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2.发明授权Development of masked therapeutic antibodies to limit off-target effects; application to anti-EGFR antibodies 有权开发掩蔽的治疗性抗体以限制脱靶效应; 应用于抗EGFR抗体公开(公告)号：US08895702B2
公开(公告)日：2014-11-25
申请号：US13542805
申请日：2012-07-06
CPC分类号： C07K16/2863 , C07K16/30 , C07K16/32 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32 , C07K2319/33 , C07K2319/50
摘要： In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a cross-masked mAb heterodimer complex is provided, comprising a first masked mAb, comprising a first signal sequence, a first masking epitope sequence, a first linker that is cleavable by a protease specific to a target tissue, and a first antibody or fragment thereof; and a second masked mAb, comprising a second signal sequence, a second masking epitope sequence, a second linker that is cleavable by a protease specific to a target tissue, and a second antibody or fragment thereof.
摘要翻译： 在一个实施方案中，提供了掩蔽的单克隆抗体（mAb），由核酸序列或包含信号序列，掩蔽表位序列的氨基酸序列分子编码的mAb，可通过蛋白酶特异性的蛋白酶切割的接头序列 目标组织; 和抗体或其功能片段。 在另一个实施方案中，提供了跨屏蔽的mAb异二聚体复合物，其包含第一掩蔽的mAb，其包含第一信号序列，第一掩蔽表位序列，可被靶组织特异性的蛋白酶切割的第一接头， 抗体或其片段; 和第二掩蔽的mAb，其包含第二信号序列，第二掩蔽表位序列，可被靶组织特异性的蛋白酶切割的第二接头和第二抗体或其片段。
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3.发明授权Azolyl-hydroxy alkanols having fungicidal and plant growth regulating properties 失效具有杀真菌和植物生长调节性质的唑基 - 羟基链烷醇
公开(公告)号：US4586947A
公开(公告)日：1986-05-06
申请号：US451763
申请日：1982-12-21
IPC分类号： A01N43/50 , A01N43/653 , C07D233/60 , C07D249/08 , C07D521/00
CPC分类号： C07D231/12 , A01N43/50 , A01N43/653 , C07D233/56 , C07D249/08
摘要： Compounds having the general formula (I): ##STR1## wherein Y is --CH.dbd. or .dbd.N--, R.sup.1 is alkyl, cycloalkyl optionally substituted phenyl and R.sup.2 and R.sup.3, which may be the same or different, are hydrogen, alkyl, cycloalkyl, (e.g. cyclopropyl, cyclopentyl or cyclohexyl) optionally substituted phenyl or optionally substituted benzyl, or together form an alkylene bridging group; and acid addition salts; metal complexes; ether and ester derivatives of the hydroxy groups; and stereoisomers thereof. These compounds have fungicidal and plant growth regulating properties.
摘要翻译： 具有通式（I）的化合物：其中Y是-CH =或= N-，R 1是烷基，环烷基任选取代的苯基，R 2和R 3可以相同或不同，是氢，烷基，环烷基 ，（例如环丙基，环戊基或环己基）任选取代的苯基或任选取代的苄基，或一起形成亚烷基桥基; 和酸加成盐; 金属配合物 乙醚和酯衍生物的羟基; 及其立体异构体。 这些化合物具有杀真菌和植物生长调节性质。
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公开(公告)号：US4547214A
公开(公告)日：1985-10-15
申请号：US451762
申请日：1982-12-21
IPC分类号： A01N43/50 , A01N43/653 , C07D233/60 , C07D249/08 , C07D521/00 , A01N43/64
CPC分类号： C07D231/12 , A01N43/50 , A01N43/653 , C07D233/56 , C07D249/08
摘要： Azole compounds having the general formula (I): ##STR1## wherein Y is --CH.dbd. or .dbd.N--, R.sup.1 is alkyl, cycloalkyl or optionally substituted phenyl and R.sup.2 and R.sup.3, which may be the same or different, are hydrogen, alkyl, cycloalkyl, (e.g. cyclopropyl, cyclopentyl or cyclohexyl), optionally substituted phenyl or optionally substituted benzyl, or together form an alkylene bridging group; and acid addition salts, metal complexes, ester and ether derivatives of the hydroxy group and stereoisomers thereof. The compounds are useful as plant fungicides and for plant growth regulation.
