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9 条记录 (耗时 0.019 秒)

    Fibrin sealants and platelet concentrates applied to effect hemostasis at the interface of an implantable medical device with body tissue
    4.
    发明申请
    Fibrin sealants and platelet concentrates applied to effect hemostasis at the interface of an implantable medical device with body tissue 审中-公开
    纤维蛋白密封剂和血小板浓缩物用于在植入式医疗装置与身体组织的界面处进行止血

    公开(公告)号：US20060190017A1

    公开(公告)日：2006-08-24

    申请号：US11282276

    申请日：2005-11-18

    申请人： John Cyr ,  Nancy Rakow ,  Linda Shecterle

    发明人： John Cyr ,  Nancy Rakow ,  Linda Shecterle

    IPC分类号： A61F2/04

    CPC分类号： A61L15/32 ,  A61F2/06 ,  A61F2/24 ,  A61L15/40

    摘要： Surgical methods of and kits for applying and stabilizing a mass of fibrin sealant or platelet concentrate at the site of surgical attachment of an implantable medical device to effect hemostasis to stem internal bleeding at the site of surgical attachment are disclosed. A mass of fibrin sealant or platelet concentrate is applied onto a porous fabric, whereby the mass is supported in the interstices or pores of the fabric, and the supported mass is applied against the site of high pressure blood leakage. The supported mass achieves hemostasis as it does not wash away from the site. The present invention is particularly useful to effect hemostasis at sutures and suture holes extending through thin-walled tissue valves and grafts when such tissue valves or grafts are sutured in place, particularly at high blood pressure sites as at the valve annulus of the aortic valve or the aorta.

    摘要翻译： 公开了用于在植入式医疗装置的手术附接部位施用和稳定大量纤维蛋白密封剂或血小板浓缩物的手术方法和试剂盒，以实现止血以阻止手术附件部位的内部出血。 将大量的纤维蛋白密封剂或血小板浓缩物施加到多孔织物上，由此将质量支撑在织物的间隙或孔中，并将支撑的物质施加在高压血液渗漏部位。 支撑的物质实现止血，因为它不会从现场洗掉。 本发明特别有用于在将这种组织瓣膜或移植物缝合到适当位置时，特别是在主动脉瓣的瓣膜环上的高血压位置时，通过延伸穿过薄壁组织瓣膜和移植物的缝合线和缝合孔进行止血，或 主动脉。

    Scalable switching fabric
    5.
    发明授权
    Scalable switching fabric 失效
    可扩展交换结构

    公开(公告)号：US06687246B1

    公开(公告)日：2004-02-03

    申请号：US09387047

    申请日：1999-08-31

    申请人： Gilbert Wolrich ,  Matthew J. Adiletta ,  John Cyr

    发明人： Gilbert Wolrich ,  Matthew J. Adiletta ,  John Cyr

    IPC分类号： H04Q1100

    CPC分类号： H04L49/10 ,  H04L49/101 ,  H04L49/254 ,  H04L49/3045 ,  H04L49/45

    摘要： A switch fabric includes a first plurality of data switches each having a plurality of input ports and a plurality of output ports the plurality of switches capable of switching any of its input ports to any of its output ports with the plurality of data switches having inputs coupled to a plurality of input buses so that a first byte of a first one of the input buses is coupled to a first one of the plurality of switches, and a succeeding byte of the first input bus is coupled to a succeeding one of the plurality of switches.

    摘要翻译： 交换结构包括每个具有多个输入端口和多个输出端口的第一多个数据开关，所述多个开关能够将其任何输入端口切换到其任何输出端口，并且所述多个数据开关具有耦合的输入 到多个输入总线，使得输入总线中的第一个的第一字节耦合到多个开关中的第一个，并且第一输入总线的后续字节耦合到多个输入总线中的后一个 开关。

    Use of ribose to alleviate rhabdomyolysis and the side effects of statin drugs
    6.
    发明申请
    Use of ribose to alleviate rhabdomyolysis and the side effects of statin drugs 审中-公开
    使用核糖缓解横纹肌溶解症和他汀类药物的副作用

    公开(公告)号：US20060135440A1

    公开(公告)日：2006-06-22

    申请号：US11300178

    申请日：2005-12-14

    申请人： Mark Houston ,  John Cyr

    发明人： Mark Houston ,  John Cyr

    IPC分类号： A61K31/70

    CPC分类号： A61K31/70

    摘要： A method of alleviating the symptoms of rhabdomyolysis or the side effects of statin DRUG administration is disclosed. The method comprises the administration of D-ribose in doses of three to ten grams at least twice a day until the symptoms or side effects are alleviated.