摘要翻译： 具有通式（I）的唑类化合物：其中Y为-CH =或= N-，R 1为烷基，环烷基或任选取代的苯基，R 2和R 3可以相同或不同，为 氢，烷基，环烷基（例如环丙基，环戊基或环己基），任选取代的苯基或任选取代的苄基，或一起形成亚烷基桥基; 和酸加成盐，金属络合物，羟基的酯和醚衍生物及其立体异构体。 该化合物可用作植物杀真菌剂和植物生长调节剂。
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5.发明授权公开(公告)号：US09193791B2
公开(公告)日：2015-11-24
申请号：US13424272
申请日：2012-03-19
申请人： John C. Williams , Cindy Zer , Kendra N. Avery
发明人： John C. Williams , Cindy Zer , Kendra N. Avery
CPC分类号： A61K47/481 , A61K47/55 , C07K16/2863 , C07K16/30 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/32 , C07K2319/50
摘要： In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.
摘要翻译： 在一个实施方案中，提供了掩蔽的单克隆抗体（mAb），由核酸序列或包含信号序列，掩蔽表位序列的氨基酸序列分子编码的mAb，可通过蛋白酶特异性的蛋白酶切割的接头序列 目标组织; 和抗体或其功能片段。 在另一个实施方案中，提供了掩蔽的单克隆抗体（mAb），其包括治疗性mAb和掩模，所述掩模包含蛋白质A和通过蛋白酶切割接头连接的蛋白质L.
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6.外观设计公开(公告)号：USD519084S1
公开(公告)日：2006-04-18
申请号：US29183928
申请日：2003-06-20
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公开(公告)号：US06406547B1
公开(公告)日：2002-06-18
申请号：US09618416
申请日：2000-07-18
IPC分类号： C13D316
CPC分类号： C13B10/00 , C13B20/00 , C13B20/165
摘要： A process for producing sugar from beets includes the step of filtering a sucrose-containing feed juice, which has been obtained by diffusion from sliced sugar beets, through a first ultrafiltration membrane that has a first molecular weight cutoff. This ultrafiltration step produces a first ultrafiltration permeate and a first ultrafiltration retentate. The first ultrafiltration permeate is filtered through a second ultrafiltration membrane that has a second molecular weight cutoff that is lower than the first molecular weight cutoff. This second ultrafiltration step produces a second ultrafiltration permeate and a second ultrafiltration retentate. The second ultrafiltration permeate is nanofiltered through a nanofiltration membrane, thereby producing a nanofiltration permeate and a nanofiltration retentate. The nanofiltration retentate has a higher concentration of sucrose on a dry solids basis than the feed juice in step (a), and can be used in evaporation and crystallization operations to produce crystals of white sugar. The process can optionally include ion exchange and/or electrodialysis purification steps, prior to or after the nanofiltration step. Recycle syrups can be treated with enzyme or a chromatographic separator to remove raffinose.
摘要翻译： 从甜菜制备糖的方法包括将通过从切片的甜菜中扩散获得的含蔗糖的进料汁通过具有第一分子量截留值的第一超滤膜过滤的步骤。 该超滤步骤产生第一超滤渗透物和第一超滤滞留物。 第一超滤渗透物通过具有低于第一分子量截止值的第二分子量截止值的第二超滤膜过滤。 该第二超滤步骤产生第二超滤渗透物和第二超滤滞留物。 第二超滤渗透物通过纳滤膜进行纳滤，从而产生纳滤膜渗透物和纳滤膜渗余物。 纳米过滤滞留物在干固体基础上具有比步骤（a）中的进料汁更高的蔗糖浓度，并且可用于蒸发和结晶操作以产生白糖晶体。 该方法可任选地包括在纳滤过程之前或之后的离子交换和/或电渗析纯化步骤。 可以用酶或色谱分离器处理回收糖浆以除去棉子糖。
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公开(公告)号：US5899700A
公开(公告)日：1999-05-04
申请号：US935370
申请日：1997-09-22
IPC分类号： G06F17/30 , G09B5/06 , G11B7/0033 , G11B7/00
CPC分类号： G09B5/062 , G06F17/30017 , G11B7/0033 , Y10S706/927
摘要： Methods and apparatus of integrating multimedia materials with didactic printed materials present selected relevant multimedia material in response to the sensing of control codes embedded in context sensitive and/or content sensitive didactic printed material. A store of multimedia information is created, and the store is correlated to related context and/or content sensitive didactic printed material. The store is categorized to transmit certain categories of the stored information from the store to a multimedia display in response to the reception of certain input signals obtained from certain codes embedded in the didactic printed material. The printed didactic material controls the display of the multimedia material. Either preexisting didactic printed material or currently created didactic printed material can be efficiently and economically integrated with multimedia materials to display certain selected multimedia materials at sensitive places of the printed materials.
摘要翻译： 将多媒体材料与教学印刷材料整合的方法和设备响应于嵌入在上下文敏感和/或内容敏感的教学印刷材料中的控制代码的感测，呈现所选择的相关多媒体材料。 创建多媒体信息存储，并将商店与相关背景和/或内容敏感的教学印刷材料相关联。 响应于从嵌入在教学印刷材料中的特定代码获得的某些输入信号的接收，商店被分类为将存储的信息的某些类别从商店传输到多媒体显示器。 打印的教学材料控制多媒体材料的显示。 预先存在的教学印刷材料或目前创建的教学印刷材料可以高效地和经济地与多媒体材料集成，以在印刷材料的敏感部位显示某些所选择的多媒体材料。
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公开(公告)号：US5115908A
公开(公告)日：1992-05-26
申请号：US515219
申请日：1990-04-27
申请人： John C. Williams
发明人： John C. Williams
摘要： An apparatus for handling and conveying packages includes a conveyor frame for housing a combination roller-slider bed and a belt mounted on the combination roller-slider bed to define a package-supporting conveyor surface. The conveyor drive includes a drive pulley in contact with the belt, a gearbox coupled directly to the drive pulley and an electric motor coupled directly to the gearbox. The shaft of the drive pulley is designed to fit within the output shaft of the gearbox. The motor and gearbox are mounted adjacent to but outside of the conveyor frame. Electrical or mechanical system associated with the apparatus controls the speed and acceleration of the belt.
摘要翻译： 用于处理和输送包装的装置包括用于容纳组合辊 - 滑块床的输送机框架和安装在组合辊 - 滑块床上的带以限定包装支撑输送机表面的输送机框架。 输送机驱动器包括与皮带接触的驱动滑轮，直接连接到驱动滑轮的齿轮箱和直接连接到齿轮箱的电动马达。 驱动滑轮的轴设计成适合齿轮箱的输出轴。 马达和齿轮箱安装在输送机框架附近但在输送机框架的外侧。 与设备相关的电气或机械系统控制皮带的速度和加速度。
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公开(公告)号：US4643645A
公开(公告)日：1987-02-17
申请号：US635859
申请日：1984-07-30
申请人： Kenneth E. Robbins , Stephen G. Ruggles , Dan Duncan , John C. Williams , Stephen K. Tung , William J. Sumner , Cuong V. Dinh
发明人： Kenneth E. Robbins , Stephen G. Ruggles , Dan Duncan , John C. Williams , Stephen K. Tung , William J. Sumner , Cuong V. Dinh
CPC分类号： F01D5/141 , F01D11/08 , F01D5/225 , F01D9/041 , F05D2240/81
摘要： A stage of an axial flow turbine includes a plurality of spaced apart buckets and a plurality of spaced apart nozzle partitions, each plurality respectively circumferentially aligned about and axially spaced from each other along a rotor of the turbine. The nozzle partitions are circumferentially spaced such that a minimum throat extends a predetermined radial distance from the root, thereby forming a converging-diverging flow passageway between nozzle partitions. The trailing edge of the nozzle partitions are disposed to include axial and tangential lean with respect to the rotor. Buckets include a plurality of covers respectively connecting the tips and having a single outward radially extending sealing rib on the radially outer surface of each cover, wherein each rib is tangentially aligned with respective adjacent ribs. Buckets are overtwisted to compensate for untwist at operational speed to achieve optimum efficiency. Buckets are circumferentially spaced to provide a converging-diverging channel therebetween and include lashing for providing mechanical coupling at operational speed.
摘要翻译： 轴流涡轮机的一个阶段包括多个间隔开的铲斗和多个间隔开的喷嘴隔板，每个分隔开的喷嘴隔板沿着涡轮机的转子沿着圆周对准并且沿轴向间隔开。 喷嘴分隔件周向间隔开，使得最小喉部从根部延伸预定的径向距离，从而在喷嘴隔板之间形成会聚 - 发散的流动通道。 喷嘴隔板的后缘设置成包括相对于转子的轴向和切向倾斜。 铲斗包括分别连接尖端并且在每个盖的径向外表面上具有单个向外径向延伸的密封肋的多个盖，其中每个肋与相应的相邻肋切线对齐。 铲斗被扭曲以在运行速度下补偿解锁以达到最佳效率。 铲斗周向间隔开，以在它们之间提供会聚发散通道，并且包括用于以操作速度提供机械联接的绑扎。
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