    摘要翻译： 公开了缓解横纹肌溶解症状或他汀类药物治疗药物副​​作用的方法。 该方法包括每日至少两次给予三至十克剂量的D-核糖，直到缓解症状或副作用。

    Distributed packet data with centralized snooping and header processing router
    7.
    发明授权
    Distributed packet data with centralized snooping and header processing router 失效
    分布式数据包采用集中侦听和报头处理路由器

    公开(公告)号：US6160809A

    公开(公告)日：2000-12-12

    申请号：US992453

    申请日：1997-12-17

    申请人： Matthew James Adiletta ,  Gilbert Wolrich ,  John Cyr

    发明人： Matthew James Adiletta ,  Gilbert Wolrich ,  John Cyr

    IPC分类号： H04L12/40 ,  H04L12/54

    CPC分类号： H04L12/403 ,  H04L12/40013 ,  H04L12/40032

    摘要： A packet processing system or router is disclosed that has at least one central packet-header processor, a packet broadcast bus, and local packet controllers that communicate with each other and the central packet-header processor via the packet broadcast bus. Packets received by media access controllers are passed to the associated local packet controllers and then broadcast on the packet broadcast bus. These broadcast packets are stored in packet buffer memories of the controllers, and the processor snoops for at least headers of the broadcast packets. The headers are analyzed and the processor issues forwarding instructions concerning the broadcast packets to the local packet controllers. As a result, the packet data only traverses the bus once. Only a relatively short forwarding decision is generated after the packets are broadcast and this can occur on a separate control bus, if desired. Thus, by employing centralized snooping for packet header processing coupled with distributed packet data at local controller, bus bandwidth is reduced by one-half over previous centralized configurations in which every packet traversed the bus at least twice.

    摘要翻译： 公开了一种分组处理系统或路由器，其具有至少一个中央分组报头处理器，分组广播总线和经由分组广播总线相互通信的中央分组报头处理器的本地分组控制器。 由媒体接入控制器接收的分组被传递到相关联的本地分组控制器，然后在分组广播总线上广播。 这些广播包被存储在控制器的包缓冲存储器中，并且处理器至少侦听广播包的头部。 分析头部，并且处理器向本地分组控制器发出关于广播分组的转发指令。 因此，分组数据只能遍历总线一次。 如果需要，在分组被广播之后仅产生相对较短的转发决定，并且这可以发生在单独的控制总线上。 因此，通过在本地控制器上与分组分组数据相结合的分组报头处理采用集中式侦听，总线带宽比之前的集中式配置减少了一半，其中每个数据包都经过总线至少两次。

    Chelators for radioactively labeled conjugates comprising a stabilizing sidechain
    9.
    发明申请
    Chelators for radioactively labeled conjugates comprising a stabilizing sidechain 失效

    公开(公告)号：US20060263295A1

    公开(公告)日：2006-11-23

    申请号：US11371241

    申请日：2006-03-09

    申请人： John Cyr

    发明人： John Cyr

    IPC分类号： A61K51/00 ,  A61K38/31

    CPC分类号： A61K51/088 ,  A61K51/083

    摘要： The invention relates to a conjugate PT comprising (a) a peptide P and (b) a targeting moiety T; wherein the peptide P contains from 4 to 20 amino acid residues with optionally a single thiol moiety at the C— or N-terminus replacing one of these amino acid residues, and including a complexing amino acid sequence comprising (iv) a tridentate or tetradentate planar chelator containing a ligand backbone defined by a perimeter containing a single sulfur donor atom, two or three non-sulfur donor atoms, and intervening atoms between the donor atoms; and (v) a stabilizing sidechain comprising a further donor atom, the further donor atom being covalently linked to the ligand backbone of the planar chelator through two or three intervening atoms, provided that said further donor atom is neither the nitrogen nor the oxgen atom of a peptide bond and if said further donor atom is part of a heterocyclic ring, no more than one of the intervening atoms can be part of that ring; and a radioactive metal complexed to the donor atoms of the planar chelator.